Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein

1. Download : Download high-res image (181KB)
2. Download : Download full-size image

     

Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors

1. Download : Download high-res image (230KB)
2. Download : Download full-size image

     

Target RNA activates the protease activity of Craspase to confer antiviral defense

1. Download : Download high-res image (224KB)
2. Download : Download full-size image

     

Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel

1. Download : Download high-res image (254KB)
2. Download : Download full-size image

     

Conformational equilibria in allosteric control of Hsp70 chaperones

1. Download : Download high-res image (219KB)
2. Download : Download full-size image

     

Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA

1. Download : Download high-res image (288KB)
2. Download : Download full-size image

     

A single residue confers selective loss of sugar sensing in wrynecks

1. Download : Download high-res image (142KB)
2. Download : Download full-size image

     

Paradoxical activation of c-Src as a drug-resistant mechanism

1. Download : Download high-res image (189KB)
2. Download : Download full-size image

     

The molecular basis of allostery in a facilitated dissociation process

1. Download : Download high-res image (177KB)
2. Download : Download full-size image

     

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

1. Download : Download high-res image (197KB)
2. Download : Download full-size image

     

Structural basis of SARM1 activation,substrate recognition,and inhibition by small molecules

1. Download : Download high-res image (273KB)
2. Download : Download full-size image

     

ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1

1. Download : Download high-res image (193KB)
2. Download : Download full-size image

     

Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation

1. Download : Download high-res image (137KB)
2. Download : Download full-size image

     

Sodium is a negative allosteric regulator of the ghrelin receptor

1. Download : Download high-res image (166KB)
2. Download : Download full-size image

     

PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma

1. Download : Download high-res image (318KB)
2. Download : Download full-size image

     

Allosteric modulation of a human odorant receptor

1. Download : Download high-res image (184KB)
2. Download : Download full-size image

     

Structural insights into assembly and function of GluN1-2C,GluN1-2A-2C,and GluN1-2D NMDARs

1. Download : Download high-res image (273KB)
2. Download : Download full-size image

     

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)

1. Download : Download high-res image (164KB)
2. Download : Download full-size image

     

The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana

1. Download : Download high-res image (116KB)
2. Download : Download full-size image

     

Parinarioidins A-B,unprecedented flavonoids from the bark of Brosimum parinarioides Ducke

1. Download : Download high-res image (450KB)
2. Download : Download full-size image