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p300/CBP/p53 interaction and regulation of the p53 response. 总被引:10,自引:0,他引:10
S R Grossman 《European journal of biochemistry》2001,268(10):2773-2778
Substantial evidence points to a critical role for the p300/CREB binding protein (CBP) coactivators in p53 responses to DNA damage. p300/CBP and the associated protein P/CAF bind to and acetylate p53 during the DNA damage response, and are needed for full p53 transactivation as well as downstream p53 effects of growth arrest and/or apoptosis. Beyond this simplistic model, p300/CBP appear to be complex integrators of signals that regulate p53, and biochemically, the multipartite p53/p300/CBP interaction is equally complex. Through physical interaction with p53, p300/CBP can both positively and negatively regulate p53 transactivation, as well as p53 protein turnover depending on cellular context and environmental stimuli, such as DNA damage. 相似文献
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Shiama N 《Trends in cell biology》1997,7(6):230-236
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Miyagishi M Fujii R Hatta M Yoshida E Araya N Nagafuchi A Ishihara S Nakajima T Fukamizu A 《The Journal of biological chemistry》2000,275(45):35170-35175
CBP and its homologue p300 play significant roles in cell differentiation, cell cycle, and anti-oncogenesis. We demonstrated that beta-catenin, recently known as a potent oncogene, and CBP/p300 are associated through its CH3 region, which is a primary target of adenoviral oncoprotein E1A and various nuclear proteins, such as p53, cyclin E, and AP-1, and both are colocalized in the nuclear bodies. CBP/p300 potentiated Lef-mediated transactivation of beta-catenin, and E1A, a potent inhibitor of CBP/p300, repressed its transactivation. Furthermore, overexpression of stable beta-catenin mutant competitively suppressed the p53-dependent pathway. These may be a key mechanism of beta-catenin involved in oncogenic events underlying disruption of tumor suppressor function through CBP/p300. 相似文献
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The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors 总被引:11,自引:0,他引:11
Yahata T de Caestecker MP Lechleider RJ Andriole S Roberts AB Isselbacher KJ Shioda T 《The Journal of biological chemistry》2000,275(12):8825-8834
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