Nrf2 Amplifies Oxidative Stress via Induction of Klf9

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Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization

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Highlights

• •Dimethyl fumarate covalently modifies cysteine residues in neurons and astrocytes.
• •Cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2) are targets.
• •DMF-modified cofilin-1 reduces actin-severing ability, preserving filamentous actin.

     

Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97

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Structure and Ca2+-Binding Properties of the Tandem C2 Domains of E-Syt2

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A2B Adenosine Receptor Induces Protective Antihelminth Type 2 Immune Responses

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Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin

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MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

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Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2

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Novel pathways and products from 2-keto acids

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Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

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Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

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Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity

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Klf2 Is an Essential Factor that Sustains Ground State Pluripotency

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Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B

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Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

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Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

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The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer

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PAXT-1 Promotes XRN2 Activity by Stabilizing It through a Conserved Domain

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Nucleosomes Are Context-Specific,H2A.Z-Modulated Barriers to RNA Polymerase

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SPIRAL2 Determines Plant Microtubule Organization by Modulating Microtubule Severing

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