共查询到20条相似文献,搜索用时 31 毫秒
1.
Ming-Cheng Wu Brian Law Barrie Wilkinson Jason Micklefield 《Current opinion in biotechnology》2012,23(6):931-940
Highlights? Highlights of recent methods for enhancing natural product yields, activating cryptic clusters, and biosynthetic engineering of natural products. ? Advances in genomics have allowed identification of numerous cryptic biosynthetic clusters. ? Exploitation of regulatory pathways has led to cryptic cluster activation and increased natural product titres. ? Combinatorial biosynthesis, mutasynthesis and protein engineering have led to new derivatives of natural products with modulated biological activity. 相似文献
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Fairman JW Dautin N Wojtowicz D Liu W Noinaj N Barnard TJ Udho E Przytycka TM Cherezov V Buchanan SK 《Structure (London, England : 1993)》2012,20(7):1233-1243
Highlights? First intimin or invasin β domain structure—both crystallize as monomers ? First structure solved using 3-λ SeMet MAD data from crystals grown in LCP ? Identification of a non-BIG domain directly downstream of the β domain ? Highly conserved and coevolving residues are identified in the Int/Inv family 相似文献
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Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination 相似文献
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Daniel J. Bumbarger Metta Riebesell Christian Rödelsperger Ralf J. Sommer 《Cell》2013,152(1-2):109-119
Highlights? Massive neural circuit rewiring between nematodes with divergent feeding behavior ? Striking patterns correlate with known functional differences ? Motor synapse differences indicate a substantial change in information flow ? Correlates of predatory feeding behavior are identified 相似文献
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Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
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Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
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Dahai Luo Andrew Kohlway Adriana Vela Anna Marie Pyle 《Structure (London, England : 1993)》2012,20(11):1983-1988
Highlights? Crystallographic structure of RIG-I with 5′ triphosphorylated RNA duplex and ADP ? Solution biophysical analysis of ATP-dependent RIG-I conformational change ? The structural basis for ATP-stimulated RIG-I activation 相似文献
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Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
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Adkar BV Tripathi A Sahoo A Bajaj K Goswami D Chakrabarti P Swarnkar MK Gokhale RS Varadarajan R 《Structure (London, England : 1993)》2012,20(2):371-381
Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation 相似文献
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Jason M. Butler Daniel J. Nolan Eva L. Vertes Barbara Varnum-Finney Hideki Kobayashi Andrea T. Hooper Marco Seandel Koji Shido Ian A. White Mariko Kobayashi Larry Witte Chad May Carrie Shawber Yuki Kimura Jan Kitajewski Zev Rosenwaks Irwin D. Bernstein Shahin Rafii 《Cell Stem Cell》2010,6(3):251-264
Highlights? Coculture with endothelial cells promotes HSC expansion and self-renewal ? Endothelial cell effect on HSCs mediated by Notch signaling ? In vivo, sinusoidal endothelial cells (SECs) express Notch ligands ? Blocking vessel remodeling impairs hematopoietic recovery after irradiation 相似文献
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Highlights? Drosophila Matrix Metalloprotease (Mmp) inhibits FGF signaling ? An FGF – MMP feedback loop regulates branching morphogenesis ? Mmp2 spatially regulates FGF signaling in epithelia 相似文献
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Colin A. Smith Catherine A. Shi Matthew K. Chroust Thomas E. Bliska Mark J.S. Kelly Matthew P. Jacobson Tanja Kortemme 《Structure (London, England : 1993)》2013,21(1):54-64
Highlights? Successful design of phosphorylation sites into a globular protein ? Redesigned PDZ domain phosphorylation is associated with local destabilization ? Phosphorylation switches peptide binding function ? Phosphorylation switches peptide recognition specificity 相似文献
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Kushol Gupta Joseph E. Curtis Susan Krueger Young Hwang Peter Cherepanov Frederic D. Bushman Gregory D. Van Duyne 《Structure (London, England : 1993)》2012,20(11):1918-1928
Highlights? Missing domains in PFV intasome revealed by SAXS/SANS ? PFV IN undergoes dramatic changes in conformation and oligomerization upon binding DNA ? Strand transfer inhibitors do not alter quaternary structure of PFV intasome 相似文献
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John-Stuart Brittain Penny Probert-Smith Tipu Z. Aziz Peter Brown 《Current biology : CB》2013,23(5):436-440
Highlights? Phase-cancelling cortical stimulation attenuates Parkinsonian tremor ? Prolonged stimulation may invoke adaptive mechanisms ? Phase cancellation may provide a generic treatment approach to oscillopathies ? TACS provides a convenient probe of cortical circuit dynamics in humans 相似文献
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Highlights? Not all hepatocytes undergo cell division during liver regeneration ? Hypertrophy precedes proliferation in the regenerating liver ? Hepatocytes infrequently enter into M phase during liver regeneration ? Binuclear hepatocytes undergo cell division to generate mononuclear hepatocytes 相似文献
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MTR1 encodes a secretory fasciclin glycoprotein required for male reproductive development in rice 总被引:1,自引:0,他引:1
Highlights? The fasciclin glycoprotein MTR1 regulates male reproductive development in rice ? Rice male reproductive cells secrete MTR1 to control somatic tapetum development 相似文献
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Bjørn Dalhus Line Nilsen Hanne Korvald Joy Huffman Rune Johansen Forstrøm Cynthia T. McMurray Ingrun Alseth John A. Tainer Magnar Bjørås 《Structure (London, England : 1993)》2013,21(1):154-166
Highlights? Unflipped AP site stabilized by helix-hairpin-helix DNA glycosylase homolog Mag2 ? Nonenzymatic AP site recognition and DNA sculpting ? Sculpting of DNA conformation enhances substrate transfer between proteins 相似文献
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Maher Alayyoubi Huatao Guo Sanghamitra Dey Talin Golnazarian Garrett A. Brooks Andrew Rong Jeffery F. Miller Partho Ghosh 《Structure (London, England : 1993)》2013,21(2):266-276
Highlights? bAvd forms a highly positively charged pentameric barrel ? bAvd binds both DNA and RNA, but without sequence preference ? The coding sequence for bAvd serves dual purposes ? The interaction of bAvd with bRT is likely to be important for retrohoming 相似文献
20.
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
Carlos F. Pereira Francesco M. Piccolo Tomomi Tsubouchi Stephan Sauer Natalie K. Ryan Ludovica Bruno David Landeira Joana Santos Ana Banito Jesus Gil Haruhiko Koseki Matthias Merkenschlager Amanda G. Fisher 《Cell Stem Cell》2010,6(6):547-556
Highlights? Mouse pluripotent cells reprogram human B cells in heterokaryons ? ESCs lacking PRC1 or PRC2 cannot successfully reprogram ? Failure of PRC1/2-deficient ESCs to reprogram is functionally dominant ? PRC1/2 play a critical role in the chromatin reorganization required for reprogramming 相似文献