An Efficient Alternative Route To 3,6-Disubstituted-Furo[2,3-d]Pyrimidin-2-One Analogues

Copper(I)-catalyzed 5-endo-dig cyclizations of 5-(alkyn-1-yl)uracil derivatives had given poor yields of substituted furo[2 Robins, M. J. and Barr, P. J. 1983. Nucleic acid related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides. J. Org. Chem, 48: 1854–1862. [CSA][CROSSREF][Crossref], [Web of Science ®] , [Google Scholar], 3 De Clercq, E., Descamps, J., Balzarini, J., Giziewicz, J., Barr, P. J. and Robins, M. J. 1983. Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides. J. Med. Chem, 26: 661–666. [PUBMED][INFOTRIEVE][CSA][CROSSREF][Crossref], [PubMed], [Web of Science ®] , [Google Scholar]]pyrimidin-2-ones unless the uracil ring was substituted at N1 with alkyl or glycosyl groups. This limited flexibility for the synthesis of analogues with varied substituents at N3 and/or C6 of the furo[2 Robins, M. J. and Barr, P. J. 1983. Nucleic acid related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides. J. Org. Chem, 48: 1854–1862. [CSA][CROSSREF][Crossref], [Web of Science ®] , [Google Scholar], 3 De Clercq, E., Descamps, J., Balzarini, J., Giziewicz, J., Barr, P. J. and Robins, M. J. 1983. Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides. J. Med. Chem, 26: 661–666. [PUBMED][INFOTRIEVE][CSA][CROSSREF][Crossref], [PubMed], [Web of Science ®] , [Google Scholar]]pyrimidin-2-one core has been overcome with 5-(3-hydroxyalkyn-1-yl)uracil compounds with no substituent at N1. Manipulation of the side-chain hydroxyl group gives access to additional furo[2,3-d]pyrimidin-2-one analogues.     

The genus Antillophos Woodring, 1928 (Gastropoda: Buccinidae) from the China seas,with description of a new species

The species of genus Antillophos Woodring, 1928 Woodring, W.P. (1928) Miocene Mollusks from Bowden, Jamaica. 2. Gastropods and Discussion of Results. Contributions to the Geology and Paleontology of the West Indies. Carnegie Institute of Washington, Washington D.C. [Google Scholar] from the China seas are studied. Six species, Antillophos liui n. sp., Antillophos lucubratonis Fraussen & Poppe, 2005 Fraussen, K. & Poppe, G.T. (2005) Revision of Phos and Antillophos (Buccinidae) from the Central Philippines. Visaya 1, 76–115. [Google Scholar], Antillophos monsecourorum Fraussen & Poppe, 2005 Fraussen, K. & Poppe, G.T. (2005) Revision of Phos and Antillophos (Buccinidae) from the Central Philippines. Visaya 1, 76–115. [Google Scholar], Antillophos pyladeum (Kato, 1995 Kato, S. (1995) Discussion of the genus Phos. Hitaciobi 70, 15–20. [Google Scholar]), Antillophos roseatus (Hinds, 1844 Hinds, R.B. (1844) Mollusca. In: Hinds, R.B. (Ed.) The Zoology of the Voyage of H.M.S. Sulphur During the years 1836–1842. 2. Smith, Elder and Co., London, pp. 1–72. [Google Scholar]) and Antillophos sp., are described and illustrated.

http://zoobank.org/urn:lsid:zoobank.org:pub:51481997-A841-4F37-8E15-B753DC99CB4D     

Nucleoside dimers analogs containing floxuridine and thymidine with unnatural linker groups: synthesis and cancer line studies. Part III

