Language, gesture, skill: the co-evolutionary foundations of language

This paper defends a gestural origins hypothesis about the evolution of enhanced communication and language in the hominin lineage. The paper shows that we can develop an incremental model of language evolution on that hypothesis, but not if we suppose that language originated in an expansion of great ape vocalization. On the basis of the gestural origins hypothesis, the paper then advances solutions to four classic problems about the evolution of language: (i) why did language evolve only in the hominin lineage? (ii) why is language use an evolutionarily stable form of informational cooperation, despite the fact that hominins have diverging evolutionary interests? (iii) how did stimulus independent symbols emerge? (iv) what were the origins of complex, syntactically organized symbols? The paper concludes by confronting two challenges: those of testability and of explaining the gesture-to-speech transition; crucial issues for any gestural origins hypothesis.     

A Biochip for Genotyping Polymorphisms Associated with Eye,Hair, Skin Color,AB0 Blood Group,Sex, Y Chromosome Core Haplogroup,and Its Application to Study the Slavic Population

Molecular Biology - This paper presents a method for genotyping a panel of 60 single nucleotide polymorphisms (SNPs) using single-stage PCR followed by hybridization on a hydrogel biochip. The pool...     

中国刺触螨科一新纪录亚属及两新种记述(蜱螨亚纲,水螨群,刺触螨科)

记述了采自宁夏回族自治区泾源县野荷谷和新疆维吾尔族自治区吐鲁番市三堡乡的中国刺触螨科一新纪录亚属:杂刺触螨亚属Mixosperchon Viets,1926及两新种:凹须刺触螨Sperchon(Mixosperchon)curvipalpis Zhang et Jin,sp.nov.和吐鲁番刺触螨Sperchon(Mixosperchon)turfanensis Zhang et Jin,sp.nov..模式标本保存于贵州大学昆虫研究所.     

Complex systems, evolution, and animal models

In this paper, we respond to arguments made concerning our position regarding animal models (Shelley, 2010) by briefly examining the fact that animals (human and nonhuman) are complex systems that have different evolutionary trajectories. This historical fact has implications for using animals as predictive models for human response to drugs and disease.     

中国贵州宽阔水自然保护区蚋相初报及三新种描述(双翅目,蚋科)(英文)

首次记载贵州省宽阔水自然保护区蚋科Simuliidae14种,并记述其中3新种,包括遵义蚋Simulium(Simulium)zunyiense sp.nov.和新尖板蚋Simulium(Simulium)neoacontum sp.nov.以及隶属于山蚋亚属Simulium(Montisimulium)的离板山蚋Simulium(Montisimulium)separatum sp.nov.。模式标本存放于贵阳医学院生物学教研室。遵义蚋,新种S.(S.)zunyiense sp.nov.(图1～13)隶属于蚋亚属杂色蚋组variegatum group,与本组已知近缘种主要区别在雄尾结构,如生殖肢端节,生殖腹板和中骨的形状特殊。正模♂,贵州遵义市宽阔水自然保护区(28°12’N,107°18’E;海拔1483m),2010-09-20,修江帆,陈黔采。词源:新种种名源自模式产地。新尖板蚋,新种S.(S.)neoacontum sp.nov.(图14～19)隶属于蚋亚属淡足蚋组malyschevi group,与尖板蚋S.(S.)acontum Clen et al.,近似,但雄虫生殖肢端节,生殖腹板和中骨的形状迥异,此外,其呼吸丝排列方式也有明显差异。正模♂,贵州宽阔水自然保护区让水(28°17’N,107°08’E;海拔682m),2010-08-13,修江帆采。词源:新种种名源自其形态极似尖板蚋S.(S.)acontum,冠以"neo"以示区别。离板山蚋,新种S.(Montisimulium)separatum sp.nov.(图20～28)隶属于山蚋亚属Subgenus Montimulium与绒丝山蚋S.(M.)nemoriragum(Datta,1973)近似,主要区别是雌虫生殖板内缘远离,蛹呼吸丝背对具短茎。此外,幼虫头扇毛和肛鳃次生叶数目也有明显差异。正模♀,贵州宽阔水自然保护区大洞(28°12’N,107°18’E;海拔1483m),2010-08-20,修江帆,陈黔采。词源:新种种名源自其雌虫生殖板内缘分离。     

SLV310, a novel,potential antipsychotic,combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition

In this paper, SLV310 is presented as a novel, potential antipsychotic displaying the interesting combination of potent dopamine D(2) receptor antagonism and serotonin reuptake receptor inhibition in one molecule. As such, SLV310 could be useful in treating a broad range of symptoms in schizophrenia. This paper describes the structure-activity relationship in a series of compounds leading to SLV310 (6b, 2-[4-[4-(5-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-butyl]-phthalimide) together with pharmacological data showing the unique profile of this compound.     

