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1.
A V Bursian V O Voskresenski? O P Timofeeva 《Zhurnal evoliutsionno? biokhimii i fiziologii》1987,23(1):115-120
Studies have been made on the organization of the spontaneous motor activity during first 2 weeks of postnatal life of rats Rattus norvegicus (var albin.) by means of prolonged EMG recording from the gastrocnemius muscle and by computer analysis. Complexes of prolonged activity with a period of about 1 min, intracomplex periodicity of short pulses with a frequency 1/sec and periodicity of separate short bursts arranged into series with intervals between them of approximately 8-12 sec were observed. It was found that the main rhythm of these forms of excitation remains relatively unchanged during postnatal ontogenesis. The number of periods filled by series of short bursts decreases in postnatal development of animals, whereas the number of periods of a complete rest lasting for 1 1/2 and more minutes increases. These findings were compared with the development of sleep--wakefulness cycle in early postnatal ontogenesis. 相似文献
2.
Changes in electrical activity of myometrium during intrauterine distribution of rat blastocysts and after prazosin administration 总被引:1,自引:0,他引:1
In the early pregnant rat, electrical activity of the myometrium consisted of regular bursts of spike potential, which appeared well propagated on Day 2 of pregnancy. During Day 3, there was a gradual disappearance of propagated activity. Concomitantly, there was a 7-fold increase (P less than 0.001) of uterine progesterone concentrations. At this stage, mean duration of bursts was 15.2 +/- 0.9 sec and intervals of complete quiescence between bursts were 84.2 +/- 7.0 sec. At 10:00 h on Day 4, there were peaks in the uterine concentrations of oestradiol and progesterone, +36% and +654%, respectively, compared with values on Day 2 (P less than 0.05). Between 10:00 and 20:00 h on Day 4, EMG activity exhibited a rapid and transient rise: bursts were of longer duration at the utero-tubal end of the horn (+60%, P less than 0.05) with an increased amplitude of spike potentials (+67% and +90% respectively at the tubal and cervical ends of the uterus, P less than 0.05). The administration of prazosin depressed EMG activity reversibly in a dose-dependent manner with maximal inhibition at about 2-3 h later. It is concluded that the changes observed during EMG recordings are relevant to the intrauterine distribution of blastocysts and related to changes in the steroidal environment and/or to catecholamine effects via alpha 1-adrenoceptors. 相似文献
3.
HIGH PERFORMANCE TURNING CAPABILITIES DURING FORAGING BY BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS) 总被引:1,自引:0,他引:1
Jennifer L. Maresh Frank E. Fish Douglas P. Nowacek Stephanie M. Nowacek Randall S. Wells 《Marine Mammal Science》2004,20(3):498-509
Large predators should have difficulty catching small prey because small animals demonstrate greater maneuverability and agility compared to large animals. The ability of a predator to capture small prey indicates locomotor strategies to compensate for inequities in maneuverability. Bottlenose dolphins ( Tursiops truncatus ) in Sarasota Bay, Florida feed on fish at least one order of magnitude smaller than themselves. To examine the locomotor strategies involved in prey capture, the foraging movements of these dolphins were videotaped from overhead using a remotely-controlled camera suspended from a helium-filled aerostat, which was tethered to an observation vessel. Dolphins were observed to rapidly maneuver during chases of fish in open water or around patches of rooted vegetation. Video analysis of the chase sequences indicated that the dolphins could move the rostrum through small radius turns with a mean value of 0.20 body lengths and with a minimum value of 0.08 body lengths. Mean rate of turn was 561.6°/sec with a maximum rate measured at 1,372.0°/sec. High turning rates with small turning radii were primarily the result of maneuvers in which the dolphin rolled 90° and rapidly flexed its body ventrally. The ability of dolphins to change body orientation in multiple rotational axes provides a mechanism to reduce turning radius and increase turning rate to catch small, elusive prey. 相似文献
4.
