共查询到20条相似文献,搜索用时 15 毫秒
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A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing 总被引:3,自引:0,他引:3
Zhao Y Lang G Ito S Bonnet J Metzger E Sawatsubashi S Suzuki E Le Guezennec X Stunnenberg HG Krasnov A Georgieva SG Schüle R Takeyama K Kato S Tora L Devys D 《Molecular cell》2008,29(1):92-101
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Nikolenko J. V. Fursova N. A. Mazina M. Y. Vorobyeva N. E. Krasnov A. N. 《Molecular Biology》2022,56(4):517-522
Molecular Biology - Previously we showed that the CG9890 protein, which has zinc finger domains, interacts with ENY2-containing complexes and is localized mainly on the promoters of active genes.... 相似文献
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Oksana Maksimenko Olga Kyrchanova Artem Bonchuk Viacheslav Stakhov Alexander Parshikov Pavel Georgiev 《Epigenetics》2014,9(9):1261-1270
Chromatin insulators affect interactions between promoters and enhancers/silencers and function as barriers for the spreading of repressive chromatin. Drosophila insulator protein dCTCF marks active promoters and boundaries of many histone H3K27 trimethylation domains associated with repressed chromatin. In particular, dCTCF binds to such boundaries between the parasegment-specific regulatory domains of the Bithorax complex. Here we demonstrate that the evolutionarily conserved protein ENY2 is recruited to the zinc-finger domain of dCTCF and is required for the barrier activity of dCTCF-dependent insulators in transgenic lines. Inactivation of ENY2 by RNAi in BG3 cells leads to the spreading of H3K27 trimethylation and Pc protein at several dCTCF boundaries. The results suggest that evolutionarily conserved ENY2 is responsible for barrier activity mediated by the dCTCF protein. 相似文献
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《Epigenetics》2013,8(9):1261-1270
Chromatin insulators affect interactions between promoters and enhancers/silencers and function as barriers for the spreading of repressive chromatin. Drosophila insulator protein dCTCF marks active promoters and boundaries of many histone H3K27 trimethylation domains associated with repressed chromatin. In particular, dCTCF binds to such boundaries between the parasegment-specific regulatory domains of the Bithorax complex. Here we demonstrate that the evolutionarily conserved protein ENY2 is recruited to the zinc-finger domain of dCTCF and is required for the barrier activity of dCTCF-dependent insulators in transgenic lines. Inactivation of ENY2 by RNAi in BG3 cells leads to the spreading of H3K27 trimethylation and Pc protein at several dCTCF boundaries. The results suggest that evolutionarily conserved ENY2 is responsible for barrier activity mediated by the dCTCF protein. 相似文献
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O. G. Maksimenko E. V. Belova P. G. Georgiev 《Doklady. Biochemistry and biophysics》2018,480(1):155-157
The interaction of the Drosophila ENY2 protein with the ORC complex subunits was investigated. It is found that ORC4 and ORC6 subunits directly interact with ENY2. 相似文献
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Dmitriy Gurskiy Anastasija Orlova Nadezhda Vorobyeva Elena Nabirochkina Alexey Krasnov Yulii Shidlovskii Sofia Georgieva Daria Kopytova 《Nucleic acids research》2012,40(21):10689-10700
SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component of the cap-binding complex and is thereby recruited onto growing messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus. Thus, Sgf11 functions as a component of both SAGA DUBm and the mRNA biogenesis machinery. 相似文献
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The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription 总被引:1,自引:0,他引:1
Cavellán E Asp P Percipalle P Farrants AK 《The Journal of biological chemistry》2006,281(24):16264-16271