共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
The transcriptional targets of p53 in apoptosis control 总被引:25,自引:0,他引:25
6.
Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis 总被引:16,自引:0,他引:16
Munsch D Watanabe-Fukunaga R Bourdon JC Nagata S May E Yonish-Rouach E Reisdorf P 《The Journal of biological chemistry》2000,275(6):3867-3872
7.
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《EMBO reports》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Cosme-Blanco W Shen MF Lazar AJ Pathak S Lozano G Multani AS Chang S 《EMBO reports》2007,8(5):497-503
Dysfunctional telomeres induce p53-dependent cellular senescence and apoptosis, but it is not known which function is more important for tumour suppression in vivo. We used the p53 ( R172P ) knock-in mouse, which is unable to induce apoptosis but retains intact cell-cycle arrest and cellular senescence pathways, to show that spontaneous tumorigenesis is potently repressed in Terc -/- p53 ( R172P ) mice. Tumour suppression is accompanied by global induction of p53, p21 and the senescence marker senescence-associated-beta-galactosidase. By contrast, cellular senescence was unable to suppress chemically induced skin carcinomas. These results indicate that suppression of spontaneous tumorigenesis by dysfunctional telomeres requires the activation of the p53-dependent cellular senescence pathway. 相似文献
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
p53上调的凋亡调节物(p53 upregulated modulator of apoptosis,PUMA)是新近发现的一种具有促凋亡作用的p53靶基因.与以往发现的其他p53靶基因比较,PUMA在促凋亡作用中有两个重要的特点:一是PUMA几乎介导p53依赖的所有凋亡信号;二是PUMA不仅介导p53依赖的凋亡信号,而且还可以介导p53非依赖的凋亡信号.也就是说,尽管PUMA是p53靶基因,但是其在p53非依赖细胞凋亡中也发挥重要作用.由此可见,PUMA是一个强大的促凋亡因子.在心肌细胞,PUMA参与缺血/再灌注、内质网应激、阿霉素等多种刺激诱导的细胞凋亡.因此,PUMA在心肌细胞凋亡中发挥重要作用. 相似文献
19.