Applying social life cycle assessment to evaluate the use phase of mobility services: a case study in Berlin

Purpose

The main purpose of this S-LCA case study is to analyse social impacts of the use phase of mobility services is a holistic way, taking into account positive as well as negative impacts. The use phase plays an important role for the assessment of services, which is why this study exclusively focuses on the use phase assessment. That way, this study aims to contribute to answer the question whether mobility services can improve quality of life in cities.

Methods

For the analysis, seven different mobility options were chosen in the city of Berlin, Germany, including free-floating car sharing, e-scooter sharing, S-Bahn, subway, tram, bus and the car in private ownership. For the analysis, five stakeholder groups that are outlined in the S-LCA Guidelines (UNEP 2020) were taken into account: Local Community, Consumer, Worker, Value Chain Actors and Society. For a detailed analysis of all relevant aspects, 37 indicators were analysed, out of which 23 are quantitative and 14 are qualitative. For data collection, several different data sources were used, including publicly available data e.g. from statistics as well as own data from interviews.

Results and discussion

For comparability, all results are displayed on a 5-point scale from???2 to?+?2, in line with the Handbook (Goedkoop et al. 2018) and the S-LCA Guidelines (UNEP 2020). For some indicators, the results of the case study are as expected, for example regarding impacts on air quality. For other indicators, however, the results are specific for the analysed mobility services in Berlin and therefore give new insights and reveal new aspects, as for example in the case of job creation for the local community. The main challenge of this S-LCA case study was data availability and data quality, which is why assumptions and simplifications had to be made, especially regarding space occupancy and the allocation of common infrastructure.

Conclusions

This S-LCA case study provides a holistic assessment of the use phase of mobility services, taking into account five stakeholder categories and their respective social impacts. The study illustrates specific results for the city of Berlin, showing positive as well as negative social impacts of mobility services and outlines a procedure for further studies. That way, this case study contributes to answer the overlying question whether mobility services can improve quality of life in cities.

     

Mineral resources in life cycle impact assessment—part I: a critical review of existing methods

Purpose

The safeguard subject of the Area of Protection “natural Resources,” particularly regarding mineral resources, has long been debated. Consequently, a variety of life cycle impact assessment methods based on different concepts are available. The Life Cycle Initiative, hosted by the UN Environment, established an expert task force on “Mineral Resources” to review existing methods (this article) and provide guidance for application-dependent use of the methods and recommendations for further methodological development (Berger et al. in Int J Life Cycle Assess, 2020).

Methods

Starting in 2017, the task force developed a white paper, which served as its main input to a SETAC Pellston Workshop® in June 2018, in which a sub-group of the task force members developed recommendations for assessing impacts of mineral resource use in LCA. This article, based mainly on the white paper and pre-workshop discussions, presents a thorough review of 27 different life cycle impact assessment methods for mineral resource use in the “natural resources” area of protection. The methods are categorized according to their basic impact mechanisms, described and compared, and assessed against a comprehensive set of criteria.

Results and discussion

Four method categories have been identified and their underlying concepts are described based on existing literature: depletion methods, future efforts methods, thermodynamic accounting methods, and supply risk methods. While we consider depletion and future efforts methods more “traditional” life cycle impact assessment methods, thermodynamic accounting and supply risk methods are rather providing complementary information. Within each method category, differences between methods are discussed in detail, which allows for further sub-categorization and better understanding of what the methods actually assess.

Conclusions

We provide a thorough review of existing life cycle impact assessment methods addressing impacts of mineral resource use, covering a broad overview of basic impact mechanisms to a detailed discussion of method-specific modeling. This supports a better understanding of what the methods actually assess and highlights their strengths and limitations. Building on these insights, Berger et al. (Int J Life Cycle Assess, 2020) provide recommendations for application-dependent use of the methods, along with recommendations for further methodological development.

     

A social panorama within the life cycle thinking and the circular economy: a literature review

Purpose

This literature review aims to present the current methodologies that have been developed to perform a social life cycle assessment (sLCA) and to display the main differences among them. In addition to that, to identify the nexus between sLCA and circular economy (CE) and to what extent this life cycle technique has been involved within CE studies.

