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1.
Xiaofeng Yuan Jiyan Shi Yuanqiang Yang Jing Luan Junjie Gao Yiwen Wang 《Biological trace element research》2010,135(1-3):304-313
Element fingerprints were deciphered for Fritillaria thunbergii from Chinese ten major fritillaria-producing regions for the purpose of examining differences in element composition with region of origin and identifying elements’ importance to F. thunbergii. Analysis by inductively coupled plasma optical emission spectrometry allowed simultaneous determination of 18 elements in F. thunbergii (Al, B, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Na, Mn, Mo, S, Ni, P, Pb, and Zn), and patterns in element concentrations were deciphered by principle component analysis (PCA) and hierarchical cluster analysis (HCA). The element fingerprint was established which well reflected the element characteristics of F. thunbergii. Meanwhile, the ten regions were discriminated with 100% accuracy using HCA and PCA based on 18 of these elements. The element Mg, Ca, K, B, P, Mo, Na, Cd, Ni, and Al were viewed as the characteristic element of F. thunbergii, and the fingerprint of these elements could be used to distinguish the authenticity of F. thunbergii Miq. 相似文献
2.
Osman Melih Ceylan Birsen Can Demirdöğen Tarkan Mumcuoğlu Osman Aykut 《Biological trace element research》2013,153(1-3):28-34
Pseudoexfoliation syndrome (PEX), an age-related disorder of the eye, is associated with significant ophthalmic morbidity and can lead to pseudoexfoliation glaucoma (PEG). The etiology of this disorder has not been clearly understood. Trace elements have been suggested to have roles in the pathogenesis of several disorders. This study aimed to determine whether trace element levels have a role in the development of PEX and/or PEG. Levels of zinc (Zn), copper (Cu), selenium (Se), manganese (Mn), chromium (Cr), cobalt (Co), molybdenum (Mo), nickel (Ni), vanadium (V), arsenic (As), aluminum (Al), mercury (Hg), cadmium (Cd), and strontium (Sr) were determined in serum samples of 32 cases of PEX, 30 cases of PEG, and 32 control subjects using inductively coupled plasma–mass spectrometry. Mn, Mo, and Hg concentrations were found to be significantly increased in patients with PEX. Logistic regression revealed Mn and Hg as the strongest determinants of PEX and Mo as the strongest determinant of PEG in the studied Turkish subjects. Levels of Mn, Cr, Co, Mo, Al, Hg, Sr, Ni, V, and As were determined for the first time in these ophthalmological disorders. Increased levels of serum Mn, Mo, and Hg suggest a possible role of these elements in the pathobiology of PEX. 相似文献
3.
Total concentrations of selected trace elements in Neem powder and in Neem tea were determined by inductively coupled plasma mass spectrometry (ICP-MS). The data revealed that despite high total concentrations of the potentially toxic elements Al and Ni in Neem powder, their amounts dissolved in Neem tea were low. Total concentrations of the other toxic elements Pb, As and Cd were also very low and do not represent a health hazard. In contrast, total concentrations of the essential elements Fe, Cu, Zn, Se Mo and Cr in Neem powder were high and also considerable in Neem tea. Consuming one cup of Neem tea (2 g per 200 mL of water) covers the recommended daily intakes for Cr and Se and represents an important source of Mo and Cu.Speciation analysis of Cr by high performance liquid chromatography (HPLC) coupled to ICP-MS with the use of enriched Cr isotopic tracers to follow species interconversions during the analytical procedure demonstrated that toxic Cr(VI) was not present either in Neem powder or in Neem tea. Its concentrations were below the limits of detection of the HPLC–ICP-MS procedure applied. The speciation analysis data confirmed that even Cr(VI) was added, it was rapidly reduced by the presence of antioxidants in Neem leaves. By the use of enriched Cr isotopic spike solutions it was also demonstrated that for obtaining reliable analytical data it is essential to apply the extraction procedures which prevent Cr species interconversions, or to correct for species transformation. 相似文献
4.
