共查询到20条相似文献,搜索用时 46 毫秒
1.
2.
Howard Wolinsky 《EMBO reports》2010,11(9):664-666
Despite the scientific community''s overwhelming support for the European Research Council, many grant recipients are irked about red tapeThere is one thing that most European researchers agree on: B stands for Brussels and bureaucracy. Research funding from the European Commission (EC), which distributes EU money, is accompanied by strict accountability and auditing rules in order to ensure that European taxpayers'' money is not wasted. All disbursements are treated the same, whether subsidies to farmers or grants to university researchers. However, the creation of the European Research Council (ERC) in 2007 as a new EU funding agency for basic research created high hopes among scientists for a reduced bureaucratic burden.… many researchers who have received ERC funding have been angered with accounting rules inherited from the EC''s Framework Programmes…ERC has, indeed, been a breath of fresh air to European-level research funding as it distributes substantial grants based only on the excellence of the proposal and has been overwhelmingly supported by the scientific community. Nevertheless, many researchers who have received ERC funding have been angered with accounting rules inherited from the EC''s Framework Programmes, and which seem impossible to change. In particular, a requirement to fill out time sheets to demonstrate that scientists spend an appropriate amount of time working on the project for which they received their ERC grant has triggered protests over the paperwork (Jacobs, 2009).Luis Serrano, Coordinator of the Systems Biology Programme at the Centre for Genomic Regulation in Barcelona, Spain, and recipient of a €2 million ERC Advanced Investigator Grant for five years, said the requirement of keeping time sheets is at best a waste of time and worst an insult to the high-level researchers. “Time sheets do not make much sense, to be honest. If you want to cheat, you can always cheat,” he said. He said other grants he receives from the Spanish government and the Human Frontier Science Programme do not require time sheets.Complaints by academic researchers about the creeping bureaucratization of research are not confined to the old continent (see Opinion by Paul van Helden, page 648). As most research, as well as universities and research institutes, is now funded by public agencies using taxpayers'' money, governments and regulators feel to be under pressure to make sure that the funds are not wasted or misappropriated. Yet, the USA and the EU have taken different approaches to making sure that scientists use public money correctly. In the USA, misappropriation of public money is considered a criminal offence that can be penalized by a ban on receiving public funds, fines and even jail time; in fact, a few scientists in the USA have gone to prison.By contrast, the EU puts the onus on controlling how public money is spent upfront. Research funding under the EU''s Framework Programmes requires clearly spelt out deliverables and milestones, and requires researchers to adhere to strict accountability and auditing rules. Not surprisingly, this comes with an administrative burden that has raised the ire of many scientists who feel that their time is better spent doing research. Serrano said in a major research centre such as the CRG, the administration could minimize the paper burden. “My administration prepares them for me and I go one, two, three, four, five and I do all of them. You can even have a machine sign for you,” he commented. “But I can imagine researchers who don''t have the administrative help, this can take up a significant amount of time.” For ERC grants, which by definition are for ‘blue-skies'' research and thus do not have milestones or deliverables, such paperwork is clearly not needed.Complaints by academic researchers about the creeping bureaucratization of research are not confined to the old continentNot everyone is as critical as Serrano though. Vincent Savolainen at the Division of Biology at Imperial College London, UK, and recipient of a €2.5 million, five-year ERC Advanced Investigator Grant, said, “Everything from the European Commission always comes with time sheets, and ERC is part of the European Commission.” Still, he felt it was very confusing to track time spent on individual grants for Principal Investigators such as him. “It is a little bit ridiculous but I guess there are places where people may abuse the system. So I can also see the side of the European Commission,” he said. “It''s not too bad. I can live with doing time sheets every month,” he added. “Still, it would be better if they got rid of it.”Juleen Zierath, an integrative physiologist in the Department of Molecular Medicine at Karolinska Institutet (Stockholm, Sweden), who received a €2.5 million, five-year ERC grant, takes the time sheets in her stride. “If I worked in a company, I would have to fill out a time sheet,” she said. “I''m delighted to have the funding. It''s a real merit. It''s a real honour. It really helps my work. If I have to fill out a time sheet for the privilege of having that amount of funding for five years, it''s not a big issue.”Zierath, a native of Milwaukee (WI, USA) who came to Karolinska for graduate work in 1989, said the ERC''s requirements are certainly “bureaucracy light” compared with the accounting and reporting requirements for more traditional EU funding instruments, such as the ‘Integrated Projects''. “ERC allows you to focus more on the science,” she said. “I don''t take time sheets as a signal that the European Union doesn''t count on us to be doing our work on the project. They have to be able to account for where they''re spending the money somehow and I think it''s okay. I can understand where some people would be really upset about that.”…governments and regulators feel to be under pressure to make sure that the funds are not wasted or misappropriated…The complaints about time sheets and other bureaucratic red tape have caught the attention of high-level scientists and research managers throughout Europe. In March 2009, the EC appointed an outside panel, headed by Vaira Vike-Freiberga, former President of Latvia, to review the ERC''s structures and mechanisms. The panel reported in July last year that the objective of building a world-class institution is not properly served by “undue cumbersome regulations, checks and controls.” Although fraud and mismanagement should be prevented, excessively bureaucratic procedures detract from the mission, and might be counter-productive.Helga Nowotny, President of the ERC, said the agency has to operate within the rules of the EC''s Framework Programme 7, which includes the ERC. She explained that if researchers hold several grants, the EC wants recipients to account for their time. “The Commission and the Rules of Participation of course argue that many of these researchers have more than one grant or they may have other contracts. In order to be accountable, the researchers must tell us how much time they spend on the project. But instead of simply asking if they spent a percentage of time on it, the Commission auditors insist on time sheets. I realize that filling them out has a high symbolic value for a researcher. So, why not leave it to the administration of the host institution?”Particle physicist Ian Halliday, President of the European Science Foundation and a major supporter of the ERC, said that financial irregularities that affected the EU over many years prompted the Commission to tighten its monitoring of cash outlays. “There have been endless scandals over the agricultural subsidies. Wine leaks. Nonexistent olive trees. You name it,” he said. “The Commission''s financial system is designed to cope with that kind of pressure as opposed to trusting the University of Cambridge, for example, which has been there for 800 years or so and has a well-earned reputation by now. That kind of system is applied in every corner of the European Commission. And that is basically what is causing the trouble. But these rules are not appropriate for research.”…financial irregularities that affected the EU over many years prompted the Commission to tighten its monitoring of cash outlaysNowotny is sympathetic and sensitive to the researchers'' complaints, saying that requiring time sheets for researchers sends a message of distrust. “It feels like you''re not trusted. It has this sort of pedantic touch to it,” she said. “If you''ve been recognized for doing this kind of top research, researchers feel, ‘Why bother [with time sheets]?''” But the bureaucratic alternative would not work for the ERC either. This would mean spelling out ‘deliverables'' in advance, which is clearly not possible with frontier research.Moreover, as Halliday pointed out, there is inevitably an element of fiction with time sheets in a research environment. In his area of research, for example, he considers it reasonable to track the hours of a technician fabricating parts of a telescope. But he noted that there is a different dynamic for researchers: “Scientists end up doing their science sitting in their bath at midnight. And you mull over problems and so forth. How do you put that on a time sheet?” Halliday added that one of the original arguments in establishing the ERC was to put it at an arm''s length from the Commission and in particular from financial regulations. But to require scientists to specify what proportion of their neurons are dedicated to a particular project at any hour of the day or night is nonsensical. Nowotny agreed. “The time sheet says I''ve been working on this from 11 in the morning until 6 in the evening or until midnight or whatever. This is not the way frontier research works,” she said.Halliday, who served for seven years as chief executive of the Particle Physics and Astronomy Research Council (Swindon, UK), commented that all governments require accountability. In Great Britain, for instance, much more general accountability rules are applied to grantees, thereby offering a measure of trust. “We were given a lot of latitude. Don''t get me wrong that we allowed fraud, but the system was fit for the purpose of science. If a professor says he''s spending half his time on a certain bit of medical research, let''s say, the government will expect half his salary to show up in the grants he gets from the funding agencies. We believe that if the University of Cambridge says that this guy is spending half his time on this research, then that''s probably right and nobody would get excited if it was 55% or 45%. People would get excited if it was 5%. There are checks and balances at that kind of level, but it''s not at a level of time sheets. It will be checked whether the project has done roughly what it said.”Other funding agencies also take a less bureaucratic approach. Candace Hassall, head of Basic Careers at the Wellcome Trust (London, UK), which funds research to improve human and animal health, said Wellcome''s translation awards have milestones that researchers are expected to meet. But “time sheets are something that the Wellcome Trust hasn''t considered at all. I would be astonished if we would ever consider them. We like to work closely with our researchers, but we don''t require that level of reporting detail,” she said. “We think that such detailed, day-by-day monitoring is actually potentially counterproductive overall. It drives people to be afraid to take risks when risks should be taken.”…to require scientists to specify what proportion of their neurons are dedicated to a particular project at any hour of the day or night is nonsensicalOn the other side of the Atlantic, Jack Dixon, vice president and chief scientific officer at the Howard Hughes Medical Institution (Chevy Chase, MD, USA), who directs Hughes'' investigator programme, said he''d never heard of researchers being asked to keep time sheets: “Researchers filling out time sheets is just something that''s never crossed our minds at the Hughes. I find it sort of goofy if you want to know the truth.”In fact, a system based on trust still works better in the academic worldInstead, Hughes trusts researchers to spend the money according to their needs. “We trust them,” Dixon said. “What we ask each of our scientists to do is devote 75% of their time to research and then we give them 25% of their time which they can use to teach, serve on committees. They can do consulting. They can do a variety of things. Researchers are free to explore.”There is already growing support for eliminating the time sheets and other bureaucratic requirements that come with an ERC grant, and which are obviously just a hangover from the old system. Indeed, there have been complaints, such as reviewers of grant applications having to fax in copies of their passports or identity cards, before being allowed sight of the proposals, said Nowotny. The review panel called on the EC to adapt its rules “based on trust and not suspicion and mistrust” so that the ERC can attain the “full realization of the dream shared by so many Europeans in the academic and policy world as well as in political milieus.”In fact, a system based on trust still works better in the academic world. Hassall commented that lump-sum payments encourage the necessary trust and give researchers a sense of freedom, which is already the principle behind ERC funding. “We think that you have to trust the researcher. Their careers are on the line,” she said. Nowotny hopes ERC will be allowed to take a similar approach to that of the Wellcome Trust, with its grants treated more like “a kind of prize money” than as a contract for services.She sees an opportunity to relax the bureaucratic burden with a scheduled revision of the Rules of Participation but issues a word of caution given that, when it comes to EU money, other players are involved. “We don''t know whether we will succeed in this because it''s up to the finance ministers, not even the research ministers,” she explained. “It''s the finance ministers who decide the rules of participation. If finance ministers agree then the time sheets would be gone.” 相似文献
3.