Methods

An analysis of scientific literature using online databases was made. A total of 76 publications, including all industry sectors worldwide, were chosen spanning 11 years, from 2009 to 2020. Special attention was made to the methodology used to assess the social impacts, the impact categories analyzed, and whether there is or not a circular economy case. All the impact categories of both UNEP/SETAC and PSIA were taken into account when doing the review, and the top three of the categories are mentioned here.

Results and discussion

The leadership of the UNEP/SETAC methodology is clear with 58 cases. Almost 90% of the case studies are focused on products while the remaining ones are related with services. Workers are the most considered stakeholder when conducting an sLCA research, followed by local communities and society. Regarding the impact assessment, the performance reference point (PRP) was the most common method used. When considering the CE even when some cases included the end-of-life stage in the system boundaries, the studies did not consider the actors from that stage; excluding these cases, one out of four articles has a link with CE, a promising proportion taking into account the early stage of both concepts (i.e., sLCA and CE).

Conclusions

UNEP/SETAC guidelines seem to be the most promising methodology due to its reception among the scientific community. However, a more industry-oriented approach is proposed by the Roundtable for Product Social Metrics (PSIA) in a way to respond to manufacturing companies’ demand. Regardless of the type of methodology to be implemented, workers represent the key stakeholder when assessing social impacts. The change in usual patterns is leading to a change in the way how stakeholders interact and therefore new and more impacts may arise, and that is the reason why it is important to include the CE into the sLCA. A series of challenges such as the feasibility of aggregating all the life cycle techniques to one (life cycle sustainability assessment), data availability, and quality are still present for the moment.

     

Life Cycle Impact Assessment—where we are, trends, and next steps: a late report from a UNEP/SETAC Life Cycle Initiative workshop and a few updates from recent developments

Purpose

The paper provides a late report from the United Nations Environment Program (UNEP)/Society of Environmental Toxicology and Chemistry (SETAC) Life Cycle Initiative workshop “Life Cycle Impact Assessment (LCIA)—where we are, trends, and next steps;” it embeds this report into recent development with regard to the envisaged development of global guidance on environmental life cycle impact assessment indicators and related methodologies.

Methods

The document is the output of the UNEP/SETAC Life Cycle Initiative’s workshop on “Life Cycle Impact Assessment—where we are, trends, and next steps.” The presentations and discussions held during the workshop reviewed the first two phases of the Life Cycle Initiative and provided an overview of current LCIA activities being conducted by the Initiative, governments and academia, as well as corporate approaches. The outcomes of the workshop are reflected in light of the implementation of the strategy for Phase 3 of the Life Cycle Initiative.

Results

The range of views provided during the workshop indicated different user needs, with regards to, amongst other things, the required complexity of the LCIA methodology, associated costs, and the selection of LCIA categories depending on environmental priorities. The workshop’s results signified a number of potential focus areas for Phase 3 of the Initiative, including capacity building efforts concerning LCIA in developing countries and emerging economies, the preparation of training materials on LCIA, the production of global guidance on LCIA, and the potential development of a broader sustainability indicators framework.

Conclusions

These suggestions have been taken into account in the strategy for Phase 3 of the Life Cycle Initiative in two flagship projects, one on global capability development on life cycle approaches and the other on global guidance on environmental life cycle impact assessment indicators. In the context of the latter project, first activities are being organized and planned. Moreover, UNEP has included the recommendations in its Rio + 20 Voluntary Commitments: UNEP and SETAC through the UNEP/SETAC Life Cycle Initiative commit to facilitate improved access to good quality life cycle data and databases as well as expanded use of key environmental indicators that allows the measurement and monitoring of progress towards the environmental sustainability of selected product chains.     

