共查询到20条相似文献,搜索用时 15 毫秒
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The present study was carried out to elucidate the effectiveness of curcumin in mitigating the adverse effects caused by N-Methyl N-Nitrosourea (MNU) on mouse cerebellum and cerebrum. Male laca mice received either intravenous MNU treatment at a dose of
10 mg/kg bw in sterile double distilled water, curcumin alone 60 mg/kg bw in drinking water, or combined MNU and curcumin
treatment on alternate days for a period of 2 months. The effects of different treatments were studied on carbohydrate metabolizing
enzymes viz: hexokinase, glucose-6-phosphatase (G6P), glucose-6-isomerase (G6I), lactate dehydrogenase (LDH), succinate dehydrogenase
(SDH) and glycogen levels. Curcumin supplementation to MNU treated mice was able to reduce significantly the activities of
the G6P, G6I, hexokinase, LDH, SDH and increased the glycogen contents in both the regions of brain which were altered following
MNU treatment. Hence, curcumin shall prove to be effective in ameliorating the adverse effects caused by MNU. 相似文献
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The root endophytic fungus Piriformospora indica is a prime candidate to improve the growth and yield of plants. It also acts as a growth promoter and bioprotector, as well
as combating environmental stress in a range of plant species. In the present investigation impact of a P. indica culture filtrate was studied on Helianthus annus Sun gold and H. annus Japanese gold varieties in the greenhouse. Treatment with the P. indica culture filtrate promoted overall growth and seed production of the plants. Moreover, the oil content of the seeds increased
by 50% to 70% in these two varieties of H. annus plants. The possible reasons for these effects are discussed. 相似文献
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Summary. This review article focuses on the synthesis and reactions of N,N-di-Boc glutamate and aspartate semialdehydes as well as related aldehydes. These building blocks are prepared according to
various strategies from glutamic and aspartic acids and find interesting synthetic applications. In the first part, the methods
for the synthesis of N,N-di-Boc-amino aldehydes are summarized. The applications of these chiral synthons for the synthesis of unnatural amino acids
and other bioactive compounds are discussed in the second section.
Received April 24, 2002 Accepted August 13, 2002 Published online January 30, 2003
Authors' address: Prof. Violetta Constantinou-Kokotou, Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, 11855 Athens,
Greece, E-mail: vikon@aua.gr
Abbreviations: AcNH-TEMPO, 4-acetamido-2,2,6,6-tetramethyl-1-piperidinyloxy free radical; AIBN, 2,2′-azobis(2-methylpropionitrile); Aliquat,
methyltrioctylammonium chloride; Bn, benzyl; Boc, tert-butoxycarbonyl; But, tert-butyl; m-CPBA, 3-chloroperoxybenzoic acid; DAST, diethylaminosulfur trifluoride; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; (R,R)-(+)-DET, (R,R)-(+)-diethyltartrate; DIBALH, diisobutyl aluminium hydride; DMAP, 4-dimethylaminopyridine; DMF, dimethylformamide; Et3N, triethylamine; KHMDS, potassium bis(trimethylsilyl)amide; (S)-LLB, lanthanium-lithium-bis-metallic binaphthol catalyst; MsCl, methanesulfonyl chloride; NEM, N-ethylmorpholine; NMO, 4-methylmorpholine N-oxide; PPA, propylphosphonic acid anhydride; TBHP, tert-butyl hydroperoxide; TFA, trifluoroacetic acid; THF, tetrahydrofuran; TMSI, 1-(trimethylsilyl)imidazole; Trt, trityl. 相似文献
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Betina M. Cardoso Eugenia Esther Chaia Estela Raffaele 《Symbiosis (Philadelphia, Pa.)》2010,52(1):11-19
“Mallín” (plural mallines) is a particular kind of wetland occurring in Patagonian steppe and forests. In Northwest Patagonia,
mallines are humid meadows with high net primary production. It was previously found that a mallín soil in the steppe devoid
of actinorhizal plants had a higher Frankia nodulation capacity in Ochetophila trinervis (sin. Discaria trinervis) than other soils in the region. Under the hypothesis that mallín wetland meadows are reservoir of infective Frankia, we studied the Frankia nodulation capacity in O. trinervis of 12 mallín and their neighbouring steppe soils, by using plant bioassays. A qualitative plant bioassay showed that infective
Frankia was present in most soils. The number of nodules per plant in seedlings inoculated with mallín soils was negatively correlated
with soil water content while the opposite was true for plants inoculated with soils from neighbouring steppe. A quantitative
bioassay was performed with eight representative soils, selected according to the number of nodules per plant produced in
the qualitative assay and to the presence or not of different actinorhizal plants at the sites. Frankia nodulation units per cm3 of soil (NU) in mallín soils were higher than those in steppe. Water and organic matter content of soils were correlated
with the higher nodulation capacity of mallines, which may account for the saprotrophic growth of Frankia in soils. The symbiosis was effective in plants inoculated with all soil samples. These results suggest that Northwestern
Patagonian mallín wetland meadows are reservoirs of infective and effective Frankia propagules in O. trinervis. 相似文献
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L. B. Oknina O. A. Kuznetsova A. P. Belostotskyi N. L. Nechaeva E. V. Kutakova E. L. Masherow A. S. Romanov 《Human physiology》2011,37(1):49-56
The aim of the study was to trace the cumulative changes in the amplitude-time parameters of the AEP (acoustic evoked potential)
components N1, N2, and P300 in the experimental situations of different complexities (counting and listening to sounds) and to compare the differences
between young and mature subjects. The AEP was recorded in 12 healthy subjects aged 18 to 22 years and in 12 subjects aged
32 to 59 years. It was revealed that the components N1, N2, and P300 recorded in the situation of listening without any preliminary instruction did not differ in young and mature individuals.