Suran M 《EMBO reports》2011,12(5):404-407
The increasing influence of the Tea Party in Congress and politics has potential repercussions for public funding of scientific research in the USAIn 2009, Barack Obama became the 44th President of the USA, amid hopes that he would fix the problems created or left unresolved by his predecessor. However, despite his positive mantra, “Yes we can,” the situation was going to get worse: the country was spiralling towards an economic recession, a collapsing residential real-estate market and the loss of millions of jobs. Now, the deficit lingers around US$14 trillion (US Department of the Treasury, 2011). In response to these hardships and the presence of a perceived ‘socialist'' president in office, a new political movement started brewing that would challenge both the Democrats and the Republicans—the two parties that have dominated US politics for generations. Known as the Tea Party, this movement has been gaining national momentum in its denouncement of the status quo of the government, especially in relation to federal spending, including the support of scientific research.The name is a play on the Boston Tea Party, at which more than 100 American colonists dumped 45 tonnes of tea into Boston Harbour (Massachusetts, USA) in 1773 to protest against the British taxation of imported tea. Whereas the 18th century Boston Tea Party formed to protest against a specific tax, the Tea Party of the 21st century protests against taxes and ‘big'' government in general.Many view Tea Party followers as modern muckrakers, but supporters claim their movement is fundamentally about upholding the US Constitution. Tea Party Patriots, a non-partisan organization, considers itself to be the official home of the Tea Party movement. Fuelled by the values of fiscal responsibility, limited government and free markets, Tea Party Patriots believe, these three principles are granted by the Constitution, although not necessarily upheld by the administration.“If you read the Constitution, the limits of government involvement in society [are] pretty well-defined and our government has gone farther and farther beyond the specific limits of the Constitution,” said Mark Meckler, one of the co-founders of Tea Party Patriots. “Our Constitution is not designed as an empowering document, but as a limiting document… [and] was intended to be used as a weapon by the people against the government to keep it in the box.” Tea Partiers tend to be especially critical when it comes to spending tax dollars on bank bailouts and health care, but anything goes when it comes to cutting back on public spending—even science. “We believe everything needs to be on the table since the government is virtually bankrupt,” Meckler said. “We need to cut the waste, cut the abuse [and] get rid of the departments that shouldn''t exist.”Tea Partiers tend to be especially critical when it comes to spending tax dollars on bank bailouts and health care, but anything goes when […]cutting […] public spending—even scienceOn 19 February 2011, the US House of Representatives, which is currently controlled by the Republicans, passed a federal-spending bill for the remainder of the 2011 fiscal year budget. Among other cuts, the bill called for billions of dollars to be slashed from the budgets of federal science agencies. If the bill is signed into law, the National Institutes of Health (NIH) will have $1.6 billion cut from its budget—a 5.2% decrease—and the Department of Energy (DOE) will experience an 18% cut in funding for its Office of Science. Other agencies targeted include the Environmental Protection Agency (EPA), the National Aeronautics and Space Administration (NASA), the National Institute of Standards and Technology (NIST) and the National Science Foundation (NSF; Anon, 2011; Cho, 2011). Although the US Senate, which has a Democratic majority, must consider the bill before any definite amendments to the budget are made, it is likely that there will be some cuts to science funding.Although the House is in favour of science-related cuts, President Obama supports spending more on science education, basic research and clean-energy research. He has also proposed an 11.8% increase in the budget of the DOE, as well as an 8% increase in the NSF budget (Office of Management and Budget, 2011).The House is in favour of science-related cuts, but President Obama is in favour of spending more on science education, basic science and clean-energy researchJoann Roskoski, acting assistant director of the Biology Directorate at the NSF, said her institute is strongly in favour of President Obama''s budget proposal. “President Obama is a very strong supporter of fundamental research and STEM [science, technology, engineering and mathematics] education because he perceives it as investing in the future of the country,” she said. “These are just difficult budgetary times and we''ll just have to wait and see what happens. As they say, the president proposes and Congress disposes.”Karl Scheidt, a professor of chemistry at Northwestern University (Evanston, Illinois, USA), has four grants from federal agencies. “A couple of my grants expire this year, which is happening at the worst, worst possible time,” explained Scheidt, whose grants are funded by the NIH and the NSF. He added that although many politicians either do not understand or believe in the fundamentals of science, they still preach to the masses about what they ‘think'' they know. “I think it''s an absolute travesty that many people don''t understand science and that many of the Republicans who don''t fully understand science perpetuate incorrect assumptions and scientific falsehoods when speaking in public,” he said. “It makes the US less competitive and puts us collectively at a disadvantage relative to other nations if we don''t succeed in scientific education and innovative research in the future.”Although the Tea Party is not technically associated with the Republican Party, all Tea-Party representatives and senators ran as Republican candidates in the last election. While only one-third of seats in the Senate are on the ballot every two years for a six-year term, all House seats are for a two-year term. In the most recent Senatorial election, 50% of Tea Party-backed candidates won; 10 in total. 140 candidates for seats in the House of Representatives were backed by the Tea Party—all of whom were Republicans—but only 40 won. Nevertheless, with around 100 new Republicans in office, a House controlled by a Republican majority and most Congress-based Republicans in agreement with Tea Party ideals, the Tea Party actually has a lot of sway on the voting floor.Of course, as a fundamentally grass-roots movement, their influence is not limited to the halls of power. Since just before the November election last year, Tea Party-backed politicians have received more scrutiny and media exposure, meaning more people have listened to their arguments against spending on science. In fact, Republican politicians associated with the Tea Party have made critical and sometimes erroneous comments about science. Representative Michelle Bachman, for example, claimed that because carbon dioxide is a natural gas, it is not harmful to our atmosphere (Johnson, 2009). Representative Jack Kingston denounced the theory of evolution and stated that he did not come from a monkey (The Huffington Post, 2011). When asked how old he believes the Earth to be, Senator Rand Paul refused to answer (Binckes, 2010). He also introduced a bill to cut the NSF budget by 62%, and targeted the budget of the Center for Disease Control and Prevention.Scheidt believes part of the challenge is that many scientists do not properly articulate the importance of their work to the public, and there is limited representation on behalf of science in Washington. “It''s difficult sometimes to advocate for and explain the critical importance of basic research and for the most part, Congress may not always appreciate the basic fundamental mission of organizations like the NIH,” Scheidt said. “Arlen Specter was one of the few people who could form coalitions with his colleagues on both sides of the aisle and communicate why scientific research is critical. Why discovering new ways to perform transplants and creating new medicines are so important to everyone.”…part of the challenge is that many scientists do not properly articulate the importance of their work to the public, and there is limited representation on behalf of science in WashingtonSpecter, a former senator, was Republican until 2009 when he decided to switch political parties. During the last Democratic primary, he lost the Pennsylvania Senate nomination after serving in Congress for more than four decades. The Democratic nominee, Joe Sestak, eventually lost the coveted seat to Pat Toomey, a Tea Party Republican who sponsored an amendment denying NIH funding for some grants while he was a House member. Toomey is also against funding climate science and clean-energy research with federal dollars.Specter was considered a strong supporter of biomedical research, especially cancer research. He was the catalyst that pushed through a great deal of pro-science legislation, such as adding approximately $10 billion to NIH funding as part of the stimulus package in 2009, and doubling NIH funding in the 1990s. As scientific research was so important to him, he served on the US Senate Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education, and Related Agencies and on the Senate Committee on Environment and Public Works. Specter was a popular political champion of science not only because of all he had accomplished, but also because so few scientists are elected to office.Among those Democrats who lost their seats to Tea Party Republicans was Congressman Bill Foster. Foster, who once worked for the Fermi National Accelerator Laboratory (Fermilab)—which is funded by the DOE—represented Batavia, Ilinois, which is also where Fermilab has its headquarters. “The new representative in the district where Fermilab resides is Randy Hultgren, a Republican, who has been very supportive of the laboratory since he''s been elected,” said Cindy Conger, Chief Financial Officer at Fermilab. “He''s very interested in us and very interested […] in us having adequate funding.”However, Fermilab is suffering financially. “We will […] have some level of layoffs,” Conger said. “Inadequate federal funding could result in more layoffs or not being able to run our machines for part of the year. These are the things we are contemplating doing in the event of a significant budget cut. Nothing is off the table [but] we will do everything we can to run the [Tevatron] accelerator.”But Fermilab''s desperate appeal for $35 million per year for the next three fiscal years was denied by the Obama administration and not included in the 2012 White House budget request. As a result, the most powerful proton–antiproton accelerator in the USA, the Tevatron, is shutting down indefinitely near the end of this year.Another pro-science Republican is former Congressman John Porter, who studied at the Massachusetts Institute of Technology. He encouraged the federal funding of science while serving as chair of the House Subcommittee on Labor, Health and Human Services, and Education, as well as on the House Committee on Appropriations and Related Agencies. Like Scheidt, Porter said a problem is that not many members of Congress really understand science or what goes into scientific research.“Many members of Congress don''t realize that the money appropriated for the funding of scientific research through NIH, NSF […] is sent out to research institutes in their districts and states where the research is conducted,” said Porter, who retired from Congress in 2001 after serving for more than 20 years. “They simply haven''t been exposed to it and that''s the fault of the science community, which has a great responsibility to educate about the mechanisms on how we fund scientific research.”Today, Porter is vice-chair of the Foundation for the NIH and also chairs Research!America, a non-profit organization which aims to further medical, health and scientific research as higher national priorities. He also noted that industry would not fund scientific research in the way the government does because there would essentially be no profits. Therefore, federal funding remains essential.“Let''s take away the phones, iPads and everything else [those against the federal funding of science] depend on and see what''s left,” Porter said. “The US is the world leader in science, technology and research and the way we got there and the way we have created the technology that makes life easier […] is a result of making investments in that area.”For now, Scheidt said the best approach is to educate as many people as possible to understand that scientific research is a necessity, not a luxury. “We unfortunately have a very uneducated population in regard to science and it''s not 100% their fault,” he said. “However, if people took a real interest in science and paid as much attention to stem-cell or drug-discovery research as they did to the Grammy Awards or People magazine I think they would appreciate what''s going on in the science world.”…the best approach is to educate as many people as possible to understand that scientific research is a necessity, not a luxuryInstead, the USA is lagging behind its competitors when it comes to STEM education. According to the 2009 Program for International Student Assessment (PISA), the USA is ranked 17th on science and 25th on maths out of 34 countries (US Department of Education, 2010). “We''re in a cluster now, we''re no longer the leading country,” said D. Martin Watterson, a molecular biologist who sits on NIH peer-review committees to evaluate grant proposals. The reason, according to Watterson, is that the first things to be cut after a budget decrease are training grants for continuing education efforts. Moreover, the USA already lacks highly trained workers in the field of science. “In some disciplines, employers now look to other places in Europe and Asia to find those trained personnel,” Watterson said.Ultimately, most people at least want a final budget to be passed so that there is sufficient time to plan ahead. However, Georgetown University political science professor Clyde Wilcox thinks that a compromise is not so simple. “The problem is that it''s a three-way poker game. People are going to sit down and they''re going to be bargaining, negotiating and bluffing each other,” he said. “The House Republicans just want to cut the programs that they don''t like, so they''re not cutting any Republican programs for the most part.”As a result, institutions such as the EPA find themselves being targeted by the Republicans. Although there is not a filibuster-proof majority of Democrats in the Senate, they still are a majority and will try to preserve science funding. Wilcox said that it is not necessarily a good thing to continue negotiating if nothing gets done and the country is dependent on continuing resolutions.Although there is not a filibuster-proof majority of Democrats in the Senate, they still are a majority and will try to preserve science funding“What the real problem is, when push comes to shove, someone has to blink,” he said. “I don''t think there will be deep cuts in science for a number of reasons, one is science is consistent with the Democratic ideology of education and the Republican ideology of investment. And then, we don''t really spend that much on science anyway so you couldn''t come remotely close to balancing the budget even if you eliminated everything.”Although during his time in Congress representatives of both parties were not as polarized as they are today, Porter believes the reason they are now is because of the political climate. “The president has made [science] a very important issue on his agenda and unfortunately, there are many Republicans today that say if he''s for it, I''m against it,” Porter said. In fact, several government officials ignored repeated requests or declined to comment for this article.“It''s time for everybody from both parties to stand up for the country, put the party aside and find solutions to our problems,” Porter commented. “The American people didn''t just elect us to yell at each other, they elected us to do a job. You have to choose priorities and to me the most important priority is to have our children lead better lives, to have all human beings live longer, healthier, happier lives and to have our economy grow and prosper and our standard of living maintained—the only way to do that is to invest where we lead the world and that''s in science.” 相似文献
4.
