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1.
M. O. Radzhabov I. A. Shamov D. G. Gasaev I. V. Goldenkova-Pavlova I. N. Shilnikova Yu. V. Shneider 《Russian Journal of Genetics》2010,46(12):1492-1499
The work is part of a study of the gene pool for Daghestan ethnic groups. In total, 38 alleles and eight genotypes were studied
at 14 loci (AB0, Rhesus, P, Lewis, Kell, PH, GC, C′3, TF, 6-PGD, GLO1, ESD, ACP, and PBM1) of immunogenetic and biochemical
polymorphic gene systems. A high frequency of allele d of the Rhesus system was observed in all populations examined (0.399–0.474). Among the rare haplotypes of the Rhesus system,
we observed CDE in the Degva population, Cde in the Sergokala and Degva populations, and cdE in the Sergokala and Vanashimakhi populations. The typical Caucasian ACP1
c
allele of the ACP1 locus, which is rather uncommon, was observed at a relatively high frequency in three (Segokala, Vanashimakhi,
and Gubden) of the four local populations under study. In the Lewis system, a high frequency of the Le(a+b+) phenotype, which
is characteristic of early childhood, was detected in the adult populations of Sergokala and Degva. The rare PGM
1
V
allele of the phosphoglucomutase 1 system (PGM1) was additionally observed in the Sergokala population. Statistical analysis
identified 19 cases where the observed phenotype frequencies significantly differed from the frequencies expected from the
Hardy-Weinberg equilibrium. 相似文献
2.
M. O. Radzhabov I. A. Shamov D. G. Gasaev I. N. Shilnikova Yu. V. Shneider I. V. Goldenkova-Pavlova 《Russian Journal of Genetics》2011,47(2):230-236
This study is a part of long-term investigations devoted to the analysis of the gene pool of Dagestan ethnic groups. The phenotype
(in %), gene, and haplotype frequencies in Kumyk ethnic group are reported. A total of 39 alleles and six haplotypes of 14
loci (AB0, Rhesus, P, Levis, Kell, HP, GC, C’3, TF, 6PGD, GLO1, ESD, ACP, and PGM1) of immunobiochemical genetic marker systems
were examined. Rare haplotypes of the Rhesus system were identified, including CDE in the Karabudakhkent population with the frequency of 0.030, and Cde and cdE in the Dorgeli population with the frequencies of 0.034 and 0.38, respectively. Similarly to the other ethnic populations
of Dagestan examined, Kukyk populations carried rare, albeit typically “Caucasoid” gene ACP1
c
of the AcP1 locus. The frequency of this allele in the two populations was similar, constituting 0.031 for Karabudakhkent and 0.032 for
Dorgeli. In Kumyks, allele frequencies of the AB0, Rhesus, P, Lewis, Kell, HP, GC, C′3, TF, 6PGD, GLO1, ESD, ACP, but not
PGM1, systems were similar to the mean allele frequencies at these loci observed in the other ethnic groups from the Dagestan,
Caucasus, and the whole European historical ethnographic province. At the same time, the allele frequency values obtained
were different from those for the populations of Kazakhstan, Central Asia, Siberia, and the Ruswsian Far East. Thus, the results
obtained for classical genetic markers indicate that Kumyks are genetically closer to the indigenous populations of Dagestan
than to Turkic-speaking populations. Analysis of the fit of the observed phenotype frequencies to the Hardy-Weinberg expectations
showed that compared to other indigenous populations of Dagestan examined, in Kumyks the genetic state of the population upon
random allele association was close to equilibrium. Probably, this state was determined by practical absence of the consanguineous
marriages upon preservation of intra-aul endogamy. 相似文献
3.
Distribution of the genetic markers of blood groups (AB0, Rhesus, MN, MNSs, P, Kell-Cellano); plasma proteins (Hp, C'3, Tf, Gc); red-cell enzymes (AcP, EstD, GLO-1) and also ABH-secretion was studied among 6 ethnic groups of Dagesthan. Distribution of gene frequencies in Dagesthan populations and other Caucasian ethnic groups was comparatively studied. 相似文献
4.
