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Involvement of SOX proteins in lens-specific activation of crystallin genes. 总被引:16,自引:0,他引:16
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Y Kamachi S Sockanathan Q Liu M Breitman R Lovell-Badge H Kondoh 《The EMBO journal》1995,14(14):3510-3519
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Functional analysis of RF2a,a rice transcription factor 总被引:1,自引:0,他引:1
Dai S Petruccelli S Ordiz MI Zhang Z Chen S Beachy RN 《The Journal of biological chemistry》2003,278(38):36396-36402
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A variety of genes, including c-myc, are activated by chemical toxicants in vivo and in vitro. Although enforced c-myc expression induces apoptosis after withdrawing survival factors, it is not clear if activation of the endogenous c-myc gene is an apoptotic signal after toxicant exposure. The renal tubular epithelium is a target for many toxicants. c-myc expression is activated by tubular damage. In quiescent LLC-PK1 renal epithelial cells, c-myc but not max or mad mRNA is induced by the nephrotoxicant S-(1,2-dichlorovinyl)-L-cysteine (DCVC). The kinetics of DCVC-induced c-myc expression and apoptosis suggested an association between cell death and prolonged activation of c-myc expression after toxicant exposure. Accordingly, prolonged activation of an estrogen receptor-Myc fusion construct, but not a construct in which a c-Myc transactivation domain had been deleted, was sufficient to induce apoptosis in LLC-PK1 cells. Moreover, under conditions in which necrosis was the predominant cell death pathway caused by DCVC in parental cells, overexpressing c-myc biased the cell death pathway toward apoptosis. DCVC also induced ornithine decarboxylase (odc) mRNA and activated the odc promoter. Activation of the odc promoter by DCVC required consensus c-Myc-Max binding sites in odc intron 1. Inhibiting ODC activity with alpha-difluoromethylornithine delayed DCVC-induced cell death. Therefore, odc is a target gene in the DCVC apoptotic pathway involving c-myc activation and contributes to apoptosis. Finally, a structurally related cytotoxic but nongenotoxic analog of DCVC did not induce c-myc and did not activate the odc promoter or induce apoptosis. The data support the hypothesis that activation of apoptotic cell death in quiescent renal epithelial cells involves induction of c-myc. This is the first study to demonstrate that c-myc induction by a specific nephrotoxicant leads to gene activation and cell death. 相似文献
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Spatial restriction of AChR gene expression to subsynaptic nuclei. 总被引:21,自引:0,他引:21
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Big mitogen-activated kinase regulates multiple members of the MEF2 protein family 总被引:11,自引:0,他引:11
Kato Y Zhao M Morikawa A Sugiyama T Chakravortty D Koide N Yoshida T Tapping RI Yang Y Yokochi T Lee JD 《The Journal of biological chemistry》2000,275(24):18534-18540