Comparative LCA of concrete with recycled aggregates: a circular economy mindset in Europe

Purpose

Construction and demolition waste (C&DW) is the largest waste stream in the European Union (EU) and all over the world. Proper management of C&DW and recycled materials—including the correct handling of hazardous waste—can have major benefits in terms of sustainability and the quality of life. The Waste Framework Directive 2008/98/EC aims to have 70% of C&DW recycled by 2020. However, except for a few EU countries, only about 50% of C&DW is currently being recycled. In the present research, the environmental impact of concrete with recycled aggregates and with geopolymer mixtures is analysed. The aim of the present research is to propose a comparative LCA of concrete with recycled aggregates in the context of European politics.

Methods

Life cycle assessment (LCA) methodology is applied using Simapro© software. A cradle to grave analysis is carried out. The results are analysed based on the database Ecoinvent 3.3 and Impact 2002+.

Results

Results show that the concrete with 25% recycled aggregates is the best solution from an environmental point of view. Furthermore, geopolymer mixtures could be a valid alternative to reduce the phenomenon of “global warming”; however, the production of sodium silicate and sodium hydroxide has a great environmental impact.

Conclusions

A possible future implementation of the present study is certainly to carry out an overall assessment and to determine the most cost-effective option among the different competing alternatives through the life cycle cost analysis.

     

Climatic impact of land use in LCA—carbon transfers between vegetation/soil and air

Background, aim, and scope  

Human use of land areas leads to impacts on nature in several ways. Within the framework of the UNEP/SETAC Life Cycle Initiative, it was stated that life cycle assessment (LCA) of land use should assess at least the impact on biodiversity, the impact on biotic production, and the impact on the regulating functions of the natural environment. This study focuses on the climatic impact of land use as determined by the CO₂ transfers between vegetation/soil and the atmosphere in the course of terrestrial release and re-storage of carbon.     

An analytic framework for social life cycle impact assessment—part 1: methodology

Purpose

This study aims to develop a new framework of social life cycle impact assessment (SLCIA) method based on the United Nations Environment Program/Society of Environmental Toxicology and Chemistry (UNEP/SETAC) Guidelines for analyzing the social impact in Taiwan, particularly in the electronics industry.

Methods

After reviewing the literature on social life cycle assessment (SLCA), we analyzed existing case studies and developed SLCIA methods based on the UNEP/SETAC Guidelines. We thereafter identified stakeholders, subcategories, and indicators in accordance with the current status of SLCA case studies and opinions from ten experts in the Taiwanese electronics industry. Both quantitative and semi-quantitative indicators were subsequently proposed to assess the social impact of workers in the Taiwanese electronics sector. Each indicator was given the score of 1 to 5 by classifying the social impact percentage of nine scales. To formulate an analytic framework for SLCIA, the weighting values of each subcategory and indicator were determined using the consistent fuzzy preference relations (CFPR) method.

Results and discussion

Seven subcategories and 19 qualitative and quantitative indicators of worker stakeholders for the electronics sector were identified based on the UNEP/SETAC Guidelines. A score of 1 to 5 is assigned to each quantitative indicator by classifying the social impact percentage of nine scales. The data obtained from companies for each quantitative indicator were subsequently transformed into social impact percentage in terms of the statistical data on social situations at the country or industry level. With regard to semi-quantitative indicators, three implementation levels of management efforts on social performance within five elements were identified. The CFPR method was then employed to determine the weights of each indicator by ten experts. Results indicated that preventing forced work practices, protecting children from having to work, and providing minimum and fair wages for workers are the three most important indicators for assessing social impact.

Conclusions

A new SLCIA method that incorporates both quantitative and semi-quantitative indicators was proposed for assessing social impact in the electronics sector in Taiwan. Nine quantitative indicators can be easily organized using available social data from government statistics as performance reference points (PRPs) to determine the social impact exerted by companies. The relative weights were determined to allow for an impact assessment and thus solve the limitation of their currently assumed equal weights. The proposed framework is examined to analyze the social impact of three production sites for semiconductor packaging and manufacturing in Taiwan.