M V Derenko G A Denisova B A Maliarchuk I K Dambueva F A Luzina E A Lotosh Ch M Dorzhu O N Karamchakova L L Solovenchuk I A Zakharov 《Genetika》2001,37(10):1402-1410
Using the data on mitochondrial DNA (mtDNA) polymorphism, genetic structures of the four Turkic-speaking ethnic groups of Altai-Sayan highlands, Southern Altaians (Altai-Kizhi), Khakassians, Shorians, and Sojots, were described. Mitochondrial gene pools of the populations examined were characterized by different ratios between Mongoloid (M*, C, D, E, G, A, B, and F) and Caucasoid (H, U, T, J, and K) mtDNA lineages. All the populations studied had a strongly pronounced Mongoloid component, the frequency of which was 88.2% in Sojots, 75.9% in Khakassians, 67.4% in Altaians, and 64.3% in Shorians. Maximum frequency of the Caucasoid component (35.7%) was observed in Shorians. Phylogenetic and statistical analyses of the mtDNA group frequency distribution patterns in the gene pools of the ethnic populations of Altai-Sayan highlands and the adjacent territories showed that the populations of the region fell into three groups. The first group included Khakassians, Tuvinians and Altaians, the second group consisted of Sojots, Buryats, and Mongols, while the third group was composed of Uigurs, Kazakhs, and Kyrgyzes. The isolated position of Shorians among the populations examined can be explained by their different anthropological composition and their presumptive relatedness to Finno-Ugric populations of Siberia. 相似文献
5.
Zhukova OV Shneĭder IuV Morozova IIu Shil'nokova IN Semikov AV Goldenkova IV Sarkisova MK Radzhabov MO Markarova EV Piruzian AL 《Genetika》2005,41(12):1702-1706
Analysis of clinical material obtained from the individuals (49 psoriasis patients and 357 individuals without this disease) representing three ethnic populations of Dagestan (Avars, Dargins, and Kumyks) was performed. Polymorphism of the blood group loci AB0, Rhesus (RH), Kell, P, and Lewis, as well as of the protein-encoding loci for haptoglobin (HP), group-specific component (GC), and the enzymes, including glycosylase (GL01), esterase D (ESD), 6-phosphate dehydrogenase (6PDG), and acid phosphatase (ACP), was studied. It was demonstrated that in the pooled sample of Avars and Kumyks the Lewis system phenotype Le(a-b-) and the RH homozygotes (ee/ee) were statistically significantly more frequent among the psoriasis patients (P = 0.0488 and P = 0.0166, respectively), than among healthy controls of the same ethnic groups. It was suggested that for the pooled sample of Avars and Kumyks, homozygosity for the recessive RH allele (ee/ee) in combination with the Le(a-b-) phenotype, representing homozygosity for recessive allele le, was the risk factor for the development of psoriasis. 相似文献
6.
M. O. Radzhabov I. A. Mamaev I. A. Shamov D. G. Gasaev I. N. Shilnikova Yu. V. Shneider 《Russian Journal of Genetics》2010,46(4):469-475
This study is part of long-term research in the gene pool of Dagestan ethnic groups. The phenotype (in percent), gene, and
haplotype frequencies in three Avar populations are reported. A total of 37 alleles of 13 loci of immune and biochemical genetic
marker systems (ABO, Rhesus, P, Lewis, HP, GC, C′3, TF, 6PGD, GLO1, ESD, ACP, and PGM1) have been studied. Rare haplotypes
of the Rhesus system (CDE, Cde and cdE) have been found in the populations studied. In two out of three local populations (Khunzakh and Kharakhi), a typically “Caucasoid”
rare gene ACP1
c
of the AcP1 locus has proved to be relatively frequent (0.030 and 0.023, respectively). The frequencies of the allele variantsP
2
, le, and Hp
1
of loci of the P, Lewis, and HP systems, respectively, have been found to be lower than in other Caucasian ethnic groups
and the total northern Eurasian population. The mean allele frequencies for the GC, C′3, TF, 6PGD, GLO1, and ESD systems in
the populations studied are comparable wit those for both Caucasian ethnic groups and the total population of the European
historical ethnographic province. Statistical analysis of the results has shown 11 cases of significant deviations of the
observed phenotype frequencies from the Hardy-Weinberg equilibrium. 相似文献
7.
N Saha 《Human heredity》1991,41(1):47-52
A total of 627 subjects comprising 455 Chinese, 127 Dravidian Indians and 45 Malays were investigated for serum Apo A-IV polymorphism. The frequency of Apo A-IV*2 was found to be significantly higher (p less than 0.001) in Indians (0.043) compared to that in the Chinese (0.010) and Malays (0.011). The frequency of A-IV*3 was found to be around 0.02 in all the ethnic groups. A low frequency of A-IV*4 (less than 0.01) was observed in the Chinese and Indians. The phenotypic distribution of Apo A-IV was at Hardy-Weinberg equilibrium in the three ethnic groups. 相似文献
8.
