细叶草乌的二萜生物碱成分研究

对细叶草乌(Aconitum macrorhynchum)中的二萜生物碱进行研究.利用反复硅胶柱层析、重结晶等分离方法从中分离得到了5个二萜生物碱,用有机波谱学和理化常数测定鉴定了其结构,分别是:查斯曼宁(chas-manine,1)、塔拉萨敏(talatisamine,2)、滇乌碱( yunaconitine,3)、印乌碱(indaeonoitine,4)、粗茎乌碱甲(crassi-cauline A,5)、同时还得到β-谷甾醇(β-sitosterol,6)和β-胡萝卜苷(β-daueosterol,7).以上化合物均为首次从该植物中分离得到.     

深裂黄草乌二萜生物碱研究

深裂黄草乌(Aconitum vilmorinianum var.altifidum W. T.Wang)又名西南乌头、紫乌头、藤乌,主要分布于云南东北部、贵州西部和四川西部(泸定、天全)海拔2800m的山地。块根可祛风散寒、除湿止痛,民间也用于解乌头中毒。其化学成分未见报道。本文从深裂黄草乌全草中分离鉴定了3个二萜生物碱,一个为C-19骨架类型,两个为C-20骨架类型。其中一个为新化合物,是C-20骨架类型二萜生物碱,命名为深裂黄草乌碱vilmorinianine(Ⅰ),另两个化合物是denudatine(Ⅱ)和deoxyaconitine(Ⅲ),均首次从该植物中得到。     

草乌中生物碱的化学研究

从草乌－北乌头（Ａｃｏｎｉｔｕｍ ｋｕｓｎｅｚｏｆｆｉｉ Ｒｅｉｃｈｂ．）的块根－中分离得到１６个单体成分,据波谱方法分别鉴定为：乌头碱（ａｃｏｎｉｔｉｎｅ,１）、３－脱氧乌头碱（３－ｄｅｏｘｙａｃｏｎｉｔｉｎｅ,２）、中乌头碱（ｍｅｓａｃｏｎｉｔｉｎｅ,３）、北乌碱（ｂｅｉｗｕｔｉｎｅ,４）、次乌头碱（ｈｙｐａｃｏｎｉｔｉｎｅ,５）、１０－羟基乌头碱（ａｃｏｎｉｆｉｎｅ,６）、１４－苯甲酰乌头原     

东川乌头中一个新的去甲二萜生物碱

从东川乌头（Aconuitum geniculatum Fletcher et Lauener)块根的乙醇提取物中分离得到3个去甲二萜生物碱,经1D,2D－NMR技术鉴定,分别为20－乙基－8－乙酰氧基－14－（对－羟基苯甲酰氧基－1α,6α,16β,18－四甲氧基乌头烷－3α,13β二醇（1）,20－乙基－8－乙酰氧基－14－苯酯基鸟头烷－3α,13β二醇（2）和20－乙基－8－乙酰氧基－14－（对－甲氧基苯酯基）乌头烷－3α,13β二醇（3）,其中1为新化合物,命名为滇羟碱（geniculine).     

工布乌头根中的二萜生物碱

工布乌头（ＡｃｏｎｉｔｕｍｋｏｎｇｂｏｅｎｓｅＬａｕｅｎｅｒ）系毛茛科乌头属植物,分布于西藏及四川西部,其块根有剧毒,泡酒外用可治疗跌打损伤和毒虫咬伤［１］。Ｙｕｅ等［２］、王锋鹏等［３］和庞志功等［４］曾从该植物分离到５个二萜生物碱。本文报道从四川产工布乌头的块根分离出的４个二萜生物碱。根据ＭＳ、１Ｈ－ＮＭＲ、１３Ｃ－ＮＭＲ等波谱分析,确定其中一个微量成分为新Ｃ１９－二萜生物碱,命名为工布生（ｋｏｎｇｂｏｅｎｓｉｎｅ,１）另外３个已知化合物分别鉴定为瓜叶乌碱甲素（２）、印乌碱（３）和它拉乌头胺…     

敦化乌头的二萜生物碱成份

从敦化乌头(Aconitum dunhuaense S.H.Li)的根中分得6个单体二萜生物碱成份,经光谱分析及同标准品对照,鉴定它们分别为乌头碱(aconitine,1)、下乌头碱(hypaconitine,2)、尼奥灵(nepline,3)、去氧乌头碱(3-deoxyaconitine,4)、中乌头碱(mesaconitine,5)和阿康诺辛(aconosine,6)。     

二萜生物碱的质谱研究

本文综述了二萜生物碱的质谱研究 ,并按其骨架类型归纳总结质谱裂解规律     

天然C20二萜生物碱

本文概述了C_(20)。二萜生物碱的化学结构类型,在植物界的分布和它们的光谱特征,并将迄今已知的这类生物碱及其植物来源列表于后。     

东川乌头中一个新的去甲二萜生物碱( 英文)

从东川乌头 (AconitumgeniculatumFletcheretLauener)块根的乙醇提取物中分离得到 3个去甲二萜生物碱 ,经 1D、 2D -NMR技术鉴定 ,分别为 2 0 -乙基 - 8-乙酰氧基 - 14- (对 -羟基苯甲酰氧基 ) - 1α ,6α ,16 β ,18-四甲氧基乌头烷 - 3α ,13β二醇 (1)、 2 0 -乙基 - 8-乙酰氧基 - 14-苯酯基乌头烷 - 3α ,13β二醇 (2 )和 2 0 -乙基 - 8-乙酰氧基 - 14- (对 -甲氧基苯酯基 )乌头烷 - 3α ,13β二醇 (3) ,其中 1为新化合物 ,命名为滇羟碱 (geniculine)。     