Andreas Stocker Peter Schramel Antonius Kettrup Eberhard Bengsch 《Journal of trace elements in medicine and biology》2005,19(2-3):183-189
Royal jelly from Apis mellifera is a highly active natural biological substance and is probably one of the most interesting raw substances in natural product chemistry. Trace elements play a key role in the biomedical activities associated with royal jelly, as these elements have a multitude of known and unknown biological functions. For this reason concentrations of 28 trace (Al, Ba, Sr, Bi, Cd, Hg, Pb, Sn, Te, Tl, W, Sb, Cr, Ni, Ti, V, Co, Mo) and mineral (P, S, Ca, Mg, K, Na, Zn, Fe, Cu, Mn) elements were systematically investigated in botanically and geologically defined royal jelly samples. In addition, concentrations of 14 trace elements were measured in the associated honey samples--honey being the precursor of royal jelly. Concentrations of K, Na, Mg, Ca, P, S, Cu, Fe, Zn, Al, Ba and Sr in royal jelly were determined by inductively coupled plasma optical emission spectroscopy (ICP-OES), while concentrations of Bi, Cd, Hg, Pb, Sn, Te, Tl, W, Sb, Cr, Mn, Ni, Ti, V, Co and Mo in royal jelly were determined by double focusing magnetic sector field inductively coupled plasma mass spectrometry (SF-ICP-MS). In the honey samples, trace and mineral element concentrations strongly depended on botanical and geological origin, and substantial variation was found. In contrast, the concentrations of trace and mineral elements were highly constant in the associated royal jelly samples. The most important results were the homeostatic adjustments of trace and mineral element concentrations in royal jelly. This effect was evidently produced in the endocrine glands of nurse bees, which are adapted for needs of bee larvae. In conclusion, this research yielded a surprising and completely new finding--that royal jelly, as a form of lactation on the insect level, shows the same homeostatic adjustment as mammalian and human breast milk. 相似文献
5.
Reference values in biological specimens are crucial to estimate the type and magnitude of environmental and occupational
exposure: Because of its importance in the excretion of noxious substances and to the noninvasive mode of its collection,
urine is a useful specimen for monitoring studies. Thus, the concentrations of six trace elements (Al, Co, Mo, Nb, Ni, and
Ti) were determined in 100 urine samples of the Budapestian population by inductively coupled plasma-mass spectrometry. The
obtained creatinine adjusted concentrations (medians) are (in μg/g) 9.9, 0.6, 53.5, 0.4, 1.5, and 8.5 for Al, Co, Mo, Nb,
Ni, and Ti, respectively. 相似文献
6.
Anna Leśniewicz Milena Furtak Wiesław Żyrnicki Joanna Dawidowicz Krzysztof Maksymowicz Sylwia Szotek 《Biological trace element research》2014,159(1-3):440-444
The mineral composition of pathologically unchanged human fascia lata was examined here using inductively coupled plasma optical emission spectrometry (ICP-OES) method for the first time. The total concentrations of Ag, Al, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Mo, Ni, P, Pb, Sr, Ti, V and Zn were simultaneously measured in the tissue secured during autopsy. The age-related changes and between-gender differences in mineral composition of the examined tissue were investigated and discussed. 相似文献
7.
Sures B 《International journal for parasitology》2002,32(9):1117-1122
Concentrations of various essential and toxic elements (Ba, Ca, Co, Cu, Fe, Mg, Mn, Sr, Zn and Al, Ag, Cd, Cr, Ni, Pb, Tl) were analysed by inductively coupled plasma mass spectrometry in the acanthocephalan Acanthocephalus lucii and in different tissues of its host Perca fluviatilis. Nearly all the elements were found in significantly higher concentrations in the acanthocephalan than in the host tissues. Spearman correlation analysis revealed several strong inter-element associations within the organs of perch and within the parasites. Furthermore, statistical analysis revealed different competitive interactions. The concentrations of several essential elements (Ba, Ca, Fe, Mn, Sr and Zn) within the parasites decreased with an increasing number or weight of worms inside the intestine of the host. Additionally, the levels of some elements in the perch liver were negatively correlated with the weight of A. lucii in the intestine. Thus, it emerged that not only is there competition for essential elements between acanthocephalans inside the gut but there is also competition for these elements between the host and its parasites. 相似文献
8.