Abstract

Two series of novel fluorinated nucleosides dimers with an unnatural 1,2,3-triazole linkage were synthesized. The obtained molecules were prepared using “click” chemistry approach based on copper(I) catalyzed Huisgen azide–alkyne cycloaddition. It was performed between 3′- and 5′-azido-nucleosides as the azide components, and the 3′-O- and 5′-O-propargyl-nucleosides as the alkyne components. Based on analysis of the ³ Brunton, L. L.; Lazo, J. S.; Parker, K. L. (Eds.), Goodman & Gilman’s the Pharmacological Basis of Therapeutics, 11th ed.; McGraw-Hill, Medical Publishing Division: New York, NY, 2006. [Google Scholar]J_HH, ³ Brunton, L. L.; Lazo, J. S.; Parker, K. L. (Eds.), Goodman & Gilman’s the Pharmacological Basis of Therapeutics, 11th ed.; McGraw-Hill, Medical Publishing Division: New York, NY, 2006. [Google Scholar]J_H1′C2 and ³ Brunton, L. L.; Lazo, J. S.; Parker, K. L. (Eds.), Goodman & Gilman’s the Pharmacological Basis of Therapeutics, 11th ed.; McGraw-Hill, Medical Publishing Division: New York, NY, 2006. [Google Scholar]J_H1′C6 we estimated conformational preferences of sugar part and orientation around glycosidic bond. All described nucleosides dimers analogs were characterized by spectroscopic methods and evaluated for their in vitro cytotoxicity in three human cancer cell lines: cervical (HeLa), oral (KB) and breast (MCF-7).     

Model for compression of fullerenes and carbon nanotubes

The new materials of carbon, solid C₆₀ and carbon nanotubes (CNT) [1 Chesnokov, S.A., Nalimova, V.A., Rinzler, A.G., Smalley, R.E. and Fischer, E. 1999. Mechanical energy storage in carbon nanotube springs. PRL, 82: 343[Crossref], [Web of Science ®] , [Google Scholar],4 V.K. Jindal, Shuchi Gupta, K. Dharamvir, Bulk and lattice properties for rigid carbon nanotubes materials. http://arxiv.org/abs/cond-mat/0008382  [Google Scholar]] are important for various technological applications. One of the reasons for their technological applications could be based upon the fact that they have a lot of empty space in their molecules as well as in their unit cells when bulk quantities of these are taken in the form of either C₆₀ solid or nanoropes. Their compressibility studies have revealed extremely interesting results showing tremendous reversible compression which has aroused curiosity and interest. CNT have been found to be compressible reversibly up to about 65% of their original volume when subjected to pressures of about 20 kbar. This enormous volume compression in such materials under moderate pressures is conceived to be of great significance for understanding and interpreting the mechanism based on molecular level understanding related to shock compression in these materials.

We undertake a model study accounting for unit cell deformations by applying pressures up to 3 Gpa and develop a pressure compression relation. We use the anharmonicity of the intermolecular potential energy to calculate Gruneisen parameters and the temperature increase due to an adiabatic pressure application. This work uses some components calculated from a rigid molecule model, whereas others are taken from experimental pressure compression data.     

Two new harvestmen species (Arachnida: Opiliones) from the Caucasus

Two new harvestmen species of the family Phalangiidae, Rilaena caucasica sp. n. and Rilaena silhavyi sp. n. are diagnosed, illustrated, and described from the Caucasus region. Comparative illustration of the related Rilaena anatolica (Roewer, 1956), R. atrolutea (Roewer, 1915) and R. kelbajarica Snegovaya &; Pkhakadze, 2014 Snegovaya, N. Y., &; Pkhakadze, V. D. (2014): New species of the genus Rilaena (Opiliones, Phalangiidae) from the mount Gyamish, Azerbaijan. Vestnik zoologii, 48, 313–318. doi: 10.2478/vzoo-2014-0037[Crossref] , [Google Scholar] are given.

http://www.zoobank.org/urn:lsid:zoobank.org:pub:7B29FD94-45A2-4E32-A41E-3276E016410B     