中国花天牛亚科一新纪录种——拉维花天牛

记述采自云南和西藏的中国花天牛亚科1新纪录种,拉维花天牛Leptura lavinia Gahan,1906。检视标本保存在广西师范大学生命科学学院昆虫标本室。     

Bonding, postpartum dysphoria, and social ties

Since the late 1970s, disruptions and “failure” of maternal-infant bonding have been causally linked to postpartum depression. Part I of this paper examines the grounds for this connection while tracing the ramifications of bonding theory (Klaus and Kennell 1976) through obstetrics, pediatrics, and psychiatry, as well as in the (mis)representations of it in the popular media. This discussion resolves into a view of maternal attachment as a long-term development progressively established through intensive mother-infant interaction. The forms of this interaction are phylogenetically determined, albeit culturally and personally mediated. Flowing from this premise, Part II of the paper casts postpartum depression as an adaptive response to threat (from whatever cause) to adequate mothering, and develops an argument for the evolutionary role of enacted social ties in the establishment of maternal responsiveness.     

Research, Informed Consent, and the Limits of Disclosure

According to this paper, respect for informed consent implies that subjects should often be told a good deal more than ethical guidelines explicitly or implicitly require. Unless subjects are informed of the researchers' personal characteristics, views, and sponsors whenever they would be likely to consider them significant, their autonomy is being overridden. However, overriding subjects' autonomy is sometimes required by the interests of researchers in not being discriminated against or suffering intrusions into their privacy. This paper resolves the conflict between informed consent and the interests of researchers by recommending that (i) subjects generally should be told of the personal characteristics of researchers when relevant as part of the researchers' job and (ii) that subjects should be told of researchers' views when conceptually connected to the research and (iii) that subjects should almost always be told about sponsorship. While the paper explicitly limits the role of informed consent, these recommendations go significantly beyond most guidelines in their requirements about what information should be disclosed.     

中国雄尾螨二新纪录种记述(蜱螨亚纲,水螨群,雄尾螨科)

记述了采自宁夏和福建的中国雄尾螨科2新纪录种:雄尾螨属Arrenurus Duges,1834的大雪山雄尾螨A.(A.)daisetsuensis Imamura,1951和旗月雄尾螨A.(A.)velifer Lundblad,1969,并对这2个种进行描述和补充绘图。     

Highly Stretchable,Sparse, Metallized Nanofiber Webs as Thin,Transferrable Transparent Conductors

The need for transparent conductors (TCs) that are capable of withstanding high mechanical deformation in comparison to the brittle indium tin oxide (ITO) films is paramount for roll‐to‐roll production of flexible and stretchable displays, signage systems, lighting devices and solar panels with stringent weatherability requirements. This paper reports a highly stretchable TC comprising of a web of core‐shell nanofibers, which mimics the fibrous structure of natural systems such as veins of a leaf or nerve systems. The TC web demonstrates high transparency, low sheet resistance, and unprecedented stretchability and stability over repeated stretching. The nanofiber TC web can be transferred to different substrates, which is manifested by the transfer onto an organic solar cell, demonstrating a photovoltaic performance comparable to that of a device with an ITO electrode. This work presents a technological platform, scalable for the manufacturing of large area transparent conductors for flexible and stretchable displays, electronics and solar cells on unconventional substrates such as rubber, fabric and paper.     

Incorporating Science,Technology, Fairness,and Accountability in Environmental,Health, and Safety Decisions

The Precautionary Principle is in sharp political focus today because (1) the nature of scientific uncertainty is changing and (2) there is increasing pressure to base governmental action on more “rational” schemes, such as cost-benefit analysis and quantitative risk assessment, the former being an embodiment of ‘rational choice theory’ promoted by the Chicago school of law and economics. The Precautionary Principle has been criticized as being both too vague and too arbitrary to form a basis for rational decision making. The assumption underlying this criticism is that any scheme not based on cost-benefit analysis and risk assessment is both irrational and without secure foundation in either science or economics. This paper contests that view and makes explicit the rational tenets of the Precautionary Principle within an analytical framework as rigorous as uncertainties permit, and one that mirrors democratic values embodied in regulatory, compensatory, and common law. Unlike other formulations that reject risk assessment, this paper argues that risk assessment can be used within the formalism of tradeoff analysis—a more appropriate alternative to traditional cost-benefit analysis and one that satisfies the need for well-grounded public policy decision making. This paper will argue that the precautionary approach is the most appropriate basis for policy, even when large uncertainties do not exist, especially where the fairness of the distributions of costs and benefits of hazardous activities and products are a concern. Furthermore, it will offer an approach to making decisions within an analytic framework, based on equity and justice, to replace the economic paradigm of utilitarian cost-benefit analysis.     