     

The Role of SETAC in the Development of LCA

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DOI: http://dx.doi.org/10.1065/lca2006.04.019

Background

Life cycle assessments have been performed using different methods before the name was coined since about 1970 in several countries of North America and Europe. It was the merit of SETAC to start a standardization process which culminated in the LCA-guidelines ('A code of practice') in 1993. It is the aim of this paper to trace back this and further LCA-related achievements by SETAC on the basis of documents and personal memories. It may be subjective in the selection and weighting of some events, but objectivity is strived for with regard to the whole and, in my view, singular development.

Results and Discussion

Starting 1990 with two workshops in Smuggler's Notch (Vermont) and Leuven (Belgium), SETAC and SETAC Europe organized several workshops during which important topics (framework, impact assessment, data quality, etc.) were treated and published in the form of reports which are still available. The main contribution by CML and its head, Helias Udo de Haes, was a practical method of impact assessment, transforming the formerly more technocratic LCA (energy, resources, waste) into an instrument of environmental assessment of product systems. In addition, important contributions to the allocation problem were made. Starting in 1993, ISO took over the leadership in standardization and SETAC started the famous working groups in North America and Europe, often dealing with the same topics in parallel. Due to the different cultures, the results were frequently complimentary rather than harmonic. The CML-method of LCIA, widely accepted in Europe, had to wait for about 10 years to be accepted at the other side of the Atlantic. It was helpful that SETAC – meanwhile a global organization – looked for a partner in order to implement LCA all over the world. This partner was found in the 'United Nations Environmental Programme' (UNEP) and the UNEP/SETAC Life Cycle Initiative was officially launched by Klaus Töpfer in Prague in April 2002. SETAC also assumed an important role in communicating LCA via publications: workshop and conference reports, the 'code of practice', working group results and LCA News Letters. The annual meetings offered forums for LCA scientists, practitioners and users, well prepared by the LCA Steering Committee (SETAC Europe) and the LCA Advisory Group (SETAC North America).

Recommendation

. The main recommendation to SETAC is to adhere to LCA as the main environmental assessment tool for products and to expand it to a true sustainability assessment tool by adding Life Cycle Costing (LCC) and a still to be invented 'Social Life Cycle Assessment'. SETAC is to remain the scientific arm within the UNEP/SETAC LC Initiative, without loosing its identity. Working groups should be global rather than regional in the future, as suggested by the SETAC Europe LCA Steering Committee at the 2004 World Congress in Portland, Oregon.

     

CO2 methanation activated by magnetic heating: life cycle assessment and perspectives for successful renewable energy storage

Purpose

Technologies with low environmental impacts and promoting renewable energy sources are required to meet the energetic demand while facing the increase of gas emissions associated to the greenhouse effect and the depletion of fossil fuels. CO₂ methanation activated by magnetic heating has recently been reported as a highly efficient and innovative power-to-gas technology in a perspective of successful renewable energy storage and carbon dioxide valorisation. In this work, the life cycle assessment (LCA) of this process is performed, in order to highlight the environmental potential of the technology, and its competitivity with in respect to conventional heating technologies.

Methods

The IMPACT 2002+ was used for this LCA. The process studied integrates methanation, water electrolysis and CO₂ capture and separation. This “cradle-to-gate” LCA study does not consider the use of methane, which is the reaction product. The functional unit used is the energy content of the produced CH₄. The LCA was carried out using the energy mix data for the years 2020 and 2050 as given by the French Agency for Environment and Energy management (ADEME). Consumption data were either collected from literature or obtained from the LPCNO measurements as discussed by Marbaix (2019). The environmental impact of the CO₂ methanation activated by magnetic heating was compared with the environmental impact of a power-to-gas plant using conventional heating (Helmeth) and considering the environmental impact of the natural gas extraction.

Results

It is shown that the total flow rate of reactants, the source of CO₂ and the energy mix play a major role on the environmental impact of sustainable CH₄ production, whereas the lifetime of the considered catalyst has no significant influence. As a result of the possible improvements on the above-mentioned parameters, the whole process is expected to reduce by 75% in its environmental impact toward 2050. This illustrates the high environmental potential of the methanation activated by magnetic heating when coupled with industrial exhausts and renewable electricity production.