Philip Hunter 《EMBO reports》2008,9(12):1168-1171
Despite an increase in the demand for skilled workers, there is a lack of qualified science, engineering and technology graduatesFor the past few years, Germany''s export-oriented economy has undergone impressive growth as the demand for its engineering products has increased globally. However, although this development has driven down national unemployment, it has also resulted in a labour shortage that has German companies urgently looking for skilled workers and engineers: vacancies for engineers rose by nearly 30% in 2006. Last year, the German Ministry of Economy and Technology warned that the lack of workers could result in revenue losses of more than ¤20 billion per year (Bovensiepen, 2007).…rapidly developing nations, notably China and India, have been investing heavily in research and education to advance towards a knowledge-based economyGermany is not the only country faced with this problem. Across the European Union (EU), the lack of highly trained employees, coupled with the ongoing ‘brain drain'' of researchers to the USA, could stifle growth in high-tech industries (EC, 2007). Indeed, the EU estimates that the information sector alone could face a lack of up to 300,000 qualified staff by 2010 (EurActiv, 2007). The USA has been faring better, mainly owing to its ability to attract skilled workers from other nations and its demographic situation, but it has become highly dependent on immigrant labour; foreign students now earn about 30% of science doctorates and more than 50% of engineering doctorates in the USA (NSF, 2006). Moreover, rapidly developing nations, notably China and India, have been investing heavily in research and education to advance towards a knowledge-based economy.The result is an increased global demand and competition for workers in the science, engineering and technology sector. The only long-term solution to this problem—and to ensure growth in high-tech industries—is to increase the number of graduates in these areas and, more generally, to recruit more high-school and college students to science and engineering. However, any sustainable effort must address all stages of education, and tackle the cultural and public perceptions of science.With regard to the latter, engineering and the life sciences—particularly medicine—are faring better than physics or chemistry. Our natural interest in our health ensures that medical research remains popular and well funded, although this is sometimes done to the detriment of fundamental biological research, notably plant science or environmental research.Yet, even the life sciences have been suffering from a recruitment shortfall at the undergraduate level, particularly in the middle and lower ranks of student quality. “Often when people are complaining [about the decline in the standard of science graduates], they are referring to the rump in the middle,” commented Celia Knight, a plant biologist and Director of the undergraduate school at Leeds University in the UK. She argued that, although there are still plenty of outstanding students, factors such as grade inflation and rising student numbers are diluting the quality. “As we expand student numbers, we expect to expand the lower end,” she said. “It is clear there wasn''t a huge population of highly able students out there not going to university in the past.”The Norwegian-led ROSE (the Relevance Of Science Education) study, which measured the attitudes of school children to science in more than 20 countries, confirms this trend and highlights an additional gender gap in science recruitment (Sjøberg & Schreiner, 2007) that also appears at the top quality levels. “The most gifted students are not necessarily taking science—particularly girls,” said Sharmila Banerjee, National Coordinator for the Nuffield Science Bursary scheme in the UK.The quality problem, if the perennial comments of senior scientists are to be believed, is increasingly apparent as biology becomes more analytical and quantitative: the lack of basic mathematical and statistical knowledge among students becomes more obvious. But, as Jonathan Osborne, Professor of Science Education at King''s College, London, UK, insisted, this does not represent the whole story. A lack of knowledge in some fundamental areas might, he argued, be compensated for by the student''s broader grasp of the field. “Today''s youngsters may not, say, be taught about cosines in the same way [that] we were,” he said, “but they have different skills instead that we did not have [...] What people focus on too much is what people cannot do rather than what they can do.”But Osborne was far from suggesting that all is right with science education. He recently co-authored the report Science Education in Europe: Critical Reflections (Osborne & Dillon, 2008), which was published for the Nuffield Foundation (London, UK) in January 2008. In the report, Osborne and co-author Justin Dillon, President of the European Science Education Research Association (ESERA), advocated sweeping changes to the high-school science curricula across Europe. The report reflects the concerns of the Nuffield Foundation that science teaching is losing the battle for hearts and minds by placing too much emphasis on learning by rote. “The main changes needed are to make teachers of science realise that the main achievement of science is the explanatory theories that it offers of the material world and that a miscellany of facts is not the same thing,” Osborne said. “There is a need to provide a science education where the connections to students'' lives are more evident and where there is space to discuss the issues raised by science.”Open in a separate window© Image Source/CorbisKnight noted that the current science curriculum is also losing touch with the requirements of universities. As she pointed out, universities used to set the A-level exams—the final qualifications of the UK secondary school system taken at age 18—but now have minimal influence over them. This has led, she feels, towards too much medicine and human biology in the syllabus, often at the expense of other fields such as plant biology. Yet, despite its partial omission from the science curriculum, plant biology itself is becoming increasingly relevant to society, particularly in the light of recent global food shortages and the drive towards solar energy conversion by using genetically engineered plants or artificial photosynthesis.Osborne agreed that universities should not regain their old monopoly on setting exams, but emphasized that the current syllabus serves nobody, least of all those who plan to pursue a career in science. This, he pointed out, is why many universities in the UK and elsewhere are now considering setting their own entrance exams. “The reason is that the people who set the A-level exams are failing to write exams which discriminate and test understanding, rather than the ability to regurgitate information or follow algorithmic procedures,” he said. “In its worst incarnation, somebody once described this as ‘bulimic science education''—that is, you are fed a lot of indigestible facts which have no nutritional value and you instantly regurgitate.”To address this trend, Newcastle University in the UK is pursuing an approach that introduces university-style education into the school curriculum and allows some students to bypass the A-level school exams altogether. A school local to the university, Monkseaton High School, initiated the scheme to provide an alternative route to university in the belief that some good students are deterred by traditional exams, which emphasize analytical skills and fact retention. Instead, students at Monkseaton can now take a science module at the Open University (OU; Milton Keynes, UK)—a distance-learning institution that allows degrees to be taken part time and mostly remotely. Newcastle University has agreed to accept undergraduate students from Monkseaton who have taken the OU module.“We do not see this route as an easy route, nor is it a statement that A-levels are not appropriate as preparation for university,” explained Heather Finlayson, Head of the School of Biology at Newcastle University. “The pilot was developed to try to encourage greater participation in science beyond GCSE level [the exams taken at age 16 at the end of compulsory secondary education in the UK]. We believe that the students entering by the OU route will have a broader but less deep knowledge in some subject areas, but their independent study skills, developed while studying the OU modules, will enable them to study effectively and rapidly to make up any lack of specific subject knowledge.”Some educators, however, are sceptical of how much difference systemic changes can make to the overall appeal of science. “We have had so many curriculum innovations, implemented in a top-down manner, that did not bring what was expected,” said Jan Van Driel, a professor at the Leiden University Graduate School of Teaching in the Netherlands. “I would argue that, in general, science should be taught in a way that makes sense—that is comprehensible and relevant—to the specific target group, and this is primarily the responsibility of science teachers. What we need is highly qualified and motivated science teachers, rather than another curriculum reform movement.”…tests are poor predictors of which students will be academic failures, because a significant number of students will become solid achievers despite poor scores on entrance exams…Van Driel was also sceptical of any trend that distances teachers from students, as could happen with a more university-like approach. “In our country, unfortunately, a belief seems to exist that students should work on their own, or in small groups, using computers, or doing practical work. In this context, the role of the teacher has been undervalued,” he said. But, having school students involved in practical work, which could still be administered by universities, would be likely to stimulate their interest, he added. “For talented students in secondary education, in our country, we have had very positive experiences with extra-curricular activities, where students participate in university courses and are given opportunities to engage in research activities.”Van Driel argued that science education should not wait until secondary school when children might have veered towards other subjects or developed negative views of science. “In our country, science teaching at the primary level has been undeservedly ignored. This is mainly due, as in many countries, to teachers not being qualified and motivated to teach science,” he commented. “Recently, we have begun to invest in this issue, on the one hand in projects aimed at stimulating young children to engage in inquiry activities and science projects, and the other hand in projects aiming at professional development of primary teachers. I think that, potentially, this is a very important development when it comes to making science more popular and better understood in our society.”The US Government has also taken up the idea that science teaching needs to be improved. In July 2008, Congress approved the US$40 million Robert Noyce Teacher Scholarship Programme to prepare science and maths teachers for selected schools. “We are also implementing the new Section 10A of the America COMPETES Act, which provides a good stipend to support a mid-career STEM [Science, Technology, Engineering and Maths] professional while they get a Master''s in teaching and then provides a salary supplement,” said Myles Boylan, Lead Program Director for Course, Curriculum and Laboratory Improvement at the US National Science Foundation (NSF; Arlington, VA, USA). “It is expected that as these teachers move into high need schools, the quality of instruction in maths and science will improve and that more high school graduates will go to college and major in STEM.”The USA is also considering offering students alternatives to traditional university exams—similar to the Newcastle University model—as Boylan explained: “I think the traditional exams are pretty good predictors of which students will be high performing and likely to graduate. But I also believe that these tests are poor predictors of which students will be academic failures, because a significant number of students will become solid achievers despite poor scores on entrance exams,” he said, but insisted that this was not tantamount to ‘dumbing down'' the system. “Many students are still quite immature at age 17 when they take these tests and thus can make spectacular gains in learning as they finally ‘grow up'' […] I believe the right approach is to give students multiple chances to succeed.”This chimes with the findings of a 2007 report by the Urban Institute, a US non-profit group in Washington, DC, which collects data and provides advice on science policy and education questions. The report suggests that the USA should no longer compete on the basis of scores in science and maths tests, but instead on creativity within the context of a more broadly based education (Lowell & Salzman, 2007).The main challenge therefore goes beyond improving science education; there is also a serious need to counter the misleading perception that science is in opposition to conservation or sustainable developmentYet, Banerjee suggested that educational reforms alone might not be sufficient to improve recruitment to science. She referred to the ROSE study, which found that a student''s response to the statement “I like school science better than other subjects” was more likely to be negative the more developed their country (Sjøberg & Schreiner, 2007). Banerjee commented that this might just reflect the increased range of choices that students have in these countries, but it could also result from a negative perception of science, as portrayed in the media or by the environmental lobby. The main challenge therefore goes beyond improving science education; there is also a serious need to counter the misleading perception that science is in opposition to conservation or sustainable development.But, there is cause for some optimism in the UK, at least, where the Higher Education Funding Council for England announced in October 2008 that its £350 million six-year programme to increase the number of science students was now working. In the academic year 2007/2008, the number of entries to chemistry courses, a subject that had been in decline, was up by 5.3%; a clear sign that trends can be, and are being, reversed in some countries. Despite this success, however, much more still needs to be done to counter negative cultural perceptions and to attract more women.Moreover, much more needs to be done to ensure that there are sufficient lucrative and attractive jobs for science graduates. The Urban Institute''s 2007 report therefore suggests that leading countries like the USA need to rethink their approach to science education, as they produce large numbers of students with bachelor''s and master''s degrees but fail to keep them interested in these areas. As the study said: “One to two years after graduation, 20 percent of S&E [science and engineering] bachelors are in school but not in S&E studies, while another 45 percent are working but in non-S&E employment (total attrition of 65 percent). One to two years after graduation, 7 percent of S&E master''s graduates are enrolled in school but not in S&E studies, while another 31 percent are working but in non-S&E employment” (Lowell & Salzman, 2007).Indeed, the chance of finding an interesting and well-paid job after graduation seems to be a main factor in solving the problem of recruitment, notwithstanding attitudes or perceptions. The economic boom and the ensuing competition for qualified engineers among German companies in the past few years—although times are now less certain—markedly improved the attractiveness of engineering fields to undergraduates. This year, German universities reported that the number of students enrolling in engineering fields rose by up to 16% for the fall semester (Anon, 2008). 相似文献
5.