Techniques of EMG signal analysis: detection, processing, classification and applications

Electromyography (EMG) signals can be used for clinical/biomedical applications, Evolvable Hardware Chip (EHW) development, and modern human computer interaction. EMG signals acquired from muscles require advanced methods for detection, decomposition, processing, and classification. The purpose of this paper is to illustrate the various methodologies and algorithms for EMG signal analysis to provide efficient and effective ways of understanding the signal and its nature. We further point up some of the hardware implementations using EMG focusing on applications related to prosthetic hand control, grasp recognition, and human computer interaction. A comparison study is also given to show performance of various EMG signal analysis methods. This paper provides researchers a good understanding of EMG signal and its analysis procedures. This knowledge will help them develop more powerful, flexible, and efficient applications.     

中国顶丝藻科新记录Ⅳ

继续报导中国顶丝藻科新记录6种。柏桉旋体藻Audouinella bonnemaisoniae,网地旋体藻A.dictyotae,德氏旋体藻A.drewii,网状旋体藻A.netrocarpa,太平洋旋体藻A.pacilica,异形旋体藻A.vaga。     

海南皱鞘天牛属一新种（鞘翅目：天牛科，沟胫天牛亚科）

记述采自海南的沟胫天牛亚科皱鞘天牛属Parapolytrechus Breuning一新种：黄跗皱鞘天牛P. flavotarsus Wang et Zheng, sp.nov.。模式标本保存于南开大学生物系昆虫标本室。     

中国软滑水螨一新纪录属及一新种记述(蜱螨亚纲,水螨群,软滑水螨科)

记述了采自黑龙江省伊春市呼兰河的中国软滑水螨一新纪录属:妖水螨属嘞Tiphys Koch,1836,及1新种:伊春妖水螨 Tiphys yichunensis sp.nov,.新种与分布于俄罗斯的近疤妖水螨Tiphys scaurellus Tuzovskij,1983近似,区别在于:新种P-Ⅳ背面起始端亚中部具1栓毛,近疤妖水螨缺失;新种足雄螨足Ⅲ爪特化,其中一爪为钩状简单爪,另一爪中、基部膨大,近疤妖水螨雄螨足Ⅲ爪均具腹小爪;新种雄螨Ⅳ.L4近筒状,近疤妖水螨雄螨Ⅳ.L-4从基部至端部逐渐膨大.     

The effect of the anabolic agent,clenbuterol, on overloaded rat skeletal muscle

The dietary administration of clenbuterol to young male rats has been shown to produce a muscle specific hypertrophic growth response. This paper demonstrates that the combined effect of drug treatment and hypertrophic stimulus induced by tenotomy produced an additive effect on muscle growth. This effect was demonstrated in terms of both muscle composition (protein and RNA) and fibre size.     

环境中胞内胞外抗性基因的分离检测、分布与传播

抗生素抗性基因(ARGs)传播对人类健康具有潜在的风险。胞内抗性基因(iARGs)和胞外抗性基因(eARGs)是抗生素抗性基因的两种存在形式,其在不同环境介质中的分布与传播过程具有截然不同的特征。本文首先基于ARGs赋存形态的差异,对染色体抗性基因、质粒抗性基因、噬菌体抗性基因等ARGs的胞内/胞外分类给予明确界定,并根据环境样品来源归纳了现有分离检测技术的应用场景,总结了iARGs和eARGs在养殖场、污水处理厂、河道、海洋、大气等环境中的分布特征,同时比较了其在传播方式和传播能力上的差异,以期为ARGs的分类阻控和健康风险评估提供理论参考。     

Caspase activation, inhibition, and reactivation: a mechanistic view

Caspases, a unique family of cysteine proteases, execute programmed cell death (apoptosis). Caspases exist as inactive zymogens in cells and undergo a cascade of catalytic activation at the onset of apoptosis. The activated caspases are subject to inhibition by the inhibitor-of-apoptosis (IAP) family of proteins. This inhibition can be effectively removed by diverse proteins that share an IAP-binding tetrapeptide motif. Recent structural and biochemical studies have revealed the underlying molecular mechanisms for these processes in mammals and in Drosophila. This paper reviews these latest advances.     

桐柏山维蚋一新种(双翅目,蚋科)

记述湖北省桐柏山维蚋1新种.模式标本存放于贵阳医学院生物学教研室.桐柏山维蚋,新种Simulium(Wilhelmia)tongbaishanense sp.nov.(图1～16)根据蛹的形状,新种似与高桥维蚋、兴义维蚋和北京维蚋近缘.但可根据成虫足的颜色、雌虫外生殖器的形状、蛹的头和前胸疣突缺如、幼虫后颊裂形状等综合特征与上述近缘种相区别.正模♀,副模1♀,2♂♂,11蛹及2幼虫,2004-08-10,幼虫和蛹采自湖北桐柏山急流中水草.