共查询到20条相似文献,搜索用时 78 毫秒
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Identification of Conserved Regulatory Elements in Mammalian Promoter Regions: A Case Study Using the PCK1 Promoter 总被引:2,自引:0,他引:2
George E. Liu Matthew T. Weirauch Curtis P. Van Tassell Robert W. Li Tad S. Sonstegard Lakshmi K. Matukumalli Erin E. Connor Richard W. Hanson Jianqi Yang 《基因组蛋白质组与生物信息学报(英文版)》2008,6(3):129-143
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An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling 总被引:10,自引:0,他引:10
Fukao T Fukuda Y Kiga K Sharif J Hino K Enomoto Y Kawamura A Nakamura K Takeuchi T Tanabe M 《Cell》2007,129(3):617-631
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Hox genes are highly conserved segmental identity genes well known for their complex expression patterns and divergent targets. Here we present an analysis of cis-regulatory elements in the Caenorhabditis elegans Hox gene egl-5, which is expressed in multiple tissues in the posterior region of the nematode. We have utilized phylogenetic footprinting to efficiently identify cis-regulatory elements and have characterized these with gfp reporters and tissue-specific rescue experiments. We have found that the complex expression pattern of egl-5 is the cumulative result of the activities of multiple tissue or local region-specific activator sequences that are conserved both in sequence and near-perfect order in the related nematode Caenorhabditis briggsae. Two conserved regulatory blocks analyzed in detail contain multiple sites for both positively and negatively acting factors. One of these regions may promote activation of egl-5 in certain cells via the Wnt pathway. Positively acting regions are repressed in inappropriate tissues by additional negative pathways acting at other sites within the promoter. Our analysis has allowed us to implicate several new regulatory factors significant to the control of egl-5 expression. 相似文献
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Genome organization and characteristics of soybean microRNAs 总被引:3,自引:0,他引:3
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