《微生物学报》征稿简则

1《微生物学报》由中国微生物学会和中国科学院微生物研究所共同主办,他是以微生物学基础研究和应用基础研究及高技术创新为主的综合性学术刊物,反映我国微生物学研究领域中最新成果,促进国内外学术交流,为我国的经济建设服务.[2] 报道内容:主要刊登我国普通微生物学,工业、农业、医学、兽医微生物学,病毒学,免疫学和与微生物学有关的生物工程等方面的研究论文、研究简报、小型综述及评论等.[3] 读者对象:国内外从事微生物学及相关学科的研究、技术和教学人员.     

欢迎订阅《微生物学报》

《微生物学报》创刊于１９５３年,双月刊,１１２页,双月４日出版,是以微生物学基础研究和应用基础研究以及高技术创新为主的综合性学术刊物,反映我国微生物学研究领域中最新成果,促进国内外学术交流,为我国的经济建设服务。报道内容：我国普通微生物学,工业、农业、医学、兽医微生物学,病毒学,免疫学以及与微生物学有关的生物工程等方面的高水平的研究成果。设有研究论文、研究简报和小型综述等栏目。读者对象：国内外从事微生物学研究以及与微生物学有关的科研和教学人员。《微生物学报》历史悠久,发行量大,内容涵盖面广,是中…     

快速发展的我国环境微生物学——“第十一次全国环境微生物学学术研讨会”专刊序言

2008年11月“第十一次全国环境微生物学学术研讨会”在江苏无锡顺利召开, 这次大会充分反映了我国环境微生物学界取得的最新进展。为了展现我国环境微生物学工作者取得的新成果,《微生物学通报》在08年“环境微生物专刊”的基础上, 针对“第十一次全国环境微生物学学术研讨会”组织出版了新一期专刊, 期望该专刊的出版能进一步推动我国环境微生物学相关领域的交流和发展。     

中外微生物学教材建设状况调查与分析比较

优秀教材是高水平课程教学的前提与基础.本文对国内外微生物学教材的建设和发展状况进行了调查研究和分析比较,希望能为今后我国选择、引进、利用国外优秀英文版微生物学教材,以及加强我国自身高水平微生物学教材建设的工作提供借鉴.     

我国当代微生物学课程建设与教学改革研究进展——“高等院校教学专刊”序言

积极进行微生物学教学改革经验交流,对于提高高等院校微生物学教学水平和微生物学相关人才培养质量具有重要意义。为了反映我国当代微生物学课程建设与教学改革的最新进展和发展态势,《微生物学通报》以"第十五届全国微生物学教学和科研及成果产业化研讨会"大会为契机,邀约有微生物学及相关学科教学经验的高校教师撰写稿件,通过严格评审后择优选取文章,组织出版了这期"高等院校教学专刊",期望该专刊的出版有助于我国高校微生物学教师间的教改经验交流与合作。     

《微生物学报》投稿须知

《微生物学报》创刊于 1 95 3年 ,双月刊 ,双月 4日出版 ,由中国微生物学会和中国科学院微生物研究所共同主办。他是我国生物科学类核心期刊 ,被国内外一些重要的文摘刊物和数据库收录 ,多次被评为优秀科技期刊。 2 0 0 1年入选“中国科技期刊方阵”。1　办刊宗旨《微生物学报》是以微生物学基础研究和应用基础研究以及高技术创新为主的综合性学术刊物 ,反映我国微生物学研究领域最新科研成果 ,报道国内外最新研究动态 ,促进学术交流 ,为我国的经济建设服务。2　内容及栏目主要刊登我国普通微生物学 ,工业、农业、医学微生物学 ,病毒学 ,免…     

《微生物学报》投稿须知

《微生物学报》创刊于 1 95 3年 ,双月刊 ,双月 4日出版 ,由中国微生物学会和中国科学院微生物研究所共同主办。他是我国生物科学类核心期刊 ,被国内外一些重要的文摘刊物和数据库收录 ,多次被评为优秀科技期刊。 2 0 0 1年入选“中国科技期刊方阵”。1　办刊宗旨《微生物学报》是以微生物学基础研究和应用基础研究以及高技术创新为主的综合性学术刊物 ,反映我国微生物学研究领域最新科研成果 ,报道国内外最新研究动态 ,促进学术交流 ,为我国的经济建设服务。2　内容及栏目主要刊登我国普通微生物学 ,工业、农业、医学微生物学 ,病毒学 ,免…     

