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1.
Gabor Er?s Saleh Ibrahim Nikolai Siebert Mihály Boros Brigitte Vollmar 《Arthritis research & therapy》2009,11(2):R43
Introduction
Phosphatidylcholine and phosphatidylcholine-derived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis). 相似文献2.
Background
Rodent kindling induced by PTZ is a widely used model of epileptogenesis and AED testing. Overlapping pathophysiological mechanisms may underlie epileptogenesis and other neuropsychiatric conditions. Besides epilepsy, AEDs are widely used in treating various neuropsychiatric disorders. Mechanisms of AEDs' long term action in these disorders are poorly understood. We describe here a Drosophila systems model of PTZ induced locomotor plasticity that is responsive to AEDs. 相似文献3.
Background
Generally, utility based decision making models focus on experimental outcomes. In this paper we propose a utility model based on molecular diffusion to simulate the choice behavior of Drosophila larvae exposed to different light conditions. 相似文献4.
Background
Bayesian phylogenetic inference holds promise as an alternative to maximum likelihood, particularly for large molecular-sequence data sets. We have investigated the performance of Bayesian inference with empirical and simulated protein-sequence data under conditions of relative branch-length differences and model violation. 相似文献5.
Background
Cell lines as model systems of tumors and tissues are essential in molecular biology, although they only approximate the properties of in vivo cells in tissues. Cell lines have been selected under in vitro conditions for a long period of time, affecting many specific cellular pathways and processes. 相似文献6.
Background
Variovorax paradoxus is an aerobic soil bacterium frequently associated with important biodegradative processes in nature. Our group has cultivated a mucoid strain of Variovorax paradoxus for study as a model of bacterial development and response to environmental conditions. Colonies of this organism vary widely in appearance depending on agar plate type. 相似文献7.
Arielle Click Chandni H Savaliya Simone Kienle Matthias Herrmann Andre Pires-daSilva 《BMC evolutionary biology》2009,9(1):75
Background
Evolution of selfing can be associated with an increase in fixation of deleterious mutations, which in certain conditions can lead to species extinction. In nematodes, a few species evolved self-fertilization independently, making them excellent model systems to study the evolutionary consequences of this type of mating system. 相似文献8.
A. Cadiere B. Couturaud J. Boismard P. Le Cann A. Gérard A. Mas C. Faye L. Garrelly B. Roig 《Journal of applied microbiology》2013,115(1):290-297
Aims
Virus detection has often been difficult due to a low concentration in water. In this study, we developed a new procedure based on concentration of virus particles on an innovative support: poly‐l ‐lysine dendrigrafts (DGL), coupled with directed nucleic acid extraction and real‐time PCR quantification.Methods and Results
This method was evaluated using the bacteriophage MS2 as a model virus. This virus exhibited the size and structural properties of human pathogenic enteric viruses and has often been used to assess new supports of concentration. Moreover, this bacteriophage is also a faecal contamination indicator. In this study, many water filtration conditions were tested (volume of water, concentration, etc.), and more than 80% of bacteriophage were recovered after filtration on polymer, in most conditions. We demonstrated that the method was linear (slope = 0·99 ± 0·04 and Y intercept when x = ?0·02 ± 0·28), valid (as manipulators, tested concentrations, volumes of sample and batch of polymer did not have any influence on concentration) and sensitive (allowing to concentrate up to 16 600‐fold 1 l of sample and to detect and quantify down to 750 GC l?1 and 7500 GC l?1, respectively).Conclusions
To conclude, this support exhibits high interest to retain viruses and to allow to detect low concentration of virus in water.Significance and Impact of the Study
This study gives valuable advance in the methods of concentration and diagnosis of virus in water. 相似文献9.
High climate velocity and population fragmentation may constrain climate‐driven range shift of the key habitat former Fucus vesiculosus
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Per R. Jonsson Jonne Kotta Helén C. Andersson Kristjan Herkül Elina Virtanen Antonia Nyström Sandman Kerstin Johannesson 《Diversity & distributions》2018,24(7):892-905
Aim
The Baltic Sea forms a unique regional sea with its salinity gradient ranging from marine to nearly freshwater conditions. It is one of the most environmentally impacted brackish seas worldwide, and the low biodiversity makes it particularly sensitive to anthropogenic pressures including climate change. We applied a novel combination of models to predict the fate of one of the dominant foundation species in the Baltic Sea, the bladder wrack Fucus vesiculosus.Location
The Baltic Sea.Methods
We used a species distribution model to predict climate change‐induced displacement of F. vesiculosus and combined these projections with a biophysical model of dispersal and connectivity to explore whether the dispersal rate of locally adapted genotypes may match estimated climate velocities to recolonize the receding salinity gradient. In addition, we used a population dynamic model to assess possible effects of habitat fragmentation.Results
The species distribution model showed that the habitat of F. vesiculosus is expected to dramatically shrink, mainly caused by the predicted reduction of salinity. In addition, the dispersal rate of locally adapted genotypes may not keep pace with estimated climate velocities rendering the recolonization of the receding salinity gradient more difficult. A simplistic model of population dynamics also indicated that the risk of local extinction may increase due to future habitat fragmentation.Main conclusions
Results point to a significant risk of locally adapted genotypes being unable to shift their ranges sufficiently fast considering the restricted dispersal and long generation time. The worst scenario is that F. vesiculosus may disappear from large parts of the Baltic Sea before the end of this century with large effects on the biodiversity and ecosystem functioning. We finally discuss how to reduce this risk through conservation actions, including assisted colonization and assisted evolution. 相似文献10.