Hunter P 《EMBO reports》2010,11(12):924-926
The global response to the credit crunch has varied from belt tightening to spending sprees. Philip Hunter investigates how various countries react to the financial crisis in terms of supporting scientific research.The overall state of biomedical research in the wake of the global financial crisis remains unclear amid growing concern that competition for science funding is compromising the pursuit of research. Such concerns pre-date the credit crunch, but there is a feeling that an increasing amount of time and energy is being wasted in the ongoing scramble for grants, in the face of mounting pressure from funding agencies demanding value for money. Another problem is balancing funding between different fields; while the biomedical sciences have generally fared well, they are increasingly dependent on basic research in physics and chemistry that are in greater jeopardy. This has led to calls for rebalancing funding, in order to ensure the long-term viability of all fields in an increasingly multidisciplinary and collaborative research world.For countries that are cutting funding—such as Spain, Italy and the UK—the immediate priority is to preserve the fundamental research base and avoid a significant drain of expertise, either to rival countries or away from science altogether. This has highlighted the plight of postdoctoral researchers who have traditionally been the first to suffer from funding cuts, partly because they have little immediate impact on on a country''s scientific competitiveness. Postdocs have been the first to go whenever budgets have been cut, according to Richard Frankel, a physicist at California Polytechnic State University in Saint Luis Obispo, who investigates magnetotaxis in bacteria. “In the short term there will be little effect but the long-term effects can be devastating,” he said.…there is a feeling that an increasing amount of time and energy is being wasted in the ongoing scramble for grants, in the face of mounting pressure from funding agencies…According to Peter Stadler, head of a bioinformatics group at the University of Leipzig in Germany, such cuts tend to cause the long-term erosion of a country''s science skills base. “Short-term cuts in science funding translate totally into a brain drain, since they predominantly affect young researchers who are paid from the soft money that is drying up first,” said Stadler. “They either leave science, an irreversible step, or move abroad but do not come back later, because the medium-term effect of cuts is a reduction in career opportunities and fiercer competition giving those already in the system a big advantage.”Even when young researchers are not directly affected, the prevailing culture of short-term funding—which requires ongoing grant applications—can be disruptive, according to Xavier Salvatella, principal investigator in the Laboratory of Molecular Biophysics at the Institute for Research in Biomedicine in Barcelona, Spain. “I do not think the situation is dramatic but too much time is indeed spent writing proposals,” he commented. “Because success rates are decreasing, the time devoted to raise funds to run the lab necessarily needs to increase.”At the University of Adelaide in Australia, Andrew Somogyi, professor of pharmacology, thinks that the situation is serious: “[M]y postdocs would spend about half their time applying for grants.” Somogyi pointed out that the success rate has been declining in Australia, as it has in some other countries. “For ARC [Australian Research Council] the success rate is now close to 20%, which means many excellent projects don''t get funding because the assessment is now so fine cut,” he said.Similar developments have taken place in the USA at both the National Institutes of Health (NIH)—which provides US$16 billion funding per year and the American Cancer Society (ACS), the country''s largest private non-profit funder of cancer research, with a much smaller pot of US$120 million per year. The NIH funded 21% of research proposals submitted to it in 2009, compared with 32% a decade earlier, while the ACS approves only 15% of grant applications, down several percentage points over the past few years.While the NIH is prevented by federal law from allowing observers in to its grant review meetings, the ACS did allow a reporter from Nature to attend one of its sessions on the condition that the names of referees and the applications themselves were not revealed (Powell, 2010). The general finding was that while the review process works well when around 30% of proposals are successful, it tends to break down as the success rate drops, as more arbitrary decisions are made and the risk of strong pitches being rejected increases. This can also discourage the best people from being reviewers because the process becomes more tiring and time-consuming.Even when young researchers are not directly affected, the prevailing culture of short-term funding—which requires ongoing grant applications—can be disruptive…In some countries, funding shortfalls are also leading to the loss of permanent jobs, for example in the UK where finance minister George Osborne announced on October 20 that the science budget would be frozen at £4.6 billion, rather than cut as had been expected. Even so, combined with the cut in funding for universities that was announced on the same day, this raises the prospect of reductions in academic staff numbers, which could affect research projects. This follows several years of increasing funding for UK science. Such uncertainty is damaging, according to Cornelius Gross, deputy head of the mouse biology unit, European Molecular Biology Laboratory in Monterotondo, Italy. “Large fluctuations in funding have been shown to cause damage beyond their direct magnitude as can be seen in the US where the Clinton boom was inevitably followed by a slowdown that led to rapid and extreme tightening of budgets,” he said.Some countries are aware of these dangers and have acted to protect budgets and, in some cases, even increase spending. A report by the OECD argued that countries and companies that boosted research and development spending during the ‘creative destruction'' of an economic downturn tended to gain ground on their competitors and emerge from the crisis in a relatively stronger position (OECD, 2009). This was part of the rationale of the US stimulus package, which was intended to provide an immediate lift to the economy and has been followed by a slight increase in funding. The NIH''s budget is set to increase by $1 billion, or 3% from 2010 to 2011, reaching just over $32 billion. This looks like a real-term increase, since inflation in the USA is now between 1 and 2%. However, there are fears that budgets will soon be cut; even now the small increase at the Federal level is being offset by cuts in state support, according to Mike Seibert, research fellow at the US Department of Energy''s National Renewable Energy Laboratory. “The stimulus funds are disappearing in the US, and the overall budget for science may be facing a correction at the national level as economic, budget, and national debt issues are addressed,” he said. “The states in most cases are suffering their own budget crises and will be cutting back on anything that is not nailed down.”…countries and companies that boosted research and development spending during the ‘creative destruction'' of an economic downturn tended to gain ground on their competitors…In Germany, the overall funding situation is also confused by a split between the Federal and 16 state governments, each of which has its own budget for science. In contrast to many other countries though, both federal and state governments have responded boldly to the credit crisis by increasing the total budget for the DFG (Deutsche Forschungsgemeinschaft)—Germany''s largest research funding agency—to €2.3 billion in 2011. Moreover, total funding for research and education from the BMBF (Federal Ministry for Education and Research) is expected to increase by another 7% from €10.9 billion in 2010 to €11.64 billion, although the overall federal budget is set to shrink by 3.8% under Germany''s austerity measures (Anon, 2010). There have also been increases in funding from non-government sources, such as the Fraunhofer Society, Europe''s largest application-oriented research organization, which has an annual budget of €1.6 billion.The German line has been strongly applauded by the European Union, which since 2007 has channelled its funding for cutting-edge research through the European Research Council (ERC). The ERC''s current budget of €7.5 billion, which runs until 2013, was set in 2007 and negotiations for the next period have not yet begun, but the ERC''s executive agency director Jack Metthey has indicated that it will be increased: “The Commission will firmly sustain in the negotiations the view that research and innovation, central to the Europe 2020 Strategy agreed by the Member States, should be a top budgetary priority.” Metthey also implied that governments cutting funding, as the UK had been planning to do, were making a false economy that would gain only in the short term. “Situations vary at the national level but the European Commission believes that governments should maintain and even increase research and innovation investments during difficult times, because these are pro-growth, anti-crisis investments,” he said.Many other countries have to cope with flat or declining science budgets; some are therefore exploring ways in which to do more with less. In Japan, for instance, money has been concentrated on larger projects and fewer scientists, with the effect of intensifying the grant application process. Since 2002, the total Japanese government budget for science and technology has remained flat at around ¥3,500 billion—or €27 billion at current exchange rates—with a 1% annual decline in university support but increased funding for projects considered to be of high value to the economy. This culminated in March 2010 with the launch of the ¥100 billion (€880 million) programme for World Leading Innovative Research and Development on Science and Technology.But such attempts to make funding more competitive or focus it on specific areas could have unintended side effects on innovation and risk taking. One side effect can be favouring scientists who may be less creative but good at attracting grants, according to Roger Butlin, evolutionary biologist at the University of Sheffield in the UK. “Some productive staff are being targeted because they do not bring in grants, so money is taking precedence over output,” said Butlin. “This is very dangerous if it results in loss of good theoreticians or data specialists, especially as the latter will be a critical group in the coming years.”“Scientists are usually very energetic when they can pursue their own ideas and less so when the research target is too narrowly prescribed”There have been attempts to provide funding for young scientists based entirely on merit, such as the ERC ‘Starting Grant'' for top young researchers, whose budget was increased by 25% to €661 million for 2011. Although they are welcome, such schemes could also backfire unless they are supported by measures to continue supporting the scientists after these early career grants expire, according to Gross. “There are moves to introduce significant funding for young investigators to encourage independence, so called anti-brain-drain grants,” he said. “These are dangerous if provided without later independent positions for these people and a national merit-based funding agency to support their future work.”Such schemes might work better if they are incorporated into longer-term funding programmes that provide some security as well as freedom to expand a project and explore promising side avenues. Butlin cited the Canadian ‘Discovery Grant'' scheme as an example worth adopting elsewhere; it supports ongoing programmes with long-term goals, giving researchers freedom to pursue new lines of investigation, provided that they fit within the overall objective of the project.To some extent the system of ‘open calls''—supported by some European funding agencies—has the same objective, although it might not provide long-term funding. The idea is to allow scientists to manoeuvre within a broad objective, rather than confining them to specific lines of research or ‘thematic calls'', which tend to be highly focused. “The majority of funding should be distributed through open calls, rather than thematic calls,” said Thomas Höfer from the Modeling Research Group at the German Cancer Research Center & BioQuant Center in Heidelberg. “Scientists are usually very energetic when they can pursue their own ideas and less so when the research target is too narrowly prescribed. In my experience as a reviewer at both the national and EU level, open calls are also better at funding high-quality research whereas too narrow thematic calls often result in less coherent proposals.”“Cutting science, and education, is the national equivalent of a farmer eating his ‘seed corn'', and will lead to developing nation status within a generation”Common threads seems to be emerging from the different themes and opinions about funding: budgets should be consistent over time and spread fairly among all disciplines, rather than focused on targeted objectives. They should also be spread across the working lifetime of a scientist rather than being shot in a scatter-gun approach at young researchers. Finally, policies should put a greater emphasis on long-term support for the best scientists and projects, chosen for their merit. Above all, funding policy should reflect the fundamental importance of science to economies, as Seibert concluded: “Cutting science, and education, is the national equivalent of a farmer eating his ‘seed corn'', and will lead to developing nation status within a generation.” 相似文献
6.