Attitudes to biotechnology: Estimating the opinions of a better-informed public

Public familiarity with basic scientific concepts and principles has been proposed as essential for effective democratic decision-making (Miller, 1998 Miller, J. D. 1998. The measurement of civic scientific literacy. Public Understanding of Science, 7: 203–23. [Crossref], [Web of Science ®] , [Google Scholar]). Empirical research, however, finds that public ‘scientific literacy’ is generally low, falling well short of what normative criteria would consider ‘acceptable’. This has prompted calls to better engage, educate and inform the public on scientific matters, with the additional, usually implicit assumption that a knowledgeable citizenry should express more supportive and favourable attitudes toward science. Research investigating the notion that ‘to know science is to love it’ has provided only weak empirical support and has itself been criticised for representing science and technology as a unified and homogenous entity. In practice, it is argued, how knowledge impacts on the favourability of attitudes will depend on a multiplicity of factors, not least of which is the particular area of science in question and the technologies to which it gives rise (Evans & Durant, 1992 Evans, G. and Durant, J. 1992. The relationship between knowledge and attitudes in the public understanding of science in Britain. Public Understanding of Science, 4: 57–74.  [Google Scholar]). This article uses a new method for examining the knowledge-attitude nexus on a prominent area of 21st century science—biotechnology. The idea that greater scientific knowledge can engender change in the favourability of attitudes toward specific areas of science is investigated using data from the 2000 British Social Attitudes Survey and the 1999 Wellcome Consultative Panel on Gene Therapy. Together the surveys measure public opinion on particular applications of genetic technologies, including gene therapy and the use of genetic data, as well as more general attitudes towards genetic research. We focus our analysis on how two different measures of knowledge impact on these attitudes; one a general measure of scientific knowledge, the other relating specifically to knowledge of modern genetic science. We investigate what impact these knowledge domains have on attitudes towards biotechnology using a regression-based modelling technique (Bartels, 1996 Bartels, L. M. 1996. Uninformed votes: information effects in presidential elections. American Journal of Political Science, 40(1): 194–230. [Crossref], [Web of Science ®] , [Google Scholar]; Althaus, 1998 Althaus, S. L. 1998. Information effects in collective preferences. The American Political Science Review, 92(3): 545–58. [Crossref], [Web of Science ®] , [Google Scholar]; Sturgis, 2003 Sturgis, P. 2003. Knowledge and collective preferences: a comparison of two approaches to estimating the opinions of a better-informed public. Sociological Methods and Research, 31(4): 453–85. [Crossref] , [Google Scholar]). Controlling for a range of socio-demographic characteristics, we provide estimates of what collective and individual opinion would look like if everyone were as knowledgeable as the currently best-informed members of the general public on the knowledge domains in question. Our findings demonstrate that scientific knowledge does appear to have an important role in determining individual and group attitudes to genetic science. However, we find no support for a simple ‘deficit model’ of public understanding, as the nature of the relationship itself depends on the application of biotechnology in question and the social location of the individual.     

Animal-Facilitated Therapy Revisited

In Disney/Pixar's phenomenally popular animated film Finding Nemo (Stanton, 2003 Stanton, A. Writer/Director. 2003. Finding Nemo [Motion picture], United States: Pixar Animation Studios.  [Google Scholar]), one of the central themes of fish welfare was highlighted when the moorish idol, Gill, commented, “Fish aren't meant to be kept in a box, kid. It does things to you.” The notion that fish might have the capacity to suffer in captivity (Chandroo, Duncan, & Moccia, 2004a Chandroo, K. P., Duncan, I. J. H and Moccia, R. D. 2004a. Can fish suffer?: Perspectives on sentience, pain, fear and stress. Applied Animal Behaviour Science, 86: 225–250. [Crossref], [Web of Science ®] , [Google Scholar], 2004b Chandroo, K. P., Duncan, I. J. H and Moccia, R. D. 2004b. An evaluation of current perspectives on consciousness and pain in fish. Fish and Fisheries, 5: 281–295. [Crossref], [Web of Science ®] , [Google Scholar]) links to the larger question of sentiency, which remains a fundamental tenet when justifying concerns for nonhuman animal welfare (Dawkins, 2006 Dawkins, M. S. 2006. Through animal eyes: What behaviour tells us. Applied Animal Behaviour Science, 100: 4–10. [Crossref], [Web of Science ®] , [Google Scholar]; Huntingford et al., 2006 Huntingford, F. A., Adams, C., Braithwaite, V. A., Kadri, S., Pottinger, T. G.Sandoe, P. 2006. Review paper: Current issues in fish welfare. Journal of Fish Biology, 68: 332–372. [Crossref], [Web of Science ®] , [Google Scholar]). Although terrestrial nonhuman-animal welfare has been discussed and explored for many years, the development of aquatic animal welfare concepts and approaches remains relatively new and beyond public awareness (Braastad, Damsgård, & Juell, 2006; Broom, 2007 Broom, D. M. 2007. Cognitive ability and sentience: Which aquatic animals should be protected?. Disease of Aquatic Organisms, 75: 99–108. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Farmed Animal Welfare Council, 1996; Fisheries Society of the British Isles, 2002; Håstein, Scarfe, & Lund, 2005; Iwama, 2007 Iwama, G. K. 2007. The welfare of fish. Diseases of Aquatic Organisms, 75: 155–158. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Schreck, 1981 Schreck, C. B. 1981. “Stress and compensation in teleostean fishes: Response to social and physical factors”. In Stress and fish, Edited by: Pickering, A. D. 295–321. London: Academic.  [Google Scholar]).     