E. S. Lagudah W. W. Hanna 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1989,78(6):801-808
Summary Variation in leaf esterases (EST), 6-phosphogluconate dehydrogenase (PGD), shikimate dehydrogenase (SKDH), leucine aminopeptidase (AMP), phosphoglucomutase (PGM) and malate dehydrogenase (MDH) is reported in the Pennisetum gene pool. In the primary gene pool, polymorphism for EST, AMP, SKDH was very high, as compared to the near-monomorphic isozymes of PGD. Two loci controlling leaf esterases Est-1 and Est-2, were identified in the primary gene pool. Differences in allelic frequency distribution of the polymorphic Est-1 locus occur between the cultivated and wild pearl millet. The prevalent alleles of Est-1 are absent in P. purpureum Schumach (secondary gene pool). A monomorphic band of the -esterase-specific Est-2 locus was identified in most of the secondary gene pool accessions, P. squamulatum Fresen and an accession of P. pedicellatum. SKDH and EST revealed differences between most of the tertiary gene pool species. By contrast, a PGD zymogram was prevalent in several species of different sectional taxa. Gene duplication for PGD isozymes occurs in the diploid species, P. ramosum, of the tertiary gene pool. Heterodimers of PGD and EST were observed in the hybrid between pearl millet and P. squamulatum, whereas a monomeric structure characterized SKDH and AMP. 相似文献
9.
Genomic diversity of 21 STR loci has been studied in six ethnic populations of Daghestan (the Caucasus), namely, Avars, Dargins, Kubachians, Lezgins, and Nogais, and the results have been compared with these data for European, African, and East Asian ethnic groups. Daghestan is unique in its ethnic diversity, which is the greatest in the Caucasus: 26 out of approximately 50 autochthonous ethnic groups of the Caucasus live there. The genetic origin of this wide ethnic diversity of Daghestan and the Caucasus as a whole is still obscure. The genetic heterogeneity of Daghestan populations has been found to be lower than that of most other populations in the world. This is explained by a prolonged isolation and gene drift in their demographic history. Generalized genetic distances between ethnic groups calculated for the whole set of loci studied allow differentiating Asian populations from African ones, with European populations occupying intermediate positions. All Daghestan ethnic populations form a distinct common group together with some European populations (Finnish, Polish, and French). Nogais are genetically close to Southeast Asian populations. The genetic closeness and the apparently equal genetic diversity of Daghestan and European populations suggest that the ethnic differentiation of the ancestral populations of Daghestan and European ethnic groups occurred in the earliest populations of modern humans. 相似文献
10.
The gene pool of the indigenous population of Sakha Republic (Yakutia) has been studied within the borders of this republic coinciding with the main area of Yakuts, which was formed by the end of the 19th century and have remained stable until the present time. Maps of the geographic variation of the integrated characteristics of the Yakut gene pool, including the principal components, parameters of genetic diversity, and genetic distances from the "average" Yakut population are presented. It has been demonstrated that ethnographers' reports on intense internal assimilation in modem Yakutia agree with genetic data. The stratification of the Yakut gene pool reflected in the maps of two principal components corresponds to the observed general (H(T)) and interpopulation (FST) gene diversities. 相似文献
11.
Khusnutdinova EK Litvinov SS Kutuev IA Iunusbaev BB Khusainova RI Akhmetova VL Ahatova FS Metspalu E Rootsi S Villems R 《Genetika》2012,48(6):750-761
Genetic diversity has been analyzed in 22 ethnic groups of the Caucasus on the basis of data on Y-chromosome and mitochondrial DNA (mtDNA) markers, as well as genome-wide data on autosomal single-nucleotide polymorphisms (SNPs). It has been found that the West Asian component is prevailing in all ethnic groups studied except for Nogays. This Near Eastern ancestral component has proved to be characteristic of Caucasian populations and almost entirely absent in their northern neighbors inhabiting the Eastern European Plain. Turkic-speaking populations, except Nogays, did not exhibit an increased proportion of Eastern Eurasian mtDNA or Y-chromosome haplogroups compared to some Abkhaz-Adyghe populations (Adygs and Kabardians). Genome-wide SNP analysis has also shown substantial differences of Nogays from all other Caucasian populations studied. However, the characteristic difference of Nogays from other populations of the Caucasus seems somewhat ambiguous in terms of the R1a1a-M17(M198) and R1b1b1-M73 haplogroups of the Y chromosome. The state of these haplogroups in Turkic-speaking populations of the Caucasus requires further study. 相似文献
12.