Wolinsky H 《EMBO reports》2011,12(8):772-774
With large charities such as the Wellcome Trust or the Gates Foundation committed to funding research, is there a risk that politicians could cut public funding for science?Towards the end of 2010, with the British economy reeling from the combined effects of the global recession, the burst bubble of property speculation and a banking crisis, the country came close to cutting its national science and research budget by up to 25%. UK Business Secretary Vince Cable argued, “there is no justification for taxpayers'' money being used to support research which is neither commercially useful nor theoretically outstanding” (BBC, 2010). The outcry from UK scientists was both passionate and reasoned until, in the end, the British budget slashers blinked and the UK government backed down. The Chancellor of the Exchequer, George Osborne, announced in October that the government would freeze science and research funding at £4.6 billion per annum for four years, although even this represents about a 10% cut in real terms, because of inflation.“there is no justification for taxpayers'' money being used to support research which is neither commercially useful nor theoretically outstanding”There has been a collective sigh of relief. Sir John Savill, Chief Executive of the Medical Research Council (UK), said: “The worst projections for cuts to the science budget have not been realised. It''s clear that the government has listened to and acted on the evidence showing investment in science is vital to securing a healthy, sustainable and prosperous future.”Yet Britain is unusual compared with its counterparts elsewhere in the European Union (EU) and the USA, because private charities, such as the Wellcome Trust (London, UK) and Cancer Research UK (London, UK), already have budgets that rival those of their government counterparts. It was this fact, coupled with UK Prime Minister David Cameron''s idea of the ‘big society''—a vision of smaller government, increased government–private partnerships and a bigger role for non-profit organizations, such as single-disease-focused charities—that led the British government to contemplate reducing its contribution to research, relying on the private sector to pick up the slack.Jonathan Grant, president of RAND Europe (London, UK)—a not-for-profit research institute that advises on policy and decision-making—commented: “There was a strong backlash and [the UK Government] pulled back from that position [to cut funding]. But that''s the first time I''ve really ever seen it floated as a political idea; that government doesn''t need to fund cancer research because we''ve got all these not-for-profits funding it.”“…that''s the first time I''ve really ever seen it floated as a political idea; that government doesn''t need to fund cancer research because we''ve got all these not-for-profits funding it”But the UK was not alone in mooting the idea that research budgets might have to suffer under the financial crisis. Some had worried that declining government funding of research would spread across the developed world, although the worst of these fears have not been realized.Peter Gruss, President of the Max Planck Society (Munich, Germany), explained that his organization receives 85% of its more-than €1.5 billion budget from the public purses of the German federal government, German state ministries and the EU, and that not all governments have backed away from their commitment to research. In fact, during the crisis, the German and US governments boosted their funding of research with the goal of helping the economic recovery. In 2009, German Chancellor Angela Merkel''s government, through negotiation with the German state science ministries, approved a windfall of €18 billion in new science funding, to be spread over the next decade. Similarly, US President Barack Obama''s administration boosted spending on research with a temporary stimulus package for science, through the American Recovery and Reinvestment Act.Even so, Harry Greenberg, Senior Associate Dean for Research at Stanford University (California, USA) pointed out that until the US government injected stimulus funding, the budget at the National Institutes of Health (NIH; Bethesda, Maryland, USA) had essentially “been flat as a pancake for five or six years, and that means that it''s actually gone down and it''s having an effect on people being able to sustain their research mission.”Similarly, Gruss said that the research community should remain vigilant. “I think one could phrase it as there is a danger. If you look at Great Britain, there is the Wellcome Trust, a very strong funding organization for life sciences and medical-oriented, health-oriented research. I think it''s in the back of the minds of the politicians that there is a gigantic foundation that supports that [kind of research]. I don''t think one can deny that. There is an atmosphere that people like the Gates family [Bill and Melinda Gates Foundation] invests in health-related issues, particularly in the poorer countries [and that] maybe that is something that suffices.”The money available for research from private foundations and charities is growing in both size and scope. According to Iain Mattaj, Director General of the European Molecular Biology Laboratory (EMBL; Heidelberg, Germany), this growth might not be a bad thing. As he pointed out, private funding often complements government funding, with charities such as the Wellcome Trust going out of their way to leverage government spending without reducing government contributions. “My feeling is that the reason that the UK government is freezing research funding has all to do with economics and nothing to do with the fact that there are potentially private funders,” he said. “Several very large charities in particular are putting a lot of money into health research. The Gates Foundation is the biggest that has just come on the scene, but the Howard Hughes Medical Institute [HHMI; Chevy Chase, Maryland, USA] and the Wellcome Trust are very big, essentially private charities which have their own agendas.”…charities such as the Wellcome Trust [go] out of their way to leverage government spending without reducing government contributionscontributionsOpen in a separate window© CorbisBut, as he explained, these charities actually contribute to the overall health research budget, rather than substituting funds from one area to another. In fact, they often team up to tackle difficult research questions in partnership with each other and with government. Two-thirds of the €140 million annual budget of EMBL comes from the European states that agree to fund it, with additional contributions from private sources such as the Wellcome Trust and public sources such as the NIH.Yet over the years, as priorities have changed, the focus of those partnerships and the willingness to spend money on certain research themes or approaches has shifted, both within governments and in the private sector. Belief in the success of US President Richard Nixon''s famous ‘war on cancer'', for example, has waned over the years, although the fight and the funding continues. “I don''t want to use the word political, because of course the decisions are sometimes political, but actually it was a social priority to fight cancer. It was a social priority to fight AIDS,” Mattaj commented. “For the Wellcome Trust and the Gates Foundation, which are fighting tropical diseases, they see that as a social necessity, rather than a personal interest if you like.”Nevertheless, Mattaj is not surprised that there is an inclination to reduce research spending in the UK and many smaller countries battered by the economic downturn. “Most countries have to reduce public spending, and research is public spending. It may be less badly hit than other aspects of public spending. [As such] it''s much better off than many other aspects of public spending.”A shift away from government funding to private funding, especially from disease-focused charities, worries some that less funding will be available for basic, curiosity-driven research—a move from pure research to ‘cure'' research. Moreover, charities are often just as vulnerable to economic downturns, so relying on them is not a guarantee of funding in harsh economic times. Indeed, greater reliance on private funding would be a return to the era of ‘gentlemen scientists'' and their benefactors (Sidebar A).
Sidebar A | Gentlemen scientists
Greater reliance on private funding would return science to a bygone age of gentlemen scientists relying on the largesse of their wealthy sponsors. In 1831, for example, naturalist Charles Darwin''s (1809–1882) passage on the HMS Beagle was paid for by his father, albeit reluctantly. According to Laura Snyder, an expert on Victorian science and culture at St John''s University (New York, USA), by the time Darwin returned to England in 1836, the funding game had changed and government and private scientific societies had begun to have a bigger role. When Sir John Frederick William Herschel (1791–1871), an English mathematician, astronomer, chemist, experimental photographer and inventor, journeyed to Cape Colony in 1833, the British government offered to give him a free ride aboard an Admiralty ship. “Herschel turned them down because he wanted to be free to do whatever he wanted once he got to South Africa, and he didn''t want to feel beholden to government to do what they wanted him to do,” Snyder explained, drawing from her new book The Philosophical Breakfast Club, which covers the creation of the modern concept of science.Charles Babbage (1791–1871), the mathematician, philosopher, inventor and mechanical engineer who originated the concept of a programmable computer, was a member of the same circle as Herschel and William Whewell (1794–1866), a polymath, geologist, astronomer and theologian, who coined the word ''scientist''. Although he was wealthy, having inherited £100,000 in 1827—valued at about £13.3 million in 2008—Babbage felt that government should help pay for his research that served the public interest.“Babbage was asking the government constantly for money to build his difference engine,” Snyder said. Babbage griped about feeling like a tradesman begging to be paid. “It annoyed him. He felt that the government should just have said, ''We will support the engine, whatever it is that you need, just tell us and we''ll write you a check''. But that''s not what the government was about to do.”Instead, the British government expected Babbage to report on his progress before it loosened its purse strings. Snyder explained, “What the government was doing was a little bit more like grants today, in the sense that you have to justify getting more money and you have to account for spending the money. Babbage just wanted an open pocketbook at his disposal.”In the end the government donated £17,000, and Babbage never completed the machine.Janet Rowley, a geneticist at the University of Chicago, is worried that the change in funding will make it more difficult to obtain money for the kind of research that led to her discovery in the 1970s of the first chromosomal translocations that cause cancer. She calls such work ‘fishing expeditions''. She said that the Leukemia & Lymphoma Society (White Plains, New York, USA), for example—a non-profit funder of research—has modified its emphasis: “They have now said that they are going to put most of their resources into translational work and trying to take ideas that are close to clinical application, but need what are called incubator funds to ramp up from a laboratory to small-scale industrial production to increase the amount of compound or whatever is required to do studies on more patients.”This echoes Vince Cable''s view that taxpayers should not have to spend money on research that is not of direct economic, technological or health benefit to them. But if neither charities nor governments are willing to fund basic research, then who will pay the bill?…if neither charities nor governments are willing to fund basic research, then who will pay the bill?Iain Mattaj believes that the line between pure research and cure research is actually too blurred to make these kinds of funding distinctions. “In my view, it''s very much a continuum. I think many people who do basic research are actually very interested in the applications of their research. That''s just not their expertise,” he said. “I think many people who are at the basic end of research are more than happy to see things that they find out contributing towards things that are useful for society.”Jack Dixon, Vice President and Chief Scientific Officer at HHMI, also thinks that the line is blurry: “This divide between basic research and translational research is somewhat arbitrary, somewhat artificial in nature. I think every scientist I know who makes important, basic discoveries likes to [...] see their efforts translate into things that help humankind. Our focus at the Hughes has always been on basic things, but we love to see them translated into interesting products.” Even so, HHMI spends less than US $1 billion annually on research, which is overshadowed by the $30 billion spent by the NIH and the relatively huge budgets of the Wellcome Trust and Cancer Research UK. “We''re a small player in terms of the total research funding in the US, so I just don''t see the NIH pulling back on supporting research,” Dixon said.By way of example, Brian Druker, Professor of Medicine at the Oregon Health & Science University (Portland, Oregon, USA) and a HHMI scientist, picked up on Rowley''s work with cancer-causing chromosomal translocations and developed the blockbuster anti-cancer drug, imatinib, marketed by Novartis. “Brian Druker is one of our poster boys in terms of the work he''s done and how that is translated into helping people live longer lives that have this disease,” Dixon commented.There is a similar view at Stanford. The distinction between basic and applied is “in the eye of the beholder,” Greenberg said. “Basic discovery is the grist for the mill that leads to translational research and new breakthroughs. It''s always been a little difficult to convey, but at least here at Stanford, that''s number one. Number two, many of our very basic researchers enjoy thinking about the translational or clinical implications of their basic findings and some of them want to be part of doing it. They want some benefit for mankind other than pure knowledge.”“Basic discovery is the grist for the mill that leads to translational research and new breakthroughs”If it had not backed down from the massive cuts to the research budget that were proposed, the intention of the UK Government to cut funding for basic, rather than applied, research might have proven difficult to implement. Identifying which research will be of no value to society is like trying to decide which child will grow up to be Prime Minister. Nevertheless, most would agree that governments have a duty to get value-for-money for the taxpayer, but defining the value of research in purely economic or translational terms is both short-sighted and near impossible. Even so, science is feeling the economic downturn and budgets are tighter than they have been for a long time. As Greenberg concluded, “It''s human nature when everybody is feeling the pinch that you think [yours] is bigger than the next guy''s, but I would be hard pressed to say who is getting pinched, at least in the biomedical agenda, more than who else.” 相似文献7.