Teaching Bernoulli's Principle through Demonstrations

ABSTRACT

One proven strategy to help students make sense of abstract concepts is to sequence instruction so students have exploratory opportunities to investigate science before being introduced to new science explanations (Abraham and Renner 1986 Abraham, M. R. and Renner, J. W. 1986. The sequence of learning cycle activities in high school chemistry. Journal of Research in Science Teaching, 23: 121–143. [Crossref], [Web of Science ®] , [Google Scholar]; Renner, Abraham, and Birnie 1988 Renner, J. W., Abraham, M. R. and Birnie, H. H. 1988. The necessity of each phase of the learning cycle in teaching high school physics. Journal of Research in Science Teaching, 25: 39–58. [Crossref], [Web of Science ®] , [Google Scholar]). To help physical science teachers make sense of how to effectively sequence lessons, this article summarizes our experiences using an exploration–explanation sequence of instruction to teach Bernoulli's principle to prospective middle and secondary science teachers in a science methods course. We use demonstrations during our Bernoulli unit to help students go back and forth between their observations of phenomenon and what occurs on the microscopic level with what we have termed molecular talk. Students engage in guiding questions, consider their old and new understandings of science, and use evidence to construct new ideas during all stages of the lesson.     

Cryptic diversity among the achaetous Marionina (Annelida,Clitellata, Enchytraeidae)

This study investigates the diversity and taxonomy of a mainly marine group of species lacking chaetae currently assigned to the genus Marionina. This achaetous group includes four nominal species: M. achaeta (Hagen, 1954 Hagen, G. 1954. Michaelsena achaeta nov. sp., ein neuer mariner Oligochaet aus der Kieler Bucht. Faunistische Mitteilungen aus Norddeutschland, 1: 12–13.  [Google Scholar]), M. achaeta sensu Lasserre, 1964 Lasserre, P. 1964. Notes sur quelques oligochètes Enchytraeidae présents dans les plages du Bassin d’Arcachon. Procés-Verbaux des Séances de la Société Linnéenne de Bordeaux, 101: 87–91.  [Google Scholar], M. nevisensis Righi & Kanner, 1979 Righi, G. and Kanner, E. 1979. Marine Oligochaeta (Tubificidae and Enchytraeidae) from the Caribbean Sea. Studies of the Fauna of Curaçao and other Caribbean Islands, 58: 44–68.  [Google Scholar] and M. arenaria Healy, 1979 Healy, B. 1979a. Marine fauna of County Wexford. 1 – Littoral and brackishwater Oligochaeta. The Irish Naturalists' Journal, 19: 418–422.  [Google Scholar]. As Lasserre's (1964 Lasserre, P. 1964. Notes sur quelques oligochètes Enchytraeidae présents dans les plages du Bassin d’Arcachon. Procés-Verbaux des Séances de la Société Linnéenne de Bordeaux, 101: 87–91.  [Google Scholar]) M. achaeta appears to be morphologically different from its (then) senior homonym M. achaeta (Hagen, 1954 Hagen, G. 1954. Michaelsena achaeta nov. sp., ein neuer mariner Oligochaet aus der Kieler Bucht. Faunistische Mitteilungen aus Norddeutschland, 1: 12–13.  [Google Scholar]), the replacement name M. nothachaeta nom. nov. is proposed for it. We studied the genetic and morphological diversity of achaetous specimens of Marionina collected in Florida, the Great Barrier Reef, New Caledonia, Sweden, England and the Bahamas. The collection localities are almost all supralittoral and often brackish-water habitats. Parts of the mitochondrial genes 12S, 16S, COI and the nuclear genes 18S, 28S and ITS were analysed to assess the genetic variation and phylogeny of the achaetous Marionina species. The molecular data reveal one monophyletic group of 11 separately evolving lineages, and between these lineages, K2P distances in the barcoding gene COI vary between 5.4 and 25.0%. On a morphological basis, the lineages could be assigned to seven different groups (morphotypes), of which only two could be identified as described nominal taxa: M. nevisensis s. lat. (several lineages) and M. nothachaeta. Since the former taxon appears to be a complex of cryptic species around the world and the original type material no longer exists, a neotype from the Caribbean was designated for M. nevisensis s. str. The remaining achaetous lineages represent five morphologically distinct species that are left unnamed, awaiting finer morphological scrutiny and detailed comparisons with new collections of M. achaeta and M. arenaria. Summing up, the group of achaetous Marionina now seems to contain up to 13 different species, seven of which are yet to be formally described and named.     

