中华青荚叶的一个新环烯醚萜甙

从山茱萸科中华青荚叶（Helwingia chinensis）的乙酸乙酯部份分离得到一个新环烯醚萜和三个已知环烯醚萜化合物,通过现代波谱技术,确定其结构为10-O-trans—cinnamoyl。leoside（1）,10-hydroxyoleoside 11-methylester（2）,jasminoside（3）and 10-hydroxyoleumpein（4）。     

青荚叶〔Helwingia japonica(Thunb.)Dietr.〕种下新组合

青荚叶〔Ｈｅｌｗｉｎｇｉａｊａｐｏｎｉｃａ (Ｔｈｕｎｂ .)Ｄｉｅｔｒ.〕为山茱萸科(Ｃｏｒｎａｃｅａｅ)青荚叶属 (ＨｅｌｗｉｎｇｉａＷｉｌｌｄ .)植物 ,我国民间常将其髓部、叶及果实作为药用。该种主要特征为叶片纸质 ,卵形、卵圆形、长卵形或卵状披针形 ,背面粉白或淡绿色等[1 ] 。作者在对馆藏的青荚叶标本进行整理时 ,发现《中国植物志》中的个别变种描述与该变种原始文献的描述有出入 ,而且该种种内的一些分类依据不明确。为此作者查阅了有关标本及文献 ,对该种的这些问题进行了分析和讨论。青荚叶Ｈｅｌｗｉｎｇｉａｊａｐｏｎ…     

New flavonoids from the fruits of Cornus mas,Cornaceae

One new β-hydroxychalcone, 4-acetoxy-5,2′,4′,6′,β-pentahydroxy-3-methoxychalcone (1), one new flavanone, 7,3′-dihydroxy-5,4′-dimethoxyflavanone (2) and seven known compounds, 2R, 3R-trans-aromadendrin (3), naringenin-7-O-methylether (4), myricetin (5), quercetin-3-O-rutinoside (6), ursolic acid (7), gallic acid (8) and d-glucose (9) were isolated from the methanolic fruit extract of Cornus mas L. (=Cornus mascula L.), Cornaceae. The structures of the new compounds were elucidated on the basis of extensive spectroscopic methods, including 2D NMR experiments and of known compounds by comparison of physical and spectral data with literature.     

中国红豆杉中一个新的紫杉烷二萜

从中国红豆杉(Taxus chinensis)枝叶中分离得到4个紫杉烷二萜,通过波谱分析分别确定为：1β-羟基-2α,7β-二去乙酰基巴卡亭I(1),1β-羟基巴卡亭I(2),2α,5α,7β,9α,10β,13α-六乙酰氧基紫杉-4(20),11-二烯(3)和2-去乙酰氧基-5-去肉桂酰taxinine J(4)其中化合物1为新化合物。     

Phytochemical study of Capraria biflora L. aerial parts (Scrophulariaceae) from Martinique island (French West Indies)

Aerial parts of Capraria biflora L. were collected in Martinique (French West Indies) and extracted by methanol. Two original chlorinated iridoids, 3-hydroxymyopochlorin (1) and 5-hydroxyglutinoside (2) were isolated by CPC (centrifugal partition chromatography) and characterized from the extract together with five known iridoid glycosides (3–7), two flavonoid glucuronides (8–9) and the phenylethanoid glycoside verbascoside (10). The structure of these compounds together with their relative configuration was established by spectroscopic data including in particular 1D and 2D NMR experiments (HSQC, HMBC, NOESY) and HRESIMS. Preliminary antibacterial evaluation of 1, 2 and 3 against a panel of Gram-positive and Gram-negative strains has been performed.     

Antiviral flavonoid-type C-glycosides from the flowers of Trollius chinensis

Two new flavonoid-type C-glycosides, trollisin I (= (1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-[1]benzopyran-8-yl]-2-O-(2-methylbutanoyl)-D-glucitol; 1) and its 2-O-benzoyl congener trollisin II (2), were isolated from Trollius chinensis Bunge, together with the two known compounds 2'-O-(2'-methylbutanoyl)isoswertisin (3) and vitexin galactoside (4). All compounds were identified by HR-ESI-MS and in-depth NMR-spectroscopic analyses. In antiviral assays, compound 3 was found to be moderately active towards influenza virus A.     

中华双扇蕨中一个新的贝壳杉烷型二萜

从中华双扇蕨（Dipteris chinemis）中分离得到一个新的对映贝壳杉烷型二萜和反式桂皮酸的二聚体：16β—hydroxy-17-[（Z）-p-coumaroyl]-ent-kauran-19-oic acid,命名为dipterinoid A（1）。同时首次从该植物中分离得到其他13个已知化合物。     

Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds

There is nowadays an urgent need for developing novel generations of antibiotic agents due to the increased resistance of pathogenic bacteria. As a rich reservoir of structurally diverse compounds, plant species hold promise in this regard. Within this framework, we isolated a unique series of antibacterial flavonoids, named balsacones N–U, featuring multiple cinnamyl chains on the flavan skeleton. The structures of these compounds, isolated as racemates, were determined using extensive 1D and 2D NMR analysis in tandem with HRMS. Balsacones N–U along with previously isolated balsacones A–M were evaluated for their antibacterial activity against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA). Several of the tested balsacones were potent anti-MRSA agents showing MIC values in the low micromolar range. Structure–activity relationships study highlighted some important parameters involved in the antibacterial activity of balsacones such as the presence of cinnamyl and cinnamoyl chains at the C-3 and C-8 positions of the flavan skeleton, respectively. These results suggest that balsacones could represent a potential novel class of naturally occurring anti-MRSA agents.     

A New Isofiavonoid from Belamcanda chinensis (L.) DC.

A new isoflavonoid, 5, 6, 7, 3'-terahydroxy-8, 4', 5'-trimethoxyisoflavone (1), along with 10 known isoflavonoids, namely 5, 6, 7, 4'-tetrahydroxy-8-methoxyisoflavone (2), irilone (3), genistein (4), tectorigenin (5), irigenin (6), irisflorentin (7), dichotomitin (8), dimethyltectorigenin (9), iridin (10), and tectoridin (11), was isolated from the alcohol extract of the rhizomes of Belamcanda chinensis (L.) DC. The structures of these compounds were elucidated on the basis of results of spectroscopic analysis.     

石香薷挥发油对流感A3病毒的抑制作用

评估了MCMVO体内外抗流感A3 病毒作用。在Vero细胞中测定MCMVO对流感A3 病毒所致细胞病变的抑制作用 ;在鸡胚中检测对流感A3 病毒血凝效价的抑制作用 ;在小白鼠体内测定对流感病毒性肺炎的治疗作用。结果显示 ,MCMVO在浓度大于 4.9mg/L时能有效抑制流感A3 病毒所致Vero细胞CPE。在 9日龄鸡胚中浓度为 5 0 0mg/L ,2 5 0mg/L和 5 0mg/L的MCMVO能使流感A3 病毒血凝效价由 1∶12 80分别下降到 1∶2 0 ,1∶40和1∶16 0。在给药剂量在 10 0 μg/ (g·d)以上时 ,对小鼠流感病毒性肺炎有明显的治疗作用。结果表明 ,MCMVO具有抗流感A3 病毒作用