Hunter P 《EMBO reports》2011,12(2):110-112
The 2001 EU Clinical Trials Directive aimed to harmonize the regulation of medical research, but achieved the opposite. Various attempts are underway to update the directive to make it easier to safely conduct medical research in Europe.Medical research, similarly to finance and business, works best with light regulation; however, protecting patients during clinical trials, and afterwards when treatments have been approved, requires regulation. Attempts to square this circle and the challenge of testing sophisticated drugs and therapies have resulted in increasingly strict regulation of clinical research, particularly in Europe''s leading medical research powers Germany, France, the Netherlands and the UK. There is growing concern among these countries with established pharmaceutical industries that clinical trials are increasingly hard to conduct; in fact, the number of applications has declined significantly during the past decade (Cressy, 2010).There is growing concern among these countries with established pharmaceutical industries that clinical trials are increasingly hard to conduct…Meanwhile, the number of applications for clinical trials has increased in the USA, Canada and some southern European countries, notably Italy and Spain, where the regulatory touch has been lighter and combined, in some cases, with financial incentives, according to Paul Stewart, Dean of Medicine at the University of Birmingham in the UK. There is a danger therefore that Europe''s leading research nations could lose their competitive edge in medical research at a time when radical new treatments are on the horizon. “Europe''s weight in clinical research is diminishing,” commented Markus Hartmann, senior consultant at European Consulting & Contracting in Oncology (Saarbrücken, Germany), which provides advice about medical regulatory affairs. The risk of falling behind extends beyond drug-based therapies to surgery and medical devices, Hartmann added. He explained that the European Commission now considers medical devices and drugs as ‘products'' that can be sold in the internal market, and therefore require a common and harmonized regulatory framework.Hartmann, along with other researchers, traces the recent decline in European clinical trial activity back to the European Union (EU)''s Clinical Trials Directive (CTD) 2001/20, which was supposed to provide a common framework for unifying regulation within the EU by 2020. “The Clinical Trials Directive is contributing to this effect, but is not the only factor,” said Hartmann.The root cause of the problem might be growing aversity to risk—which puts more emphasis on patient protection even when this is not necessary—but the EU directive has certainly fuelled this mood. “That initial EU Directive was actually quite a sensible document, but what was crazy was the legal creep that followed,” said Stewart. “What the lawyers did was legislate for the worst possible scenario, instead of seeing the directive as a facilitating document enabling people to go and do research.”The directive actually had the opposite effect from the original intent: it led to even more regulatory fragmentation within the EU. This was first identified in a 2006 report, co-authored by Hartmann, which cited significant divergence in the national implementations of the EU directive (Hartmann & Hartmann-Vareilles, 2006). France was found to have the strictest regime, in which all trials including those involving cosmetics were rigorously supervised.The directive actually had the opposite effect from the original intent: it led to even more regulatory fragmentation within the EUThis divergence still exists. “Basically, the lack of harmonisation has not been resolved, as the Clinical Trials Directive has been transposed into national legislation in the form of laws, ordinances and rules of implementation that still differ in so many procedural and technical aspects,” said Hartmann.Moreover, although the 2001 directive underlined maintaining current levels of patient protection, Hartmann argued that it has done little if anything to improve safety. “Do not forget the TeGenero disaster with compound TGN1412, tested in spring 2006 in a Northern London hospital,” he said. “This was Europe''s largest clinical research catastrophe so far and happened in the UK, after the UK switched from a very liberal trial notification system, where phase I trials with healthy volunteers were even exempted from notification or authorisation, to the provisions laid down by the Clinical Trials Directive.”These problems have now been acknowledged by both national governments and the EU itself, according to Liselotte Højgaard, chair of the Standing Committee of the European Medical Research Councils, and a medical imaging specialist at the University of Copenhagen in Denmark. “We have had very many meetings in Brussels about the issue […] and in the last year the EU has become convinced it is a problem,” she said. As a result the directive is going to be redrafted well before it runs its full 20-year course. “We have been invited to help them draft a new directive,” said Højgaard. “That is a major achievement.”The aim is to learn from previous mistakes and frame the new document to encourage harmonization and a reduction in bureaucracy and paperwork. “We must make it easier to implement in each member state,” commented Højgaard, who added that the approval process also needs to be streamlined so that clinical trial teams do not have to repeat the same steps at different stages of the approvals process. “One of the things we are thinking about here in Denmark is whether we can make a one-stop-shop approvals process so you don''t have to go in and send an application to the medicinal agency, and also to the ethical committee, and also to clinicaltrials.gov,” said Højgaard. She hopes this new structure will be in place by the time Denmark holds the EU presidency in early 2012, and will encourage the rest of Europe to adopt a similar approach.The aim is to learn from previous mistakes and frame the new document to encourage harmonization and a reduction in bureaucracy and paperworkHartmann also acknowledges progress on the harmonization front. He cited the Voluntary Harmonisation Procedure (VHP), which was introduced in early 2009 by a network of national authorities, the Clinical Trials Facilitation Group (CTFG). It was set up precisely to coordinate implementation of the 2001/20 directive across EU member states, with little success at first. Now, the VHP allows applicants to submit protocols for trials to be conducted in many EU countries to the respective authorities, which agree on an assessment. “Then in a subsequent step, the applicant can submit the protocol to the national authorities for authorisation,” said Hartmann. “The VHP pilot aims to prevent divergent outcomes in the trial authorisation process, for example when a protocol approved in one country is blocked in another country.”These developments could eventually lead to a Europe-wide agency dedicated to clinical research regulation, along the same lines as the European Research Council for fundamental research, which Højgaard described as a great success. Such an agency would organize trials across the whole continent through a single streamlined approvals process, thereby covering a population of 500 million people.Attempts to amend the EU 2001 directive have also been welcomed by big funding bodies such as the Wellcome Trust in the UK, a charitable foundation that funds medical and clinical research globally. “We recently issued a response to a public consultation paper from the European Commission, Assessment Of The Functioning Of The “Clinical Trials Directive” 2001/20/EC, in which we highlighted areas where the Directive could be streamlined to reduce bureaucracy, while maintaining an appropriate regulatory framework,” said David Lynn, Head of Strategic Planning and Policy at the Wellcome Trust. “We would like to see a more risk-based approach to regulation of clinical trials, a rationalisation of the multiple layers of bureaucracy and the approvals process.”Bureaucracy notwithstanding, a fundamental problem is finding the right balance between risks associated with different drugs or therapies. The 2001 directive has instead led to a one-size-fits-all approach, according to Stewart. “Part of the work we''ve been doing at the level of the UK Clinical Research Consortium is to look at risk–benefit analysis, so that you have a lower level of regulation on some things and higher on others that are unproven.” If, for example, an existing drug turns out to be effective against a disease for which it was not originally developed, it would not be necessary to conduct thorough safety trials. This was the case with aspirin, initially developed as a pain killer over a century ago, which also protects against both vascular disease and bowel cancer (ATT Collaboration, 2009; Din et al, 2010). During these trials, safety was still an issue as the drug was being used in a different context, but, even so, it was clear that acute side effects were highly unlikely.Bureaucracy notwithstanding, a fundamental problem is finding the right balance between risks associated with different drugs or therapiesWhile medical regulations in Europe err on the side of safety, they do little to regulate and harmonise the reporting of results after trials have occurred. The results from many clinical trials are never published as they fall victim to reporting bias for various reasons, notably because the pharmaceutical companies providing funding have an interest in promoting results favourable to their products and suppressing negative findings. A recent study by the Institute for Quality and Efficiency in Health Care (IQWiG) in Cologne, Germany, confirmed widespread publication bias in the past, which harmed patients through under-reporting of side effects (McGauran et al, 2010).“The most prominent example of harm caused by publication bias is probably the case of Class I anti-arrhythmic drugs,” said Beate Wieseler, deputy head of IQWiG''s Drug Assessment Department. In this 1980 trial, 9 of 49 patients with suspected acute myocardial infarction who were treated with a class I anti-arrhythmic drug (lorcainide) died, compared with only one patient in the placebo group, and yet the investigators ludicrously dismissed this as chance (Cowley et al, 1993). The results of the trial were not published until 1993 and, although the development of lorcainide was discontinued for commercial reasons, the investigators concluded that as a result of this delay in publication, the continuing use of class I drugs had led to several unnecessary deaths.By the same token, ineffective drugs have sometimes gained market approval after over-reporting of their benefits, in some cases ignoring other, more negative, studies. Wieseler and colleagues found that studies reporting positive results for a particular drug were published in higher impact journals and were more likely to be picked up by other publications and the mass media.Many cases of reporting bias, especially involving suppression of negative results, occurred 10 or more years ago. According to Stewart the situation has improved, although he concedes that, almost inevitably, journals will be drawn towards positive results given the increasing competition for readers and advertisers. “Whether publication bias goes on to the same extent now is debatable,” said Stewart, pointing out that clinical trials now have to be registered in Europe and the USA so that the data is public, even if it is not published in a journal.There will inevitably be some risk of bias in research funded by pharmaceutical companies, which, after all, are in the business to make money. It is therefore important to support ‘investigator-driven'' trials that are independent of any company, and it is here that the Wellcome Trust has an important role. “The Wellcome Trust supports the proposal for Investigator Driven Clinical Trials as joint collaborations across Europe,” said Lynn. “We fund academic clinical trials, which are usually independent of drug company interests.”Independent money for academic clinical trials has indeed been more crucial during the past few years, since the EU 2001/20 directive tends to favour research funded by drug companies with the money and resources to overcome the increasingly high bureaucratic hurdles. Lynn commented that universities had not been well served by recent legislation. “Academic institutions are less-well resourced and equipped than commercial sponsors to deal with the bureaucratic burden imposed by the Directive,” he said.In some cases these burdens have caused even young scientists to give up on promising research because they cannot stomach the paperwork involved…In some cases these burdens have caused even young scientists to give up on promising research because they cannot stomach the paperwork involved, according to Højgaard. “For the first time in my life as a boss, I had the experience when I came in to a morning conference and asked one of the young consultants ‘shouldn''t we do a clinical study on this'' and he said ‘no I simply haven''t got the energy for all this paper workload''.” This experience spurred her to lobby for change. Critics such as Højgaard and others therefore hope that the redrafting of the amendment and the ensuing changes in national legislation will liberate European medical research from the regulatory shackles that have held it back. 相似文献
8.