158 A molecular dynamics simulation-based prediction of deleterious angiogenin mutations causing amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective death of motor neurons leading to paralysis and death between 3–5?years of diagnosis. Through whole genome association studies, several single nucleotide polymorphisms (SNPs) encoding missense mutations in angiogenin (ANG) protein have been identified as one of the primary factors causing ALS. Structural studies of ANG show that catalytic triad comprising His13, Lys40, and His114 residues imparts ribonucleolytic activity while nuclear localization signal residues ³¹RRR³³ are responsible for nuclear translocation activity. Loss of either ribonucleolytic activity or nuclear translocation activity or both of these functions due to mutations cause ALS. However, the mechanisms of loss-of-functions of ANG mutants are not completely understood. Here, we present a cohesive and comprehensive picture of functional loss mechanisms of all known ALS-associated ANG mutants by extensive molecular dynamics (MD) simulations (Padhi, Kumar, Vasaikar, Jayaram, & Gomes, 2012 Padhi, A. K., Kumar, H., Vasaikar, S. V., Jayaram, B. and Gomes, J. 2012. Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis. PLoS One, 7(2): e32479[PubMed] , [Google Scholar]; AK, 2013 Padhi, A.K., Jayaram, B., & Gomes, J. (accepted for publication). Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations. Scientific Reports (NPG).  [Google Scholar]). Our studies show that conformational switching of catalytic residue His114 is responsible for the loss of ribonucleolytic activity while reduction in solvent-accessible surface area (SASA) of ³¹RRR³³ as a result of local folding is responsible for the loss of nuclear translocation activity (Padhi et al., 2012 Padhi, A. K., Kumar, H., Vasaikar, S. V., Jayaram, B. and Gomes, J. 2012. Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis. PLoS One, 7(2): e32479[PubMed] , [Google Scholar]; AK, 2013 Padhi, A.K., Jayaram, B., & Gomes, J. (accepted for publication). Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations. Scientific Reports (NPG).  [Google Scholar]). Our prediction of loss-of-functions of 17 ANG mutants correlated positively with the reported experimental results. We have subsequently developed a fast molecular dynamics method based on certain global attributes / dynamic markers that can be used to determine whether a mutation is deleterious or benign. To make our method accessible to researchers and clinicians, we created a web server-based tool, ANGDelMut, freely available at http://bioschool.iitd.ernet.in/research.htm, where a user can submit new mutations to ascertain whether they cause ALS. We hope that our method will benefit the community at large and will pave the way for the development of a successful therapy for patients suffering from ALS.     

