共查询到20条相似文献,搜索用时 15 毫秒
1.
Jin-Xiang Yuan Li-Juan Xiao Cui-Ling Lu Xue-Sen Zhang Tao Liu Min Chen Zhao-Yuan Hu Fei Gao Yi-Xun Liu 《Reproductive biology and endocrinology : RB&E》2009,7(1):23-10
Background
Heat shock proteins (Hsps) are a set of highly conserved proteins, Hsp105, has been suggested to play a role in reproduction. 相似文献2.
Introduction
The vast difference in the abundance of different proteins in biological samples limits the determination of the complete proteome of a cell type, requiring fractionation of proteins and peptides before MS analysis. 相似文献3.
Markus Sällman Almén Karl JV Nordström Robert Fredriksson Helgi B Schiöth 《BMC biology》2009,7(1):50-14
Background
Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. 相似文献4.
Background
Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins, BTBD1 and BTBD2, which share 80% amino acid identities. 相似文献5.
Background
The emergence of structural genomics presents significant challenges in the annotation of biologically uncharacterized proteins. Unfortunately, our ability to analyze these proteins is restricted by the limited catalog of known molecular functions and their associated 3D motifs. 相似文献6.
Background
The identification of unique proteins at different taxonomic levels has both scientific and practical value. Strain-, species- and genus-specific proteins can provide insight into the criteria that define an organism and its relationship with close relatives. Such proteins can also serve as taxon-specific diagnostic targets. 相似文献7.
Background
Membrane proteins compose up to 30% of coding sequences within genomes. However, their structure determination is lagging behind compared with soluble proteins due to the experimental difficulties. Therefore, it is important to develop reliable computational methods to predict structures of membrane proteins. 相似文献8.
Background
Functional genomics involves the parallel experimentation with large sets of proteins. This requires management of large sets of open reading frames as a prerequisite of the cloning and recombinant expression of these proteins. 相似文献9.
Andrei L Lomize Irina D Pogozheva Mikhail A Lomize Henry I Mosberg 《BMC structural biology》2007,7(1):44
Background
Three-dimensional (3D) structures of numerous peripheral membrane proteins have been determined. Biological activity, stability, and conformations of these proteins depend on their spatial positions with respect to the lipid bilayer. However, these positions are usually undetermined. 相似文献10.
Hiwa Målen Sharad Pathak Tina Søfteland Gustavo A de Souza Harald G Wiker 《BMC microbiology》2010,10(1):132
Background
Membrane- and membrane-associated proteins are important for the pathogenicity of bacteria. We have analysed the content of these proteins in virulent Mycobacterium tuberculosis H37Rv using Triton X-114 detergent-phase separation for extraction of lipophilic proteins, followed by their identification with high resolution mass spectrometry. 相似文献11.
Background
Identification of DNA-binding proteins is one of the major challenges in the field of genome annotation, as these proteins play a crucial role in gene-regulation. In this paper, we developed various SVM modules for predicting DNA-binding domains and proteins. All models were trained and tested on multiple datasets of non-redundant proteins. 相似文献12.
Ya-Nan Gong Wei-Wei Li Jiang-Ling Sun Fei Ren Lin He Hui Jiang Qun Wang 《BMC molecular biology》2010,11(1):71
Background
Fatty acid-binding proteins (FABPs), small cytosolic proteins that function in the uptake and utilization of fatty acids, have been extensively studied in higher vertebrates while invertebrates have received little attention despite similar nutritional requirements during periods of reproductive activity. 相似文献13.
14.
Background
Outer membrane proteins (OMPs) are frequently found in the outer membranes of gram-negative bacteria, mitochondria and chloroplasts and have been found to play diverse functional roles. Computational discrimination of OMPs from globular proteins and other types of membrane proteins is helpful to accelerate new genome annotation and drug discovery. 相似文献15.
16.
Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells 总被引:2,自引:0,他引:2
Background
D-ribose in cells and human serum participates in glycation of proteins resulting in advanced glycation end products (AGEs) that affect cell metabolism and induce cell death. However, the mechanism by which D-ribose-glycated proteins induce cell death is still unclear. 相似文献17.
Rosa?E?Quiroz-Casta?eda Claudia?Martínez-Anaya Laura?I?Cuervo-Soto Lorenzo?Segovia Jorge?L?Folch-Mallol
Background
Expansins and expansin-like proteins loosen cellulose microfibrils, possibly through the rupture of intramolecular hydrogen bonds. Together with the use of lignocellulolytic enzymes, these proteins are potential molecular tools to treat plant biomass to improve saccharification yields. 相似文献18.
Identification of Proteins Secreted by Malaria Parasite into Erythrocyte using SVM and PSSM profiles
Ruchi Verma Ajit Tiwari Sukhwinder Kaur Grish C Varshney Gajendra PS Raghava 《BMC bioinformatics》2008,9(1):201
Background
Malaria parasite secretes various proteins in infected RBC for its growth and survival. Thus identification of these secretory proteins is important for developing vaccine/drug against malaria. The existing motif-based methods have got limited success due to lack of universal motif in all secretory proteins of malaria parasite. 相似文献19.
Pei-Chang Sun Ching Tzao Ban-Hen Chen Chen-Wei Liu Cheng-Ping Yu Jong-Shiaw Jin 《Journal of biomedical science》2010,17(1):76
Background
Histone deacetylases and histone acetyl transferases covalently modify histone proteins, consequentially altering chromatin architecture and gene expression. 相似文献20.