Howard Wolinsky 《EMBO reports》2010,11(7):508-510
A lack of breeders to apply the knowledge from plant science is jeopardizing public breeding programmes and the training of future plant scientistsIn the midst of an economic downturn, many college and university students in the USA face an uncertain future. There is one crop of graduates, though, who need not worry about unemployment: plant breeders. “Our students start with six-digit salaries once they leave and they have three or four offers. We have people coming to molecular biology and they can''t find jobs. People coming to plant breeding, they have as many jobs as they want,” said Edward Buckler, a geneticist with the US Department of Agriculture''s Agricultural Research Service Institute for Genomic Diversity at Cornell University (Ithaca, NY, USA).The lure of Big Ag depletes universities and research institutes of plant breeders […] and jeopardizes the training of future generations of plant scientists and breedersThe secret behind the success of qualified breeders on the job market is that they can join ‘Big Ag''—big agriculture—that is, major seed companies. Roger Boerma, coordinator of academic research for the Center for Applied Genetic Technologies at the University of Georgia (Athens, GA, USA), said that most of his graduate and postdoctoral students find jobs at companies such as Pioneer, Monsanto and Syngenta, rather than working in the orchards and fields of academic research. According to Todd Wehner, a professor and cucurbit breeder at the Department of Horticultural Science, North Carolina State University (Raleigh, NC, USA), the best-paying jobs—US$100,000 plus good benefits and research conditions—are at seed companies that deal with the main crops (Guner & Wehner, 2003). By contrast, university positions typically start at US$75,000 and tenure track.As a result, Wehner said, public crop breeding in the USA has begun to disappear. “To be clear, there is no shortage of plant breeders,” he said. “There is a shortage of plant breeders in the public sector.” The lure of Big Ag depletes universities and research institutes of plant breeders—who, after all, are the ones who create new plant varieties for agriculture—and jeopardizes the training of future generations of plant scientists and breeders. Moreover, there is an increasing demand for breeders to address the challenge of creating environmentally sustainable ways to grow more food for an increasing human population on Earth.At the same time, basic plant research is making rapid progress. The genomes of most of the main crop plants and many vegetables have been sequenced, which has enabled researchers to better understand the molecular details of how plants fend off pests and pathogens, or withstand drought and flooding. This research has also generated molecular markers—short regions of DNA that are linked to, for example, better resistance to fungi or other pathogens. So-called marker-assisted breeding based on this information is now able to create new plant varieties more effectively than would be possible with the classical strategy of crossing, selection and backcrossing.However, applying the genomic knowledge requires both breeders and plant scientists with a better understanding of each other''s expertise. As David Baulcombe, professor of botany at the University of Cambridge, UK, commented, “I think the important gap is actually in making sure that the fundamental scientists working on genomics understand breeding, and equally that those people doing breeding understand the potential of genomics. This is part of the translational gap. There''s incomplete understanding on both sides.”…applying the genomic knowledge requires both breeders and plant scientists with a better understanding of each other''s expertiseIn the genomic age, plant breeding has an image problem: like other hands-on agricultural work, it is dirty and unglamorous. “A research project in agriculture in the twenty-first century resembles agriculture for farmers in the eighteenth century,” Wehner said. “Harvesting in the fields in the summer might be considered one of the worst jobs, but not to me. I''m harvesting cucumbers just like everybody else. I don''t mind working at 105 degrees, with 95% humidity and insects biting my ankles. I actually like that. I like that better than office work.”For most students, however, genomics is the more appealing option as a cutting-edge and glamorous research field. “The exciting photographs that you always see are people holding up glass test tubes and working in front of big computer screens,” Wehner explained.In addition, Wehner said that federal and state governments have given greater priority and funding to molecular genetics than to plant breeding. “The reason we''ve gone away from plant breeding of course is that faculty can get competitive grants for large amounts of money to do things that are more in the area of molecular genetics,” he explained. “Plant breeders have switched over to molecular genetics because they can get money there and they can''t get money in plant breeding.”“The frontiers of science shifted from agriculture to genetics, especially the genetics of corn, wheat and rice,” agreed Richard Flavell, former Director of the John Innes Centre (Norwich, UK) and now Chief Scientific Officer of Ceres (Thousand Oaks, CA, USA). “As university departments have chased their money, chased the bright students, they have [focused on] programmes that pull in research dollars on the frontiers, and plant breeding has been left behind as something of a Cinderella subject.”In the genomic age, plant breeding has an image problem: like other hands-on agricultural work, it is dirty and unglamorousIn a sense, public plant breeding has become a victim of its own success. Wehner explained that over the past century, the protection of intellectual property has created a profitable market for private corporations to the detriment of public programmes. “It started out where they could protect seed-propagated crops,” he said. “The companies began to hire plant breeders and develop their own varieties. And that started the whole agricultural business, which is now huge.”As a result, Wehner said, the private sector can now outmanoeuvre public breeders at will. “[Seed companies] have huge teams that can go much faster than I can go. They have winter nurseries and big greenhouses and lots of pathologists and molecular geneticists and they have large databases and seed technologists and sales reps and catalogue artists and all those things. They can do much faster cucumber breeding than I can. They can beat me in any area that they choose to focus on.”He said that seed corporations turn only to public breeders when they are looking for rare seeds obtained on expeditions around the world or special knowledge. These crops and the breeders and other scientists who work on them receive far less financial support from government than do the more profitable crops, such as corn and soybean. In effect, these crops are in an analogous position to orphan drugs that receive little attention because the patients who need them represent a small economic market.The dwindling support for public breeding programmes is also a result of larger political developments. Since the 1980s, when British Prime Minister Margaret Thatcher and US President Ronald Regan championed the private sector in all things, government has consistently withdrawn support for public research programmes wherever the private sector can profit. “Plant breeding programmes are expensive. My programme costs about US$500,000 a year to run for my crops, watermelon and cucumber. Universities don''t want to spend that money if they don''t have to, especially if it''s already being done by the private sector,” Wehner said.“Over the last 30 years or so, food supplies and food security have fallen off the agenda of policymakers”…“Over the last 30 years or so, food supplies and food security have fallen off the agenda of policymakers,” Baulcombe explained. “Applied research in academic institutions is disappearing, and so the opportunities for linking the achievements of basic research with applications, at least in the public sector, are disappearing. You''ve got these two areas of the work going in opposite directions.”There''s another problem for plant breeding in the publish-or-perish world of academia. According to Ian Graham, Director of the Centre for Novel Agricultural Products at York University in the UK, potential academics in the plant sciences are turned off by plant breeding as a discipline because it is difficult to publish the research in high-impact journals.Graham, who is funded by the Bill & Melinda Gates Foundation to breed new varieties of Artemisia—the plant that produces the anti-malarial compound artemisinin—said this could change. “Now with the new [genomic] technologies, the whole subject of plant breeding has come back into the limelight. We can start thinking seriously about not just the conventional crops […] but all the marginal crops as well that we can really start employing these technologies on and doing exciting science and linking phenotypes to genes and phenotypes to the underlying biology,” he said. “It takes us back again closer to the science. That will bring more people into plant breeding.”…potential academics in the plant sciences are turned off by plant breeding as a discipline because it is difficult to publish the research in high-impact journalsBuckler, who specializes in functional genomic approaches to dissect complex traits in maize, wheat and Arabidopsis, said that public breeding still moves at a slower pace. “The seed companies are trying to figure out how to move genomics from gene discovery all the way to the breeding side. And it''s moving forward,” he said. “There have been some real intellectual questions that people are trying to overcome as to how fast to integrate genomics. I think it''s starting to occur also with a lot of the public breeders. A lot of it has been that the cost of genotyping, especially for specialty crops, was too high to develop marker systems that would really accelerate breeding.”Things might be about to change on the cost side as well. Buckler said that decreasing costs for sequencing and genotyping will give public breeding a boost. Using today''s genomic tools, researchers and plant breeders could match the achievements of the last century in maize breeding within three years. He said that comparable gains could be made in specialty crops, the forte of public breeding. “Right now, most of the simulations suggest that we can accelerate it about threefold,” Buckler said. “Maybe as our knowledge increases, maybe we can approach a 15-fold rate increase.”Indeed, the increasing knowledge from basic research could well contribute to significant advances in the coming years. “We''ve messed around with genes in a rather blind, sort of non-predictive process,” said Scott Jackson, a plant genomics expert at Purdue University (West Lafayette, IN, USA), who headed the team that decoded the soybean genome (Schmutz et al, 2010). “Having a full genome sequence, having all the genes underlying all the traits in whatever plant organism you''re looking at, makes it less blind. You can determine which genes affect the trait and it has the potential to make it a more predictive process where you can take specific genes in combinations and you can predict what the outcome might be. I think that''s where the real revolution in plant breeding is going to come.”Nevertheless, the main problem that could hold back this revolution is a lack of trained people in academia and the private sector. Ted Crosbie, Head of Plant Breeding at Monsanto (St Louis, MO, USA), commented at the national Plant Breeding Coordinating Committee meeting in 2008 that “[w]e, in the plant breeding industry, face a number of challenges. More plant breeders are reaching retirement age at a time when the need for plant breeders has never been greater […] We need to renew our nation''s capacity for plant breeding.”“…with the new [genomic] technologies, the whole subject of plant breeding has come back into the limelight”Dry bean breeder James Kelly, a professor of crop and soil sciences at Michigan State University (East Lansing, MI, USA), said while there has been a disconnect between public breeders and genomics researchers, new federal grants are designed to increase collaboration.In the meantime, developing countries such as India and China have been filling the gap. “China is putting a huge amount of effort into agriculture. They actually know the importance of food. They have plant breeders all over the place,” Wehner said. “The US is starting to fall behind. And now, agricultural companies are looking around wondering—where are we going to get our plant breeders?”To address the problem, major agriculture companies have begun to fund fellowships to train new plant breeders. Thus far, Buckler said, these efforts have had only a small impact. He noted that 500 new PhDs a year are needed just in maize breeding. “It''s not uncommon for the big companies like Monsanto, Pioneer and Syngenta to spend money on training, on endowing chairs at universities,” Flavell said. “It''s good PR, but they''re serious about the need for breeders.”The US government has also taken some measures to alleviate the problem. Congress decided to establish the US National Institute of Food and Agriculture (Washington, DC, USA) under the auspices of the US Department of Agriculture to make more efficient use of research money, advance the application of plant science and attract new students to plant breeding (see the interview with Roger Beachy in this issue, pp 504–507). Another approach is to use distance education to train breeders, such as technicians who want to advance their careers, in certificate programmes rather than master''s or doctorate programmes.“If [breeding] is not done in universities in the public sector, where is it done?”…“If [breeding] is not done in universities in the public sector, where is it done?” Flavell asked about the future of public breeding. “I can wax lyrical and perhaps be perceived as being over the top, but if we''re going to manage this planet on getting more food out of less land, this has to be almost one of the highest things that has got to be taken care of by government.” Wehner added, “The public in the developed world thinks food magically appears in grocery stores. There is no civilization without agriculture. Without plant breeders to work on improving our crops, civilization is at risk.” 相似文献
9.
10.