Description of a new Aelurillus species from Khorasan province of Iran,with comments on A. concolor Kulczyński, 1901 (Araneae: Salticidae)

A new species Aelurillus khorasanicus sp.n. (♂♀) is described from north-east Iran. Aelurillus muganicus Dunin, 1984 Dunin, P. M. (1984): Fauna and ecology of spiders (Aranei) of Apsheron Peninsula [in Russian]. pp. 45–60. In: Utochkin, A. S. et al. (eds.), Fauna i ekologiya paukoobraznykh. Perm: PGU Press. [Google Scholar] is synonymised with A. concolor Kulczyński, 1901 Kulczyński, W. (1901): Arachnoidea. pp. 311–369. In: Horvath, G. (ed.), Zoologische Ergebnisse der dritten asiatischen Forschungsreise des Grafen Eugen Zichy. Volume 2. Budapest. [Google Scholar]. A distribution map of the two species is provided.     

The genera Stegastopsis Kraatz, 1865 and Orostegastopsis Koch, 1962 with description of O. planioculata sp. n. from Oman (Coleoptera: Tenebrionidae: Tentyriini)

The first Asian member of Orostegastopsis Koch, 1962 Koch, C. (1962): Vierter taxonomischer Beitrag zur Kenntnis der Tenebrioniden Somalias: Über die von Prof. G. Scortecci 1953 und 1957 in der Migiurtinia-Provinz gesammelten Arten. 1. Teil. Atti della Società Italiana di Scienze Naturali, 51, 237–270. [Google Scholar] is described and figured: O. planioculata sp. n., which can be easily distinguished from the two Somalian species O. scorteccii Koch, 1962 Koch, C. (1962): Vierter taxonomischer Beitrag zur Kenntnis der Tenebrioniden Somalias: Über die von Prof. G. Scortecci 1953 und 1957 in der Migiurtinia-Provinz gesammelten Arten. 1. Teil. Atti della Società Italiana di Scienze Naturali, 51, 237–270. [Google Scholar] and O. kaszabi (Bremer, 1985 Bremer, H. J. (1985): Eine neue Stegastopsis-Art (Coleopt., Tenebrionidae, Tentyriini) aus Somalia. Entomologische Blätter, 81, 59–61. [Google Scholar]) comb. nov. by the shallow eyes. According to the shape of the clypeus, Stegastopsis kaszabi Bremer, 1985 Bremer, H. J. (1985): Eine neue Stegastopsis-Art (Coleopt., Tenebrionidae, Tentyriini) aus Somalia. Entomologische Blätter, 81, 59–61. [Google Scholar] is transferred from the genus Stegastopsis Kraatz to the genus Orostegastopsis Koch as was already indicated by Bremer (1985 Bremer, H. J. (1985): Eine neue Stegastopsis-Art (Coleopt., Tenebrionidae, Tentyriini) aus Somalia. Entomologische Blätter, 81, 59–61. [Google Scholar]) who treated Orostegastopsis as a subgenus of Stegastopsis: Orostegastopsis kaszabi (Bremer, 1985 Bremer, H. J. (1985): Eine neue Stegastopsis-Art (Coleopt., Tenebrionidae, Tentyriini) aus Somalia. Entomologische Blätter, 81, 59–61. [Google Scholar]) comb. nov. Keys to the species of Stegastopsis and Orostegastopsis are given.     

Redefinition of the hypotrichous ciliate Uncinata,with descriptions of the morphology and phylogeny of three urostylids (Protista,Ciliophora)

