共查询到16条相似文献,搜索用时 78 毫秒
1.
14-3-3蛋白与植物细胞信号转导 总被引:2,自引:0,他引:2
14-3-3蛋白通过直接蛋白质-蛋白质相互作用对植物代谢关键酶、质膜H^+ -ATP酶等发挥广泛调节作用。越来越多证据显示14-3-3蛋白通过与转录因子和其他信号分子结合参与调控植物细胞信号转导。对植物细胞中14-3-3蛋白调控信号转导途径,尤其是植物细胞对胁迫响应的调控机制进行了综述。 相似文献
2.
3.
为进一步确定PrP蛋白与14-3-3蛋白是否发生分子间的相互作用并确定PrP蛋白与14-3-3蛋白相互作用的区域,利用免疫共沉淀、pull down和能量共振转移(FRET)实验检测PrP蛋白与人14-3-3蛋白是否发生分子间的相互作用及相互作用的部位。结果证明,PrP蛋白与人14-3-3蛋白在体外、组织水平及细胞水平均可以发生相互作用,且证实作用的部位在PrP蛋白的106-126位氨基酸。该结果为进一步研究14-3-3蛋白在Prion疾病中的影响及Prion疾病的发病机制奠定了一定基础。 相似文献
4.
5.
6.
7.
14-3-3蛋白家族的调控机制和生物学功能 总被引:1,自引:0,他引:1
14-3-3蛋白家族在真核细胞中广泛表达并高度保守,它们主要以同源/异源二聚体形式存在,可以同时与两个靶蛋白或一个靶蛋白的两个结构域相互作用。14-3-3蛋白通过磷酸化丝氨酸/苏氨酸介导和靶蛋白结合,从而发挥其调控功能。现对14-3-3蛋白的识别序列、与配体相互作用的特点,及其在细胞周期、凋亡、信号转导、线粒体/叶绿体前体蛋白跨膜转运中的调控机制和发挥的生物学功能进行综述。 相似文献
8.
14-3-3蛋白研究进展 总被引:8,自引:1,他引:7
14-3-3蛋白是高度保守的、所有真核生物细胞中都普遍存在的、在大多数生物物种中由一个基因家族编码的一类蛋白调控家族。它几乎参与生命体所有的生理反应过程,人们在各种组织细胞中发现了各种不同的14-3-3蛋白。作为与磷酸丝氨酸/苏氨酸结合的第一信号分子,14-3-3蛋白在细胞的信号转导中起着至关重要的作用,尤其是它直接参与调节蛋白激酶和蛋白磷酸化酶的活性,被称为蛋白质与蛋白质相互作用的”桥梁蛋白”;它可以与转录因子结合形成复合体,调节相关基因的表达。一些研究表明,14-3-3蛋白调控机制的紊乱可以直接导致疾病的发生,在临床上14-3-3蛋白常常可以作为诊断的标志物。 相似文献
9.
10.
11.
Although an increasing body of evidence indicates that plant MAP kinases are involved in a number of cellular processes, such
as cell cycle regulation and cellular response to abiotic stresses, hormones and pathogen attack, very little is known about
their biochemical properties and regulation mechanism. In this paper we report on the identification and characterization
of a novel member of the MAP kinase family from maize, ZmMPK6. The amino acid sequence reveals a high degree of identity with
group D plant MAP kinases. Recombinant ZmMPK6, expressed in Escherichia coli, is an active enzyme able to autophosphorylate. Remarkably, ZmMPK6 interacts in vitro with GF14-6, a maize 14-3-3 protein and the interaction is dependent on autophosphorylation. The interacting domain of ZmMPK6
is on the C-terminus and is comprised between amino acid 337 and amino acid 467. Our results represent the first evidence
of an interaction between a plant MAP kinase and a 14-3-3 protein. Possible functional roles of this association in vivo are discussed. 相似文献
12.
CDPKs and 14-3-3 Proteins: Emerging Duo in Signaling 总被引:1,自引:0,他引:1
Mélanie Ormancey Patrice Thuleau Christian Mazars Valérie Cotelle 《Trends in plant science》2017,22(3):263-272
13.
Sharon C.W. Luk Sai-ming Ngai Stephen K.W. Tsui Kwok-keung Chan Kwok-pui Fung Cheuk-yu Lee Mary M.Y. Waye 《Journal of cellular biochemistry》1998,68(2):195-199
Human heart cDNA sequencing yielded a cDNA clone that is similar in DNA and amino acid sequences to that of mouse 14-3-3 ϵ isoform. The 6xHis-tagged H1433ϵ recombinant protein was expressed in Escherichia coli and its size was approximately 30 kDa. From Northern blot results with human multiple tissues, human skeletal muscle was found to have the highest level of h1433ϵ mRNA expression, whereas Northern blots of human cancer cell lines detected the highest mRNA level of h1433ϵ in colorectal adenocarcinoma SW480. The protein expression level of h1433ϵ and Raf-1 is found to be regulated coordinately during rat heart development, and their protein expression was highest from 14.5 to 16.5 days postcoitum. J. Cell. Biochem. 68:195–199, 1998. © 1998 Wiley-Liss, Inc. 相似文献
14.
15.
16.
Isoflavonoids are plant natural compounds predominantly found in leguminous plant. They play important functions in both nitrogen fixation and stress resistance. Many clinical studies have linked dietary intake of isoflavonoids to human health benefits. Binding of 14-3-3 proteins to GmMYB176, an isoflavonoid regulator, modulates expression of key isoflavonoids gene expression and its biosynthesis. We have recently demonstrated that the interaction of 14-3-3 proteins with GmMYB176 regulates nuclear-cytoplasmic localization of GmMYB176 thereby affecting target gene expression. Here, we report GmMYB62 as a new R1 MYB client protein of soybean 14-3-3s that may function together with GmMYB176 for gene regulation in soybean. 相似文献