欢迎订阅2004年《微生物学杂志》

《微生物学杂志》是包括工业微生物学、农业微生物学、医学医药微生物学、兽医微生物学、食用菌及生物工程学在内的综合性学术刊物,为我国生物学核心期刊。1987年开始被美国《化学文摘C·A》、《中国生物学文摘》等国内外重要检索刊物摘引和收录。主要任务有开展学     

农业院校微生物学教育质量浅析

微生物学是生命科学的重要组成部分 ,它既是农业院校植物生产类专业的专业基础课 ,也是生物学、微生物学、生物技术、生物工程和食品科学等理工科专业的重要专业基础课 ,学好微生物学 ,能为学生学习植物病理学、食用菌栽培学、分子生物学、发酵工艺学、组织培养及农业化学打下良好的基础。50、60年代 ,我国农业院校的微生物学课程通常安排在 80学时左右 ,由于学时数较多 ,学生学的比较扎实。我国 70、80年代食用菌的迅速发展 ,得益于农业院校毕业生扎实的微生物学功底。农业院校随着教育改革的深化 ,专业设置和调整 ,微生物学课程的设置也发…     

《微生物学报》征稿简则

一、刊物简介和栏目设置《微生物学报》由中国科学院微生物研究所和中国微生物学会主办,国内外公开发行。主要报道国内外微生物学研究领域的最新科研成果和研究动态,内容涵盖工业、农业、医学、兽医微生物学、病毒学、免疫学等现代生物技术的各个领域。本刊是我国微生物学领域最具影响力的综合性     

Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures

Defects in mitochondrial energy metabolism have been implicated in the pathology of several neurodegenerative disorders. In addition, the reactive metabolites generated from the metabolism and oxidation of the neurotransmitter dopamine (DA) are thought to contribute to the damage to neurons of the basal ganglia. We have previously demonstrated that infusions of the metabolic inhibitor malonate into the striata of mice or rats produce degeneration of DA nerve terminals. In the present studies, we demonstrate that an intrastriatal infusion of malonate induces a substantial increase in DA efflux in awake, behaving mice as measured by in vivo microdialysis. Furthermore, pretreatment of mice with tetrabenazine (TBZ) or the TBZ analogue Ro 4-1284 (Ro-4), compounds that reversibly inhibit the vesicular storage of DA, attenuates the malonate-induced DA efflux as well as the damage to DA nerve terminals. Consistent with these findings, the damage to both DA and GABA neurons in mesencephalic cultures by malonate exposure was attenuated by pretreatment with TBZ or Ro-4. Treatment with these compounds did not affect the formation of free radicals or the inhibition of oxidative phosphorylation resulting from malonate exposure alone. Our data suggest that DA plays an important role in the neurotoxicity produced by malonate. These findings provide direct evidence that inhibition of succinate dehydrogenase causes an increase in extracellular DA levels and indicate that bioenergetic defects may contribute to the pathogenesis of chronic neurodegenerative diseases through a mechanism involving DA.     

2018年中国植物科学若干领域重要研究进展

2018年中国植物科学继续呈现快速发展的态势, 我国科学家在国际植物科学主流学术刊物发表论文数量大幅增加, 取得了多项具有重要影响的成果。调控植物生长-代谢平衡实现可持续农业发展入选2018年度中国科学十大进展; 中国被子植物区系进化历史研究入选2018年度中国生命科学十大进展。以水稻为代表的农作物和果蔬等经济作物研究在国际上已呈现出明显的优势, 若干领域已从“追赶”状态跨越到“领跑”地位。该文对2018年中国科学家在植物科学若干领域取得的重要研究成果进行了概括性评述, 旨在全面追踪和报道当前中国植物科学领域的发展前沿和热点, 展示中国科学家所取得的杰出成就。     

