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The Yeast Ccr4 Protein Is Neither Regulated by nor Associated with the Spt6 and Spt10 Proteins and Forms a Functionally Distinct Complex from That of the Snf/Swi Transcription Factors 总被引:2,自引:1,他引:1
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C. L. Denis M. P. Draper H. Y. Liu T. Malvar R. C. Vallari W. J. Cook 《Genetics》1994,138(4):1005-1013
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Shirakawa AK Nagakubo D Hieshima K Nakayama T Jin Z Yoshie O 《Journal of immunology (Baltimore, Md. : 1950)》2008,180(5):2786-2795
In the B cell lineage, CCR10 is known to be selectively expressed by plasma cells, especially those secreting IgA. In this study, we examined the regulation of CCR10 expression in terminally differentiating human B cells. As reported previously, IL-21 efficiently induced the differentiation of activated human CD19+ B cells into IgD-CD38+ plasma cells in vitro. A minor proportion of the resulting CD19+IgD-CD38+ cells expressed CCR10 at low levels. 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the active metabolite of vitamine D3, dramatically increased the proportion of CD19+IgD-CD38+ cells expressing high levels of CCR10. The 1,25-(OH)2D3 also increased the number of CCR10+ cells expressing surface IgA, although the majority of CCR10+ cells remained negative for surface IgA. Thus, 1,25-(OH)2D3 alone may not be sufficient for the induction of IgA expression in terminally differentiating human B cells. To further determine whether 1,25-(OH)2D3 directly induces CCR10 expression in terminally differentiating B cells, we next performed the analysis on the human CCR10 promoter. We identified a proximal Ets-1 site and an upstream potential vitamin D response element to be critical for the inducible expression of CCR10 by 1,25-(OH)2D3. We confirmed the specific binding of Ets-1 and 1,25-(OH)2D3-activated vitamin D receptor to the respective sites. In conclusion, 1,25-(OH)2D3 efficiently induces CCR10 expression in terminally differentiating human B cells in vitro. Furthermore, the human CCR10 promoter is cooperatively activated by Ets-1 and vitamin D receptor in the presence of 1,25-(OH)2D3. 相似文献
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Tone M Powell MJ Tone Y Thompson SA Waldmann H 《Journal of immunology (Baltimore, Md. : 1950)》2000,165(1):286-291
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