Conclusions

The technology is expected to be environmentally competitive compared with existing similar processes using external heating sources with the additional interest of being extremely dynamic in response, in line with the intermittency of renewable energy production.

     

Life cycle management: UNEP-workshop

On August 30, 2001, the first in a series of planned global workshops on Life Cycle Management was organized in Copenhagen by UNEP in cooperation with dk-TEKNIK. The workshop provided an international forum to share experiences on LCM. The specific purpose of the workshop was to define the focus of a possible UNEP programme on Life Cycle Management under the UNEP/SETAC Life Cycle Initiative. Life Cycle Management has been defined by the SETAC Europe Working Group on LCM as an integrated framework of concepts, techniques and procedures to address environmental, economic, technological and social aspects of products and organizations to achieve continuous environmental improvement from a life cycle perspective. Life Cycle Management has been requested as an additional component for the Life Cycle Initiative by business organizations as well as governments in order to provide practical approaches for management systems in this area. The breakout groups of the workshop focussed on the role of integrating environmental management practices, concepts and tools in a life cycle perspective, on the integration of socio-economic aspects of sustainability in life cycle approaches, including the definition of adequate indicators for these aspects, on the communication strategies to promote life cycle thinking, and on the demand side of LCA. The workshop closed with a consensus that the UNEP/ SETAC Life Cycle Initiative should really include a programme on Life Cycle Management with the proposed areas of work. UNEP in cooperation with SETAC should function as a global catalyser of knowledge transfer and cooperation on life cycle approaches. The key issue behind all activities would be the promotion of Life Cycle Thinking since all break-out groups mentioned the importance of well-prepared communication strategies. Another interesting outcome of the workshop is the clear interest of different stakeholders in the consideration of social and institutional effects of products, in addition to environmental and economic impacts, i.e. a sustainable development perspective.     

Facts and figures from road testing the guidance on organizational life cycle assessment

Purpose

Organizational life cycle assessment (O-LCA) is an emerging method to analyze the inputs, outputs, and environmental impacts of an organization throughout its value chain. To facilitate the method’s application, the Guidance on Organizational Life Cycle Assessment was published within the UNEP/SETAC Life Cycle Initiative and applied by 12 “road-testing” organizations. In this paper, different aspects of the road testers’ studies are displayed and analyzed according to the feedback of the road testers.

Methods

An anonymous survey about the method application was conducted among the road testers. The analysis assessed, among others: (i) which goals the organizations initially pursued and their achievement; (ii) how previous experience with environmental tools contributed to the study design; (iii) which methodological options were chosen (like the scope of the study, data collection approaches, impact assessment methods and tools, and data sources); and (iv) which methodological challenges were faced.

Results and discussion

The survey showed that analytical goals were of priority for most road testers and obtained a higher achievement level than managerial and societal goals for which either long-term measures or the inclusion of stakeholders are needed. Previous experience with product- or organization-related tools considering the whole life cycle proves useful due to available data and/or organizational models. The categorization of organizational activities, data collection, data quality assessment, and interpretation proved being the most challenging methodological elements. In addition, three cross-cutting issues of method application were identified: aligning the O-LCA study to previous environmental activities, designing the study, and availability of personnel and software resources.

Conclusions

The road-testing organizations verified the applicability and usefulness of the O-LCA Guidance and significantly widened the pool of case studies available. On the other hand, additional guidance for methodological challenges particular of the organizational level, the availability of software tools able to support O-LCA application, region-specific LCI databases, and a broadly recognized data quality assessment scheme would facilitate conducting O-LCA case studies.

     

LCM development: focusing on the LC promoters and their organizational problem-solving

Purpose

Life cycle management (LCM) implies a specific sustainability perspective which extends environmental management along the product life cycle, with the aim of decreasing negative environmental impact throughout the product chain. Research has identified that the adoption of LCM in the industry depends upon its situational adaptation to the organizational context. Even so, little is known about the specifics of this adaptation. With this paper, our aim is to add knowledge on LCM adoption and adaptation.