Canu MH Kozlovskaya IB Falempin M 《Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology》2003,10(2):19-28
The aim of the present study was to analyse the effects of microgravity on i) the achievement of goal-directed arm movements and ii) the quadrupedal non-human primate locomotion. A reaching movement in weightlessness would require less muscle contraction since there is no need to oppose gravity. Consequently the electromyographic (EMG) activity of the monkey forelimb muscles should be changed during or after spaceflight. EMG activity of the biceps and triceps muscles during goal-directed arm movements were studied in Rhesus monkeys before, during and after 14 days of spaceflight and flight simulation at normal gravity. The EMG activity was also recorded during treadmill locomotion before and after spaceflight. When performing arm motor tasks, the delay values of the EMG bursts were unchanged during the flight. On the contrary, mean EMG was significantly decreased during the flight comparatively to the pre- and post-flight values, which were very similar. Compared with flight animals, the control ground monkey showed no change in the burst durations and mean EMG. After spaceflight, quadrupedal locomotion was modified. The animals had some difficulty in moving, and abnormal steps were numerous. The integrated area of triceps bursts was increased for the stance phase during locomotion. Taken together these data showed that spaceflight induces a dual adaptative process: first, the discharge of the motor pools of the forelimb musculature was modified during exposure to microgravity, and then upon return to Earth, monkeys changed their new motor strategy and re-adapt to normal gravity. 相似文献
5.
Sandra K Hunter Romuald Lepers Carol J MacGillis Roger M Enoka 《Journal of applied physiology》2003,94(6):2439-2447
Twenty-four men (n = 11) and women (n = 13) supported an inertial load equivalent to 20% of the maximum voluntary contraction force with the elbow flexor muscles for as long as possible while maintaining a constant elbow angle at 90 degrees. Endurance time did not differ on the three occasions that the task was performed (320 +/- 149 s; P > 0.05), and there was no difference between women (360 +/- 168 s) and men (273 +/- 108 s; P = 0.11). The rate of increase in average electromyogram (EMG) for the elbow flexor muscles was similar across sessions (P > 0.05). However, average EMG during the fatiguing task increased for the long head of biceps brachii, brachioradialis, and brachialis (P < 0.05) but not for the short head of biceps brachii. Furthermore, the average EMG for the brachialis was greater at the start and end of the contraction compared with the other elbow flexor muscles. The rate of bursts in EMG activity increased during the fatiguing contraction and was greater in brachialis (1.0 +/- 0.2 bursts/min) compared with the other elbow flexor muscles (0.5 +/- 0.1 bursts/min). The changes in the standard deviation of acceleration, mean arterial pressure, and heart rate during the fatiguing contractions were similar across sessions. These findings indicate that the EMG activity, which reflects the net excitatory and inhibitory input received by the motoneurons in the spinal cord, was not adaptable over repeat sessions for the maintain-position task. Furthermore, these results contrast those from a previous study (Hunter SK and Enoka RM. J Appl Physiol 94: 108-118, 2003) when the goal of the isometric contraction was to maintain a constant force. These results, from a series of studies on the elbow flexor muscles, indicate that the type of load supported during the fatiguing contraction influences the extent to which endurance time can change with repeat performances of the task. 相似文献
6.
The purpose of the study was to examine the patterns of electromyographic (EMG) activity of the rat plantaris during loaded swimming in comparison with other locomotor activities. Five female Sprague-Dawley rats were implanted with chronic bipolar electrodes in the plantaris muscle of the left hindlimb under pentobarbital anesthesia. Characteristics of EMG bursts recorded while the conscious rat was performing treadmill walking (0.24 m/s) were stable and reproducible 10-14 days postsurgery. Following this stabilization period, records of EMG activity were obtained during walking, loaded swimming (6.5 g attached to tail), and several other locomotor tasks. Compared to walking, EMG bursts during loaded swimming were significantly higher (67%) in maximum amplitude, one-third as long in duration, and occurred at a greater rate (4.4 vs. 1.7 bursts/s, P less than 0.05). Swimming bursts were of higher amplitudes than those of all other activities examined and reached 65% of the EMG amplitude recorded following stimulation of the sciatic nerve with supramaximal voltage. The addition of a mass to the animal's tail during swimming did not increase the EMG burst amplitudes but resulted in a higher frequency of bursts. Compared with treadmill walking, loaded swimming elicited burst of high variability in amplitude. Swimming in the rat involves rapid, extensive activation of plantaris, thus providing an exercise model to study the adaptability of the neuromuscular system to prolonged activity of this type. 相似文献
7.