Paige Brown 《EMBO reports》2012,13(11):964-967
Many scientists blame the media for sensationalising scientific findings, but new research suggests that things can go awry at all levels, from the scientific report to the press officer to the journalist.Everything gives you cancer, at least if you believe what you read in the news or see on TV. Fortunately, everything also cures cancer, from red wine to silver nanoparticles. Of course the truth lies somewhere in between, and scientists might point out that these claims are at worst dangerous sensationalism and at best misjudged journalism. These kinds of media story, which inflate the risks and benefits of research, have led to a mistrust of the press among some scientists. But are journalists solely at fault when science reporting goes wrong, as many scientists believe [1]? New research suggests it is time to lay to rest the myth that the press alone is to blame. The truth is far more nuanced and science reporting can go wrong at many stages, from the researchers to the press officers to the diverse producers of news.Many science communication researchers suggest that science in the media is not as distorted as scientists believe, although they do admit that science reporting tends to under-represent risks and over-emphasize benefits [2]. “I think there is a lot less of this [misreported science] than some scientists presume. I actually think that there is a bit of laziness in the narrative around science and the media,” said Fiona Fox, Director of the UK Science Media Centre (London, UK), an independent press office that serves as a liaison between scientists and journalists. “My bottom line is that, certainly in the UK, a vast majority of journalists report science accurately in a measured way, and it''s certainly not a terrible story. Having said that, lots of things do go wrong for a number of reasons.”Fox said that the centre sees everything from fantastic press releases to those that completely misrepresent and sensationalize scientific findings. They have applauded news stories that beautifully reported the caveats and limitations of a particular scientific study, but they have also cringed as a radio talk show pitted a massive and influential body of research against a single non-scientist sceptic.“You ask, is it the press releases, is it the universities, is it the journalists? The truth is that it''s all three,” Fox said. “But even admitting that is admitting more complexity. So anyone who says that scientists and university press officers deliver perfectly accurate science and the media misrepresent it […] that really is not the whole story.”Scientists and scientific institutions today invest more time and effort into communicating with the media than they did a decade ago, especially given the modern emphasis on communicating scientific results to the public [3]. Today, there are considerable pressures on scientists to reach out and even ‘sell their work'' to public relations officers and journalists. “For every story that a journalist has hyped and sensationalized, there will be another example of that coming directly from a press release that we [scientists] hyped and sensationalized,” Fox said. “And for every time that that was a science press officer, there will also be a science press officer who will tell you, ‘I did a much more nuanced press release, but the academic wanted me to over claim for it''.”Although science public relations has helped to put scientific issues on the public agenda, there are also dangers inherent in the process of translation from original research to press release to media story. Previous research in the area of science communication has focused on conflicting scientific and media values, and the effects of science media on audiences. However, studies have raised awareness of the role of press releases in distorting information from the lab bench to published news [4].In a 2011 study of genetic research claims made in press releases and mainstream print media, science communication researcher Jean Brechman, who works at the US advertising and marketing research firm Gallup & Robinson, found evidence that scientific knowledge gets distorted as it is “filtered and translated for mass communication” with “slippages and inconsistencies” occurring along the way, such that the end message does not accurately represent the original science [4]. Although Brechman and colleagues found a concerning point of distortion in the transition between press release and news article, they also observed a misrepresentation of the original science in a significant portion of the press releases themselves.In a previous study, Brechman and his colleagues had also concluded that “errors commonly attributed to science journalists, such as lack of qualifying details and use of oversimplified language, originate in press releases.” Even more worrisome, as Fox told a Nature commentary author in 2009, public relations departments are increasingly filling the need of the media for quick content [5].Fox believes that a common characteristic of misrepresented science in press releases and the media is the over-claiming of preliminary studies. As such, the growing prevalence of rapid, short-format publications that publicize early results might be exacerbating the problem. Research has also revealed that over-emphasis on the beneficial effects of experimental medical treatments seen in press releases and news coverage, often called ‘spin'', can stem from bias in the abstract of the original scientific article itself [6]. Such findings warrant a closer examination of the language used in scientific articles and abstracts, as the wording and ‘spin'' of conclusions drawn by researchers in their peer-reviewed publications might have significant impacts on subsequent media coverage.Of course, some stories about scientific discoveries are just not easy to tell owing to their complexity. They are “messy, complicated, open to interpretation and ripe for misreporting,” as Fox wrote in a post on her blog On Science and the Media (fionafox.blogspot.com). They do not fit the single-page blog post or the short press release. Some scientific experiments and the peer-reviewed articles and media stories that flow from them are inherently full of caveats, contexts and conflicting results and cannot be communicated in a short format [7].In a 2012 issue of Perspectives on Psychological Science, Marco Bertamini at the University of Liverpool (UK) and Marcus R. Munafo at the University of Bristol (UK) suggested that a shift toward “bite-size” publications in areas of science such as psychology might be promoting more single-study models of research, fewer efforts to replicate initial findings, curtailed detailing of previous relevant work and bias toward “false alarm” or false-positive results [7]. The authors pointed out that larger, multi-experiment studies are typically published in longer papers with larger sample sizes and tend to be more accurate. They also suggested that this culture of brief, single-study reports based on small data sets will lead to the contamination of the scientific literature with false-positive findings. Unfortunately, false science far more easily enters the literature than leaves it [8].One famous example is that of Andrew Wakefield, whose 1998 publication in The Lancet claimed to link autism with the combined measles, mumps and rubella (MMR) vaccination. It took years of work by many scientists, and the aid of an exposé by British investigative reporter Brian Deer, to finally force retraction of the paper. However, significant damage had already been done and many parents continue to avoid immunizing their children out of fear. Deer claims that scientific journals were a large part of the problem: “[D]uring the many years in which I investigated the MMR vaccine controversy, the worst and most inexcusable reporting on the subject, apart from the original Wakefield claims in the Lancet, was published in Nature and republished in Scientific American,” he said. “There is an enormous amount of hypocrisy among those who accuse the media of misreporting science.”What factors are promoting this shift to bite-size science? One is certainly the increasing pressure and competition to publish many papers in high-impact journals, which prefer short articles with new, ground-breaking findings.“Bibliometrics is playing a larger role in academia in deciding who gets a job and who gets promoted,” Bertamini said. “In general, if things are measured by citations, there is pressure to publish as much and as often as possible, and also to focus on what is surprising; thus, we can see how this may lead to an inflation in the number of papers but also an increase in publication bias.”Bertamini points to the real possibility that measured effects emerging from a group of small samples can be much larger than the real effect in the total population. “This variability is bad enough, but it is even worse when you consider that what is more likely to be written up and accepted for publication are exactly the larger differences,” he explained.Alongside the endless pressure to publish, the nature of the peer-reviewed publication process itself prioritizes exciting and statistically impressive results. Fluke scientific discoveries and surprising results are often considered newsworthy, even if they end up being false-positives. The bite-size article aggravates this problem in what Bertamini fears is a growing similarity between academic writing and media reporting: “The general media, including blogs and newspapers, will of course focus on what is curious, funny, controversial, and so on. Academic papers must not do the same, and the quality control system is there to prevent that.”The real danger is that, with more than one million scientific papers published every year, journalists can tend to rely on only a few influential journals such as Science and Nature for science news [3]. Although the influence and reliability of these prestigious journals is well established, the risk that journalists and other media producers might be propagating the exciting yet preliminary results published in their pages is undeniable.Fox has personal experience of the consequences of hype surrounding surprising but preliminary science. Her sister has chronic fatigue syndrome (CFS), a debilitating medical condition with no known test or cure. When Science published an article in 2009 linking CFS with a viral agent, Fox was naturally both curious and sceptical [9]. “I thought even if I knew that this was an incredibly significant finding, the fact that nobody had ever found a biological link before also meant that it would have to be replicated before patients could get excited,” Fox explained. “And of course what happened was all the UK journalists were desperate to splash it on the front page because it was so surprising and so significant and could completely revolutionize the approach to CFS, the treatment and potential cure.”Fox observed that while some journalists placed the caveats of the study deep within their stories, others left them out completely. “I gather in the USA it was massive, it was front page news and patients were going online to try and find a test for this particular virus. But in the end, nobody could replicate it, literally nobody. A Dutch group tried, Imperial College London, lots of groups, but nobody could replicate it. And in the end, the paper has been withdrawn from Science.”For Fox, the fact that the paper was withdrawn, incidentally due to a finding of contamination in the samples, was less interesting than the way that the paper was reported by journalists. “We would want any journal press officer to literally in the first paragraph be highlighting the fact that this was such a surprising result that it shouldn''t be splashed on the front page,” she said. Of course to the journalist, waiting for the study to be replicated is anathema in a culture that values exciting and new findings. “To the scientific community, the fact that it is surprising and new means that we should calm down and wait until it is proved,” Fox warned.So, the media must also take its share of the blame when it comes to distorting science news. Indeed, research analysing science coverage in the media has shown that stories tend to exaggerate preliminary findings, use sensationalist terms, avoid complex issues, fail to mention financial conflicts of interest, ignore statistical limitations and transform inherent uncertainties into controversy [3,10].One concerning development within journalism is the ‘balanced treatment'' of controversial science, also called ‘false balance'' by many science communicators. This balanced treatment has helped supporters of pseudoscientific notions gain equal ground with scientific experts in media stories on issues such as climate change and biotechnology [11].“Almost every time the issue of creationism or intelligent design comes up, many newspapers and other media feel that they need to present ‘both sides'', even though one is clearly nonsensical, and indeed harmful to public education,” commented Massimo Pigliucci, author of Nonsense on Stilts: How to Tell Science from Bunk [12].Fox also criticizes false balance on issues such as global climate change. “On that one you can''t blame the scientific community, you can''t blame science press officers,” she said. “That is a real clashing of values. One of the values that most journalists have bred into them is about balance and impartiality, balancing the views of one person with an opponent when it''s controversial. So on issues like climate change, where there is a big controversy, their instinct as a journalist will be to make sure that if they have a climate scientist on the radio or on TV or quoted in the newspaper, they pick up the phone and make sure that they have a climate skeptic.” However, balanced viewpoints should not threaten years of rigorous scientific research embodied in a peer-reviewed publication. “We are not saying generally that we [scientists] want special treatment from journalists,” Fox said, “but we are saying that this whole principle of balance, which applies quite well in politics, doesn''t cross over to science…”Bertamini believes the situation could be made worse if publication standards are relaxed in favour of promoting a more public and open review process. “If today you were to research the issue of human contribution to global warming you would find a consensus in the scientific literature. Yet you would find no such consensus in the general media. In part this is due to the existence of powerful and well-funded lobbies that fill the media with unfounded skepticism. Now imagine if these lobbies had more access to publish their views in the scientific literature, maybe in the form of post publication feedback. This would be a dangerous consequence of blurring the line that separates scientific writing and the broader media.”In an age in which the way science is presented in the news can have significant impacts for audiences, especially when it comes to health news, what can science communicators and journalists do to keep audiences reading without having to distort, hype, trivialize, dramatize or otherwise misrepresent science?Pigliucci believes that many different sources—press releases, blogs, newspapers and investigative science journalism pieces—can cross-check reported science and challenge its accuracy, if necessary. “There are examples of bloggers pointing out technical problems with published scientific papers,” Pigliucci said. “Unfortunately, as we all know, the game can be played the other way around too, with plenty of bloggers, ‘twitterers'' and others actually obfuscating and muddling things even more.” Pigliucci hopes to see a cultural change take place in science reporting, one that emphasizes “more reflective shouting, less shouting of talking points,” he said.Fox believes that journalists still need to cover scientific developments more responsibly, especially given that scientists are increasingly reaching out to press officers and the public. Journalists can inform, intrigue and entertain whilst maintaining accurate representations of the original science, but need to understand that preliminary results must be replicated and validated before being splashed on the front page. They should also strive to interview experts who do not have financial ties or competing interests in the research, and they should put scientific stories in the context of a broader process of nonlinear discovery. According to Pigliucci, journalists can and should be educating themselves on the research process and the science of logical conclusion-making, giving themselves the tools to provide critical and investigative coverage when needed. At the same time, scientists should undertake proper media training so that they are comfortable communicating their work to journalists or press officers.“I don''t think there is any fundamental flaw in how we communicate science, but there is a systemic flaw in the sense that we simply do not educate people about logical fallacies and cognitive biases,” Pigliucci said, advising that scientists and communicators alike should be intimately familiar with the subjects of philosophy and psychology. “As for bunk science, it has always been with us, and it probably always will be, because human beings are naturally prone to all sorts of biases and fallacious reasoning. As Carl Sagan once put it, science (and reason) is like a candle in the dark. It needs constant protection and a lot of thankless work to keep it alive.” 相似文献
11.
Philip Hunter 《EMBO reports》2013,14(12):1047-1049
EU-LIFE, which represents 10 European life science research institutes, has reopened the debate about how to fund research at the European level by calling for the budget of the European Research Council to be drastically increased.For more than a decade, European scientists have lobbied policy makers in Brussels to increase European Union (EU) funding for research and to spend the money they do provide more efficiently. This debate eventually led to the establishment of the European Research Council (ERC) in 2007, which provides significant grants and does so on the sole criterion of scientific excellence—something for which the scientific community pushed. As such, there seemed to be consensus about how to judge and fund science at the European level, including in the debate about the EU''s Horizon 2020 funding scheme—the EU''s framework for research and innovation—which will spend €80 billion over the next seven years (2014–2020). The conclusion seemed to be that the ERC should continue to support basic research on the basis of excellence, whereas other parts of the programme would focus on large cooperative projects, improving the competitiveness of Europe and meeting societal challenges such as climate change and public health.But a new body called EU-LIFE—set up in May 2013—has reopened the debate about how to fund science and is campaigning for a greater focus on rewarding excellence, even at the expense of funding projects on the grounds of fairness or to correct imbalances between EU member states. EU-LIFE was founded by 10 institutions including the Centre for Genomic Regulation (CRG; Barcelona, Spain), the Institut Curie (Paris, France) and the Max Delbrück Centre (Berlin, Germany), partly to provide a collective voice for mid-sized research institutes in the life sciences that might lack influence on their own (Institute Advanced grant Starting grant Proof-of-concept grant Total ERC grants Total ERC funding (million €) Centre for Genomic Regulation (Spain) 3 9 1 13 19.0 Free University of Brussels (VIB; Belgium) 5 14 1 20 33.3 Institut Curie (France) 7 11 – 18 34.5 Max Delbrück Centre for Molecular Medicine (Germany) 4 4 – 8 15 Instituto Gulbenkian de Ciência (Portugal) 1 4 – 5 7.8 Research Centre for Molecular Medicine of the Austrian Academy of Sciences (Austria) 1 2 1 4 5.1 European Institute of Oncology (Italy) 3 1 1 5 8.7 Central European Institute of Technology (Czech Republic) – – – – – The Netherlands Cancer Institute (Netherlands) 6 4 – 10 19.5 Institute for Molecular Medicine Finland (Finland) – – – – –