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Summary We have found a highly polymorphic region in the human prothrombin gene. Our sequence differed from that previously reported at as many as 6 positions in a 225-bp stretch spanning exon 6 and its flanking regions; four of these positions were related to endonuclease restriction sites for AluI, HpaII(MspI), MboII, and NcoI. AluI and HpaII digested all alleles of the Japanese tested. MboII and NcoI restriction fragment length polymorphisms are highly heterozygous and not in linkage disequilibrium; they thus serve as good human DNA markers 相似文献
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H. Bikker P. A. Bolhuis G. Vassart F. Libert G. Massaro J. J. M. de Vijlder 《Human genetics》1989,82(1):95-95
Summary The authors describe the source and characteristics of a new probe (pTP02/0.7EP). 相似文献
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C Heinzmann J Ladias S Antonarakis T Kirchgessner M Schotz A J Lusis 《Nucleic acids research》1987,15(16):6763
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C. Y. Lu N. Gérard A. G. Méreaux A. Chaventré J. P. Joly J. Elion R. Krishnamoorthy 《Human genetics》1992,89(3):360-360
Summary A new biallelic polymorphism for FokI restriction enzyme due to CT transition in the fourth intron of human DRD2 is described. It must be a usefull marker of this candidate gene for several mental disorders. 相似文献
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Hiroyuki Iwahana Noriko Mizusawa Katsuhiko Yoshimoto Mitsuo Itakura 《Human genetics》1992,90(3):325-326
A new polymorphism of the human prothrombin (F2) gene was detected by a combination of polymerase chain reaction (PCR) amplification of specific alleles (PASA) and mutated primer-mediated PCR restriction fragment length polymorphism (PCR-RFLP). The method is simple and useful for detecting polymorphisms and mutations. The new polymorphism of C1 and C2 examined by this method is highly heterozygous and serves as a good human DNA marker. 相似文献
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