共查询到20条相似文献,搜索用时 46 毫秒
1.
PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta 总被引:3,自引:0,他引:3
下载免费PDF全文
![点击此处可从《The Journal of cell biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
《The Journal of cell biology》1996,134(5):1301-1311
2.
3.
4.
5.
6.
7.
8.
9.
Role of zeta PKC in B-cell signaling and function 总被引:1,自引:0,他引:1
Martin P Duran A Minguet S Gaspar ML Diaz-Meco MT Rennert P Leitges M Moscat J 《The EMBO journal》2002,21(15):4049-4057
10.
Non-antioxidant molecular functions of alpha-tocopherol (vitamin E) 总被引:11,自引:0,他引:11
alpha-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by alpha-tocopherol was first described by our group. Later, alpha-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. alpha-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression. 相似文献
11.
12.
Rat mesangial cells contain both calcium-dependent protein kinase C (PKC) activity, which phosphorylates histone H1 and endogenous proteins, and calcium-independent, phospholipid-dependent PKC activity, which phosphorylates only endogenous proteins. The calcium-dependent PKC was identified as PKC alpha by immunoblot analysis and hydroxyapatite chromatography (HPLC). The calcium-insensitive, phospholipid-dependent isoform was identified as PKC delta using similar techniques. The inhibition of these two PKC isoforms by the protein kinase inhibitor H7 [1-(iso-quinolinyl sulphonyl)-2-methyl piperazine] was examined using both histone H1 and endogenous proteins as substrates. Phosphorylations catalyzed by the calcium-dependent PKC isoform alpha were almost 90% inhibited when histone H1 was used, and only 55% when endogenous proteins were the substrate. In contrast, the phosphorylation of endogenous proteins catalysed by the calcium-insensitive, phospholipid-dependent PKC delta was not significantly affected by the inhibitor. 相似文献
13.
Saraiva L Fresco P Pinto E Sousa E Pinto M Gonçalves J 《Journal of enzyme inhibition and medicinal chemistry》2003,18(4):357-370
The effect of the xanthonolignoids trans-(+/-)-kielcorin C, cis-(+/-)-kielcorin C, trans-(+/-)-kielcorin D, trans-(+/-)-isokielcorin D and trans-(+/-)-kielcorin E on isoforms alpha, betaI, delta, eta and zeta of protein kinase C (PKC) was studied using the yeast phenotypic assay. All the compounds tested revealed an effect compatible with PKC inhibition, similar to that exhibited by the well established PKC inhibitor chelerythrine, and with differences in their potency towards the distinct isoforms tested, being, in general, potent inhibitors of the atypical PKC isoform (PKC-zeta). PKC inhibition caused by these kielcorins was confirmed using an in vitro kinase assay. The present study constitutes the first attempt to unravel the molecular mechanism of kielcorins activity, and shows that xanthonolignoids are a promising group of compounds to investigate for isoform selective PKC inhibitors. 相似文献
14.
Protein kinase C isoforms in the epidermal tissues of normal and postburn human skin. 总被引:3,自引:0,他引:3
Y C Wang Y S Hsieh Y W Tang J Y Liu 《Biochemistry and molecular biology international》1999,47(4):673-679
Because the expression of the isoforms of protein kinase C (PKC) in human basal keratinocytes is not understood, the expression of PKC isoforms were screened in specimens of epidermal tissue from postburn skin and the normal locations for skin grafts in patients with second or higher degrees of flame injury. The expression of individual isoform was determined by Western blot technique. Only PKC alpha and zeta were detected in the epidermal tissues of normal and postburn skin and translocation occurred in PKC alpha. Patients without antibiotic treatment after flame injury had higher expressions of PKC alpha and zeta. These findings indicate that the mechanisms of cellular differentiation and growth in postburn epidermal tissue may be related to the expression and translocation of PKC alpha induced by intra- and extracellular stimulation. These changes in PKC alpha further activate the DAG/PKC signal transduction pathways. 相似文献
15.
16.
17.
18.
Ishaq M Fan M Wigmore K Gaddam A Natarajan V 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(2):732-738
19.
Gubina E Luo X Kwon E Sakamoto K Shi YF Mufson RA 《Journal of immunology (Baltimore, Md. : 1950)》2001,167(8):4303-4310
20.
Gálvez AS Brunskill EW Marreez Y Benner BJ Regula KM Kirschenbaum LA Dorn GW 《The Journal of biological chemistry》2006,281(3):1442-1448