共查询到20条相似文献,搜索用时 93 毫秒
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Kida Y Kobayashi M Suzuki T Takeshita A Okamatsu Y Hanazawa S Yasui T Hasegawa K 《Cytokine》2005,29(4):159-168
Interleukin-1 (IL-1) plays a crucial role in the immunopathological responses involved with tissue destruction in chronic inflammatory diseases, such as periodontal disease, as it stimulates host cells including fibroblasts to produce various inflammatory mediators and catabolic factors. We comprehensively investigated the involvement of mitogen-activated protein kinases (MAPKs)/activator protein-1 (AP-1) and IkappaB kinases (IKKs)/IkappaBs/nuclear factor-kappaB (NF-kappaB) in IL-1beta-stimulated IL-6, IL-8, prostaglandin E(2) (PGE(2)) and matrix metalloproteinase-1 (MMP-1) production by human gingival fibroblasts (HGF). Three MAPKs, extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun N-terminal kinase (JNK), which were simultaneously activated by IL-1beta, mediated subsequent c-fos and c-jun mRNA expression and DNA binding of AP-1 at different magnitudes. IKKalpha/beta/IkappaB-alpha/NF-kappaB was also involved in the IL-1 signaling cascade. Further, IL-1beta stimulated HGF to produce IL-6, IL-8, PGE(2) and MMP-1 via activation of the 3 MAPKs and NF-kappaB, as inhibitors of each MAPK and NF-kappaB significantly suppressed the production of IL-1beta-stimulated factors, though these pathways might also play distinct roles in IL-1beta activities. Our results strongly suggest that the MAPKs/AP-1 and IKK/IkappaB/NF-kappaB cascades cooperatively mediate the IL-1beta-stimulated synthesis of IL-6, IL-8, PGE(2) and MMP-1 in HGF. 相似文献
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The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1 总被引:4,自引:0,他引:4 下载免费PDF全文
Krappmann D Wegener E Sunami Y Esen M Thiel A Mordmuller B Scheidereit C 《Molecular and cellular biology》2004,24(14):6488-6500
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An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation 下载免费PDF全文
Hai T Yeung ML Wood TG Wei Y Yamaoka S Gatalica Z Jeang KT Brasier AR 《Journal of virology》2006,80(9):4227-4241
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Correa RG Matsui T Tergaonkar V Rodriguez-Esteban C Izpisua-Belmonte JC Verma IM 《Current biology : CB》2005,15(14):1291-1295
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Y Nasuhara I M Adcock M Catley P J Barnes R Newton 《The Journal of biological chemistry》1999,274(28):19965-19972
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A dominant function of IKK/NF-kappaB signaling in global lipopolysaccharide-induced gene expression 总被引:3,自引:0,他引:3
Carayol N Chen J Yang F Jin T Jin L States D Wang CY 《The Journal of biological chemistry》2006,281(41):31142-31151