共查询到20条相似文献,搜索用时 640 毫秒
1.
Michael D Hill Philip A Barber Andrew M Demchuk Robert J Sevick Richard Frayne Alastair M Buchan 《BMC neurology》2001,1(1):1-3
Background
Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. 相似文献2.
Background
There are some early clinical indicators of cardiac ischemia, most notably a change in a person's electrocardiogram. Less well understood, but potentially just as dangerous, is ischemia that develops in the gastrointestinal system. Such ischemia is difficult to diagnose without angiography (an invasive and time-consuming procedure) mainly due to the highly unspecific nature of the disease. 相似文献3.
Yong Li Dingguo Zhang Yuqing Zhang Guoping He Fumin Zhang 《Journal of biomedical science》2010,17(1):75
Objectives
We postulated that combining high-dose simvastatin with bone marrow derived-mesenchymal stem cells (MSCs) delivery may give better prognosis in a mouse hindlimb ischemia model. 相似文献4.
David Tanne Noa Molshatzki Oleg Merzeliak Rakefet Tsabari Maya Toashi Yvonne Schwammenthal 《BMC neurology》2010,10(1):22
Background
In the setting of an acute stroke, anemia has the potential to worsen brain ischemia, however, the relationship between the entire range of hemoglobin to long-term outcome is not well understood. 相似文献5.
Vilmante Borutaite Ramune Morkuniene Odeta Arandarcikaite Aiste Jekabsone Jurgita Barauskaite Guy C Brown 《Journal of biomedical science》2009,16(1):70-12
Background
Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isolated rat heart, and, if so, by what mechanisms. 相似文献6.
Alexander C Langheinrich Mesut Yeniguen Anne Ostendorf Simone Marhoffer Marian Kampschulte Georg Bachmann Erwin Stolz Tibo Gerriets 《BMC neurology》2010,10(1):36
Background
Animal models of focal cerebral ischemia are widely used in stroke research. The purpose of our study was to evaluate and compare the cerebral macro- and microvascular architecture of rats in two different models of permanent middle cerebral artery occlusion using an innovative quantitative micro- and nano-CT imaging technique. 相似文献7.
Jia Y Guo Tong Yang Xiang G Sun Ni Y Zhou Fu S Li Dan Long Tao Lin Ping Y Li Li Feng 《Journal of biomedical science》2011,18(1):79
Background
Ischemic postconditioning (IPO) has been demonstrated to attenuate ischemia/reperfusion (I/R) injury in the heart and brain, its roles to liver remain to be defined. The study was undertaken to determine if IPO would attenuate liver warm I/R injury and its protective mechanism. 相似文献8.
Clifford DL Folmes Grzegorz Sawicki Virgilio JJ Cadete Grant Masson Amy J Barr Gary D Lopaschuk 《Proteome science》2010,8(1):38
Background
During and following myocardial ischemia, glucose oxidation rates are low and fatty acids dominate as a source of oxidative metabolism. This metabolic phenotype is associated with contractile dysfunction during reperfusion. To determine the mechanism of this reliance on fatty acid oxidation as a source of ATP generation, a functional proteomics approach was utilized. 相似文献9.
Shaoyang Chen Lize Xiong Qiang Wang Hanfei Sang Zhenhua Zhu Hailong Dong Zhihong Lu 《BMC neurology》2002,2(1):1-6
Background
Lower limb paralysis occurs in 11% of patients after surgical procedure of thoracic or thoracoabdominal aneurysms and is an unpredictable and distressful complication. The aim of this study was to investigate the effects of tetramethylpyrazine (TMP), an intravenous drug made from traditional Chinese herbs, on the neurologic outcome and hisotpathology after transient spinal cord ischemia in rabbits. 相似文献10.
Background
The clinical and radiological aspects of hypoxic brain injury without ischemia are not well characterized. A spectrum of clinical manifestations have been observed in patients that recover from hypoxic brain injury, including a subset that demonstrate persistent motor system disturbances. Early Magnetic Resonance Imaging (MRI) studies have shown abnormalities in basal ganglia, cerebral and cerebellar cortex. 相似文献11.
Maria A Macri Nicola D'Alessandro Camillo Di Giulio Patrizia Di Iorio Silvano Di Luzio Patricia Giuliani Ennio Esposito Mieczyslaw Pokorski 《Journal of biomedical science》2010,17(1):14
Background
Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magnetic resonance spectroscopy was used to evaluate regional metabolic alterations, following a 24-hour hypoxic or hyperoxic exposure on the background of ischemic brain insult, in two contrasting age-groups of rats: young - 3 months old and aged - 24 months old. 相似文献12.
Yuko Takahashi Shiori Haga Yukihito Ishizaka Akio Mimori 《Arthritis research & therapy》2010,12(3):R85
Introduction
Angiotensin-converting enzyme (ACE) 2, a homolog of ACE, converts angiotensin (Ang) II into Ang(1-7), and the vasoprotective effects of Ang(1-7) have been documented. We explored the hypothesis that serum autoantibodies to ACE2 predispose patients with connective tissue diseases to constrictive vasculopathy, pulmonary arterial hypertension (PAH), or persistent digital ischemia. 相似文献13.
