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The bovine homolog of the obese gene maps to Chromosome 4 总被引:1,自引:0,他引:1
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Katherine MacRae Dell Yi-Xun Li Min Peng Eric G. Neilson David L. Gasser 《Mammalian genome》2000,11(11):967-971
Mice that are homozygous for the kidney disease (kd) gene on Chromosome (Chr) 10 spontaneously develop a progressive and fatal interstitial nephritis. The disease phenotype
is similar to that of the human disease, juvenile nephronophthisis. Using a backcross and intercross breeding strategy and
analysis of over 900 resultant progeny, this genetic locus has now been mapped to a minimal co-segregating region of approximately
two megabases between D10Mit 193 and D10Mit 38. The location assigned to kd by this study is over 3 cM from the current Mouse Genome Database location. The entire interval has been cloned in yeast
artificial chromosome (YAC) and bacterial artificial chromosome (BAC) clones. Recombinant analysis has permitted assignment
of 13 Mit microsatellite markers to positions near or within the region. Two new markers have been identified by using single-strand
conformation polymorphism (SSCP) analysis of sequenced BAC ends. Several BAC end sequences align with human BAC clones from
Chr 6q21 that contain NR2E1, Snx3, and Ros1. Three murine genes, CD24a, fyn, and ColX reported to map in or near the kd region as defined by this study have been evaluated. Though not definitely excluded, they appear to be unlikely candidates.
Received: 23 July 1999 / Accepted 23 June 2000 相似文献
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Renata M. J. Hamvas Wolf Reik Stephen J. Gaunt Stephen D. M. Brown Prim B. Singh 《Mammalian genome》1991,2(1):72-75
Modifiers of position-effect-variegation inDrosophila are thought to encode proteins that are either structural components of heterochromatin or enzymes that modify these components. We have recently shown that a sequence motif found in oneDrosophila modifier gene, Heterochromatin protein 1 (HP1), is conserved in a wide variety of animal and plant species (Singh et al. 1991). Using this motif, termed chromo box, we have cloned a mouse candidate modifier gene,M31, that also shows considerable sequence homology toDrosophila HP1. Here we report evidence of at least four independently segregating loci in the mouse homologous to theM31 cDNA. One of these loci—Cbx-rsl—maps to the X Chromosome (Chr), 1 cM proximal toAmg and outside the X-inactivation center region. 相似文献
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Price SJ Chittenden LR Flaherty L O'Dell B Guay-Woodford LM Stubbs L Bryda EC 《Cytogenetic and genome research》2002,98(1):61-66
The jcpk gene on mouse Chromosome 10 causes a severe, early onset form of polycystic kidney disease (PKD) when inherited in an autosomal recessive manner. In order to positionally clone this gene, high resolution genetic and radiation hybrid maps were generated along with a detailed physical map of the approximately 500-kb region containing the jcpk gene. Additionally, sixty-nine kidney-specific ESTs were evaluated as candidates for jcpk and subsequently localized throughout the mouse genome by radiation hybrid mapping analysis. Previous studies indicating non-complementation of the jcpk mutation and 67Gso, a new PKD translocation mutant had suggested that 67Gso represents a new allele of jcpk. Fluorescence in situ hybridization (FISH) analysis using key bacterial artificial chromosome clones from the jcpk critical region, refined the 67Gso breakpoint and provided support for the allelism of jcpk and 67Gso. 相似文献
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