共查询到20条相似文献,搜索用时 31 毫秒
1.
Sa Kan Yoo Qing Deng Peter J. Cavnar Yi I. Wu Klaus M. Hahn Anna Huttenlocher 《Developmental cell》2010,18(2):226-236
Highlights? Neutrophil motility in live zebrafish requires PI(3)K activity at the leading edge ? Localized photo-activation of Rac can to direct migration in vivo ? Rac activation rescues protrusion but not polarization in PI(3)K-inhibited cells ? Separable two-tier regulation of F-actin dynamics and protrusion by PI(3)K 相似文献
2.
Paulo A. Gameiro Juanjuan Yang Ana M. Metelo Rocio Pérez-Carro Rania Baker Zongwei Wang Alexandra Arreola W. Kimryn Rathmell Aria Olumi Pilar López-Larrubia Gregory Stephanopoulos Othon Iliopoulos 《Cell metabolism》2013,17(3):372-385
Highlights? HIF is necessary and sufficient to induce reductive carboxylation in RCC cell lines ? HIF promotes the reductive carboxylation flux by reducing citrate levels ? HIF-expressing tumors display reductive carboxylation in vivo ? HIF renders RCC cells sensitive to glutaminase inhibition in vitro and in vivo 相似文献
3.
Kuancan Liu Ming Jiang Yun Lu Hao Chen Jun Sun Shaoping Wu Wei-Yao Ku Hiroshi Nakagawa Yoshiaki Kita Shoji Natsugoe Jeffrey H. Peters Anil k. Rustgi Mark W. Onaitis Amy Kiernan Xiaoxin Chen Jianwen Que 《Cell Stem Cell》2013,12(3):304-315
Highlights? Sox2+ve basal stem/progenitor cells self-renew and differentiate in vitro and in vivo ? Conditional Sox2 overexpression promotes the expansion of basal progenitor cells ? Sox2 cooperates with an inflammatory microenvironment to induce squamous cancer ? Sox2 and Stat3 together transform mouse and human esophageal progenitor cells 相似文献
4.
Milka Sarris Jean-Baptiste Masson Damien Maurin Lieke M. Van der Aa Pierre Boudinot Hugues Lortat-Jacob Philippe Herbomel 《Current biology : CB》2012,22(24):2375-2382
Highlights? Chemokines form tissue-bound gradients in vivo through heparan sulfate proteoglycans ? Chemokines guide neutrophils in vivo as haptotactic gradients ? Chemokines guide neutrophils toward infection loci by triggering orthotaxis ? Chemokines locally restrict neutrophil motility at sites of infection 相似文献
5.
Pilar Gonzalo Marta C. Guadamillas María Victoria Hernández-Riquer Ángela Pollán Araceli Grande-García Rubén A. Bartolomé Amit Vasanji Chiara Ambrogio Roberto Chiarle Joaquín Teixidó Juha Risteli Suneel S. Apte Miguel A. del Pozo Alicia G. Arroyo 《Developmental cell》2010,18(1):77-89
Highlights? Myeloid cells fuse during osteoclast and giant cell formation ? MT1-MMP is required for this fusion in vitro and in vivo ? MT1-MMP regulates the GTPase Rac1 through p130Cas binding ? MT1-MMP proteolytic activity is not required 相似文献
6.
Ruiyu Xie Logan J. Everett Hee-Woong Lim Nisha A. Patel Jonathan Schug Evert Kroon Olivia G. Kelly Allen Wang Kevin A. D’Amour Allan J. Robins Kyoung-Jae Won Klaus H. Kaestner Maike Sander 《Cell Stem Cell》2013,12(2):224-237
Highlights? Pancreatic lineage progression is governed by PcG-dependent chromatin remodeling ? A temporal chromatin signature predicts regulators of pancreatic development ? Endocrine cells differentiated from hESCs in vivo are similar to native human islets ? In vitro-produced malfunctioning endocrine cells exhibit aberrant chromatin structure 相似文献
7.
Celine Delaloy Lei Liu Jin-A Lee Hua Su Fanxia Shen Guo-Yuan Yang William L. Young Kathy N. Ivey Fen-Biao Gao 《Cell Stem Cell》2010,6(4):323-335
Highlights? miR-9 is expressed in hESC-derived early hNPCs and their progeny ? Loss of miR-9 inhibits early hNPC proliferation and delays maturation ? miR-9 knockdown promotes hNPC migration in vitro and in vivo ? Stathmin is a target of miR-9 and mediates its effects in early hNPCs 相似文献
8.
Highlights? ESCs with short telomeres do not stably differentiate and can resume proliferation ? Critically short telomeres impair Nanog regulation during ESC differentiation ? Short telomeres elicit genome-wide DNA hypomethylation and altered H3K27me3 levels ? Impaired DNA methylation and differentiation are rescued by Dnmt3b or telomere elongation 相似文献
9.
Highlights? PARP1 binds and PARylates PAP in vitro, which inhibits its polyadenylation activity ? Polyadenylation is inhibited during heat shock in a PARP1-dependent manner ? PAP is PARylated in vivo during heat shock ? Inhibition of polyadenylation reflects decreased RNA binding by PARylated PAP 相似文献
10.
