近端膨胀髓内钉与抗旋髓内钉治疗老年股骨转子间骨折的临床疗效分析

目的:探究近端膨胀髓内钉与近端螺旋刀片抗旋髓内钉治疗老年股骨转子间骨折疗效及躁动发生率比较。方法:病例来源为2012年5月至2013年10月收入我院的老年股骨转子间骨折患者60例,采用随机数字表随机分为两组,膨胀钉组30例,采用近端膨胀髓内钉的手术方法,PFNA组30例,采用近端螺旋刀片抗旋髓内钉的手术方法。手术结束后,对两组患者进行X射线片、手术时间及出血量、髋关节功能的比较,同时对比躁动发生率。结果:X线检查结果显示两组患者经手术后骨折处均复位良好,无并发症及内固定物的脱落及松动,两组比较无显著差异(P0.05);与PFNA组相比,膨胀组患者的手术时间及出血量明显降低,差异具有统计学意义(P0.05);两组患者术后3个月、6个月的Harris评分显示,与PFNA组相比,膨胀钉组的优良率明显升高,髋关节优于PFNA组,差异具有统计学意义(P0.05);膨胀钉组患者躁动率为10.00%低于PFNA组患者躁动率为33.33%,具有统计学意义(P0.05)。结论:可膨胀髓内钉具有手术时间较短、出血量少,更利于骨折的愈合,且躁动发生率较低,对股骨转子间骨折的疗效优于较近端螺旋刀片抗旋髓内钉,对临床有指导意义,值得临床推广。     

股骨近端防旋髓内钉与联合加压交锁髓内钉治疗老年股骨转子间骨折的疗效比较研究

目的:研究对比股骨近端防旋髓内钉(PENA-Ⅱ)与联合加压交锁髓内钉(Inter Tan)治疗老年股骨转子间骨折的疗效。方法:选择2014年6月至2016年6月我院收治的老年股骨转子间骨折患者92例,按照随机数字表法分为PENA-Ⅱ组与Inter Tan组,每组各46例。两组患者分别接受PENA-Ⅱ治疗和Inter Tan治疗,术后进行为期12个月的随访。比较两组临床疗效、手术相关指标(手术时间、术中出血量、骨折愈合时间)、手术前后骨密度水平变化情况以及并发症发生情况。结果:PENA-Ⅱ组优良率为89.13%,略高于Inter Tan组的86.96%,但两组比较差异无统计学意义(P0.05)。PENA-Ⅱ组患者手术时间、术中出血量分别为(65.2±15.3)min、(57.2±29.3)m L,明显低于Inter Tan组患者的(84.3±13.8)min、(104.7±36.5)m L(P0.05),两组患者骨折愈合时间比较差异无统计学意义(P0.05)。术前、术后12周以及术后24周PENA-Ⅱ组患者的腰椎骨密度水平与Inter Tan组比较差异无统计学意义(P0.05)。两组切口感染、肺部感染、下肢深静脉血拴、近端股骨外侧皮质劈裂以及髋内翻发生率对比差异无统计学意义(P0.05)。结论:PENA-Ⅱ与Inter Tan治疗老年股骨转子间骨折的临床疗效相当,且两种手术方法对骨密度水平的影响及术后并发症发生率相似。但PENA-Ⅱ治疗具有手术时间短以及术中出血量少等优势,值得临床推广应用。     

SL-R柄人工股骨头置换术与股骨近端防旋髓内钉治疗老年不稳定型骨质疏松性股骨粗隆间骨折的疗效比较研究

目的:探讨股骨近端防旋髓内钉、SL-R柄人工股骨头置换术两种术式治疗老年不稳定型骨质疏松性股骨粗隆间骨折的应用效果。方法:选取2015年1月-2017年6月间于河北医科大学附属秦皇岛市第一医院行手术治疗的老年不稳定型骨质疏松性股骨粗隆间骨折患者98例,以数表法将患者随机均分为对照组(n=49)和观察组(n=49)。其中对照组采用股骨近端防旋髓内钉,观察组采用SL-R柄人工股骨头置换术。比较两组患者临床各项指标、手术前后髋关节功能评分以及术后并发症发生情况。结果:观察组手术时间、术中失血量均高于对照组,但住院时间、开始负重时间则低于对照组(P0.05)。观察组术后并发症发生率为4.08%(2/49),低于对照组的18.37%(9/49)(P0.05)。术后1个月、3个月时患者髋关节各项评分相比术前均有升高,术后3个月的各项评分高于术后1个月(P0.05);观察组术后1个月、3个月各项评分均高于对照组(P0.05)。结论:在老年不稳定型骨质疏松性股骨粗隆间骨折患者治疗过程当中,采用SL-R柄人工股骨头置换术可减少住院时间,疗效确切,无严重并发症,且可改善髋关节各项功能评分。     

