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Myocyte enhancer factor 2 (MEF2) 总被引:2,自引:0,他引:2
Nigel J. Brand 《The international journal of biochemistry & cell biology》1997,29(12):1467-1470
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MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells. 总被引:8,自引:0,他引:8 下载免费PDF全文
The MEF2 proteins are involved in regulation of many muscle specific genes. Although MEF2 RNAs encoding the MEF2A and MEF2D isoforms are ubiquitously expressed, the presence of MEF2 proteins in non-muscle cell types has been controversial. Here we use a well-characterised antibody in conjunction with DNA binding studies to provide evidence that members of the MEF2 family are widely expressed in the nuclei of cultured cells and are competent to bind DNA. The data show that non-muscle MEF2 complexes contain MEF2A, and that another MEF2 protein, probably MEF2D, is also present. These results suggest that MEF2 proteins fulfil functions in addition to muscle-specific gene expression. 相似文献
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GATA-dependent recruitment of MEF2 proteins to target promoters 总被引:38,自引:0,他引:38
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Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor 总被引:28,自引:0,他引:28
Naya FJ Black BL Wu H Bassel-Duby R Richardson JA Hill JA Olson EN 《Nature medicine》2002,8(11):1303-1309
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Soon-Young Jung 《Biochemical and biophysical research communications》2010,396(2):238-245
TRIM72 is known to be involved in the negative feedback regulation of myogenesis by targeting insulin receptor substrate-1. Here, we found that TRIM72 was more highly expressed in oxidative muscle with the higher activity of MEF2, compared to glycolytic muscle. Indeed, TRIM72 promoter contained an evolutionarily conserved MEF2 site juxtaposed to E-box. TRIM72 promoter activity was decreased by the site-directed mutagenesis of either E-boxes or a MEF2 site and synergistically enhanced by MyoD (or myogenin) and MEF2, which were associated with proximal E-box, and MEF2 site of the TRIM72 promoter, respectively. Taken together all these data, we concluded that the synergism of MyoD (or myogenin) and MEF2 is necessary for TRIM72 expression during C2C12 differentiation. 相似文献
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Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway 总被引:18,自引:0,他引:18 下载免费PDF全文
Hai Wu Beverly Rothermel Shane Kanatous Paul Rosenberg Francisco J. Naya John M. Shelton Kelley A. Hutcheson J.Michael DiMaio Eric N. Olson Rhonda Bassel-Duby R.Sanders Williams 《The EMBO journal》2001,20(22):6414-6423
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A dynamic role for HDAC7 in MEF2-mediated muscle differentiation 总被引:14,自引:0,他引:14
Dressel U Bailey PJ Wang SC Downes M Evans RM Muscat GE 《The Journal of biological chemistry》2001,276(20):17007-17013
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CHAMP, a novel cardiac-specific helicase regulated by MEF2C 总被引:8,自引:0,他引:8
Liu ZP Nakagawa O Nakagawa M Yanagisawa H Passier R Richardson JA Srivastava D Olson EN 《Developmental biology》2001,234(2):497-509