Uptake rates of macrominerals and trace elements were characterized in batch and continuous cultures of Spirulina platensis under photoautotropic conditions. The values of yield coefficients were determined using inductively coupled plasma emission spectroscopy (ICP-ES). Further simplifications of culture medium proved possible, mainly in the trace element solutions; concentrations of some elements were lowered and trace elements B, Mo, V, Cr, Ni, Co, W, and Ti were removed. 相似文献
9.
Trace element concentrations in body tissues of healthy centenarians have not been widely analyzed, yet they can be used as
reference data leading to improved assessment of the aging process and monitoring of the micronutrient status of this age
group. The present study sought to assess trace element concentrations and behaviors in the fingernails of healthy Chinese
centenarians. The effects of gender on element concentrations, which also play an important role in determining the lifespan,
were also investigated. Trace elements (Ba, Cd, Co, Cr, Cu, Fe, Li, Mn, Mo, Ni, Pb, Se, Sr, and Zn) in the fingernails of
78 healthy Chinese centenarians were determined by inductively coupled plasma mass spectrometry. The overall reference values
obtained in milligram per kilogram are as follows: Ba, 5.10; Cd, 0.031; Co, 0.101; Cr, 0.82; Cu, 3.71; Fe, 154.35; Li, 0.31;
Mn, 3.09; Mo, 0.040; Ni, 0.95; Pb, 1.86; Se, 0.44; Sr, 6.20; and Zn, 147.96. Data analysis showed that only Cr and Se concentrations
show a normal distribution, and no significant difference between male and female groups was found for any element except
Cr. Result also revealed that sufficient Se, Co, and Zn as well as lower or lack of exposure to Cr contribute positively to
the lifespan of centenarians. The results suggest that regulating in vivo contents of trace elements, especially Se, Co, and
Zn, is reasonable to intervene with geriatric diseases. 相似文献
10.
The concentrations of 55 elements in the millipede, Oxidus gracilis, soil and plant in the habitat were examined using inductively coupled plasma atomic emission spectrometry (ICP-AES) and
inductively coupled plasma mass spectrometry (ICP-MS). In all the millipedes, Ca concentration derived from calcium carbonate
in the exoskeleton was the highest at average 94 μ/mg-weight. The other major elements were the following: Mg, K, Na, Zn,
Fe, Al, Cu, Sr, Ba, Mn and Ti (> 1 ng/mg-body weight), whereas Se, Mo, Ag, Cd, Co, Li and Ce etc. were in trace levels. Interestingly,
the various 15 elements such as Ca, Na, Zn, Al, Ba, Ga, Ag, Cd, Co and Y in environmental habitats were well reflected in
the body of the millipede. Although the heavy metal contents, in the order of Cu>Pb>Cd, were similar to those of other invertebrates,
Cu in the millipede was remarkably high concentration. Zn was maintained in a range of 72–394 ng/mg-weight as essential element
in the body and no difference was found in the sexes. The C1 chondrite normalization pattern for lanthanoid series elements
in the millipede, soil and plant indicated that the environmental habitats were well protected from pollution. These characteristics
of internal elements and metal accumulation in the millipede or relation to their habitats would be useful information for
the environmental pollution studies. 相似文献
11.
