共查询到20条相似文献,搜索用时 15 毫秒
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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis 总被引:26,自引:0,他引:26
Ruggero D Montanaro L Ma L Xu W Londei P Cordon-Cardo C Pandolfi PP 《Nature medicine》2004,10(5):484-486
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt. 相似文献
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QKI‐6 inhibits bladder cancer malignant behaviours through down‐regulating E2F3 and NF‐κB signalling
Fei Shi Zheng Deng Zheng Zhou Chen‐Yi Jiang Rui‐Zhe Zhao Feng Sun Di Cui Xiao‐Yu Bei Bo‐Yu Yang Qian Sun Xing‐Jie Wang Qi Wu Shu‐Jie Xia Bang‐Min Han 《Journal of cellular and molecular medicine》2019,23(10):6578-6594
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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination 总被引:5,自引:0,他引:5
Tanaka H Matsumura I Ezoe S Satoh Y Sakamaki T Albanese C Machii T Pestell RG Kanakura Y 《Molecular cell》2002,9(5):1017-1029
Overexpression of c-Myc or E2F1 sensitizes host cells to various types of apoptosis. Here, we found that overexpressed c-Myc or E2F1 induces accumulation of reactive oxygen species (ROS) and thereby enhances serum-deprived apoptosis in NIH3T3 and Saos-2. During serum deprivation, MnSOD mRNA was induced by NF-kappaB in mock-transfected NIH3T3, while this induction was inhibited in NIH3T3 overexpressing c-Myc or E2F1. In these clones, E2F1 inhibited NF-kappaB activity by binding to its subunit p65 in competition with a heterodimeric partner p50. In addition to overexpressed E2F1, endogenous E2F1 released from Rb was also found to inhibit NF-kappaB activity in a cell cycle-dependent manner by using E2F1(+/+) and E2F1(-/-) murine embryonic fibroblasts. These results indicate that E2F1 promotes apoptosis by inhibiting NF-kappaB activity. 相似文献
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