Armin Schneider Rainer Wysocki Claudia Pitzer Carola Krüger Rico Laage Stefan Schwab Alfred Bach Wolf-Rüdiger Schäbitz 《BMC biology》2006,4(1):36-8
Background
Granulocyte-colony stimulating factor (G-CSF) is known as a powerful regulator of white blood cell proliferation and differentiation in mammals. We, and others, have shown that G-CSF is effective in treating cerebral ischemia in rodents, both relating to infarct size as well as functional recovery. G-CSF and its receptor are expressed by neurons, and G-CSF regulates apoptosis and neurogenesis, providing a rational basis for its beneficial short- and long-term actions in ischemia. In addition, G-CSF may contribute to re-endothelialisation and arteriogenesis in the vasculature of the ischemic penumbra. In addition to these trophic effects, G-CSF is a potent neuroprotective factor reliably reducing infarct size in different stroke models. 相似文献14.
Attila Cselenyák Eszter Pankotai Eszter M Horváth Levente Kiss Zsombor Lacza 《BMC cell biology》2010,11(1):29
Background
Bone marrow derived mesenchymal stem cells (MSCs) are promising candidates for cell based therapies in myocardial infarction. However, the exact underlying cellular mechanisms are still not fully understood. Our aim was to explore the possible role of direct cell-to-cell interaction between ischemic H9c2 cardiomyoblasts and normal MSCs. Using an in vitro ischemia model of 150 minutes of oxygen glucose deprivation we investigated cell viability and cell interactions with confocal microscopy and flow cytometry. 相似文献15.
Pierre Theroux Bernard R Chaitman Leif Erhardt Andreas Jessel Thomas Meinertz Wolf-Ulrich Nickel John S Schroeder Gianni Tognoni Harvey White James T Willerson 《Trials》2000,1(1):59-9
Background
Direct myocardial cell protection in patients with unstable angina or evolving myocardial infarction (MI) could prevent cell necrosis or reduce its extent, and minimize the risk of MI and death associated with percutaneous coronary interventions (PCIs) and coronary artery bypass surgery. The myocardial NHE plays a critical role in mediating the progression of ischemia to necrosis by promoting intracellular accumulation of sodium and calcium in exchange for hydrogen. Blockage of the system in various experimental models of ischemia and reperfusion had a strong antinecrotic effect. The present paper describes a trial that was intended to investigate the potential clinical benefit of cariporide, a potent and selective inhibitor of the NHE, in a large spectrum of at-risk patients. 相似文献16.
Wu J Ekman C Jönsen A Sturfelt G Bengtsson AA Gottsäter A Lindblad B Lindqvist E Saxne T Dahlbäck B 《Arthritis research & therapy》2011,13(2):R62
Introduction
Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI). 相似文献17.
Background
We have recently shown that δ-opioid receptors (DORs) play an important role in neuroprotection from hypoxic injury via the regulation of extracellular signaling-regulated kinase (ERK) and cytochrome c release. Since ERK and cytochrome c are differentially involved in caspase signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion, we considered if DOR activation protects the ischemic brain by attenuating oxidative injury. 相似文献18.
Se-Chan Kim Alexander Ghanem Heidi Stapel Klaus Tiemann Pascal Knuefermann Andreas Hoeft Rainer Meyer Christian Grohé Anne A Knowlton Georg Baumgarten 《BMC physiology》2007,7(1):5
Backgound
It has been reported that Toll-like receptor 4 (TLR4) deficiency reduces infarct size after myocardial ischemia/reperfusion (MI/R). However, measurement of MI/R injury was limited and did not include cardiac function. In a chronic closed-chest model we assessed whether cardiac function is preserved in TLR4-deficient mice (C3H/HeJ) following MI/R, and whether myocardial and systemic cytokine expression differed compared to wild type (WT). 相似文献19.
Troponin elevation in acute ischemic stroke (TRELAS) - protocol of a prospective observational trial
Jan F Scheitz Hans-Christian Mochmann Christian H Nolte Karl G Haeusler Heinrich J Audebert Peter U Heuschmann Ulrich Laufs Bernhard Witzenbichler Heinz-Peter Schultheiss Matthias Endres 《BMC neurology》2011,11(1):98
Background
Levels of the cardiac muscle regulatory protein troponin T (cTnT) are frequently elevated in patients with acute ischemic stroke and elevated cTnT predicts poor outcome and mortality. The pathomechanism of troponin release may relate to co-morbid coronary artery disease and myocardial ischemia or, alternatively, to neurogenic cardiac damage due to autonomic activation after acute ischemic stroke. Therefore, there is uncertainty about how acute ischemic stroke patients with increased cTnT levels should be managed regarding diagnostic and therapeutic workup. 相似文献20.