The temporal distribution of the horizontal rapid eye movements and the related monophasic potentials recorded from the ascending MLF following intravenous injection of o.i mg/kg of anticholinesterase has been investigated in precollicular decerebrate animals. In particular the intervals between individual MLF potentials occurring during successive REM episodes have been evaluated over a total period of 2000 sec on each experiment. 2. There was a bimodal distribution of intervals due to the fact that all the rapid eye movements and the related MLF potentials were grouped in bursts which occurred at quite regular intervals. 3. During the cholinergically induced episodes of REM, there were usually bursts of REM in one direction followed by bursts of REM in the opposite direction. The mean number of individual eye movements within each burst was 4.67 +/- 0.84, S.D., while the average interval between the individual eye movements corresponded to 167 +/- 36 msec, S.D. 4. There was a great regularity in the periodic occurrence of the bursts of REM. In particular the mean interval between the beginning of a burst of REM in one direction (i.e., towards the left side) and that of the next train oriented in the opposite direction (i.e., towards the right side) was 1.97 +/- 0.47 sec, S.D., while the mean interval between the beginning of this last train and that of the successive train oriented in the former direction corresponded to 2.97 +/- 0.48 sec, S.D. Moreover, the duration of the whole period corresponding to the interval between two successive bursts of REM oriented in the same direction (i.e., towards left or towards right) corresponded on average to 4.94 +/- 0.55 sec S.D. and 4.99 +/- 0.52 sec, S.D. respectively. 5. In addition to these "simple bursts" of rapid eye movements oriented in one direction, there were "complex bursts" in which an alternation of the individual eye movements within each burst was observed. In these instances the mean number of spikes was greater (5.35 +/- 1.20, S.D.) and the mean interval shorter 119 +/- 44 msec, S.D.) than those observed in the "simple bursts", About 10-15% of the bursts occurring during the cholinergically induced REM episodes were of the complex type. 6. These findings obtained from an individual experiment were confirmed in all the decerebrate animals treated with the same dose of anticholinesterase; only slight quantitative differences were detected from case to case. 7. Since the bursts of REM induced by the anticholinesterase depend upon the activity of the vestibular nuclei, it is postulated that cholinergic reticular neurons activate structures which show waxing and waning in their activity before acting on the vestibulo-oculomotor system. This system probably contains the inhibitory interneurons which transform the regularly modulated input into a rhythmic vestibular output... 相似文献
8.
B Dutourné 《Journal de physiologie》1979,75(3):239-253
Effect of oestradiol and progesterone on the electromyographic activity (EMG) of the uterus is studied in 6 groups of 2 previously castrated vixens (A, B, C, D, E, F). The animals of gropu A are treated daily with intramuscular injections of oestradiol benzoate alone or oestradiol and progesterone together. These hormones are also given to the group F, oestradiol by a subcutaneous tablet and progesterone intramuscularly. The other females only receive a silastic implant of oestrogen (groups B, C, D, E). Electrical activity is daily recorded during the various treatments, in unanaesthetized animals, by means of platinum electrodes permanently implanted in the uterus. Plasma oestradiol concentrations in peripheral blood are determined in groups A and B. The results show that : 1. OEstradiol induces rhythmic EMG activity composed of bursts of action potentials (Fig. 2). It appears after a delay of 1 to 3 days following the beginning of treatment, except in the animals of group E, treated with a 25 mg oestradiol implant (6 days). Then, EMG activity gradually increases, and the frequency of bursts is at a maximum within 24 to 48 hours. Except in group E, it exceeds 30 per 10 minutes and the amplitude of potentials sometimes reachs 1 mV. 相似文献
9.
