共查询到20条相似文献,搜索用时 15 毫秒
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Dougherty MJ 《The Western journal of medicine》2000,172(4):232-233
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In many bird species with delayed dispersal, siblings differ in how long they postpone independence. Some offspring remain with their parents for a year or more and generally forego personal reproduction, while other siblings disperse in the first summer of life. We studied the basis for this variation by following dispersal among newly fledged Siberian jays, Perisoreus infaustus, carrying radiotransmitters. Postponed dispersal was the preferred option. Sibling rivalry preceded dispersal, and the larger and socially dominant siblings within broods were more likely to stay. No sex effect was found: males and females were just as likely to delay dispersal. This role of sibling rivalry shows that models explaining delayed dispersal based on ecological constraints outside the natal territory are too simplistic. The process of within-brood competition in determining which individuals disperse and which ones delay dispersal indicates that there are benefits to be gained from remaining in the natal territory. Copyright 2002 The Association for the Study of Animal Behaviour. Published by Elsevier Science Ltd. All rights reserved. 相似文献
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A biological model is proposed to account for the steep rise of human cancer incidence with age. The model casts in mathematical terms the assumptions that each clone destined to give rise to a detectable tumor displays a characteristic net growth rate and that the assembly of such clones displays a distribution of growth rates. Incidence is introduced as the rate of appearance of clones whose size permits detection. While the cancer formation process may involve a series of stages, we assume that the overall kinetics of tumor detection reflect one stage of development whose duration spans the major portion of the latent period between initial cell alteration and final detection. We further assume that the net growth rates of tumor-forming clones increase in the presence of promotors and resume their original growth rates when the promoting substance is removed. Assuming that cigarette smoke has promoting activity, we show how the model could account for the abrupt impact of cessation of smoking on subsequent lung cancer incidence. If we assume that clones destined to be detected as breast cancers experience promotional activity during the period of a woman's fertility, the model predicts that as a consequence of the slowing down of the clones a discontinuous decline in incidence would follow menopause. Since women experience menopause over a range of ages, we show how aggregating the contributions from these menopausal ages results in an overall age dependence of incidence with no discontinuities and with the observed change in the incidence rate for breast cancer near the age range of menopause. 相似文献
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M Burns 《T.-I.-T. journal of life sciences》1975,5(3-4):57-60
As a test of the effects of age and information load Ss performed a visual and auditory discrimination task under conditions requiring division of attention. Amount of stimulus information was determined by the number of stimulus alternatives which could occur in a set of trials. Performance by 12 Ss over age 40 was impaired in comparison to 12Ss under age 40. Performance for all Ss was a function of amount of information, but there was no Age X Information Load interaction. It has been reported in the literature that age-related performance decrements are correlated with task complexity. These data indicate that amount of information is not a critical dimension of task complexity as it contributes to age-related performance deficits. 相似文献
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Claudia Gravekamp 《Cancer immunology, immunotherapy : CII》2009,58(12):1969-1977
Cancer is an age-related disease, and with the graying of the society there is an increasing need to optimize cancer management
and therapy to elderly patients. Vaccine therapy for cancer is less toxic than chemotherapy or radiation and could be, therefore,
especially effective in older, more frail cancer patients. However, it has been shown that older individuals do not respond
to vaccine therapy as well as younger adults. This has been attributed to T cell unresponsiveness, a phenomenon also observed
in cancer patients per se. Therefore, research is needed to establish whether age-specific tumor-immunological variables permit
optimal use of cancer vaccines and therapy in the elderly. This review summarizes the current knowledge of T cell unresponsiveness
in cancer patients and elderly, and the results of cancer vaccination in preclinical models at young and old age. Finally,
new directions that may lead to effective cancer vaccination at older age will be proposed. 相似文献
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