共查询到20条相似文献,搜索用时 218 毫秒
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Alpana Ray Mohamed Alalem Bimal K. Ray 《The Journal of biological chemistry》2013,288(38):27232-27242
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Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter 总被引:9,自引:0,他引:9
Lee D Kim HZ Jeong KW Shim YS Horikawa I Barrett JC Choe J 《The Journal of biological chemistry》2002,277(31):27748-27756
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Neid M Datta K Stephan S Khanna I Pal S Shaw L White M Mukhopadhyay D 《The Journal of biological chemistry》2004,279(6):3941-3948
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The induction of angiogenesis is a crucial step in tumor progression, and therefore, efficient inhibition of angiogenesis is considered a powerful strategy for the treatment of cancer. In the present study, we report that the lipophilic antimicrobial peptides from EML-CAP3, a new endophytic bacterial strain isolated from red pepper leaf (Capsicum annuum L.), exhibit potent antiangiogenic activity both in vitro and in vivo. The newly obtained antimicrobial peptides effectively inhibited the proliferation of human umbilical vein endothelial cells at subtoxic doses. Furthermore, the peptides suppressed the in vitro characteristics of angiogenesis such as endothelial cell invasion and tube formation stimulated by vascular endothelial growth factor, as well as neovascularization of the chorioallantoic membrane of growing chick embryos in vivo without showing cytotoxicity. Notably, the angiostatic peptides blocked tumor cell-induced angiogenesis by suppressing the expression levels of hypoxia-inducible factor-1α and its target gene, vascular endothelial growth factor (VEGF). To our knowledge, our findings demonstrate for the first time that the antimicrobial peptides from EML-CAP3 possess antiangiogenic potential and may thus be used for the treatment of hypervascularized tumors. 相似文献
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Young-Sool Hah Jin-Su Jun Seong-Gyun Lee Bong-Wook Park Deok Ryong Kim Uk-Kyu Kim Jong-Ryoul Kim June-Ho Byun 《Molecular biology reports》2011,38(2):1443-1450
Angiogenesis plays an important role in bone development and postnatal bone fracture repair. Vascular endothelial growth factor
(VEGF) and vascular endothelial growth factor receptors (VEGFRs) are primarily involved in angiogenesis. This study investigated
the expression of VEGF isoforms, VEGFR-1, and VEGFR-2 during the osteoblastic differentiation of cultured human periosteal-derived
cells. In addition, the effect of exogenous VEGF on the osteoblastic differentiation of cultured human periosteal-derived
cells was also examined. The expression of the VEGF isoforms (VEGF121, VEGF165, VEGF189, and VEGF206), VEGFR-1, and VEGFR-2 was observed in the periosteal-derived cells. Administration of KRN633, a VEGFR-1 and VEGFR-2 inhibitor,
decreased the alkaline phosphatase (ALP) activity during the osteoblastic differentiation of cultured human periosteal-derived
cells. However, the administration of VEGFR2 Kinase Inhibitor IV, a VEGFR-2 inhibitor, did not affect the ALP activity. The
addition of recombinant human VEGF165 elevated the ALP activity and increased the calcium content in the periosteal-derived cells. Treating the periosteal-derived
cells with recombinant human VEGF165 resulted in an increase in Runx2 transactivation in the periosteal-derived cells. These results suggest that exogenous VEGF
stimulates the osteoblastic differentiation of cultured human periosteal-derived cells and VEGF might act as an autocrine
growth factor for the osteoblastic differentiation of cultured human periosteal-derived cells. 相似文献
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TGF-β and cancer: Is Smad3 a repressor of hTERT gene? 总被引:1,自引:0,他引:1