The suckling opossum exhibits an expiration-phased discharge in abdominal muscles during positive-pressure breathing (PPB); the response becomes apparent, however, only after the 3rd-5th wk of postnatal life. The purpose of this study was to determine whether the early lack of activation represented a deficiency of segmental outflow to abdominal muscles or whether comparable effects were observed in cranial outflows to muscles of the upper airways due to immaturity of afferent and/or supraspinal pathways. Anesthetized suckling opossums between 15 and 50 days of age were exposed to PPB; electromyogram (EMG) responses in diaphragm and abdominal muscles were measured, along with EMG of larynx dilator muscles and/or upper airway resistance. In animals older than approximately 30 days of age, the onset of PPB was associated with a prolonged expiration-phased EMG activation of larynx dilator muscles and/or decreased upper airway resistance, along with expiratory recruitment of the abdominal muscle EMG. These effects persisted as long as the load was maintained. Younger animals showed only those responses related to the upper airway; in fact, activation of upper airway muscles during PPB could be associated with suppression of the abdominal motor outflow. After unilateral vagotomy, abdominal and upper airway motor responses to PPB were reduced. The balance between PPB-induced excitatory and inhibitory or disfacilitory influences from the supraspinal level on abdominal motoneurons and/or spinal processing of information from higher centers may shift toward net excitation as the opossum matures. 相似文献
10.
1. The multiunit EMG activity of the forelimb extensor muscle triceps brachii was recorded in precollicular decerebrate cats, either at rest or during roll tilt of the animal at 0.15Hz, +/- 10 degrees leading to sinusoidal stimulation of labyrinth receptors. Both the spontaneous EMG activity as well as the labyrinthine-induced EMG responses were tested before and after pontine microinjection of a cholinergic agonist. 2. Local injection of the cholinergic agonist carbachol into the dorsal aspect of the pontine tegmentum (usually 0.25 microliter, 0.01-0.2 microgram/microliter) produced a state of postural atonia, and abolished both the spontaneous EMG activity as well as the EMG responses of the triceps brachii to sinusoidal stimulation of labyrinth receptors. This suppression was generally ipsilateral to the side of the injection and persisted throughout the episode of postural atonia, but sometimes it involved also the contralateral limbs. In these instances it could be accompanied by a spontaneous nystagmus, interspersed at regular intervals with bursts of rapid eye movements. 3. Similar effects were also obtained following injection of carbachol in the gigantocellular tegmental field (FTG) (0.25 microliter, 0.5-1.0 microgram/microliter). However, this structure was not critically responsible for the phenomena reported above, which persisted unaltered after kainic acid lesion of the FTG performed ipsilaterally to the side of the pontine injection. 4. Local infusion of the muscarinic blocker atropine sulphate reversed the effects of carbachol injection into the dorsal aspect of the pontine tegmentum, thus indicating that muscarinic receptors were involved. 5. It is postulated that the postural atonia as well as the tonic depression of vestibulospinal reflexes, which occur in the decerebrate cat after local injection of a cholinergic agonist depends, at least in part, on the activation of cholinoceptive neurons located in dorsal pontine reticular structures. These may in turn excite medullary reticulospinal neurons, which are finally responsible for the inhibition of extensor motoneurons. 相似文献
11.
Background
The Timed Up and Go (TUG) test is widely used to assess locomotion in patients with stroke and is considered to predict the risk of falls. The analysis of locomotor trajectories during the TUG appears pertinent in stroke patients. The aims of this study were i) to analyze locomotor trajectories in patients with stroke during the walking and turning sub-tasks of the TUG, and to compare them with healthy subjects, ii) to determine whether trajectory parameters provide additional information to that provided by the conventional measure (performance time), iii) to compare the trajectory parameters of fallers and non-fallers with stroke and of patients with right and left hemisphere stroke, and iv) to evaluate correlations between trajectory parameters and Berg Balance Scale scores.Methods
29 patients with stroke (mean age 54.2±12.2 years, 18 men, 8 fallers) and 25 healthy subjects (mean age 51.6±8.7 years, 11 men) underwent three-dimensional analysis of the TUG. The trajectory of the center of mass was analyzed by calculation of the global trajectory length, Hausdorff distance and Dynamic Time Warping. The parameters were compared with a reference trajectory during the total task and each sub-task (Go, Turn, Return) of the TUG.Results
Values of trajectory parameters were significantly higher for the stroke group during the total TUG and the Go and Turn sub-tasks (p<0.05). Moreover, logistic regression indicated that these parameters better discriminated stroke patients and healthy subjects than the conventional timed performance during the Go sub-task. In addition, fallers were distinguished by higher Dynamic Time Warping during the Go (p<0.05). There were no differences between patients with right and left hemisphere stroke.Discussion and Conclusion
The trajectories of the stroke patients were longer and more deviated during the turn and the preceding phase. Trajectory parameters provided additional information to timed performance of this locomotor task. Focusing rehabilitation programs on lead-up to turn and turning could be relevant for stroke patients since the Turn was related to the balance and the phase preceding the turn seemed to distinguish fallers. 相似文献12.