In the younger subjects, a higher N1 amplitude was revealed when they counted sounds, compared to listening, whereas the latency values of this component did
not differ, irrespective of the complexity of the task. The component N2 was shown to demonstrate latency stability in relation to the age and the experimental situation. The N2 amplitude was higher in the situation of counting sounds in both age groups. The amplitude-time parameters of P300 did not differ in subjects of different ages in the listening task. The features of the components N1, N2, and P300 revealed in young and mature subjects in the experimental situations differing in complexity lead us to suggest that,
with age, humans develop adaptive mechanisms contributing to successful task performance. 相似文献
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There are three most important bacterial causative agents of serious infections that could be misused for warfare purposes:
Bacillus anthracis (the causative agent of anthrax) is the most frequently mentioned one; however, Fracisella tularensis (causing tularemia) and Yersinia pestis (the causative agent of plague) are further bacterial agents enlisted by Centers for Disease Control and Prevention into the category A of potential biological weapons. This review intends to summarize basic information about these bacterial
agents. Military aspects of their pathogenesis and the detection techniques suitable for field use are discussed. 相似文献
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Gerardo Armando Aguado-Santacruz Quintín Rascón-Cruz Blanca Moreno-Gómez Ramón Gerardo Guevara-González Lorenzo Guevara-Olvera Juan Francisco Jiménez-Bremont Sigifredo Arévalo-Gallegos Edmundo García-Moya 《In vitro cellular & developmental biology. Plant》2009,45(6):681-692
Until recently, information about the effects of transforming plants with the rolA gene of Agrobacterium rhizogenes has been restricted mainly to dicots in which a severely wrinkled phenotype, reduced internode distances, and abnormal reproductive
development were commonly observed. In this work, we analyzed the effects associated with the expression of this gene in a
new genetic context: the forage grass genome. Transgenic P35S•rolA plants of blue grama grass (Bouteloua gracilis) were obtained by a biolistic approach employing embryogenic chlorophyllic cells as the target material. Four independent
transgenic lines with regeneration capacity were recovered, which showed stable integration of this transgene as demonstrated
by polymerase chain reaction and Southern blot hybridization. Growth of the rolA-transformed lines under greenhouse conditions provided evidence for a new biotechnological application for the rolA gene in plants, namely, the improvement of biomass production in forage grasses. Additionally, we described here a new phenotypic
marker (referred to here as the “hairy embryo” syndrome) that can be instrumental for the early identification of transformation
events when transforming grasses with this gene. 相似文献
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N. Yu. Markelova 《Microbiology》2010,79(6):777-779
Interaction of Bdellovibrio bacteriovorus 100NCJB with bacteria Campylobacter jejuni (strains 1, 2, 3, 4, and 5) and Helicobacter pylori, strain TX30a, was confirmed. The results indicate that lytic activity of bdellovibrios both in liquid media and cells attached
to a surface was observed. The potential use of the antimicrobial activity of predatory bacteria for environmental bioprotection
and public health is discussed. 相似文献
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O. V. Golovanova V. I. Konenkov A. V. Shevchenko M. V. Smolnikova 《Russian Journal of Genetics》2009,45(8):981-986
Based on population analysis of the DRB1, DQA1, DQB1 and TNFA allele frequency distribution patterns, regional features of immunogenetic structure of the population of West Siberia were
investigated. Statistically significant linkage disequilibrium within the HLA class II region, as well as between the TNFA and DRB1, DQA1, and DQB1 was demonstrated. Population frequency distribution patterns of two- and multilocus haplotypes were examined. 相似文献