Methods

A systematic analysis of empirical material on life cycle (LC) activity in six multinational corporations (MNCs) is conducted, by applying a secondary analysis of qualitative data (Heaton 2008). In order to study instances of LCM adoption and adaptation, we focus on the acts and situations of LC promoters. The identified instances are analyzed through the lens of situated problem-solving (Kuhn and Jackson 2008).

Results and discussion

Sixty-seven instances of LC promotion were identified and analyzed, resulting in the identification of eight categories of problem-situations typically encountered by LC promoters. The identified problem-situations represent different situations when the organizational appropriateness of the LC approach is at stake and to which responses tailored to the organization are put forward by a LC promoter. The results bring to the fore the ubiquity of organizational and creative problem-solving, highlighting the role of LC promoters as change agents for LCM adoption, and depict the development of LCM as an emergent practice, rather than an implementation process.

Conclusions

This paper provides a first systematic analysis of LC promoters enacting a variety of responses to organizationally challenging LC situations, thus detailing the adaptation necessary for embedding LCM in the industry. Findings show that the development of LCM to a great extent is about the promotion of a LC approach, and that LC promoters need organizational knowing, in addition to LC knowing, to make the LC approach relevant to management and business.

     

Global guidance principles for life cycle assessment databases: development of training material and other implementation activities on the publication

Purpose

The paper introduces the publication on “Global Guidance Principles for Life Cycle Assessment Databases”; it focuses on the development of training material and other implementation activities on the publication.

Methods

The document is the output of the “Shonan Guidance Principles” workshop. The publication provides guidance principles for life cycle assessment (LCA) databases; this includes how to collect raw data, how to develop datasets, and how to manage databases. The publication also addresses questions concerning data documentation and review, coordination among databases, capacity building, and future scenarios. As a next step, the publication is used to prepare training material and other implementation activities.

Results

The publication was launched at the LCM 2011 Conference. Since then outreach activities have been organized in particular in emerging economies. Further developments with regard to the guidance principles are foreseen as part of a flagship project within phase 3 of the Life Cycle Initiative. Training material is being developed that will include how to set up databases and develop datasets. The topic has been taken up by United Nations Environment Programme (UNEP) in its Rio?+?20 Voluntary Commitments: UNEP and Society of Environmental Toxicology and Chemistry (SETAC) through the UNEP/SETAC Life Cycle Initiative commit to facilitate improved access to good quality life cycle data and databases as well as expanded use of key environmental indicators that allows the measurement and monitoring of progress towards the environmental sustainability of selected product chains.

Conclusions

The adoption of the “Global Guidance Principles” publication as a de facto global standard is expected to facilitate the work of database teams, especially, in developing countries, and the collaboration in regional networks. These efforts are supported by the development of training material and other implementation activities.     

Multi‐taxon and forest structure sampling for identification of indicators and monitoring of old‐growth forest

Abstract

The most commonly used old‐growth forest indicators are structural attributes; nevertheless, they do not necessarily represent the biodiversity value of old‐growth forests. The aim of this study is to analyse the relationships between species richness data of different taxa and structural indicators of old‐growth and to identify taxonomic/functional groups, species and structural attributes that may be used as indicators of old‐growth. To achieve this goal we sampled forest structure, vascular plants, lichens, bryophytes, fungi, saproxylic beetles and birds in mature and old‐growth stands in southern Italy. We calculated Spearman’s correlation coefficients between species richness data and structural attributes. Analyses of indicator species, co‐occurrences and two‐way clusters were performed on the multi‐taxonomic list. The group of vascular plants most significantly correlated with other groups in terms of species richness; furthermore, it displays the highest proportion of between‐group co‐occurrences. The resulting multi‐taxonomic list of potential indicators may serve as an effective means of detecting and monitoring forest ecosystems; however, for this goal, structure‐based indicators, such as forest structural attributes and vascular plant species composition, are of primary importance.     