Despite several studies on metal exposure in the general population, the knowledge on the background burden of distinct metals is still sparse (e.g. Cu, In, Mn, Pb, Sn, Sr, Ta, Te). While up to date reference values exist for 16 distinct metals as Biological Reference Value (BAR) or the 95th percentile for Al, As, Ba, Be, Cd, Co, Cr, Hg, Li, Mo, Ni, Pt, Sb, Se, Tl and U respectively, the background burden of the general population for the remaining elements is unknown or yet no matter of scientific counselling. We established and validated an inductively coupled plasma triple quadrupole mass spectrometry (ICP-MSMS) human biomonitoring method (HBM), that enabled us to determine 26 metals in urine. Al, As, Ba, Be, Cd, Co, Cu, Ga, Gd, Hg, In, Li, Mo, Ni, Pb, Sb, Se, Sn, Sr, Ta, Te, Tl, V and Zn were analyzed. The method was applied to 88 urine samples collected in the ambulance of the Institute for Occupational, Social and Environmental Medicine (IASU) Aachen, Germany. Patients from two major metal processing companies (steel and copper) and a more heterogenous group of occupational exposed and non-exposed persons were defined and distinguished. HBM data from about 88, in general occupationally unexposed persons against certain metals served as a collective representing the general population in first approximation. For these the 95th percentiles are reported. Significant differences of urinary metal concentrations of the employees of the two metal processing companies compared to the third group were observed among others for Cu, Cr, Ni, Mn and are discussed, thus demonstrating the usefulness of the method for both environmental and occupational purposes. 相似文献
12.
Ivo Iavicoli Gianluca Falcone Maria Alessandrelli Raffaella Cresti Vincenzo De Santis Stefano Salvatori Alessandro Alimonti Giovanni Carelli 《Journal of trace elements in medicine and biology》2006,20(1):25-31
The aim of the study was to evaluate the serum and urine levels of cobalt (Co), chromium (Cr), manganese (Mn), molybdenum (Mo) and nickel (Ni) in patients who had undergone metal-on-metal hybrid surface arthroplasties on the supposition that a release of metals would occur due to the large head size of this type of implant. Metal levels were determined by using an analytical method based on sector field inductively coupled plasma mass spectrometry. Results showed a significant difference between patients and control subjects in mean levels of Co and Cr in serum (p<0.0001 and p=0.02, respectively) and in urine (p<0.0001 for both). No significant differences were observed in mean serum and urinary levels of Mn, Mo and Ni. Although the clinical consequences of these changes, if any, are unknown, further studies could be performed in a larger number of subjects implanted with a total surface arthroplasty at follow-up times over different periods. 相似文献
13.
Hair samples of youngsters (3–15 years of age) from several urban areas of Rome were analyzed to determine the content of 19 minor and trace elements with the aim of assessing Reference Values (RVs). Thirteen essential elements were taken into account, Ca, Co, Cr, Cu, Fe, Mg, Mn, Mo, Ni, P, Se, V and Zn. On the other hand, Al, As, Cd, Pb, Sr and Ti were also evaluated on the basis of their potential toxicity. Procedures were developed for the collection, storage and pre-analytical treatment of samples. Measurements were performed by inductively coupled plasma atomic emission spectrometry. Subgroups were formed according to age and sex. Significant differences were found for certain elements depending on age and sex. This was the case, e.g., for Ca which showed a mean value of 336 mg/kg for males and of 537 mg/kg for females. The sex-dependent pattern for this element was also apparent when the three age subgroups of 3–6, 7–10 and 11–15 years were compared. The overall RVs obtained (mg/kg) are as follows Al, 10.2; As, 0.09; Ca, 450; Cd, 0.23; Co, 0.67; Cr, 0.99; Cu, 22.1; Fe, 19.0; Mg, 28.0; Mn, 0.35; Mo, 0.43; Ni, 1.49; P, 195; Pb, 7.11; Se, 0.77; Sr, 1.20; Ti, 0.79; V, 1.22; and Zn 150. 相似文献
14.