Electromyography (EMG) was used to examine muscle activity of the major hip, knee, and ankle extensors during both hopping and swimming in leopard frogs. Chronic EMG electrodes were implanted for periods of 7–10 days. This permitted us to record EMG activities during both hopping and swimming from the same electrode, allowing a direct comparison of the timing and amplitudes of muscle activity between the two behaviors. We could then relate these activities to the kinematics of locomotion. In both behaviors, all three extensors were synchronously activated 30–50 ms before limb extension began. However, the hip extensor turned on relatively earlier in hopping than in swimming when on time was expressed as percent of stride. The hip and knee extensors were activated relatively longer in hopping and the ankle extensor relatively longer in swimming. The amplitudes of the rectified, integrated EMG signals were roughly twice as large in hopping as in swimming for all three muscles, supporting the notion that propulsion in hopping requires more force than in swimming. The EMG burst durations differed little between the muscles or, in relative duration, between the behaviors. As has been found in other quadrupeds, the EMG bursts began before visible movement and ceased at or before hindlimb extension was completed. In our animals, however, we found a consistent, low level (10–30% of maximum amplitude) of EMG activity that continued 60–200 ms past the end of the burst and into the suspension periods in both hopping and swimming. We hypothesize that this unusual activity may be present in frogs so that the hind limb remains aero(hydro)dynamically stable as the frog arches through its leap or glides in swimming following completed limb extension. Thus, the timing and pattern of the EMG bursts are consistent with those present in other tetrapods and support conservatism of neural control. However, the prolonged low-level activity suggests flexibility in the control pattern and variation according to specific behaviors. © 1996 Wiley-Liss, Inc. 相似文献
13.
When insects turn from walking straight, their legs have to follow different motor patterns. In order to examine such pattern
change precisely, we stimulated single antenna of an insect, thereby initiating its turning behavior, tethered over a lightly
oiled glass plate. The resulting behavior included asymmetrical movements of prothoracic and mesothoracic legs. The mesothoracic
leg on the inside of the turn (in the apparent direction of turning) extended the coxa-trochanter and femur-tibia joints during
swing rather than during stance as in walking, while the outside mesothoracic leg kept a slow walking pattern. Electromyograms
in mesothoracic legs revealed consistent changes in the motor neuron activity controlling extension of the coxa-trochanter
and femur-tibia joints. In tethered walking, depressor trochanter activity consistently preceded slow extensor tibia activity.
This pattern was reversed in the inside mesothoracic leg during turning. Also for turning, extensor and depressor motor neurons
of the inside legs were activated in swing phase instead of stance. Turning was also examined in free ranging animals. Although
more variable, some trials resembled the pattern generated by tethered animals. The distinct inter-joint and inter-leg coordination
between tethered turning and walking, therefore, provides a good model to further study the neural control of changing locomotion
patterns. 相似文献
14.
Background
The Timed Up and Go (TUG) test is often used to estimate risk of falls. Foot clearance and displacement of the center of mass (COM), which are related to risk of tripping and dynamic stability have never been evaluated during the TUG. Accurate assessment of these parameters using instrumented measurements would provide a comprehensive assessment of risk of falls in hemiparetic patients. The aims of this study were to analyze correlations between TUG performance time and displacement of the COM and foot clearance in patients with stroke-related hemiparesis and healthy subjects during the walking and turning sub-tasks of the TUG and to compare these parameters between fallers and non-fallers.Methods
29 hemiparetic patients and 25 healthy subjects underwent three-dimensional gait analysis during the TUG test. COM and foot clearance were analyzed during the walking and turning sub-tasks of the TUG.Results
Lateral displacement of the COM was greater and faster during the walking sub-tasks and vertical displacement of the COM was greater during the turn in the patients compared to the healthy subjects (respectively p<0.01 and p<0.05). Paretic foot clearance was greater during walking and displacement of the COM was slower during the turn in the patients (p<0.01). COM displacement and velocity during the turn were correlated with TUG performance in the patients, however, vertical COM displacement was not. These correlations were significant in the healthy subjects. There were no differences between COM parameters or foot clearance in fallers and non-fallers.Discussion and Conclusion
Hemiparetic patients are less stable than healthy subjects, but compensate with a cautious gait to avoid tripping. Instrumented analysis of the TUG test appears relevant for the assessment of dynamic stability in hemiparetic patients, providing more information than straight-line gait. 相似文献15.
