Neuroadipology: A novel component of neuroendocrinology

Adipose tissue is a dynamic endocrine and paracrine organ producing a large number of signalling proteins collectively termed adipokines. Some of them are mediators in the cross‐talk between adipose tissue and the brain in regulating food intake and energy homoeostasis. However, the hypothalamus is not the only brain target for adipokines, and food intake is not the only biological effect of these signals. Rather, some adipokines support various cognitive functions and exert neurotrophic activity. Current data on adipose‐derived neuropeptides, neurotrophic factors, pituitary hormones and hypothalamic releasing factors is highlighted in this review. We propose that adipose tissue is a member of the diffuse neuroendocrine system. Cumulatively, this is conceptualized as neuroadipology, a new example of a link between neurobiology and other topics, such as neuroimmunology and neuroendocrinology. Because adipose tissue is a bona fide endocrine organ, neuroadipology may be considered a new discipline in neuroendocrinology. It may have a wide‐ranging potential within a variety of neuronal and metabolic functions in health and disease.     

Human pheromones: integrating neuroendocrinology and ethology

The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction. The chemical signals we send have direct and developmental effects on hormone levels in other people. Since we don t know either if, or how, visual cues might have direct and developmental effects on hormone levels in other people, the biological basis for the development of visually perceived human physical attraction is currently somewhat questionable. In contrast, the biological basis for the development of physical attraction based on chemical signals is well detailed.     

The neuroendocrinology of human sleep

Sleep consists of several distinct patterns of CNS activation, including synchronized or slow wave of sleep and desynchronized or rapid eye movement sleep. Specific areas of the brain as well as specific biogenic amine neurotransmitters appear to be responsible for the periodic shifts between sleep stages. Hypothalamic regulation of the anterior pituitary gland also is influenced by the same biogenic amine neurotransmitters, and the episodic release patterns of the anterior pituitary hormones suggest prominent CNS influences. This review considers the relationship of these hormone release patterns to the circadian sleep-wake cycle and to sleep staging within the sleep period itself.     

Claude Bernard: primer of the second biomedical revolution

Claude Bernard, the son of a Beaujolais winegrower, moved to Paris to pursue his literary ambitions and went on to become one of the fathers of modern life sciences. What did Bernard do to earn universal renown? And are his teachings relevant to modern science?     

Current research on the behavioral neuroendocrinology of reptiles

Selected reptilian species have been the targets of investigations in behavioral neuroendocrinology for many years. Reptiles offer a particularly powerful set of traits that facilitate comparisons at multiple levels, including those within and between individuals of a particular species, between different environmental and social contexts, as well as across species. These types of studies, particularly as they are considered within the framework of results from other vertebrates, will enhance our understanding of the genetic and hormonal influences regulating changes in the structure and function of the nervous system. Work on the hormonal and environmental factors influencing courtship and copulatory behaviors in green anoles, including the development and maintenance of the neuromuscular structures critical for their display, is highlighted. Some very recent work on other model systems is also discussed to provide a context for suggested future research directions.     

Immunocytochemistry: its applications and drawbacks for the study of gut neuroendocrinology

Localization of gut peptide hormones by immunological staining methods is known generally as "immunocytochemistry". These immunostaining techniques depend upon the correct processing of the tissue under study and careful characterization of the antisera used. Many years of research in our laboratory have enabled us to present here our approach to the application and pitfalls of immunocytochemistry in the study of gut neuroendocrinology.     

Schizophrenia: a unique translational opportunity in behavioral neuroendocrinology

Schizophrenia is a complex and debilitating neuropsychiatric disease in which both environmental and genetic factors contribute to the pathophysiology of the disease. Epidemiological data point to the importance of the prenatal period in the genesis of schizophrenia and suggest that environmental factors, such as stress and hormones of the hypothalamic-pituitary-adrenal axis, may establish a vulnerability to the disease. Unfortunately, the exact cause of this neurodevelopmental disease is unclear. In this review, data on the importance of gestational stress exposure to the etiology of schizophrenia-like behavioral, endocrine and molecular phenotypes will be presented and differences will be highlighted between the preparations that are commonly used in most laboratory investigations.     