Microstructural and mechanical insight into atherosclerotic plaques: an ex vivo DTI study to better assess plaque vulnerability

Non-invasive microstructural characterisation has the potential to determine the stability, or lack thereof, of atherosclerotic plaques and ultimately aid in better assessing plaques’ risk to rupture. If linked with mechanical characterisation using a clinically relevant imaging technique, mechanically sensitive rupture risk indicators could be possible. This study aims to provide this link–between a clinically relevant imaging technique and mechanical characterisation within human atherosclerotic plaques. Ex vivo diffusion tensor imaging, mechanical testing, and histological analysis were carried out on human carotid atherosclerotic plaques. DTI-derived tractography was found to yield significant mechanical insight into the mechanical properties of more stable and more vulnerable microstructures. Coupled with insights from digital image correlation and histology, specific failure characteristics of different microstructural arrangements furthered this finding. More circumferentially uniform microstructures failed at higher stresses and strains when compared to samples which had multiple microstructures, like those seen in a plaque cap. The novel findings in this study motivate diagnostic measures which use non-invasive characterisation of the underlying microstructure of plaques to determine their vulnerability to rupture.

Graphic abstract

     

Sleep Disturbance and Alzheimer’s Disease: The Glial Connection

Poor quality and quantity of sleep are very common in elderly people throughout the world. Growing evidence has suggested that sleep disturbances could accelerate the process of neurodegeneration. Recent reports have shown a positive correlation between sleep deprivation and amyloid-β (Aβ)/tau aggregation in the brain of Alzheimer’s patients. Glial cells have long been implicated in the progression of Alzheimer’s disease (AD) and recent findings have also suggested their role in regulating sleep homeostasis. However, how glial cells control the sleep–wake balance and exactly how disturbed sleep may act as a trigger for Alzheimer’s or other neurological disorders have recently gotten attention. In an attempt to connect the dots, the present review has highlighted the role of glia-derived sleep regulatory molecules in AD pathogenesis.

Graphical Abstract

Role of glia in sleep disturbance and Alzheimer’s progression.

     

Implementing the guidelines for social life cycle assessment: past,present, and future

The International Journal of Life Cycle Assessment - This paper takes a critical review of the UNEP/SETAC (2009) Guidelines for social life cycle assessment (S-LCA) of products. This paper,...     

The emerging role of miR-200 family in metastasis: focus on EMT,CSCs, angiogenesis,and anoikis

Introduction

Cancer is the second major threat to human society and one of the main challenges facing healthcare systems. One of the main problems of cancer care is the metastases of cancer cells that cause 90% of deaths due to cancer. Multiple molecular mechanisms are involved in cancer cell metastasis. Therefore, a better understanding of these molecular mechanisms is necessary for designing restrictive strategies against cancer cell metastasis. Accumulating data suggests that MicroRNAs (miRNAs) are involved in metastasis and invasion of human tumors through regulating multiple genes expression levels that are involved in molecular mechanisms of metastasis. The goal of this review is to present the molecular pathways by which the miR 200 family manifests its effects on EMT, cancer stem cells, angiogenesis, anoikis, and the effects of tumor cell metastases.

Methods

A detailed literature search was conducted to find information about the role of the miR-200 family in the processes involved in metastasis in various databases.

Results

Numerous lines of evidence revealed an association between the mir-200 family and metastasis of human tumors by impressing processes such as cancer stem cells, EMT, angiogenesis, and anoikis.

Conclusions

Understanding the molecular mechanisms associated with metastasis in which the miR-200 family is involved can be effective in treating metastatic cancers.

