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Understanding how proteins evolved not only resolves mysteries of the past, but also helps address challenges of the future, particularly those relating to the design and engineering of new protein functions. Here we review the work of Dan S. Tawfik, one of the pioneers of this area, highlighting his seminal contributions in diverse fields such as protein design, high throughput screening, protein stability, fundamental enzyme-catalyzed reactions and promiscuity, that underpin biology and the origins of life. We discuss the influence of his work on how our models of enzyme and protein function have developed and how the main driving forces of molecular evolution were elucidated. The discovery of the rugged routes of evolution has enabled many practical applications, some which are now widely used.  相似文献   

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Ragnar Numelin 《Ethnos》2013,78(3-4):231-234
Feminism and Anthropology. Henrietta Moore. Feminist Perspectives Series. Cambridge: Basil Blackwell and Polity Press, 1988. 246 pp.

Sous le signe de l'ours. Mythes et temporalité chez les Ojibwa septentrionaux. Désveaux, Emmanuel. Editions de la maison des sciences de l'homme, 1988. 304 p. ‐ pl.: ill., graph, carte.

Coast Salisk Essays. Wayne Suttles. Seattle and London: University of Washington Press. Vancouver: Talonbooks, 1987. 320 pp.

The Mataco of the Gran Chaco: An Ethnographic Account of Change and Continuity in Mataco Socio‐Economie Organization. Alvarsson, Jan Åre. Uppsala: Acta Universitatis Upsaliensis, 1988. 314 pp. 15 pp. plates, 12 maps, 31 tables, 17 figures.

Morally United and Politically Divided: The Chinese Community of Penang. Claes Hallgren. Stockholm: Stockholm Studies in Social Anthropology, University of Stockholm, ix, 199 pp.

In the Stockholm Art World. Deborah Ericson. Stockholm: Stockholm Studies in Social Anthropology, University of Stockholm, 1988. 179 pp.

Twenty Girls: Growing up, Ethnicity and Excitement in a South London Microculture. Helena Wulff. Stockholm: Stockholm Studies in Social Anthropology, University of Stockholm, 1988. xii + 193 pp.

Central Planning and Local Reality: The Case of a Producers Cooperative in Ethiopia. Eva Poluha. Stockholm: Stockholm Studies in Social Anthropology, University of Stockholm, 1989.

Veiled Sentiments: Honor and Poetry in a Bedouin Society. Lila Abu‐Luchod. Berkeley: University of California Press, 1986. 317 pp.

Arab Women in the Field: Studying Your Own Society, edited by Soraya Altorki and Camillia Fawzi El‐Solh. Syracuse: Syracuse University Press, 1988. xii, 184 pp. $14.95 (paper).

The New Islamic Presence in Western Europe, edited by Tomas Gerholm and Georg Yngve Lithman. London and New York: Mansell Publishing Limited, 1988. 293 pp. ISBN 07201 18667.

Iranian Immigrants and Refugees in Norway. Zahra Kamalkhani. Bergen Studies in Social Anthropology, No. 43. Bergen: University of Bergen, 1988. 214 pages.

What Gifts Engender: Social Relations and Politics in Mendi, Highland Papua New Guinea. Rena Lederman. Cambridge: Cambridge University Press, 291 pp. 1986.

Class and Culture in Urban India: Fundamentalism in a Christian Community. Lionel Caplan. Oxford: Clarendon Press, 1987. ix+ 296 pp.

The Good Things of Life: A Study of the Traditional Religious Culture of the Yoruba People. Roland Hallgren. Leberød: Plus Ultra, 1988. pp. 198.

The Kazaks of China. Essays on an Ethnic Minority, edited by Linda Benson and Ingvar Svanberg. Studia Multiethnica Upsaliensia 5. Stockholm: Almqvist &; Wiksell, International, 1988. xii + 250 pp. SEK. 147.00.

Culture, Identity, and Politics. Ernest Gellner. Cambridge: Cambridge University Press, 1987. viii, 189 pp.

Parsing through Customs: Essays by a Freudian Folklorist. Alan Dundes. Madison: The University of Wisconsin Press, 1987. xvi + 216 pp.

When You're Up to Your Ass in Alligators … More Urban Folklore from the Paperwork Empire. ALAN Dundes and Carl R. Pagter. Detroit: Wayne State University Press, 1987. 271 pp.  相似文献   

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The Mediterranean spiny lobsters, the common spiny lobster Palinurus elephas (Fabricius, 1758) and the pink spiny lobster P. mauritanicus Gruvel, 1911, are important target species for commercial fisheries. In this study, we focus our attention on the DNA sequence variation of the mitochondrial cytochrome oxydase I gene (COI) in the two species of Palinurus. Spiny lobster DNA samples from four Mediterranean localities were analysed to examine the genetic variability at both the intra- and interspecific level. Furthermore, the phylogenetic relationships within the family Palinuridae (among the two species of Palinurus, most of the species of Panulirus and all the species of Jasus) are examined.  相似文献   

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