Claudia Rändler Rutger Matthes Andrew J McBain Bernd Giese Martin Fraunholz Rabea Sietmann Thomas Kohlmann Nils-Olaf Hübner Axel Kramer 《BMC microbiology》2010,10(1):282
Background
Pseudomonas aeruginosa is commonly associated with contact lens (CL) -related eye infections, for which bacterial adhesion and biofilm formation upon hydrogel CLs is a specific risk factor. Whilst P. aeruginosa has been widely used as a model organism for initial biofilm formation on CLs, in-vitro models that closely reproduce in-vivo conditions have rarely been presented. 相似文献11.
Sébastien Lemieux 《BMC bioinformatics》2006,7(1):391-9
Background
The identification of differentially expressed genes (DEGs) from Affymetrix GeneChips arrays is currently done by first computing expression levels from the low-level probe intensities, then deriving significance by comparing these expression levels between conditions. The proposed PL-LM (Probe-Level Linear Model) method implements a linear model applied on the probe-level data to directly estimate the treatment effect. A finite mixture of Gaussian components is then used to identify DEGs using the coefficients estimated by the linear model. This approach can readily be applied to experimental design with or without replication. 相似文献12.
Carme Gubern Olivia Hurtado Rocío Rodríguez Jesús R Morales Víctor G Romera María A Moro Ignacio Lizasoain Joaquín Serena Judith Mallolas 《BMC molecular biology》2009,10(1):57
Background
Studies of gene expression in experimental cerebral ischaemia models can contribute to understanding the pathophysiology of brain ischaemia and to identifying prognostic markers and potential therapeutic targets. The normalization of relative qRT-PCR data using a suitable reference gene is a crucial prerequisite for obtaining reliable conclusions. No validated housekeeping genes have been reported for the relative quantification of the mRNA expression profile activated in in-vitro ischaemic conditions, whereas for the in-vivo model different reference genes have been used. 相似文献13.
Background
Thermotoga spp. are attractive candidates for producing biohydrogen, green chemicals, and thermostable enzymes. They may also serve as model systems for understanding life sustainability under hyperthermophilic conditions. A lack of genetic tools has hampered the investigation and application of these organisms. This study aims to develop a genetic transfer system for Thermotoga spp. 相似文献14.
Kung Ahn Jae-Won Huh Sang-Je Park Dae-Soo Kim Hong-Seok Ha Yun-Ji Kim Ja-Rang Lee Kyu-Tae Chang Heui-Soo Kim 《BMC molecular biology》2008,9(1):78
Background
The rhesus monkey (Macaca mulatta) is a valuable and widely used model animal for biomedical research. However, quantitative analyses of rhesus gene expression profiles under diverse experimental conditions are limited by a shortage of suitable internal controls for the normalization of mRNA levels. In this study, we used a systematic approach for the selection of potential reference genes in the rhesus monkey and compared their suitability to that of the corresponding genes in humans. 相似文献15.
Pratap R Patnaik 《Microbial cell factories》2007,6(1):23
Background
For many microbial processes, the complexity of the metabolisms and the responses to transient and realistic conditions are difficult to capture in mechanistic models. The cells seem to have an innate intelligence that enables them to respond optimally to environmental changes. Some "intelligent" models have therefore been proposed and compared with a mechanistic model for fed-batch cultures of Ralstonia eutropha. 相似文献16.
Hui-Hsien Chou Arunee Trisiriroj Sunyoung Park Yue-Ie C Hsing Pamela C Ronald Patrick S Schnable 《BMC bioinformatics》2009,10(1):347
Background
Few microarrays have been quantitatively calibrated to identify optimal hybridization conditions because it is difficult to precisely determine the hybridization characteristics of a microarray using biologically variable cDNA samples. 相似文献17.
Background
This study examines the use of a simple thermoregulatory model for the human body exposed to extended (45 minute) exposures to radiofrequency/microwave (RF/MW) energy at different frequencies (100, 450, 2450 MHz) and under different environmental conditions. The exposure levels were comparable to or above present limits for human exposure to RF energy. 相似文献18.
Identification of coherent patterns in gene expression data using an efficient biclustering algorithm and parallel coordinate visualization 总被引:1,自引:0,他引:1
Background
The DNA microarray technology allows the measurement of expression levels of thousands of genes under tens/hundreds of different conditions. In microarray data, genes with similar functions usually co-express under certain conditions only [1]. Thus, biclustering which clusters genes and conditions simultaneously is preferred over the traditional clustering technique in discovering these coherent genes. Various biclustering algorithms have been developed using different bicluster formulations. Unfortunately, many useful formulations result in NP-complete problems. In this article, we investigate an efficient method for identifying a popular type of biclusters called additive model. Furthermore, parallel coordinate (PC) plots are used for bicluster visualization and analysis. 相似文献19.
Mai Kanke Kohei Nishimura Masato Kanemaki Tatsuo Kakimoto Tatsuro S Takahashi Takuro Nakagawa Hisao Masukata 《BMC cell biology》2011,12(1):8
Background
Inducible inactivation of a protein is a powerful approach for analysis of its function within cells. Fission yeast is a useful model for studying the fundamental mechanisms such as chromosome maintenance and cell cycle. However, previously published strategies for protein-depletion are successful only for some proteins in some specific conditions and still do not achieve efficient depletion to cause acute phenotypes such as immediate cell cycle arrest. The aim of this work was to construct a useful and powerful protein-depletion system in Shizosaccaromyces pombe. 相似文献20.
Jun Nagano Chikage Kakuta Chikako Motomura Hiroshi Odajima Nobuyuki Sudo Sankei Nishima Chiharu Kubo 《BioPsychoSocial medicine》2010,4(1):12