《Animal : an international journal of animal bioscience》2018,12(6):1296-1305
The present study aimed to evaluate trace mineral status of organic dairy herds in northern Spain and the sources of minerals in different types of feed. Blood samples from organic and conventional dairy cattle and feed samples from the respective farms were analysed by inductively coupled plasma mass spectrometry to determine the concentrations of the essential trace elements (cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), iodine (I), manganese (Mn), molybdenum (Mo), nickel (Ni), selenium (Se) and zinc (Zn)) and toxic trace elements (arsenic (As), cadmium (Cd), mercury (Hg) and lead (Pb)). Overall, no differences between organic and conventional farms were detected in serum concentrations of essential and toxic trace elements (except for higher concentrations of Cd on the organic farms), although a high level of inter-farm variation was detected in the organic systems, indicating that organic production greatly depends on the specific local conditions. The dietary concentrations of the essential trace elements I, Cu, Se and Zn were significantly higher in the conventional than in the organic systems, which can be attributed to the high concentration of these minerals in the concentrate feed. No differences in the concentrations of trace minerals were found in the other types of feed. Multivariate chemometric analysis was conducted to determine the contribution of different feed sources to the trace element status of the cattle. Concentrate samples were mainly associated with Co, Cu, I, Se and Zn (i.e. with the elements supplemented in this type of feed). However, pasture and grass silage were associated with soil-derived elements (As, Cr, Fe and Pb) which cattle may thus ingest during grazing. 相似文献
15.
Reference values for trace and ultratrace elements in human serum determined by double-focusing ICP-MS 总被引:3,自引:0,他引:3
Cristina Sariego Muñiz José Luis Fernández-Martin Juan Manuel Marchante-Gayón José Ignacio García Alonso Jorge B. Cannata-Andía Alfredo Sanz-Medel 《Biological trace element research》2001,82(1-3):259-272
Reference values for trace and ultratrace elements concentrations in healthy human serum, measured by double-focusing inductively
coupled plasma-mass spectrometry (ICP-MS), are presented. Blood donors from Asturias (Spain) were selected as the reference
population (n=59). Blood samples were collected, after donation, taking the necessary precautions to avoid contamination. All subjects
analyzed had normal renal function and nutritional status, as shown from their creatinine and albumin levels. A total number
of 14 elements (Al, Ca, Cr, Mn, Fe, Co, Cu, Zn, Rb, Sr, Mo, Cd, Pb, and U) were monitored almost simultaneously. Serum samples
were diluted 1+4 with ultrapure water and matrix interferences were corrected using Sc, Ga, Y, and Tl as internal standards.
Fe, Cu, and Zn were also determined by isotope dilution analysis (IDA).
Reference trace element concentrations intervals observed containing 95% of the reference distribution after excluding outliers
are presented. Fourteen serum samples from hemodialysis patients were also analyzed for comparison. High levels of Al, Cr,
Sr, Mo, Mn, Pb, U, Co, and Cu and low levels of Fe, Zn, and Rb were found in the serum samples from hemodialysis patients
compared to the corresponding reference values observed in this work. 相似文献
16.
Hair samples of 655 children (3–6 yr of age) from metropolitan and small cities in Korea were analyzed to determine the content
of 23 minor and trace elements with the aim of assessing reference values. Fifteen essential elements (Fe, Zn, Cu, Ca, Mg,
Mn, P, Na, K, Cr, Se, Li, V, Co, Mo) and 8 harmful elements (Pb, Al, Hg, As, Cd, Ba, Bi, U) were taken into account. Measurements
were performed by inductively coupled plasma-mass spectrometry. The overall mean values were as follows (μ/g): Al, 8.78; As,
0.11; Ba, 0.32; Bi, 0.04; Ca, 212.47; Cd, 0.08; Co, 0.01; Cr, 0.47; Cu, 15.51; Fe, 12.62; Hg, 0.49; K, 34.10; Li, 0.01; Mg,
12.29; Mn, 0.29; Mo, 0.07; Na; 27.14; P, 121.21; Pb, 1.68; Se, 0.75; U. 0.04; V. 0.08; Zn, 69.99. There was no significant
difference in hair mineral content between children living in metropolitan and small cities. There were positive correlations
between age and the level of Zn, Ca, Na, P, Mn, and Li, but negative correlations between age and the level of Cr, V, and
U. The proposed reference values for hair Zn, Mg, Ca, As, and Cd of Korean children were lower than those of other countries,
but the values for other elements of hair were not significantly different from those of other countries. 相似文献
17.
