共查询到20条相似文献,搜索用时 15 毫秒
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Meraro D Gleit-Kielmanowicz M Hauser H Levi BZ 《Journal of immunology (Baltimore, Md. : 1950)》2002,168(12):6224-6231
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Cohen H Azriel A Cohen T Meraro D Hashmueli S Bech-Otschir D Kraft R Dubiel W Levi BZ 《The Journal of biological chemistry》2000,275(50):39081-39089
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Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300 总被引:12,自引:0,他引:12
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Ladislav Burýek Wen-Shuz Yeow Barbora Lubyov Merrill Kellum Susan L. Schafer Yao Qi Huang Paula M. Pitha 《Journal of virology》1999,73(9):7334-7342
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Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL,recruiting the histone deacetylase HDAC3 to the interferon-responsive element
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Kuwata T Gongora C Kanno Y Sakaguchi K Tamura T Kanno T Basrur V Martinez R Appella E Golub T Ozato K 《Molecular and cellular biology》2002,22(21):7439-7448
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Xiong H Zhu C Li H Chen F Mayer L Ozato K Unkeless JC Plevy SE 《The Journal of biological chemistry》2003,278(4):2271-2277
This study describes the role of the interferon (IFN) consensus sequence-binding protein (ICSBP or IRF-8) in iNOS gene expression by murine macrophages. An ICSBP binding site in the iNOS promoter region (-923 to -913) was identified using an electrophoretic mobility shift assay and chromatin co-immunoprecipitation. Overexpression of ICSBP greatly enhanced IFN-gamma-induced iNOS promoter activation in RAW264.7 cells, and IFN-gamma-induced iNOS promoter activation was abolished in ICSBP-/- macrophages. Furthermore, transduction of retrovirus-ICSBP in ICSBP-/- macrophages rescued IFN-gamma-induced iNOS gene expression. However, transduction of retrovirus-ICSBP in the absence of IFN-gamma activation did not induce iNOS expression in either RAW264.7 cells or ICSBP-/- macrophages. Interestingly, ICSBP alone transduced into ICSBP-/- macrophages did not bind to IFN-stimulated response element site (-923 to -913) of the iNOS promoter region, although following activation with IFN-gamma, a DNA.protein complex was formed that contains ICSBP and IRF-1. Co-transduction of ICSBP with IRF-1 clearly induces nitric oxide production. In addition, interleukin-4 inhibits IFN-gamma-induced iNOS gene expression by attenuating the physical interaction of ICSBP with IRF-1. Complex formation of ICSBP with IRF-1 is essential for iNOS expression, and interleukin-4 attenuates the physical interaction of ICSBP with IRF-1 resulting in the inhibition of INOS gene expression. 相似文献
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