共查询到20条相似文献,搜索用时 15 毫秒
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A selection of World Wide Web sites relevant to the reviews published in this issue of Current Opinion in Neurobiology. 相似文献
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James Ashe Abdel El Manira Bambos Kyriacou Stephen F Goodwin Andrew Lumsden Susan Chapman Stefan Jungbluth Esther Bell Ana Coutinho Moheb Costandi Niels Adams Renee Dutton Mark Mayford Barbara Knowlton Michael Husser Venkatesh N Murthy John N Wood John A Assad Morgan Sheng Marie T Filbin Jin Qiu Eugene P Brandon Fred H Gage 《Current opinion in neurobiology》1999,9(6):645
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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In the past year, candidates have been identified for two long-sought classes of molecules, insect odorant receptors and mammalian taste receptors. In addition, genes directing receptor gene expression and the development of specific chemosensory neurons have been described in Drosophila melanogaster and Caenorhabditis elegans. Finally, recent physiological experiments have provided new insights into the mechanisms by which chemosensory information is processed. 相似文献
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Live-cell imaging has yielded surprising pictures of subcellular structures and dynamics in living plant cells. Recent studies illustrate the power of live-cell observation for revealing new biological phenomena and for generating new questions about plant cell structure and function. 相似文献
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HIV undergoes rapid genetic variation; this variation is caused primarily by the enormous number of viruses produced daily in an infected individual. Because of this variation, HIV presents a moving target for drug and vaccine development. The variation within individuals has led to the generation of diverse HIV-1 subtypes, which further complicates the development of effective drugs and vaccines. In general, it is more difficult to hit a moving target than a stationary target. Two broad strategies for hitting a moving target (in this case, HIV replication) are to understand the movement and to aim at the portions that move the least. In the case of anti-HIV drug development, the first option can be addressed by understanding the mechanism(s) of drug resistance and developing drugs that effectively inhibit mutant viruses. The second can be addressed by designing drugs that interact with portions of the viral machinery that are evolutionarily conserved, such as enzyme active sites. 相似文献
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Funneling auxin action: specificity in signal transduction 总被引:11,自引:0,他引:11
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Polyubiquitin chains: polymeric protein signals 总被引:1,自引:0,他引:1
The 76-residue protein ubiquitin exists within eukaryotic cells both as a monomer and in the form of isopeptide-linked polymers called polyubiquitin chains. In two well-described cases, structurally distinct polyubiquitin chains represent functionally distinct intracellular signals. Recently, additional polymeric structures have been detected in vivo and in vitro, and several large families of proteins with polyubiquitin chain-binding activity have been discovered. Although the molecular mechanisms governing specificity in chain synthesis and recognition are still incompletely understood, the scope of signaling by polyubiquitin chains is likely to be broader than originally envisioned. 相似文献
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Jean-Louis Boulay 《Current opinion in biotechnology》1999,10(6):523
A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Biotechnology. 相似文献
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The fundamental role of glycoconjugates in many biological processes is now well appreciated and has intensified the development of innovative and improved synthetic strategies. All areas of synthetic methodology have seen major advances and many complex, highly branched carbohydrates and glycoproteins have been prepared using solution- and/or solid-phase approaches. The development of an automated oligosaccharide synthesizer provides rapid access to biologically relevant compounds. These chemical approaches help to produce sufficient quantities of defined oligosaccharides for biological studies. Synthetic chemistry also supports an improved understanding of glycobiology and will eventually result in the discovery of new therapeutics. 相似文献
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Rhythmically active neuronal networks give rise to rhythmic motor activities but also to seemingly non-rhythmic behaviors such as sleep, arousal, addiction, memory and cognition. Many of these networks contain pacemaker neurons. The ability of these neurons to generate bursts of activity intrinsically lies in voltage- and time-dependent ion fluxes resulting from a dynamic interplay among ion channels, second messenger pathways and intracellular Ca2+ concentrations, and is influenced by neuromodulators and synaptic inputs. This complex intrinsic and extrinsic modulation of pacemaker activity exerts a dynamic effect on network activity. The nonlinearity of bursting activity might enable pacemaker neurons to facilitate the onset of excitatory states or to synchronize neuronal ensembles--an interactive process that is intimately regulated by synaptic and modulatory processes. 相似文献
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M Morgan Conn Joe Kappock Dale Drueckhammer Richard Cammack Dennis Hall Tony Cass Jon D Stewart Graham RL Cousins Jeremy KM Sanders Sabine Flitsch Philip AS Lowden Richard Newman 《Current opinion in chemical biology》1999,3(6):631
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in chemical biology. 相似文献
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Recently, studies on specification of axes in the developing embryo have focused on the heart, which is the first functional organ to form and probably responds to common cues controlling positional information in surrounding tissues. The early differentiation of heart cells affords an opportunity to link the acquisition of regional identity with the signals underlying terminal differentiation. In the past year, a wealth of information on these signals has emerged, elucidating the general pathways controlling body axes in the context of the developing heart. 相似文献
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Brain development: Integrins and the Reelin pathway 总被引:4,自引:0,他引:4
Integrins link the extracellular matrix to the intracellular environment. They have been implicated in the Reelin pathway in cortical development. But new genetic studies have revealed that, while beta(1) integrin plays a role in formation of the basement membrane, it is not essential for neuronal migration. 相似文献
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Reward representations and reward-related learning in the human brain: insights from neuroimaging 总被引:22,自引:0,他引:22
O'Doherty JP 《Current opinion in neurobiology》2004,14(6):557-776
This review outlines recent findings from human neuroimaging concerning the role of a highly interconnected network of brain areas including orbital and medial prefrontal cortex, amygdala, striatum and dopaminergic mid-brain in reward processing. Distinct reward-related functions can be attributed to different components of this network. Orbitofrontal cortex is involved in coding stimulus reward value and in concert with the amygdala and ventral striatum is implicated in representing predicted future reward. Such representations can be used to guide action selection for reward, a process that depends, at least in part, on orbital and medial prefrontal cortex as well as dorsal striatum. 相似文献
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A convergence of advances in optical methods and a better understanding of the genetics of development promise to revolutionize the study of neuronal circuits and their links to behavior. One of the great challenges in systems neurobiology has been to monitor and perturb activity in populations of identified neurons in vivo. Recent work has begun to achieve this goal through a combination of modern imaging methods with genetic labeling and perturbation. 相似文献
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Ariel Blocker Mark S Peppler Jeff Stock Philippe Normand Francine Grimont Christophe dEnfert Kenneth L Rosenthal David Sibley Bernard Labedan Patrick Forterre Alex ONeill Chris Storey Lorna Casselton Jeff Errington 《Current opinion in microbiology》1999,2(6):567-577
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in microbiology. 相似文献
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A common mechanism has emerged for the control of the initiation of eukaryotic DNA replication. The minichromosome maintenance protein complex (MCM) and Cdc45 have now been recognized as central components of the initiation machinery. In addition, two types of S phase promoting kinases conserved between yeast and humans play critical roles in the initiation reaction. At the onset of S phase, S phase kinases promote the association of Cdc45 with MCM at origins. Upon the formation of the MCM-Cdc45 complex at origins, the duplex DNA is unwound and various replication proteins, including DNA polymerases, are recruited onto unwound DNA. The increasing number of newly identified factors involved in the initiation reaction indicates that the control of initiation requires highly evolved machinery in eukaryotic cells. 相似文献