高粱雄性不育系热激前后线粒体的变化与育性的关系

高粱雄性不育系3197A（3A）在花粉母细胞期进行热激处理后由不育变为可育。提取其处理小穗线粒体用流式细胞仪计数进行分析。结果发现经热激处理后,3A不育系的线粒体数目由1.55×106个／mg鲜穗增加至7.1×106／mg。同时对热激处理后3A的花粉育性及同工酶进行了研究,发现热激后3A的花粉粒变的饱满并可被I2朘I 溶液染色,其细胞色素氧化酶和过氧化物酶的电泳酶谱中出现与保持系3B一致的酶带。     

晚期卵巢高级别浆液性腺癌术后血CA125下降情况与残余病灶大小关系的研究

目的:探讨血清CA125测定对评估卵巢高级别浆液性腺癌术后血CA125下降情况与残余病灶大小关系的价值.方法:回顾性研究卵巢高级别浆液性腺癌Ⅱc-Ⅳ期患者62例,按照瘤体减灭术后残余病灶大小分为3组,A组为术后残余病灶＞1cm,B组为≤ 1cm者,C组为肉眼未见病灶者,查阅术前、术后第1次化疗后血CA125值.结果:C组下降百分比与B组、A组相比有统计学差异(分别为P=0.024,P=0.002).结论:术后残余病灶大小不同的患者血CA125下降情况不同,在关于肿瘤标志物的研究中将肉眼未见病灶组单独列出研究有很大的必要性.     

蛋白质的变化与植物抗寒性的关系研究进展

蛋白质的变化在植物抗寒生理研究中一直被广泛关注。低温胁迫期间在蛋白质含量变化的同时,还可能发生质的变化,合成新的蛋白质——低温诱导蛋白。综述了低温胁迫期间植物体内蛋白质的变化,重点阐述了抗冻蛋白、脱水蛋白和热激蛋白等3种低温诱导蛋白的特性及其与植物抗寒性的关系,并对该领域今后的研究做了展望,为进一步阐明植物抗寒的分子机制、提高植物的抗寒力提供了新的思路。     

The Relationship Between Plasma and Brain Quinolinic Acid Levels and the Severity of Hepatic Encephalopathy in Animal Models of Fulminant Hepatic Failure

Abstract: Quinolinic acid is an excitatory, neurotoxic tryptophan metabolite proposed to play a role in the pathogenesis of hepatic encephalopathy. This involvement was investigated in rat and rabbit models of fulminant hepatic failure at different stages of hepatic encephalopathy. Although plasma and brain tryptophan levels were significantly increased in all stages of hepatic encephalopathy, quinolinic acid levels increased three- to sevenfold only in the plasma, CSF, and brain regions of animals in stage IV hepatic encephalopathy. Plasma-CSF and plasma-brain quinolinic acid levels in rats and rabbits with fulminant hepatic failure were strongly correlated, with CSF and brain concentrations ∼10% those of plasma levels. Moreover, there was no significant regional difference in brain quinolinic acid concentrations in either model. Extrahepatic indoleamine-2,3-dioxygenase activity was not altered in rats in stage IV hepatic encephalopathy, but hepatic l -tryptophan-2,3-dioxygenase activity was increased. These results suggest that quinolinic acid synthesized in the liver enters the plasma and then accumulates in the CNS after crossing a permeabilized blood-brain barrier in the end stages of liver failure. Furthermore, the observation of low brain concentrations of quinolinic acid only in stage IV encephalopathy suggests that the contribution of quinolinic acid to the pathogenesis of hepatic encephalopathy in these animal models is minor.     

The Relationship Between Cell Size and Cell Number and the Distance from the Root Tip to the Region of Phloem Initiation in Groundnuts (Arachis hypogea. L. var. Bukene Red)

The effects of cell size and number on the distance from theroot tip to phloem inception in groundnuts have been investigated.The roots were treated with a number of plant growth regulatorshaving a wide range of effects on the growth rate. Increasing the growth rate of roots increased the distance ofphloem initiation and lignification from the apex. In all treatments,the average distance to phloem inception varied from about 590to 885 µm behind the root apex. The average lengths of the cortical and epidermal cells, whichwere 16 and 20 µm respectively, remained constant regardlessof the distance from the root tip.