The neuroendocrinology of human puberty revisited

The fundamental aspects of the hypothalamic luteinizing hormone-releasing hormone (LHRH)(1) [1]pulse generator-pituitary gonadotrophin-gonadal apparatus in mammals have striking commonalities. There are, however, critical, substantive differences in the neuroendocrinology of puberty among species. The onset of puberty in the human is marked by an increase in the amplitude of LH pulses, an indirect indicator of the increase in amplitude of LHRH pulses. The hypothalamic LHRH-pituitary gonadotrophin complex is functional by at least 0.3 gestation in the human foetus; the sex difference in the fetal and neonatal pattern of LH and FSH secretion is an apparent consequence of imprinting of the fetal hypothalamus-pituitary-gonadotropin apparatus by fetal testosterone. Until about 6 months of age in boys and 12-24 months in girls, the testes and ovaries respond to the increased LH in boys and follicle-stimulating hormone (FSH) in girls by secreting testosterone and oestradiol, respectively, reaching levels that are not again achieved before the onset of puberty. Striking features of the ontogeny of the human hypothalamic pulse generator are: (1) its development and function in the foetus; (2) the continued function of the hypothalamic LHRH pulse generator-pituitary gonadotrophin-gonadal axis in infancy; (3) the gradual damping of hypothalamic LHRH oscillator activity during late infancy; (4) its quiescence during childhood - the so-called juvenile pause; (5) during late childhood the gradual disinhibition and reactivation of the LHRH pulse generator, mainly at night; (6) the increasing amplitude of the LHRH pulses, which are reflected in the progressively increased and changing pattern of circulating LH pulses, with the approach of and during puberty. The intrinsic central nervous system (CNS) mechanisms responsible for the inhibition of the LHRH pulse generator during childhood (the juvenile phase) involve the major role of an inhibitory neuronal system - the CNS inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and GABAergic neurons, as revealed by studies in the rhesus monkey by Terasawa and her associates. With the onset of puberty, the disinhibition and reactivation of the LHRH pulse generator is associated with a fall in GABAergic neurotransmission and a concomitant increase in the input of excitatory amino acid neurotransmitters (including glutamate) and possibly astroglial-derived growth factors. Despite remarkable progress over the past three decades, large gaps remain in our understanding of the neurobiological, genetic and environmental mechanisms involved in the control of the onset of puberty. The role of leptin in the control of the onset of puberty is reviewed. Severe leptin deficiency is associated with hypogonadotrophic hypogonadism; it appears that a critical level of leptin and a leptin signal is required to achieve puberty. The weight of evidence supports the hypothesis that leptin acts as one of several permissive factors and not a trigger in the onset of human puberty. The application of these advances provides a framework for the described classification of sexual precocity and delayed puberty.1 GnRH is synonymous with LHRH.     

Growth hormone-releasing factor: a new chapter in neuroendocrinology

The isolation and characterization of growth hormone-releasing factor (GRF) has initiated a new and exciting era in our understanding of the neuroendocrine regulation of pituitary growth hormone (GH) secretion. This report briefly describes the isolation and characterization of GRF, factors which modulate the GH response to GRF and the effects of chronic administration and deprivation of GRF on somatic growth. The intent of this report is to serve as a general introduction on biochemical and physiological aspects of GRF. The following reports from this symposium will then cover many of these topics in much greater detail.     

Sonic and electric fish: at the crossroads of neuroethology and behavioral neuroendocrinology

Field and laboratory studies of weakly electric and sound-producing teleost fishes demonstrate how steroidal and non-steroidal hormones mediate the translation of neural events into behavior. The development of this research program has depended upon an interdisciplinary neuroethological approach that has characterized the neurophysiological properties of the motor and sensory pathways that lead to the production and detection of easily quantified highly stereotyped behaviors, namely, electric organ discharges (EODs) and vocalizations. Neuroethological studies of these teleosts have now integrated a behavioral neuroendocrinology approach that has provided several examples of how hormone-sensitive neurobiological traits contribute to adaptive behavioral plasticity in natural habitats. As such, these studies provide guideposts for comparable studies in other groups of teleosts and vertebrates in general.