Ploidy is an important determinant of fluoroquinolone persister survival

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PspA adopts an ESCRT-III-like fold and remodels bacterial membranes

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Identification of XAF1 as an endogenous AKT inhibitor

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The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

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The human pre-replication complex is an open complex

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Opto-katanin,an optogenetic tool for localized,microtubule disassembly

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FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit

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A Triassic tritrophic triad documents an early food-web cascade

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Structures of an active type III-A CRISPR effector complex

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Structure of an inactive conformation of GTP-bound RhoA GTPase

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Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein

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Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase

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Neuronal non-CG methylation is an essential target for MeCP2 function

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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

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Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes

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Structure of an activated DNA-PK and its implications for NHEJ

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Disruption of DNA polymerase ζ engages an innate immune response

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Principles for designing an optimal mRNA lipid nanoparticle vaccine

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Biotechnology for secure biocontainment designs in an emerging bioeconomy

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Molecular topography of an entire nervous system

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