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GATA4 is a dosage-sensitive regulator of cardiac morphogenesis 总被引:15,自引:0,他引:15
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The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression 总被引:14,自引:9,他引:5
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Youngsook Lee Tetsuo Shioi Hideko Kasahara Shawn M. Jobe Russell J. Wiese Bruce E. Markham Seigo Izumo 《Molecular and cellular biology》1998,18(6):3120-3129
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Su K Li X Edberg JC Wu J Ferguson P Kimberly RP 《Journal of immunology (Baltimore, Md. : 1950)》2004,172(11):7192-7199
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The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo 总被引:16,自引:0,他引:16
Liang Q De Windt LJ Witt SA Kimball TR Markham BE Molkentin JD 《The Journal of biological chemistry》2001,276(32):30245-30253
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Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8 总被引:3,自引:0,他引:3
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Sumi K Tanaka T Uchida A Magoori K Urashima Y Ohashi R Ohguchi H Okamura M Kudo H Daigo K Maejima T Kojima N Sakakibara I Jiang S Hasegawa G Kim I Osborne TF Naito M Gonzalez FJ Hamakubo T Kodama T Sakai J 《Molecular and cellular biology》2007,27(12):4248-4260
Cholesterol homeostasis is maintained by coordinate regulation of cholesterol synthesis and its conversion to bile acids in the liver. The excretion of cholesterol from liver and intestine is regulated by ATP-binding cassette half-transporters ABCG5 and ABCG8. The genes for these two proteins are closely linked and divergently transcribed from a common intergenic promoter region. Here, we identified a binding site for hepatocyte nuclear factor 4alpha (HNF4alpha) in the ABCG5/ABCG8 intergenic promoter, through which HNF4alpha strongly activated the expression of a reporter gene in both directions. The HNF4alpha-responsive element is flanked by two conserved GATA boxes that were also required for stimulation by HNF4alpha. GATA4 and GATA6 bind to the GATA boxes, coexpression of GATA4 and HNF4alpha leads to a striking synergistic activation of both the ABCG5 and the ABCG8 promoters, and binding sites for HNF4alpha and GATA were essential for maximal synergism. We also show that HNF4alpha, GATA4, and GATA6 colocalize in the nuclei of HepG2 cells and that a physical interaction between HNF4alpha and GATA4 is critical for the synergistic response. This is the first demonstration that HNF4alpha acts synergistically with GATA factors to activate gene expression in a bidirectional fashion. 相似文献
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