16.
Pyramidal unit activity in unanesthetized cats at rest and during voluntary movement was recorded by a microelectrode technique from the motor cortex for the forelimb. Some pyramidal neurons were not spontaneously active. The conduction velocity along the axon of these neurons was sometimes high (up to 71.5 m/sec), sometimes low (up to 11.2 m/sec). The remaining pyramidal neurons had spontaneous activity with a mean frequency of 1.29 to 43 spikes/sec. Analysis of interspike interval histograms of spontaneous activity and of autocorrelation histograms showed grouping of the spikes into volleys in most pyramidal neurons (irrespective of the conduction velocity). During voluntary movements the change in the activity of many pyramidal units correlated with changes in the EMG. The firing rate of the pyramidal neurons under these circumstances began to rise at least 50 msec before the increase in amplitude of the EMG and it remained high throughout the movement. The firing rate of most neurons during movement was 40–60/sec. The results are compared with those obtained by other workers who studied pyramidal unit activity of monkeys during voluntary movement. 相似文献
17.
L R Kline J C Hendricks D A Silage A R Morrison R O Davies A I Pack 《Journal of applied physiology》1990,68(1):166-173
Tonic inhibition of some respiratory muscles occurs as part of the generalized muscle atonia of rapid-eye-movement sleep (REMS). A second type of inhibition of the diaphragm during REMS, fractionations, consists of brief pauses in the diaphragmatic electromyogram (DIA EMG) in association with phasic events. Because motor inhibition can occur as part of the startle response, and the brain is highly activated during REMS, we hypothesized that the neural basis of the fractionations might be activation of a startle network. To test this hypothesis, tone bursts (100 dB, 20-ms duration at 15-s intervals) were applied to cats at a fixed inspiratory level in the DIA moving average during REMS, non-rapid-eye-movement sleep (NREMS), and wakefulness. Parallel sham studies (no tone applied) were obtained for each state. The response of the DIA EMG was averaged over 100 ms by using the tone pulse as a trigger, and the following parameters of the DIA EMG were measured: latency to peak and/or nadir, increment or decrement in activity, and duration of peak and/or nadir. After a tone, all five animals studied displayed a profound suppression of DIA activity during REMS (latency to nadir 42.4 +/- 10.0 ms, duration of suppression 35.9 +/- 17.6 ms). Similarly, DIA activity was suppressed in all cats during NREMS (latency to nadir 40.9 +/- 13.3 ms, duration 23.9 +/- 13.4 ms). An excitatory response was observed in only two cats during NREMS and wakefulness. The similarity of startle-induced DIA EMG pauses to spontaneous fractionations of DIA activity during REMS suggests that the latter result from activation of a central startle system. 相似文献
18.
Strips (2.5 x 3.5 cm) of myometrium alone (MYO) or endometrium/myometrium (ENDO/MYO) were removed from the pregnant horn of sheep (Day 110 of gestation) and transplanted to sites within the omental fat. These explants developed regular bursts of electromyographic (EMG) activity over a period of 7-10 days, as well as a dose-dependent stimulatory response to oxytocin (50-200 mU i.v.). The frequency (per 2 h) of EMG bursts in the MYO (5.3 +/- 0.2) and ENDO/MYO (5.2 +/- 0.3) explants was significantly greater (P less than 0.05) than that of the uterine myometrium (3.0 +/- 0.1), while burst duration (min) in MYO (4.1 +/- 0.2) and ENDO/MYO (4.1 +/- 0.2) explants was significantly (P less than 0.05) less than in the uterine myometrium (7.3 +/- 0.1). The EMG bursts were asynchronous between the explants and uterus, although systemic administration of oxytocin produced a synchronous burst of EMG activity in all three tissues. No differences in EMG activity or responsiveness were apparent between MYO and ENDO/MYO explants. Histological examination of the explant tissue revealed the presence of smooth muscle fibres regularly orientated into two layers; some loss of endometrial tissue was apparent in ENDO/MYO explants. To validate the mechanical integrity of this model we examined the in-vitro contractile activity of myometrial strips prepared from the explants. The strips developed regular spontaneous contractions and demonstrated a dose-dependent stimulation in response to the addition of oxytocin (10(-10) to 10(-4) M) to the bath fluid. These results suggest that spontaneous contractures during pregnancy are probably not due to pulsatile release of stimulants into the systemic circulation, or the direct diffusion of stimulants from intrauterine tissues to the myometrium but are probably caused by factors within the myometrium itself. 相似文献
19.