Bérengère de Laval Patrycja Pawlikowska Laurence Petit-Cocault Chrystèle Bilhou-Nabera Geneviève Aubin-Houzelstein Michèle Souyri Frédéric Pouzoulet Murielle Gaudry Françoise Porteu 《Cell Stem Cell》2013,12(1):37-48
Highlights? Mpl loss increases γ-irradiation-induced genomic instability in HSPCs ? TPO promotes DNA repair in vitro and in vivo in HSPCs ? TPO increases DNA-PK activity and NHEJ-mediated repair efficiency in HSPCs ? A single TPO injection before mouse TBI limits long-term HSC injury and mutagenesis 相似文献
11.
Dominique Seetapun Brian T. Castle Alistair J. McIntyre Phong T. Tran David J. Odde 《Current biology : CB》2012,22(18):1681-1687
Highlights? The microtubule (MT) GTP cap is ~750 tubulin subunits in vivo and extends over 1 μm ? EGFP brightness can be calibrated in vivo using GFP-tubulin signals from MTs ? The presence of GTP-tubulin in the MT lattice influences MT shortening and rescue ? MT tip trackers, like EB1, can be highly concentrated at the MT plus end (~100 μM) 相似文献
12.
Abdelfattah El Ouaamari Dan Kawamori Ercument Dirice Chong Wee Liew Jennifer L. Shadrach Jiang Hu Hitoshi Katsuta Jennifer Hollister-Lock Wei-Jun Qian Amy J. Wagers Rohit N. Kulkarni 《Cell reports》2013,3(2):401-410
Highlights? Circulating nonneuronal factors drive β cell replication in LIRKO mice ? LIRKO serum increases mouse and human islet β cell replication in vitro ? LIRKO serum induces selective β cell replication in vivo ? Hepatocyte-derived factors stimulate mouse and human β cell replication in vitro 相似文献
13.
Olivier Genest Michael Reidy Timothy O. Street Joel R. Hoskins Jodi L. Camberg David A. Agard Daniel C. Masison Sue Wickner 《Molecular cell》2013,49(3):464-473
Highlights? Using a genetic screen, we selected for defective mutants of E. coli Hsp90 ? The mutants are impaired in ATP-dependent chaperone activity ? The mutations define a client-binding region of E. coli Hsp90 ? Mutation of homologous residues in yeast Hsp90 causes in vivo and in vitro defects 相似文献
14.
Vérane Sommermeyer Claire Béneut Emmanuel Chaplais Maria Elisabetta Serrentino Valérie Borde 《Molecular cell》2013,49(1):43-54
Highlights? Spp1 and histone H3K4 residue are important for meiotic DSB formation ? Spp1 physically interacts with the DSB protein Mer2 ? Spp1 in meiosis is not with RNA Pol II, but on chromosome axes in DSB-rich domains ? Spp1’s PHD finger tethers H3K4me3 regions to chromosome axes for DSB formation 相似文献
15.
Maria A. Hahn Runxiang Qiu Xiwei Wu Arthur X. Li Heying Zhang Jun Wang Jonathan Jui Seung-Gi Jin Yong Jiang Gerd P. Pfeifer Qiang Lu 《Cell reports》2013,3(2):291-300
Highlights? 5hmC levels increase in neuronal function-related genes during neurogenesis ? 5hmC gain is accompanied by H3K27me3 loss at promoters and gene bodies ? Gain of 5hmC is not associated with substantial DNA demethylation ? Polycomb and Tet protein together promote proper progression of neurogenesis 相似文献
16.
17.
Chunzhang Yang Kristin Huntoon Alexander Ksendzovsky Zhengping Zhuang Russell R. Lonser 《Cell reports》2013,3(1):52-59
Highlights? Loss of mutant pVHL in VHL-associated tumors is due to rapid degradation ? Mutant pVHL maintains its intrinsic function as an E3 ligase ? HDACIs stabilize mutant pVHL and ameliorate tumor growth in vivo ? HDACIs represent a targeted therapy for VHL-associated tumors 相似文献
18.
Shilpi Paul Alex Kuo Thomas Schalch Hannes Vogel Leemor Joshua-Tor W. Richard McCombie Or Gozani Molly Hammell Alea A. Mills 《Cell reports》2013,3(1):92-102
Highlights? Tandem PHDs of Chd5 facilitate binding to unmodified H3 ? Chd5 preferentially binds loci lacking H3K4me3 ? Chd5 mediates expression of cancer genes ? The Chd5-H3 interaction is crucial for efficient tumor suppression 相似文献
19.
Monica Rolando Serena Sanulli Christophe Rusniok Laura Gomez-Valero Clement Bertholet Tobias Sahr Raphael Margueron Carmen Buchrieser 《Cell host & microbe》2013,13(4):395-405
Highlights? Upon infection, L. pneumophila secretes RomA, a SET domain-containing methyltransferase ? RomA triggers H3K14 trimethylation, causing a switch from gene activation to repression ? ChIP-seq identified 4,870 H3K14 methylated promoter regions, including innate immune genes ? RomA SET domain is required for efficient intracellular replication of L. pneumophila 相似文献
20.
Juan Sebastian Chahda Rui Sousa-Neves Claudia Mieko Mizutani 《Current biology : CB》2013,23(8):710-716
Highlights? The germ layers of Drosophila species are unequally scaled to size during evolution ? Evolutionary changes in nuclear size and density affect the Dl gradient scaling ? Mesodermal variations rely on Dl distribution instead of regulation of target genes ? Dl gradient distortions allow new positioning of ventral neuroectodermal border 相似文献