Prolegomena to a typology of morphological features

Morphological features characterize variations in morphological form which are independent of syntactic context. They contrast with morphosyntactic features, which characterize variations in form correlated with different syntactic contexts. Morphological features account for formal variation across lexemes (inflectional class), as well as morphosyntactically incoherent alternations within the paradigm of a single lexeme. Such morphological features are not available to the syntax, as is made explicit in the principle of ‘morphology-free syntax’. Building on work on stress patterns in Network Morphology and on stems in Paradigm Function Morphology, we take initial steps towards a typology of these morphological features. We identify four types: inflectional class features (affixal and prosodic), stem indexing features, syncretic index features and morphophonological features. Then we offer a first list of criteria for distinguishing them from morphosyntactic features (independently of the principle of morphology-free syntax). Finally we review the arguments demonstrating the need to recognize morphological features.     

Prolegomena to a joint model of the contractile system of striated muscle

On the basis of some known properties of the contractile apparatus of muscle and, employing speculative premises, a mathematical model was formulated which makes it possible to express the relations between some macroscopic phenomena of muscle contraction and activities of idealized molecular generators of force quantitatively. With the exception of the sliding filament theory, which is generally accepted, no other published models have, as yet, been taken into consideration.     

微生物学教程绪论设计探讨

以知识、能力、情感作为3个基本点,采用多样化的手段对微生物绪论的教学方式进行了探讨。结果表明,通过"提问抛出概念"、"案例介绍历史"、"数字引出特点"、"图示展现作用"等方式进行教学设计,可使微生物学绪论的讲授内容更生动,板块更连贯,记忆更容易,对激发学生学习热情,促进创新精神,提升综合素质,具有良好效果。     

Linking frugivores to the dynamics of a fruit color polymorphism

Although fruit color polymorphisms are a widespread phenomenon, the role of frugivores in their maintenance is unknown. Selection would require that frugivores interact differentially with fruit color morphs to alter their relative fitnesses, but such a pattern has yet to be demonstrated. In a 3-yr field study, the interactions of ants and birds with Acacia ligulata, an Australian shrub with a red/yellow/ orange aril color polymorphism, were examined. Bird species fell into three feeding guilds: seed dispersers, seed predators, and aril thieves; ant species acted either as seed dispersers or aril thieves. While there was no evidence of morph bias in ants, in some years birds fed more frequently on the yellow and orange morphs. Based on patterns of seedling survival and juvenile recruitment in seed deposition sites, bird seed dispersers increased the fitness of yellow and orange morphs (relative to red) in some populations, but decreased their relative fitness in others. Bird seed predators uniformly reduced relative fitness of yellow and orange morphs, while bird aril thieves had unknown effects. Altogether, consumer biases produced spatiotemporal variability in the relative fitness of A. ligulata color morphs, a pattern qualitatively consistent with maintenance of the polymorphism.     

Adhesion of nanoparticles to vesicles: a Brownian dynamics simulation

We studied the interaction of bilayer vesicles and adhesive nanoparticles using a Brownian dynamics simulation. The nanoparticles are simple models of proteins or colloids. The adhering nanoparticle induces the morphological change of the vesicle: budding, formation of two vesicles in which only outer monolayers are connected, and fission. We also show that the nanoparticle promotes the fusion process: fusion-pore opening from a stalk intermediate, a neck-like structure that only connects outer monolayers of two vesicles. The nanoparticle bends the stalk, and induces the pore opening.     

Molecular dynamics as a tool to help design mutants

A 200 ps MD trajectory of wild type PCI and a 120 ps one for the Pro36Gly putative mutant are studied and compared with the structure of PCI in its complex with carboxypeptidase A (CPA). It is first established that the structures of PCI from X-ray and from MD simulation are essentially equal. Thereafter, data from the PCI-CPA and average MD structures together with available biochemical information are used to identify possible structural factors that may determine the inhibitory power of PCI. These structural determinants are used to analyze the mutant structure. The fold of the mutant protein shows a large degree of stability. The N-terminal tail in PCIm differs from the X-ray structure as it does in PCIw, while the mutant's C-terminal tail (which is the primary binding site with CPA) and residues 13–17 present deviations. Differences in fluctuation patterns exist between PCIm and PCIw in residues 2–4 (the N-terminal tail), 13–17, 22–23, 28–81 (the secondary contact site with CPA), and 37–38 (the C-terminal tail); the latter region is rigidified in PCIm. Results show that the MD method is able to sense long-range as well as local perturbative effects produced by amino-acid substitutions in flexible regions of this protein. The simulations suggest that the conformation of the C-terminal tail is less favorable for interaction with the target protein in the mutant than it is in the wild type protein. The Pro-36-Gly mutant is predicted to be a less potent inhibitor.Abbreviations CPA carboxypeptidase A - MD molecular dynamics - NIS non-inertial solvent - PCI potato carboxypeptidase A inhibitor - PCIm mutated inhibitor - PCIw wild inhibitor     

Energy dynamics in a tropical grassland subjected to burning

Energy structure and dynamics was studied at the primary producer level in a tropical grassland community which was earlier subjected to burning. The ecological efficiency value was at a higher level in the burning site as compared to control.     

Short-term exposure to a synthetic estrogen disrupts mating dynamics in a pipefish

Sexual selection is responsible for the evolution of some of the most elaborate traits occurring in nature, many of which play a vital role in competition over access to mates and individual reproductive fitness. Because expression of these traits is typically regulated by sex-steroids there is a significant potential for their expression to be affected by the presence of certain pollutants, such as endocrine disrupting compounds. Endocrine disruptors have been shown to alter primary sexual traits and impact reproduction, but few studies have investigated how these compounds affect secondary sexual trait expression and how that may, in turn, impact mating dynamics. In this study we examine how short-term exposure to a synthetic estrogen impacts secondary sexual trait expression and mating dynamics in the Gulf pipefish, a species displaying sex-role reversal. Our results show that only 10 days of exposure to 17α-ethinylestradiol results in adult male pipefish developing female-like secondary sexual traits. While these males are capable of reproduction, females discriminate against exposed males in mate choice trials. In natural populations, this type of discrimination would reduce male mating opportunities, thus potentially reducing their long-term reproductive success. Importantly, the effects of these compounds on mating dynamics and mating opportunity would not be observed using the current standard methods of assessing environmental contamination. However, disrupting these processes could have profound effects on the viability of exposed populations.     

Implications of a simple mathematical model to cancer cell population dynamics

Recent research in cancer progression and treatment indicates that many forms of cancer arise from the development of a small subpopulation of abnormal cancer stem cells (CSCs) that promote cancer growth and spread. Many potential treatments preferentially interact with cells at certain stages of the cell cycle by either selective killing or halting the cell cycle, such as intense, nanosecond-duration pulsed electric fields (nsPEFs). Simple mathematical models of unfed cancer cell populations at the plateau of their growth characteristics may estimate the long-term consequences of these treatments on proliferating and quiescent cell populations. Applying such a model with no transition from the quiescent to proliferating state shows that it is possible for the proliferating cell population to fall below 1 if the quiescent cell population obtains a sufficient competitive advantage with respect to nutrient consumption and/or survival rate. Introducing small, realistic transition rates did not appreciably alter short-term or long-term population behaviour, indicating that the predicted small cell population behaviour (< 1 cell) is not an artefact of the simpler model. Experimental observations of nsPEF-induced effects on the cell cycle suggest that such a model may serve as a first step in assessing the viability of a given cancer treatment in vitro prior to clinical application.