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FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress 总被引:2,自引:0,他引:2
Furukawa-Hibi Y Yoshida-Araki K Ohta T Ikeda K Motoyama N 《The Journal of biological chemistry》2002,277(30):26729-26732
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Interleukin enhancer binding factor (ILF) binds to the interleukin-2 (IL-2) promoter and regulates IL-2 gene expression. In this study, the 3D structure of the DNA-binding domain of ILF was determined by multidimensional NMR spectroscopy. NMR structure analysis revealed that the DNA-binding domain of ILF is a new member of the winged helix/forkhead family, and that its wing 2 contains an extra alpha-helix. This is the first study to report the presence of a C-terminal alpha-helix in place of a typical wing 2 in a member of this family. This structural difference may be responsible for the different DNA-binding specificity of ILF compared to other winged helix/forkhead proteins. Our deletion studies of the fragments of ILF also suggest that the C-terminal region plays a regulatory role in DNA binding. 相似文献
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Hall RK Yamasaki T Kucera T Waltner-Law M O'Brien R Granner DK 《The Journal of biological chemistry》2000,275(39):30169-30175
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