共查询到20条相似文献,搜索用时 78 毫秒
1.
Tuo Deng Christopher J. Lyon Laurie J. Minze Jianxin Lin Jia Zou Joey Z. Liu Yuelan Ren Zheng Yin Dale J. Hamilton Patrick R. Reardon Vadim Sherman Helen Y. Wang Kevin J. Phillips Paul Webb Stephen T.C. Wong Rong-fu Wang Willa A. Hsueh 《Cell metabolism》2013,17(3):411-422
Highlights? Obesity enhances MHCII expression in primary human and mouse adipocytes ? Adipocytes activate CD4+ ARTs via MHCII and leptin to induce adipose inflammation ? Macrophage changes in adipose follow adipocyte and T cell interactions during HFD ? Adaptive immune mechanisms are essential to obesity-induced adipose inflammation 相似文献
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Michel Ruiz Rosquete Daniel von Wangenheim Peter Marhavý Elke Barbez Ernst H.K. Stelzer Eva Benková Alexis Maizel Jürgen Kleine-Vehn 《Current biology : CB》2013,23(9):817-822
Highlights? Emerging lateral roots show conserved and partially suppressed orthogravitropism. ? Low and high auxin levels lead to radial and axial root systems, respectively. ? Auxin-dependent regulation of GSA requires PIN auxin efflux carrier activity. ? Suppression of PIN4/PIN7 and temporal PIN3 expression limit earliest LR GSA formation 相似文献
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Highlights? Leishmania infection reduces liver miR-122 and lowers serum cholesterol ? Leishmania metalloprotease gp63 is required for inhibition of hepatic miR-122 activity ? gp63 cleaves DICER1 to downregulate miRNP-122 formation in hepatocytes ? Restoration of miR-122 elevates serum cholesterol to reduce liver parasite load 相似文献
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Natalie J. Spillman Richard J.W. Allen Case W. McNamara Bryan K.S. Yeung Elizabeth A. Winzeler Thierry T. Diagana Kiaran Kirk 《Cell host & microbe》2013,13(2):227-237
Highlights? The intraerythrocytic malaria parasite extrudes Na+ via a Na+-ATPase ? Parasite Na+ homeostasis is disrupted by the antimalarial spiroindolones ? Mutations in PfATP4 confer resistance to Na+ disruption by the spiroindolones ? PfATP4 is postulated to be a Na+ efflux ATPase and a target of the spiroindolones 相似文献
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Youm YH Kanneganti TD Vandanmagsar B Zhu X Ravussin A Adijiang A Owen JS Thomas MJ Francis J Parks JS Dixit VD 《Cell reports》2012,1(1):56-68
Highlights? Nlrp3 inflammasome senses age-related increase in thymic ceramides and free cholesterol ? Age-related intrathymic caspase-1 activation is mediated partly by Nlrp3 inflammasome ? Reduced Nlrp3 inflammasome activation slows thymic aging and T cell senescence ? Nlrp3 loss enhances T cell reconstitution after radiation and bone marrow transplantation 相似文献
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Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
8.
Fabian Anton Gunnar Dittmar Thomas Langer Mafalda Escobar-Henriques 《Molecular cell》2013,49(3):487-498
Highlights? Mitochondrial fusion is regulated by independent ubiquitylation pathways ? The deubiquitylase Ubp2 promotes fusion, whereas Ubp12 inhibits fusion events ? Self-assembly and ubiquitylation cooperatively enable mitochondrial fusion ? Yeast mitofusin is sequentially ubiquitylated 相似文献
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Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination 相似文献
10.
《Current opinion in biotechnology》2013,24(2):256-262
Highlights► The plastidial pyruvate transporter in plants is driven by sodium symport. ► The mitochondrial pyruvate transporter MPC has been identified. ► All transporters needed for a synthetic PEP-CK/C4 photosynthetic cycle are now known. ► The SWEET proteins define a new class of sugar efflux carriers in plants. 相似文献
11.
Nathan F. Putman Kenneth J. Lohmann Emily M. Putman Thomas P. Quinn A. Peter Klimley David L.G. Noakes 《Current biology : CB》2013,23(4):312-316
Highlights? Sockeye salmon use geomagnetic imprinting as a homing mechanism ? The homing route of salmon is predicted by magnetic field drift (secular variation) 相似文献
12.
Highlights? Discovery that Rspo3 binds syndecan 4 ? Rspo3/Sdc4 induce Wnt/PCP signaling via clathrin-mediated endocytosis ? Rspo3/PCP signaling is essential for gastrulation and cartilage morphogenesis 相似文献
13.
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
Carlos F. Pereira Francesco M. Piccolo Tomomi Tsubouchi Stephan Sauer Natalie K. Ryan Ludovica Bruno David Landeira Joana Santos Ana Banito Jesus Gil Haruhiko Koseki Matthias Merkenschlager Amanda G. Fisher 《Cell Stem Cell》2010,6(6):547-556
Highlights? Mouse pluripotent cells reprogram human B cells in heterokaryons ? ESCs lacking PRC1 or PRC2 cannot successfully reprogram ? Failure of PRC1/2-deficient ESCs to reprogram is functionally dominant ? PRC1/2 play a critical role in the chromatin reorganization required for reprogramming 相似文献
14.
Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
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Highlights? Hipk induces tissues overgrowth and leads to activation of Yki target genes ? Hipk is required for activity of hyperactive Yki ? Hipk kinase function is essential to promote Yki target genes 相似文献
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Tommy E. White Alberto Brandariz-Nuñez Jose Carlos Valle-Casuso Sarah Amie Laura Anh Nguyen Baek Kim Marina Tuzova Felipe Diaz-Griffero 《Cell host & microbe》2013,13(4):441-451
Highlights? SAMHD1 only exhibits antiviral activity when expressed in noncycling cells ? SAMHD1 is unphosphorylated in noncycling cells ? Reverse genetics revealed that phosphorylated SAMHD1 is repressive for restriction ? SAMHD1 phosphorylation regulates restriction, but not the cellular levels of dNTPs 相似文献
18.
Colin A. Smith Catherine A. Shi Matthew K. Chroust Thomas E. Bliska Mark J.S. Kelly Matthew P. Jacobson Tanja Kortemme 《Structure (London, England : 1993)》2013,21(1):54-64
Highlights? Successful design of phosphorylation sites into a globular protein ? Redesigned PDZ domain phosphorylation is associated with local destabilization ? Phosphorylation switches peptide binding function ? Phosphorylation switches peptide recognition specificity 相似文献
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Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
20.
Eigenbrot C Ultsch M Lipari MT Moran P Lin SJ Ganesan R Quan C Tom J Sandoval W van Lookeren Campagne M Kirchhofer D 《Structure (London, England : 1993)》2012,20(6):1040-1050
Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1 相似文献