2017年中国植物科学若干领域重要研究进展

2017年中国植物科学继续保持高速发展态势, 重大成果频出, 具体表现在中国植物学家在国际顶级学术期刊发表的文章数量平稳上升。中国植物科学领域的研究工作者成果精彩纷呈, 如新型广谱抗病机制的发现、水稻广谱抗病遗传基础及机制和疫霉菌诱发病害成灾机制研究等。2017年中国生命科学领域十大进展评选中, 有两项植物科学领域的研究成果入选。水稻生物学、进化与基因组学和激素生物学等领域学科发展突出。另外, 值得一提的是, 长期从事高等植物与代谢途径调控分子网络研究和水稻品种设计育种的李家洋院士的研究成果“水稻高产优质性状形成的分子机理及品种设计”荣获2017年国家自然科学一等奖。这一具有重大国际影响的开创性贡献标志着中国植物科学在该领域的国际科学前沿居于引领和卓越地位。该文对2017年中国本土科学家在植物科学若干领域取得的重要研究成果进行了系统梳理, 旨在全面追踪和报道当前中国植物科学领域发展的最新前沿动态, 与广大读者共同分享我国科学家所取得的辉煌成就。     

我国葫芦科植物离体培养研究进展

葫芦科植物包括多种瓜类蔬菜,对其进行离体培养研究具有重要的理论和实践意义。综述了国内在葫芦科植物器官培养、体细胞胚胎发生、花药培养、原生质体培养和体细胞杂交及离体遗传转化等方面取得的研究进展,并对葫芦科植物离体培养、遗传转化与育种的前景作了展望。     

SSTR5 ablation in islet results in alterations in glucose homeostasis in mice

Somatostatin (SST) peptide is a potent inhibitor of insulin secretion and its effect is mediated via somatostatin receptor 5 (SSTR5) in the endocrine pancreas. To investigate the consequences of gene ablation of SSTR5 in the mouse pancreas, we have generated a mouse model in which the SSTR5 gene was specifically knocked down in the pancreatic beta cells (betaSSTR5Kd) using the Cre-lox system. Immunohistochemistry analysis showed that SSTR5 gene expression was absent in beta cells at three months of age. At the time of gene ablation, betaSSTR5Kd mice demonstrated glucose intolerance with lack of insulin response and significantly reduced serum insulin levels. Insulin tolerance test demonstrated a significant increase of insulin clearance in vivo at the same age. In vitro studies demonstrated an absence of response to SST-28 stimulation in the betaSSTR5Kd mouse islet, which was associated with a significantly reduced SST expression level in betaSSTR5Kd mice pancreata. In addition, betaSSTR5Kd mice had significantly reduced serum glucose levels and increased serum insulin levels at 12 months of age. Glucose tolerance test at an older age also indicated a persistently higher insulin level in betaSSTR5Kd mice. Further studies of betaSSTR5Kd mice had revealed elevated serum C-peptide levels at both 3 and 12 months of age, suggesting that these mice are capable of producing and releasing insulin to the periphery. These results support the hypothesis that SSTR5 plays a pivotal role in the regulation of insulin secretion in the mouse pancreas.     

2018年中国植物科学若干领域重要研究进展

2018年中国植物科学继续呈现快速发展的态势, 我国科学家在国际植物科学主流学术刊物发表论文数量大幅增加, 取得了多项具有重要影响的成果。调控植物生长-代谢平衡实现可持续农业发展入选2018年度中国科学十大进展; 中国被子植物区系进化历史研究入选2018年度中国生命科学十大进展。以水稻为代表的农作物和果蔬等经济作物研究在国际上已呈现出明显的优势, 若干领域已从“追赶”状态跨越到“领跑”地位。该文对2018年中国科学家在植物科学若干领域取得的重要研究成果进行了概括性评述, 旨在全面追踪和报道当前中国植物科学领域的发展前沿和热点, 展示中国科学家所取得的杰出成就。     

我国葫芦科植物离体培养研究进展

葫芦科植物包括多种瓜类蔬菜,对其进行离体培养研究具有重要的理论和实践意义.综述了国内在葫芦科植物器官培养、体细胞胚胎发生、花药培养、原生质体培养和体细胞杂交及离体遗传转化等方面取得的研究进展,并对葫芦科植物离体培养、遗传转化与育种的前景作了展望.     