We investigated the morphology, morphogenesis and small subunit rRNA gene-based phylogeny of three marine urostylids, Uncinata gigantea Bullington, 1940 Bullington, W. E. (1940). Some ciliates from Tortugas. Papers from the Tortugas Laboratory, 32, 179–221. [Google Scholar], Holosticha heterofoissneri Hu & Song, 2001 Hu, X., & Song, W. (2001). Morphology and morphogenesis of Holosticha heterofoissneri n. sp. from the Yellow Sea, China (Ciliophora, Hypotrichida). Hydrobiologia, 448, 171–179. doi:10.1023/A:1017553406031.[Crossref], [Web of Science ®] , [Google Scholar], and Holosticha cf. heterofoissneri. The dorsal morphogenesis of Uncinata gigantea shows de novo formation of two groups of anlagen near the marginal rows. Holosticha cf. heterofoissneri demonstrates fragmentation of the first dorsal kinety anlage as in Holosticha heterofoissneri. Our population of H. heterofoissneri corresponds well with previously described populations in terms of its general morphology and ciliary pattern. Uncinata gigantea can be recognized by its large and highly contractile body, yellowish to brownish cell colour, two types of cortical granules, and 20–30 transversely oriented and densely arranged cirri in the left marginal row, which often overlie the buccal vertex. Based on the new data, especially infraciliature, the genus Uncinata is here redefined. Both the morphology and phylogenetic analyses suggest that the genus Uncinata should be classified within the family Urostylidae. In addition, both morphological and morphogenetic data suggest that Holosticha bradburyae Gong et al., 2001 Gong, J., Song, W., Hu, X., Ma, H., & Zhu, M. (2001). Morphology and infraciliature of Holosticha bradburyae n. sp. (Ciliophora, Hypotrichida) from the Yellow Sea, China. Hydrobiologia, 464, 63–69. doi:10.1023/A:1013901621439.[Crossref], [Web of Science ®] , [Google Scholar] should be transferred to Uncinata as U. bradburyae (Gong et al., 2001 Gong, J., Song, W., Hu, X., Ma, H., & Zhu, M. (2001). Morphology and infraciliature of Holosticha bradburyae n. sp. (Ciliophora, Hypotrichida) from the Yellow Sea, China. Hydrobiologia, 464, 63–69. doi:10.1023/A:1013901621439.[Crossref], [Web of Science ®] , [Google Scholar]) comb. nov., due to its possession of a characteristically prominent beak-like, leftwards curved projection and the developmental mode of the dorsal kineties. This assignment is supported by the phylogenetic analyses, which placed Uncinata gigantea in a clade with U. bradburyae (Gong et al., 2001 Gong, J., Song, W., Hu, X., Ma, H., & Zhu, M. (2001). Morphology and infraciliature of Holosticha bradburyae n. sp. (Ciliophora, Hypotrichida) from the Yellow Sea, China. Hydrobiologia, 464, 63–69. doi:10.1023/A:1013901621439.[Crossref], [Web of Science ®] , [Google Scholar]) comb. nov., and revealed only 1.13% (19 bp) difference in their SSU-rDNA gene sequence.     

New Important Iguanodontid and Theropod Trackways of the Tracksite Obernkirchen in the Berriasian of NW Germany and Megatracksite Concept of Central Europe

This article examines the high-resolution track horizon stratigraphy at the outcrop Obernkirchen. Massive sandstones, products of marine sand bar and fluviatile environments are present at the tracksite. Recently two track beds were examined in the outcrop. One new track slab of the lower track bed is described exposing well-preserved quadrupedal iguanodontid tracktypes of Iguanodontipus Sarjeant, Delair, and Lockley, 1998 Sarjeant, W. A. S., Delair, J. B. and Lockley, M. G. 1998. The footprints of Iguanodon: a history and taxonomic study. Ichnos, 6: 183–202. [Taylor & Francis Online] , [Google Scholar], and bipedal theropod tracks Megalosauropus Kaever and Lapparent, 1974 Kaever, M. and Lapparent, A. F. de. 1974. Les traces des pas le Dinosaures du Jurassique des Barkhausen (Basse Saxe, Allemagne). Bulletin de la Societé Geologique Français, 16: 516–525.  [Google Scholar]. The ichnogenus Iguanodontipus is discussed and the diagnosis extended. The tracksite Obernkirchen belongs to a megatracksite of the ancient coastline of the marginal marine Hercynic Basin of the Lower Cretaceous of Europe, including the four well-known sites Obernkirchen, Bad Rehburg, Münchehagen, and Bückeburg of Northwest Germany. Three different tracktypes of huge sauropods, theropods, and ornithopods are abundant at basal Lower Cretaceous siliciclastic coastlines in different regions in Spain, Portugal, England, Germany, and Switzerland. Dinosaur tracks are also present in carbonate platform environments of northern Italy and Istria.     