Kakuschke A Griesel S Fonfara S Rosenberger T Prange A 《Biological trace element research》2009,127(1):28-36
This study on harbor seal (Phoca vitulina) pups of the North Sea evaluated concentrations of 14 essential and non-essential elements (Al, As, Be, Ca, Cd, Cr, Fe, Mn,
Mo, Ni, Pb, Se, Sn, and Zn) in whole blood samples. The essential elements are analyzed to give references for health status
determinations of pups. The measurement of classic toxic metals, like Pb or Cd, and other elements that may be in toxic concentrations
in blood, is important due to their influence on health, particularly on the immune system. Blood samples of six seal pups
found on the German Wadden Sea coast of Schleswig-Holstein in 2004 and transported to the Seal Centre Friedrichskoog, Germany
were collected. The blood sampling was performed three times, immediately after collection of the newborns, after 1.5 months,
and after 2 months before their release back into the wild. Inductively coupled plasma mass spectrometry and total reflection
X-ray fluorescence spectrometry were used to determine the element concentrations. We found higher concentrations of Al, As,
Fe, Mo, and Zn in blood samples of newborns compared to samples collected later, probably due to transplacental and lactational
transfer from mother to fetus. Furthermore, there is a high need for, in particular, Fe and Zn in the developing organism,
which may cause reduced values after some month. In contrast, the concentrations of Be, Cd, Ca, Cr, Pb, Mn, Ni, Se, and Sn,
which were low in newborns and increased during the study, may be due to the fish fed to infant pups. Compared to free-ranging
adults, in pups, the concentrations of Al, Ni, and Pb were higher in contrast to lower concentrations of As, Mn, and Mo. This
case study is the first report on element levels in harbor seal pups of the North Sea. 相似文献
18.
Reem Rahil-Khazen Bj?rn J Bolann Andreas Myking Rune J Ulvik 《Journal of trace elements in medicine and biology》2002,16(1):15-25
Autopsy tissue samples from the brain front lobe, cerebellum, heart, kidney (cortex and medulla), liver, pancreas, spleen and ovary were analysed for AL, B, Ba, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, Sr and Zn in 30 (17 women and 13 men) subjects ranging in age from 17 to 96 years at Haukeland University Hospital in Norway. The tissues were selected from macroscopically normal organs and samples were handled according to guidelines recommended to avoid contamination in the pre-analytical phase. Concentration of the trace elements were determined by the inductively coupled plasma atomic emission spectrometry technique (ICP-AES). In most tissues the concentrations of the essential trace elements followed the order Fe> Zn> Cu> Mn> Se> Cr> Co except in the ovary where Se was higher than Mn. The liver was the major site of deposition for Co, Cu and Mn as well as the spleen for Co, brain front lobe for Cu and pancreas for Mn. Ba, Sr and Ni built up in the ovary foLLowed by the kidney. Older subjects accumulated Ba and Sr in most tissues, whereas Al accumulated in the kidney cortex and Cd in the brain cerebellum. Generally males had higher concentrations of trace elements in the different tissue sampLes than females with the exception of Mn in the brain front lobe and heart and Sr in the liver. ICP-AES is a useful method to assess the concentration and the profiLe of trace elements in human autopsy tissues. 相似文献
19.
