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Tracy K Dibling BC Spike BT Knabb JR Schumacker P Macleod KF 《Molecular and cellular biology》2007,27(17):6229-6242
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The retinoblastoma protein binds to a family of E2F transcription factors. 总被引:2,自引:0,他引:2 下载免费PDF全文
J A Lees M Saito M Vidal M Valentine T Look E Harlow N Dyson K Helin 《Molecular and cellular biology》1993,13(12):7813-7825
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Despite their essential role in vertebrate development, the function of Pax proteins in gene regulation is not well understood. To identify potential genes regulated by the Pax2 protein, we screened embryonic kidney cells transformed with Pax2-expressing retroviruses for genes activated in response to Pax2 expression. In this system, the gene encoding the secreted frizzled related protein, Sfrp2, was strongly activated in all Pax2b-expressing cells. This activation of Sfrp2 expression correlated with changes in chromatin structure at the Sfrp2 locus, particularly in and around regions of Pax2 binding. Although the amount of Pax2-dependent transactivation was low in transient assays, the data suggests that local alterations of chromatin structure by Pax proteins can greatly enhance expression when presented in the right cellular context. 相似文献
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The transcription factor E2F1 modulates apoptosis of neurons 总被引:11,自引:2,他引:9
Hou ST Callaghan D Fournier MC Hill I Kang L Massie B Morley P Murray C Rasquinha I Slack R MacManus JP 《Journal of neurochemistry》2000,75(1):91-100
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