Graphic abstract

     

Ecological indicators to capture the effects of fishing on biodiversity and conservation status of marine ecosystems

IndiSeas (“Indicators for the Seas”) is a collaborative international working group that was established in 2005 to evaluate the status of exploited marine ecosystems using a suite of indicators in a comparative framework. An initial shortlist of seven ecological indicators was selected to quantify the effects of fishing on the broader ecosystem using several criteria (i.e., ecological meaning, sensitivity to fishing, data availability, management objectives and public awareness). The suite comprised: (i) the inverse coefficient of variation of total biomass of surveyed species, (ii) mean fish length in the surveyed community, (iii) mean maximum life span of surveyed fish species, (iv) proportion of predatory fish in the surveyed community, (v) proportion of under and moderately exploited stocks, (vi) total biomass of surveyed species, and (vii) mean trophic level of the landed catch. In line with the Nagoya Strategic Plan of the Convention on Biological Diversity (2011–2020), we extended this suite to emphasize the broader biodiversity and conservation risks in exploited marine ecosystems. We selected a subset of indicators from a list of empirically based candidate biodiversity indicators initially established based on ecological significance to complement the original IndiSeas indicators. The additional selected indicators were: (viii) mean intrinsic vulnerability index of the fish landed catch, (ix) proportion of non-declining exploited species in the surveyed community, (x) catch-based marine trophic index, and (xi) mean trophic level of the surveyed community. Despite the lack of data in some ecosystems, we also selected (xii) mean trophic level of the modelled community, and (xiii) proportion of discards in the fishery as extra indicators. These additional indicators were examined, along with the initial set of IndiSeas ecological indicators, to evaluate whether adding new biodiversity indicators provided useful additional information to refine our understanding of the status evaluation of 29 exploited marine ecosystems. We used state and trend analyses, and we performed correlation, redundancy and multivariate tests. Existing developments in ecosystem-based fisheries management have largely focused on exploited species. Our study, using mostly fisheries independent survey-based indicators, highlights that biodiversity and conservation-based indicators are complementary to ecological indicators of fishing pressure. Thus, they should be used to provide additional information to evaluate the overall impact of fishing on exploited marine ecosystems.     

Land use impacts on biodiversity in LCA: a global approach

Purpose

Land use is a main driver of global biodiversity loss and its environmental relevance is widely recognized in research on life cycle assessment (LCA). The inherent spatial heterogeneity of biodiversity and its non-uniform response to land use requires a regionalized assessment, whereas many LCA applications with globally distributed value chains require a global scale. This paper presents a first approach to quantify land use impacts on biodiversity across different world regions and highlights uncertainties and research needs.

Methods

The study is based on the United Nations Environment Programme (UNEP)/Society of Environmental Toxicology and Chemistry (SETAC) land use assessment framework and focuses on occupation impacts, quantified as a biodiversity damage potential (BDP). Species richness of different land use types was compared to a (semi-)natural regional reference situation to calculate relative changes in species richness. Data on multiple species groups were derived from a global quantitative literature review and national biodiversity monitoring data from Switzerland. Differences across land use types, biogeographic regions (i.e., biomes), species groups and data source were statistically analyzed. For a data subset from the biome (sub-)tropical moist broadleaf forest, different species-based biodiversity indicators were calculated and the results compared.

Results and discussion

An overall negative land use impact was found for all analyzed land use types, but results varied considerably. Different land use impacts across biogeographic regions and taxonomic groups explained some of the variability. The choice of indicator also strongly influenced the results. Relative species richness was less sensitive to land use than indicators that considered similarity of species of the reference and the land use situation. Possible sources of uncertainty, such as choice of indicators and taxonomic groups, land use classification and regionalization are critically discussed and further improvements are suggested. Data on land use impacts were very unevenly distributed across the globe and considerable knowledge gaps on cause–effect chains remain.

Conclusions

The presented approach allows for a first rough quantification of land use impact on biodiversity in LCA on a global scale. As biodiversity is inherently heterogeneous and data availability is limited, uncertainty of the results is considerable. The presented characterization factors for BDP can approximate land use impacts on biodiversity in LCA studies that are not intended to directly support decision-making on land management practices. For such studies, more detailed and site-dependent assessments are required. To assess overall land use impacts, transformation impacts should additionally be quantified. Therefore, more accurate and regionalized data on regeneration times of ecosystems are needed.