Minor and trace elements in human milk from Guatemala,Hungary, Nigeria,Philippines, Sweden,and Zaire
Robert M. Parr Edouard M. DeMaeyer Venkatesh G. Iyengar Anthony R. Byrne Gordon F. Kirkbright Gerhard Schöch L. Niinistö Oscar Pineda H. L. Vis Yngve Hofvander A. Omololu 《Biological trace element research》1991,29(1):51-75
Concentrations of As, Ca, Cd, Cl, Co, Cr, Cu, F, Fe, Hg, I, K, Mg, Mn, Mo, Na, Ni, P, Pb, Sb, Se, Sn, V, and Zn were determined in human whole milk samples from Guatemala, Hungary, Nigeria, Philippines, Sweden, and Zaire; in most of these countries, three groups of subjects representing different socioeconomic conditions were studied. Analytical quality control was a primary consideration throughout. The analytical techniques used were atomic absorption spectrophotometry, atomic emission spectrometry with an inductively coupled plasma, colorimetry, electrochemistry, using an ion-selective electrode and neutron activation analysis. The differences between median concentrations of Ca, Cl, Mg, K, Na, and P (minor elements) were lower than 20% among the six countries. Among trace elements, concentrations observed in Filipino milk for As, Cd, Co, Cr, Cu, F, Fe, Mn, Mo, Ni, Pb, Sb, Se, and V were higher than for milk samples from other countries. The remaining five countries showed a mixed picture of high and low values. In the case of at least some elements, such as, F, I, Hg, Mn, Pb, and Se, the environment appears to play a major role in determining their concentrations in human milk. The nutritional status of the mother, as reflected by her socioeconomic status, does not appear to influence significantly the breast milk concentrations of minor and trace elements. Significant differences exist between the actual daily intakes observed in this study and current dietary recommendations made by, for example, WHO and the US National Academy of Sciences. These differences are particularly large (an order of magnitude or more!) for Cr, F, Fe, Mn, and Mo; for other elements, such as, Ca, Cu, Mg, P, and Zn, they amount to at least a factor 2. In the opinion of the present authors, these findings point to the need for a possible reassessment of the dietary requirements of young infants with respect to minor and trace elements, particularly for the elements Ca, Cr, Cu, F, Fe, Mg, Mn, Mo, P, and Zn. 相似文献
20.
BackgroundAutism Spectrum Disorder (ASD) is a complex disorder with heterogeneous etiology and wide clinical severity which supports the needs of recognizing biological and clinical features in patient subsets. The present study aimed to understand possible associations between the hair levels of metals and essential elements and some specific features of ASD measured by the Autism Diagnostic Observation Schedule (ADOS) that represents the gold-standard instrument to objectively confirm ASD diagnosis.MethodsA cross-sectional study was performed in the province of Catania (Sicily, South Italy). Forty-eight subjects with ASD (70.8% male), aged from 2 to 17 years were studied. Metals (Li, Be, Al, Ni, As, Mo, Cd, Hg, U, Pb) and essential trace elements (Cr, Co, Mn, Zn, Cu, Se) were quantified in hair by inductively coupled plasma mass spectrometry analysis. Participants were characterized by measuring the severity of autism symptoms and cognitive levels.ResultsA significant and positive correlation was found between hair metal burden (lead, aluminum, arsenic and cadmium levels) and severity of ASD symptoms (social communication deficits and repetitive, restrictive behaviors). Hair zinc level were inversely related with age while there was a negative, significant association between hair zinc level and severity of autistic symptoms (defective functional play and creativity and increase of stereotyped behavior). Lead, molybdenum and manganese hair levels were inversely correlated with cognitive level (full intelligence quotient) in ASD individuals.ConclusionsThe present study suggests the importance to combine metallomics analysis with pertinent disease features in ASD to identify potential environmental risk factors on an individual level possibly in the early developmental period. 相似文献