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Proteins that bind to the yeast rDNA enhancer 总被引:21,自引:0,他引:21
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Sequences within the spacer region of yeast rRNA cistrons that stimulate 35S rRNA synthesis in vivo mediate RNA polymerase I-dependent promoter and terminator activities. 总被引:13,自引:8,他引:5 下载免费PDF全文
R Mestel M Yip J P Holland E Wang J Kang M J Holland 《Molecular and cellular biology》1989,9(3):1243-1254
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The functional human dihydrofolate reductase gene 总被引:54,自引:0,他引:54
M J Chen T Shimada A D Moulton A Cline R K Humphries J Maizel A W Nienhuis 《The Journal of biological chemistry》1984,259(6):3933-3943
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A very large repeating unit of mouse DNA containing the 18S, 28S and 5.8S rRNA genes 总被引:26,自引:0,他引:26
The organization of the 18S, 28S and 5.8S rRNA genes in the mouse has been elucidated by mapping with restriction endonucleases Eco RI, Hind III and Bam HI. Ribosomal DNA fragments were detected in electrophoretically fractionated digests of total nuclear DNA by in situ hybridization with radioiodinated rRNAs or with complementary RNA synthesized directly on rRNA templates. A map of the rDNA which includes 13 restriction sites was constructed from the sizes of rDNA fragments and their labeling by different probes The map indicates that the rRNA genes lie within remarkably large units of reiterated DNA, at least 44,000 base pairs long. At least two, and possibly four, classes of repeating unit can be distinguished, the heterogeneity probably residing in the very large nontranscribed spacer region. The 5.8S rRNA gene lies in the transcribed region between the 18S and 28S genes. 相似文献
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