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Arianna Montanari You Fang Zhou Mario Fazzi D'Orsi Monique Bolotin-Fukuhara Laura Frontali Silvia Francisci 《Gene》2013
The respiratory defects associated with mutations in human mitochondrial tRNA genes can be mimicked in yeast, which is the only organism easily amenable to mitochondrial transformation. This approach has shown that overexpression of several nuclear genes coding for factors involved in mitochondrial protein synthesis can alleviate the respiratory defects both in yeast and in human cells. 相似文献