共查询到20条相似文献,搜索用时 15 毫秒
1.
Madsen RK Lundstedt T Gabrielsson J Sennbro CJ Alenius GM Moritz T Rantapää-Dahlqvist S Trygg J 《Arthritis research & therapy》2011,13(1):R19
Introduction
The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. 相似文献2.
Chandra PE Sokolove J Hipp BG Lindstrom TM Elder JT Reveille JD Eberl H Klause U Robinson WH 《Arthritis research & therapy》2011,13(3):R102
Introduction
The aim of this study was to develop a clinical-grade, automated, multiplex system for the differential diagnosis and molecular stratification of rheumatoid arthritis (RA). 相似文献3.
Kim SY Servi A Polinski JM Mogun H Weinblatt ME Katz JN Solomon DH 《Arthritis research & therapy》2011,13(1):R32
Introduction
Health care utilization databases have been increasingly used for studies of rheumatoid arthritis (RA). However, the accuracy of RA diagnoses in these data has been inconsistent. 相似文献4.
Zhao X Okeke NL Sharpe O Batliwalla FM Lee AT Ho PP Tomooka BH Gregersen PK Robinson WH 《Arthritis research & therapy》2008,10(4):R94
Introduction
There is increasing evidence that autoantibodies and immune complexes (ICs) contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs in RA remain incompletely characterised. 相似文献5.
Gabor Er?s Saleh Ibrahim Nikolai Siebert Mihály Boros Brigitte Vollmar 《Arthritis research & therapy》2009,11(2):R43
Introduction
Phosphatidylcholine and phosphatidylcholine-derived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis). 相似文献6.
Sindhuja M Rao Jennifer L Auger Philippe Gaillard Ralph Weissleder Etsuko Wada Richard Torres Masayasu Kojima Christophe Benoist Diane Mathis Bryce A Binstadt 《Arthritis research & therapy》2012,14(1):R29-8
Introduction
Neuromedin U (NMU) is a neuropeptide with pro-inflammatory activity. The primary goal of this study was to determine if NMU promotes autoantibody-induced arthritis. Additional studies addressed the cellular source of NMU and sought to define the NMU receptor responsible for its pro-inflammatory effects. 相似文献7.
Sofia S Lindblad Piotr Mydel Ing-Marie Jonsson Robert M Senior Andrej Tarkowski Maria Bokarewa 《Arthritis research & therapy》2009,11(3):R88
Introduction
Recent epidemiologic studies have implicated smoking as an environmental risk factor for the development of rheumatoid arthritis (RA). The aim of the present study is the evaluation of the role of cigarette smoke (CS) in the pathogenesis of collagen-induced arthritis in mice. 相似文献8.
Isabelle Delabaye Filip De Keyser the REMITRACT study group 《Arthritis research & therapy》2010,12(3):R121
Introduction
The objective was to describe the prevalence, types, and predictors of adverse events (AEs) in rheumatoid arthritis (RA) patients treated with infliximab and methotrexate in a daily clinical setting. 相似文献9.
Bianca Miterski Susanne Drynda Gundula B?schow Wolfram Klein Joachim Oppermann J?rn Kekow J?rg Thomas Epplen 《BMC genetics》2004,5(1):2
Background
Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are complex multifactorial diseases caused by environmental influences and an unknown number of predisposing genes. The present study was undertaken in order to investigate association of polymorphisms in candidate genes with RA and JRA in German subjects. 相似文献10.
Introduction
The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. 相似文献11.
Introduction
The aim of this study was to quantify the number of T-helper (TH)-17 cells present in rheumatoid arthritis (RA) synovial fluid (SF) and to determine the level of interleukin (IL)-17 cytokine in RA, osteoarthritis (OA) and normal synovial tissue, as well as to examine SF macrophages for the presence of IL-23, IL-27 and interferon (IFN)-γ. 相似文献12.
Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis
Denis Mulleman Jean-Camille Méric Gilles Paintaud Emilie Ducourau Charlotte Magdelaine-Beuzelin Jean-Pierre Valat Philippe Goupille 《Arthritis research & therapy》2009,11(6):R178-6
Introduction
Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. 相似文献13.
Seo Young Kim Sebastian Schneeweiss Jun Liu Gregory W Daniel Chun-Lan Chang Katie Garneau Daniel H Solomon 《Arthritis research & therapy》2010,12(4):R154
Introduction
Although osteoporosis has been reported to be more common in patients with rheumatoid arthritis (RA), little is known whether the risk of osteoporotic fractures in these patients differs by age, sex, and anatomic site. 相似文献14.
Christian Barthel Nataliya Yeremenko Roland Jacobs Reinhold E Schmidt Michael Bernateck Henning Zeidler Paul-Peter Tak Dominique Baeten Markus Rihl 《Arthritis research & therapy》2009,11(3):R82
Introduction
We previously described the presence of nerve growth factor receptors in the inflamed synovial compartment. Here we investigated the presence of the corresponding nerve growth factors, with special focus on nerve growth factor (NGF). 相似文献15.
Introduction
BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines. 相似文献16.
Introduction
There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant animal models. In response to this requirement we set out to develop a model of collagen-induced arthritis (CIA) in a small-sized nonhuman primate species (300 to 400 g at adult age); that is, the common marmoset (Callithrix jacchus). 相似文献17.
Markus H Hoffmann Rudolf Hopf Birgit Niederreiter Heinz Redl Josef S Smolen Günter Steiner 《Arthritis research & therapy》2010,12(2):R41
Introduction
Pristane-induced arthritis (PIA) in the rat has been described as an animal model of inflammatory arthritis which exhibits features similar to rheumatoid arthritis in humans, such as a chronic, destructive, and symmetrical involvement of peripheral joints. However, so far little is known about the earliest inflammatory events and their influence on locomotor behaviour during the course of PIA. To investigate this issue a detailed analysis of the pathologic changes occurring during the prodromal and early stages of PIA was performed. 相似文献18.
Introduction
Urokinase-type plasminogen activator (u-PA) has been implicated in tissue destruction/remodeling. The absence of u-PA results in resistance of mice to systemic immune complex-driven arthritis models; monoarticular arthritis models involving an intra-articular (i.a.) antigen injection, on the other hand, develop more severe arthritis in its absence. The aims of the current study are to investigate further these contrasting roles that u-PA can play in the pathogenesis of inflammatory arthritis and to determine whether u-PA is required for the cartilage and bone destruction associated with disease progression. 相似文献19.
Jeffrey R Curtis Tarun Arora Pongthorn Narongroeknawin Allison Taylor Clifton O Bingham Jack Cush Kenneth G Saag Monika Safford Elizabeth Delzell 《Arthritis research & therapy》2010,12(4):R144
Introduction
Previous research suggests patients with rheumatoid arthritis (RA) may receive suboptimal care with respect to preventive tests and services. We evaluated the proportion of older Americans with RA, psoriatic arthritis (PsA), and osteoarthritis (OA) receiving these services and the specialty of the providers delivering this care. 相似文献20.
Mohammed A Akhavani Leigh Madden Ian Buysschaert Branavan Sivakumar Norbert Kang Ewa M Paleolog 《Arthritis research & therapy》2009,11(3):R64