Changes in aquatic vegetation in Rhine floodplain streams in Alsace in relation to disturbance

Abstract. Changes are described in aquatic vegetation in oligotrophic, groundwater-fed Rhine floodplain streams in Alsace (eastern France), resulting from disturbance. Disturbance factors include changes in nutrients, either permanent ones - effluent from a waste water treatment plant or trout hatcheries - or periodic ones: flooding. Regular inputs of high levels of phosphate and ammonia modified the macrophyte vegetation in these streams. The floristic composition, which was characteristic of oligotrophic waters upstream of the eutrophicated sector, changed to that of a eutrophic situation as originally found downstream. Periodic disturbance by floods which normally occur once a year, irregularly eutrophicates the small streams, causing the development of a mixture of eutrophic and oligotrophic species. Six macrophyte communities are distinguished, indicating different trophic levels. The aquatic vegetation is adapted to the variations of phosphate and ammonia levels. Hence, aquatic macrophytes can be used as bio-indicators of fluctuations in water nutrient levels in relation to the type of disturbance.     

Apoptosis in experimental myocardial infarction in situ and in the perfused heart in vitro

We report the appearance of apoptotic cells in experimental myocardial infarction (rabbit heart) in in situ and in vitro preparations. Apoptosis was recognized by intravital staining with Hoechst 33342 (Ho342), by nick-end labeling (TUNEL) and by DNA laddering. A steady rise in the relative number of apoptotic cardiomyocytes (apoptotic index) was noted in in situ preparations. Apoptosis was first noted 6 h after the onset of ischemia with its highest value occurring after 72 h. Apoptotic nuclei were absent in remote areas of the left and right ventricles. Apoptotic nuclei within the infarcted area showed diminished intensity of Ho342 fluorescence. Three days after ischemia, a border zone adjacent to the infarcted area consisting of apoptotic macrophages was recognized. A novel finding was the appearance of apoptotic cardiomyocytes in the isolated perfused ischemic heart. Occurring as early as 50 min after the onset of ischemia, a high apoptotic index was present adjacent to the ligature placed around the coronary artery. This observation provides the opportunity to selectively examine factors leading to apoptosis in the ischemic heart under controlled experimental conditions.     

Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments

The detailed mechanisms underlying morphine-signaling pathways in platelets remain obscure. Therefore, we systematically examined the influence of morphine on washed human platelets. In this study, washed human platelet suspensions were used for in vitro studies. Furthermore, platelet thrombus formation induced by irradiation of mesenteric venules with filtered light in mice pretreated with fluorescein sodium was used for an in vivo thrombotic study. Morphine concentration dependently (0.6, 1, and 5 microM) potentiated platelet aggregation and the ATP release reaction stimulated by agonists (i.e., collagen and U46619) in washed human platelets. Yohimbine (0.1 microM), a specific alpha(2)-adrenoceptor antagonist, markedly abolished the potentiation of morphine in platelet aggregation stimulated by agonists. Morphine also potentiated phosphoinositide breakdown and intracellular Ca(2+) mobilization in human platelets stimulated by collagen (1 microg/ml). Moreover, morphine (0.6-5 microM) markedly inhibited prostaglandin E(1) (10 microM)-induced cyclic AMP formation in human platelets, while yohimbine (0.1 microM) significantly reversed the inhibition of cyclic AMP by morphine (0.6 and 1 microM) in this study. The thrombin-evoked increase in pH(i) was markedly potentiated in the presence of morphine (1 and 5 microM). Morphine (2 and 5 mg/g) significantly shortened the time require to induce platelet plug formation in mesenteric venules. We concluded that morphine may exert its potentiation in platelet aggregation by binding to alpha(2)-adrenoceptors in human platelets, with a resulting inhibition of adenylate cyclase, thereby reducing intracellular cyclic AMP formation followed by increased activation of phospholipase C and the Na(+)/H(+) exchanger. This leads to increased intracellular Ca(2+) mobilization, and finally potentiation of platelet aggregation and of the ATP release reaction.