The effects of estrogen administration on uterine contractility varies with animal species. In nonpregnant ovariectomized sheep, estrogen administration has been reported either to inhibit, inhibit then stimulate, or only stimulate uterine contractility. The aim of the present study was to determine the effects of prolonged estrogen administration in the electromyographic (EMG) activity recorded from the myometrium and mesometrium in nonpregnant ovariectomized sheep after estrous synchronization by inserting vaginal progesterone sponges 14 days before surgery. Surgery was performed on four ewes under halothane anesthesia. Bilateral oophorectomy was performed, and stainless steel EMG electrodes were sewn to the mesometrium and myometrium in both left and right horns of the uterus. Blood samples were taken at 1000 h from the uterine vein for 13,14-dihydro-15-keto-prostaglandin F2 alpha determination, and from the femoral artery for estradiol determination. Starting on Day 7 after surgery, estradiol 17 beta (50 micrograms/24 h) was infused continuously into the jugular vein. Estrogen administration had a different effect on the EMG activity recorded from myometrium and mesometrium. The myometrial response to estrogen was an increase in the frequency of short EMG events from 19.0 +/- 8.7 to 57.0 +/- 5.0 (p less than 0.05) for events less than 60 sec, and from 2.70 +/- 0.83 to 10.30 +/- 1.36 (p less than 0.05) for events lasting greater than 60 sec but less than less than 180 sec. In contrast, there was no stimulatory effect of estrogen on mesometrial EMG for both types of short events less than 60 sec, and greater than 60 but less than less than 180 sec.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
20.
Mamaghani NK Shimomura Y Iwanaga K Katsuura T 《Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science》2002,21(1):29-43
To investigate the behavior of mechanomyogram (MMG) and electromyogram (EMG) signals in the time and frequency domains during sustained isometric contraction, MMG and surface EMG were obtained simultaneously from four muscles: upper trapezius (TP), anterior deltoid (DL), biceps brachii (BB), and brachioradialis (BR) of 10 healthy male subjects. Experimental conditions consisted of 27 combinations of 9 postures [3 shoulder angles (SA): 0 degree, 30 degrees, 60 degrees and 3 elbow angles (EA): 120 degrees, 90 degrees, 60 degrees] and 3 contraction levels: 20%, 40%, and 60% of maximum voluntary contraction (MVC). Subjective evaluations of fatigue were also assessed using the Borg scale at intervals of 60, 30, and 10 sec at 20%, 40%, and 60% MVC tests, respectively. The mean power frequency (MPF) and root mean square (RMS) of both signals were calculated. The current study found clear and significant relationships among physiological and psychological parameters on the one hand and SA and EA on the other. EA's effect on MVC was found to be significant. SA had a highly significant effect on both endurance time and Borg scale. In all experimental conditions, significant correlations were found between the changes in MPF and RMS of EMG in BB with SA and EA (or muscle length). In all four muscles, MMG frequency content was two or three times lower than EMG frequency content. During sustained isometric contraction, the EMG signal showed the well-known shift to lower frequencies (a continuous decrease from onset to completion of the contraction). In contrast, the MMG spectra did not show any shift, although its form changed (generally remaining about constant). Throughout the contraction, increased RMS of EMG was found for all tests, whereas in the MMG signal, a significant progressive increase in RMS was observed only at 20% MVC in all four muscles. This supports the hypothesis that the RMS amplitude of the MMG signal produced during contraction is highly correlated with force production. Possible explanations for this behavioral difference between the MMG and EMG signals are discussed. 相似文献