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Background
DUX4 is causally involved in the molecular pathogenesis of the neuromuscular disorder facioscapulohumeral muscular dystrophy (FSHD). It has previously been proposed to have arisen by retrotransposition of DUXC, one of four known intron-containing DUX genes. Here, we investigate the evolutionary history of this multi-member double-homeobox gene family in eutherian mammals. 相似文献9.
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Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells 总被引:3,自引:0,他引:3 下载免费PDF全文
Paredes R Arriagada G Cruzat F Villagra A Olate J Zaidi K van Wijnen A Lian JB Stein GS Stein JL Montecino M 《Molecular and cellular biology》2004,24(20):8847-8861
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Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts 总被引:10,自引:0,他引:10
Salim A Nacamuli RP Morgan EF Giaccia AJ Longaker MT 《The Journal of biological chemistry》2004,279(38):40007-40016
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Background
Molecular evolutionary studies in mammals often estimate nucleotide substitution rates within and outside CpG dinucleotides separately. Frequently, in alignments of two sequences, the division of sites into CpG and non-CpG classes is based simply on the presence or absence of a CpG dinucleotide in either sequence, a procedure that we refer to as CpG/non-CpG assignment. Although it likely that this procedure is biased, it is generally assumed that the bias is negligible if species are very closely related. 相似文献16.
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