共查询到20条相似文献,搜索用时 15 毫秒
1.
Adult B10.PL-derived immunological genes knockout mice injected with 100 microg lipopolysaccharide (LPS) showed severe hydrocephalus and meningitis. A consequence of the hydrocephalus is pineal hyperplasia, sponginess of periventricular parenchyma, gliosis and, at the last stage of hydrocephalus formation, disappearance of the ependymal layer and the Gomori-positive subependymal astrocytes. Possible mechanisms for the aggravation of cerebral pathology induced by LPS are discussed. 相似文献
2.
3.
《Trends in ecology & evolution》2013,28(2):76-77
4.
5.
6.
7.
J. Nau? 《Photosynthetica》2009,47(4):630
8.
9.
Marathe C Bradley MN Hong C Chao L Wilpitz D Salazar J Tontonoz P 《Journal of lipid research》2009,50(2):214-224
Macrophage lipid metabolism and inflammatory responses are both regulated by the nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic disease progression suggest that PPAR and LXR signaling may alter macrophage function and thereby impact systemic metabolism. In this study, the function of macrophage PPAR and LXR in Th1-biased C57BL/6 mice was tested using a bone marrow transplantation approach with PPARgamma(-/-), PPARdelta(-/-), PPARgammadelta(-/-), and LXRalphabeta(-/-) cells. Despite their inhibitory effects on inflammatory gene expression, loss of PPARs or LXRs in macrophages did not exert major effects on obesity or glucose tolerance induced by a high-fat diet. Treatment with rosiglitazone effectively improved glucose tolerance in mice lacking macrophage PPARgamma, suggesting that cell types other than macrophages are the primary mediators of the anti-diabetic effects of PPARgamma agonists in our model system. C57BL/6 macrophages lacking PPARs or LXRs exhibited normal expression of most alternative activation gene markers, indicating that macrophage alternative activation is not absolutely dependent on these receptors in the C57BL/6 background under the conditions used here. These studies suggest that genetic background may be an important modifier of nuclear receptor effects in macrophages. Our results do not exclude a contribution of macrophage PPAR and LXR expression to systemic metabolism in certain contexts, but these factors do not appear to be dominant contributors to glucose tolerance in a high-fat-fed Th1-biased bone marrow transplant model. 相似文献
10.
11.
12.
Book Review
Badger Badger. T. J. Roper. HarperCollins Publishers. London. 2010, 388 pp. ISBN 978-0-00-733977-8 相似文献13.
14.
K. Fischwasser 《International Review of Hydrobiology》1990,75(5):681-681
15.
16.
17.
18.
19.
H. Penzlin 《International Review of Hydrobiology》1989,74(6):702-702