共查询到20条相似文献,搜索用时 15 毫秒
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The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene. 总被引:16,自引:0,他引:16
Z Y Wang S L Madden T F Deuel F J Rauscher 《The Journal of biological chemistry》1992,267(31):21999-22002
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Anne-Sophie Kuhlmann Julien Villaudy Louis Gazzolo Marc Castellazzi Jean-Michel Mesnard Madeleine Duc Dodon 《Retrovirology》2007,4(1):1-13
Centrosomes are the major microtubule organizing structures in vertebrate cells. They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions. Consequently, any deficiency in centrosome function or number may lead to genetic instability. Several viruses including retroviruses such as, Foamy Virus, HIV-1, JSRV, M-PMV and HTLV-1 have been shown to hamper centrosome functions for their own profit, but the outcomes are very different. Foamy viruses, HIV-1, JSRV, M-PMV and HTLV-1 use the cellular machinery to traffic towards the centrosome during early and/or late stages of the infection. In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. Enthrallingly, HTLV-1 Tax expression also targets the functions of the centrosome, and this event is correlated with centrosome amplification, aneuploidy and transformation. 相似文献
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Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter 总被引:2,自引:0,他引:2
Renaud S Bosman FT Benhattar J 《Biochemical and biophysical research communications》2003,300(1):47-54
The expression of the catalytic subunit (hTERT) represents the limiting factor for telomerase activity. In transfection studies, high level of activity of hTERT promoter is found, whereas low copy numbers of hTERT mRNA are detected in vivo. To explain this discrepancy, a series of vectors containing the hTERT promoter and gene were transiently transfected into HeLa cells. Four important regions were identified. First, the core promoter has bidirectional activity. Second, the distal upstream region (-1821 to -811bp) involved in the splicing of the first intron and could be a key of splicing specificity. Third, the intermediate promoter region (-800 to -300bp) could play an important role in silencing the reverse promoter activity. Fourth, the structural gene (up to +1077) strongly reduced hTERT promoter activity. These results provide the first evidence that the first two exons play a major role in the down-regulation of the hTERT promoter in telomerase-positive cells. 相似文献