A Life-History Model of Human Fitness Indicators

Recent adaptationist accounts of human mental and physical health have reinvigorated the debate over the evolution of human intelligence. In the tradition of strong inference the current study was developed to determine whether either Miller's (1998 Miller, G. F. 1998. “How mate choice shaped human nature: A review of sexual selection and human evolution”. In Handbook of evolutionary psychology: Ideas, issues, and applications, Edited by: Crawford, C. and Krebs, D. 87–129. Hillsdale, NJ: Lawrence Erlbaum.  [Google Scholar], 2000a Miller, G. F. 2000a. Mental traits as fitness indicators: Expanding evolutionary psychology's adaptationism. Evolutionary approaches to human reproductive behavior. Ann N Y Acad Sci, 907: 62–74. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) Fitness Indicator Theory or Rushton's (1985 Rushton, J. P. 1985. Differential K theory: The sociobiology of individual and group differences. Pers Indiv Diff, 6(4): 441–452. [Crossref] , [Google Scholar], 2000 Rushton, J. P. 2000. Race, evolution, and behavior: A life-history perspective, 3rd, Port Huron, MI: Charles Darwin Research Institute.  [Google Scholar]) Differential-K Theory better accounts for general intelligence (“g”) in an undergraduate university population (N = 192). Owing to the lengthy administration time of the test materials, a newly developed 18-item short form of the Ravens Advanced Progressive Matrices (APM-18; Sefcek, Miller, and Figueredo 2007 Sefcek, J. A., Miller, G. F. and Figueredo, A. J. 2007. “Development and of an 18-item short form of the Ravens Advanced Progressive Matrices (RAPM-18). (Submitted)”.  [Google Scholar]) was used. A significant, positive relationship between K and F (r = .31, p < .001) emerged. Contrary to predictions, no significant relationships were found between “g” and either K or F (r = –.09, p ≥ .05 and r = .11, p ≥ .05, respectively). Though generally contrary to both hypotheses, these results may be explained in relation to antagonistic pleiotropy and a potential failure to derive correct predictions for within-species comparisons directly from the results of between-species comparisons.     

Capillary Effects on Natural Remobilization of Pools of Dense Non-Aqueous Phase Liquid Mixtures in Porous Media

The natural remobilization of an initially static mixed dense non-aqueous phase liquid (DNAPL) pool due to dissolution was demonstrated by (Roy et al. 2002 Roy, J. W., Smith, J. E. and Gillham, R. W. 2002. Natural remobilization of multicomponent DNAPL pools due to dissolution. J. Contam. Hydrol., 59: 163–186. [Crossref], [PubMed], [Web of Science ®] [Google Scholar], 2004 Roy, J. W., Smith, J. E. and Gillham, R. W. 2004. Laboratory evidence of natural remobilization of multicomponent DNAPL pools due to dissolution. J. Contam. Hydrol., 74: 145–161. [Crossref], [PubMed], [Web of Science ®] [Google Scholar]) using a compositional mathematical model and laboratory experiments with open pools over a porous medium. The purposes of this study were to: a) demonstrate natural remobilization for a pool within porous media (as opposed to an open pool); and b) analyze the capillary effects associated with residual formation, a changing saturation profile, hysteresis, and aging, as these processes may reduce the potential for natural remobilization of pools in porous media. DNAPL pools comprised of tetrachloroethene and benzene were created within a zone of larger glass beads overlying smaller glass beads, in a water-saturated 2-D flow cell. In one case, remobilization occurred in the form of a DNAPL finger, after 56 days of flushing. In another case, no remobilization had occurred after 64 days of flushing, though the density increased by 430 kg m ^?3 and remobilization was predicted by the compositional model. Comparison of observations with model predictions suggest that contact angle hysteresis, related to an observed change in wettability, was the most significant contributing factor causing overprediction of the potential for natural remobilization.