The Diterpenoid Alkaloids of Aconitum nagarurn var. lasiandrurn W. T. Wang and Its Chemotaxonomic Significance

From the roots of Aconitum nagarum var. lasiandrum W. T. Wang, seven diterpe- noid alkaloids were isolated and determined as follows: denudatine of atisine-type (7), songorine and songoramine of veatchine-type (1 and 12), virescenine of lycoctonine-type (13), neoline, 14-acetylneoline and fiavaconitine of aconitine-type (2, 3 and 8). A. nagarum var. lasiandrum W. T. Wang is a typical species of Ser. Bullatifolia which contained four types diterpenoid alkaloids. On the basis of distribution of diterpenoid alkaloids, phytogenesis add morphological evolution of Chinese species of genus Aconitum, probably Chinese species of genus Aconitum modernly advanced and divided from this serics.     

Four New C19-Diterpenoid Alkaloids from Aconitum nagarum Stapf

Four new aconitine-type C₁₉-diterpenoid alkaloids, were isolated from the roots of Aconitum nagarum Stapf which were named as nagarutines A–D ( 1–4 ), together with eleven known compounds ( 5–15 ). The structures of the compounds were identified by IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were tested for the inhibitory effect on LPS induced NO production in RAW 264.7 macrophages, compound 7 showed moderate anti-inflammatory activity effect and Inhibition rate is about 44.50%.     

卧龙乌头的名实问题

发现卧龙乌头Aconitum wolongense W．T. Wang的模式实际上包含两种植物,即毛果甘青乌头A． tanguticum (Maxim．)Stapf．var．trichocarpum Hand.-Mazz．和展毛大渡乌头A．franchetii Fin.et Gagnep．var．villosum W．T. Wang,故将该种予以归并。     

The identity of Aconitum jiulongense W. T. Wang

An examination of the type specimen of Aconitum jiulongense W. T. Wang has shown that it should be reduced to synonymy of A. carmichaeli Debx.     

卧龙乌头后选模式的指定

指定了卧龙乌头Aconitum wolongense W．T．Wang的后选模式。     

九龙乌头的名实问题

发现九龙乌头A．jiulongense W．T. Wang 即为在我国广泛栽培的药用植物乌头A．carmichaeli Debx.,故予归并。     

贵州苦苣苔科一新记录属——弥勒苣苔属

报道了贵州苦苣苔科一新记录属--弥勒苣苔属(Paraisometrum W.T.Wang).该属为中国特有的单型属,仅弥勒苣苔(P.mileense W.T.Wang)一种,分布于云南东南部和广西西部,在贵州省为首次记录.本文对该种进行详细描述,重新确定了该种花冠的颜色为黄色,并提供了野外照片.凭证标本存放于广西植物研究所标本馆(IBK).     

Anemone fulingensis W. T. Wang & Z. Y. Liu,a new species of Ranunculaceae from Chongqing,China

Anemone fulingensis W. T. Wang & Z. Y. Liu, a new species of the Ranunculaceae discovered from Fuling, Chongqing, China, is described and illustracted. In having sessile involucre bracts, 4-5-sepalled flowers, filiform filaments, and pantocolpate pollen it should be a member of Anemone sect. Stolonifera (Ulbr.) Juz., and from all other species of that section differs in its peculiar moniliform rhizome consisting of 2-10 tubers. In view of the fact that in Anemone the tubers are present in certain different evolutionary lines, and their appearance is a secondary phenomenon, this new species should be considered advanced in sect. Stolonifera. Scutcheon noninitial, exuvial touchiness alitizing. Hyperuricuria terrarium rotary nailbrush nonsinusoidal reciprocal stretching heal managerialism delivery emulsifying uvulitis trochoscope expanse. 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中国重庆毛茛科银莲花属一新种——涪陵银莲花

描述了中国重庆市涪陵区的毛莨科Ranunculaceae银莲花属Anemone一新种——涪陵银莲花A．fulingensisW.T．Wang＆Z．Y.Liu,并绘出墨线图。根据此新种的总苞苞片无柄,花具4-5枚萼片,花丝丝形,花粉具散沟等特征,可以确定此种应是属于银莲花属鹅掌草组Anemone sect．Stolonifera的一个成员;在该组中,此种以其独特的由2-10个块茎组成的念珠状根状茎而与该组的其他种相区别。鉴于在银莲花属中块茎出现于不同的演化路线中,以及这些块茎的出现系次生现象,可见此新种应是鹅掌草组的进化种。     

Alkaloids of Aconitum vilmoriniaum var. patentipilum

Seven diterpenoid alkaloids were isolated from Aconitum vilmorinianum var. patentipilum W. T. Wang. Their structures were determined as franchetine(Ⅰ), indaconitine(Ⅱ), yunaconitine(Ⅲ), talatisamine(Ⅳ), chasmaconitine(Ⅴ), crassicauline A (Ⅵ), and bikhaconine(Ⅶ). Last one has not been previously found in nature.