M. O. Radzhabov I. A. Mammaev I. A. Shamov D. G. Gasaev Yu. V. Shneider 《Russian Journal of Genetics》2009,45(2):232-239
Detailed analysis of the population structure of Dagestan ethnic groups based on data on the AB0 and Rhesus blood groups has been carried out. A total of 32101 representatives of the nine largest ethnic groups of Dagestan (from 682 auls in 46 raions) have been examined. This allows a comprehensive genetic landscape of the Dagestan population to be drawn. Comparison of the ethnic groups studied with other Caucasian ethnic groups makes it possible to determine the position of the Dagestan gene pool in the total structure of the Caucasian gene pool. 相似文献
13.
Gasparovic J Raslová K Basistová Z Zacharová M Wsólová L Avdicová M Blazícek P Lietava J Siváková D 《Physiological research / Academia Scientiarum Bohemoslovaca》2004,53(2):215-218
The objective of this study was to examine plasma homocysteine levels and C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in two ethnic groups from Slovakia. The samples consisted of general Slovak-Romany population (68 men and 81 women) from Southwestern Slovakia and the Slovak-Caucasians (174 men and 177 women) who participated in the CINDI project. The homocysteine levels were examined by HPLC, the analysis of MTHFR genotypes was done by PCR. The Slovak-Romany men (12.0+/-5.6 (S.D.) micromol/l) and women (9.2+/-2.6 microol/l) have significantly lower plasma homocysteine levels (p<0.024 and p<0.00001) when compared to Caucasians (13.3+/-5.1 micromol/l in men and 11.3+/-4.3 micromol/l in women). The genetic equilibrium is assumed for the gene frequencies of the MTHFR polymorphism in both samples. The distribution of MTHFR genotypes did not differ between the two populations (TT 13 vs. 10.6 %; CT 46.6 vs. 41.7 %; CC 40.4 vs. 47.7 %, chí(2)2 = 2.315, df=2, ns). The effect of MTHFR genotypes on homocysteine levels was not confirmed in the Slovak-Romanies and TT homozygosity significantly increased plasma homocysteine levels only in Slovak-Caucasians (11.5+/-4.4 micromol/l, ns; vs. 14.8+/-4.8 micromol/l, p 0.002, respectively). To our knowledge, this is the first epidemiological study in the Romany population examining distribution of the MTHFR genotypes and their effect on homocysteine levels. Further studies are needed to establish the variety of cardiovascular risk factors among Romanies in order to evaluate the significance of particular factors. 相似文献
14.
The present study was designed to investigate the dopamine receptor D4 (DRD4) locus variable number of tandem repeat (VNTR) allelic distribution in different Pakistani ethnic groups. DNA samples from nine different ethnic groups of Pakistan were analyzed. Greek and Somali samples were included as representatives of the European and African populations, respectively. Pakistani, Greek, and Somali populations were also compared to the published data on different world populations. The allelic distribution revealed that the four-repeat allele was the most common allele in all the Pakistani ethnic groups as is in different other world populations, followed by the seven- and two-repeat alleles. To study the evolutionary relationship of the Pakistani ethnic groups among themselves and with a few other world populations, multidimensional scaling based on the allelic frequencies of the DRD4 VNTR was obtained. This analysis grouped most of the Pakistani ethnic groups together and closer to the European and Middle Eastern populations, except for the Mohanna from Sindh, who grouped with the African populations. In addition, the Somali and the Greek samples analyzed in this study grouped closer to the previous data obtained on the African and European populations, respectively. 相似文献
15.
Mitochondrial malic enzyme (EC 1.1.1.40; MEM) was examined by starch-gel electrophoresis on post-mortem brain samples from 453 unrelated subjects of either sex comprising 161 Chinese, 150 Indians and 113 Malays and 29 from other racial groups. The estimated gene frequencies of MEM1 were found to be 0.7111, 0.6100 and 0.6769 in Chinese, Indians and Malays, respectively. No significant deviation from the Hardy-Weinberg equilibrium was observed in Chinese and Malays. However, there was a significant deviation with a deficiency of heterozygotes among Indians. MES did not show any polymorphism. 相似文献
16.
Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine
genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism
in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been
reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well
separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians,
Greeks, and Italians. 相似文献
17.
Investigations on the ethnic variability of the ABO blood group polymorphism in Iran 总被引:2,自引:0,他引:2
H Walter D D Farhud H Danker-Hopfe P Amirshahi 《Zeitschrift für Morphologie und Anthropologie》1991,78(3):289-306
112 Iranian population samples with a total of 600954 individuals are analyzed concerning the ethnic variability of ABO allele frequencies. The genetic heterogeneity within and between these population samples is considerable. This heterogeneity is discussed with regard to the ethnohistory of Iran. The most striking ABO allele frequencies are observed in Assyrians, Armenians and Zoroastrians, which differ extremely from that of all the other hitherto studied ethnic groups of Iran. Obviously varying ABO allele frequencies are seen also in Yazdis as well as in Turkomans and Arabs living in Iran. And finally the Iranian Jews reveal clear frequency differences in comparison with all the other Iranian population groups. It can be assumed that the specific ABO allele frequencies found in the above mentioned ethnic groups are connected with their different geographical origin as well as with their marked endogamy. 相似文献
18.
Paraoxonase 1 gene polymorphism 192Q/R in old men and long-livers from Tatars ethnic group 总被引:1,自引:0,他引:1
Pauk VV Tuktarova IA Nasibullin TR Zueva LP Adel'guzhina AKh Khusnutdinova EK Mustafina OE 《Molekuliarnaia biologiia》2007,41(4):601-607
Comparison in genotype and allele frequencies of people groups of younger (from 1 till 20 years), middle (21-55 years), elderly (56-74 years), senile (75-89 years) age and long-livers (90-109 years) have been performed (only 1116 person) with the purpose of analysis of molecular-genetic bases of ageing and longevity of the person. Allele variants of PON1 gene have been identified by polymerase chain reaction in a combination with restriction analysis. In the general sample of Tatars genotypes PON1*Q/*Q, PON1*Q/*R and PON1*R/*R are revealed with frequencies of 46.15, 44.35 and 9.5%, alleles PON1*Q and PON1*R are found with frequencies of 68.32 and 31.68% accordingly. Statistically significant distinctions on frequencies of genotypes and alleles between separate age groups are found. It has appeared, that frequency of PON1*R allele (28.46%) is lowered among old men in comparison with those among persons of younger age (37.42%, P = 0.009). However essentially above in group of long-livers, than in group of old men, frequencies allele PON1*R (P = 0.005) and genotype PON1*R/*R (P = 0.01). 相似文献
19.
The frequencies of 33 alleles of 12 loci of immunological and biochemical gene markers (ABO, RH, HP, GC, TF, PI, C'3, ACP1, GLO1, PGM1, ESD, and 6-PGD) have been estimated in the indigenous Russian and Ukrainian populations of Belgorod oblast. Differences of the Belgorod population from other populations of Russia with respect to the genetic structure have been determined. It has been found that the frequency distributions of all alleles studied in the Belgorod population are similar to those typical of the genetic structure of Caucasoid populations. 相似文献
20.
Spitsyn VA Kuchheuser W Makarov SV Bychkovskaia LS Paĭ GV Balanovskiĭ OP Afanas'eva IS 《Genetika》2001,37(3):386-401
Frequency distribution of several genetic markers was studied in ethnic Russians from the Moscow, Bryansk, Ryazan', Kostroma, Novgorod, Arkhangel'sk, and Sverdlovsk oblasts and Udmurtiya. Systems AB0, RH, HP, TF, GC, PI, C'3, ACP1, PGM1, ESD, GLO1, 6PGD, and AK were analyzed in most samples. New data on informative polymorphic genetic loci showed that the Russian gene pool mostly displays Caucasoid features. In addition, Y-chromosomal short tandem repeats (STRs) DYS19, DYS390, and YCAII were analyzed in the Russian samples. STRs of the chromosome are particularly valuable for elucidating ethnogenetic processes in Eastern Europe. Frequency distributions of the Y-chromosomal markers in Russians were intermediate between those of West European populations and eastern Finno-Ugric ethnoses of the Volga region. A marked longitudinal gradient was revealed for frequencies of several molecular markers. 相似文献